基本信息

张丽娟  女  博导  中国科学院深圳先进技术研究院
电子邮件: lj.zhang@siat.ac.cn
通信地址: 中国科学院深圳先进技术研究院
邮政编码: 518055

研究领域

使用包括DTI, MRS, RS-fMRI, SWI, CESST 等功能磁共振和定量磁共振技术, 从结构, 功能, 代谢等方面深入探讨大脑发育, 衰老, 肿瘤, 缺血, 退行性改变等生理及病理机制.

招生信息

模式识别与智能系统

生物医学工程

生物化学与分子生物学

影像医学与核医学

磁共振成像

神经科学

教育背景

1995-07--1998-07   中国解放军总医院研究生院   硕士
1990-07--1995-07   哈尔滨医科大学   医学学士

工作经历

2013-10~今, 中国科学院深圳先进技术研究院, 研究员
2010-10~2013-10,中国科学院深圳先进技术研究院, 副研究员
2010-01~2010-10,Mount Sinai Medical College, 助理教授
2007-09~2009-12,Weill Cornell Medical College, 助理研究员
2002-01~2007-08,Weill Cornell Medical College, 博士后
1998-08~2002-01,南方医院, 放射科执业医师

教授课程

医学影像学基础

专利与奖励

(1) 张丽娟,黄文慧,钟耀祖,刘新,郑海荣,基于弹性成像的图像处理方法及系统. 中国 201110350385.0。授权  

(2) 张丽娟,朱燕杰,刘新,郑海荣,脑部图像处理方法和系统,中国,201310289449.X授权

(3) 郑海荣,张丽娟,刘新,钟耀祖,黄文慧,曾成志,蔡葳蕤,激励装置及其系统.中国,CN202198595U。授权

(4) 隆晓菁,张丽娟,姜春香,安一硕,刘新,郑海荣,医学图像分类方法和系统.中国,201410849727.7。授权  

(5) 周武,张丽娟,谢耀钦,基于梯度直方图分布匹配确定三维旋转量的方法和系统.中国,CN201410708512.3 2018-01-09。 授权

(6) 周武,张丽娟,谢耀钦,三维图像配准方法和系统,中国,CN104537638A2015-04-22

(7) 史彩云,张丽娟,谢国喜,张晓咏,一种磁共振大脑血氧水平测量方法,中国,201410787820.x 授权

(8) 姜春香,张丽娟,隆晓菁,刘新,郑海荣,大脑异常参数的提取方法和系统,中国,CN104346530A2015-02-11

(9) 隆晓菁,张丽娟,姜春香,刘新,郑海荣,用于脑部医学图像分类的图像预处理方法和系统,中国,2014105427997 

(10) 史彩云,张丽娟,谢国喜,刘新,冯祥,氧代谢参数估测方法和系统,中国,201310501061.1。授权  

(11) 史彩云,谢国喜,张丽娟,张晓咏,刘新,郑海荣,动态磁共振图像成像方法和系统,中国,201410545673.5 授权

(12) 史彩云,谢国喜,张丽娟,刘新,郑海荣,功能磁共振成像方法和装置,中国,201410559198.7。授权

(13) 丁玉琼,黄文慧,钟耀祖,张丽娟,刘新,郑海荣,磁共振弹性成像精确度检测方法,中国,201210460717.5 

(14) 隆晓菁,潮毅,邱本胜,张丽娟,刘新,郑海荣,图像分析方法和系统,中国,201110403723.2。授权  

(15) 丁玉琼,黄文慧,钟耀祖,张丽娟,刘新,郑海荣,磁共振弹性成像精确度检测方法,中国,201210460717.5。授权

(16) 史彩云,谢国喜,张晓咏,张丽娟,脑功能磁共振成像方法和系统,中国,201410572855.1;。授权

(17) 丁玉琼,梁栋,蔡葳蕤,钟耀祖,张丽娟,刘新,郑海荣,磁共振弹性成像中的弹性模量重建方法和系统,中国,201210572449.6 授权

(18) 钟耀祖,朱燕杰,刘新,郑海荣,张丽娟,磁共振弹性成像三维可视化方法及系统,中国,201210110880.9 授权

(19)张丽娟,蔡思琦,孟锐,姜春香,隆晓菁. 脑胶质瘤恶性程度预判模型的构建方法、装置和计算设备. 201810686593.x,申请日2018628

(20)苏适,谢国喜,张丽娟,史彩云,张晓咏,任亚楠,姜春香,张行,隆晓菁,刘新.一种磁共振T2*加权快速成像方法及装置. 2019.05.07, 中国,CN201611126358.4, 授权

(21)周武,程文强,张丽娟。一种基于影像信息融合的病灶虚拟穿刺系统。 2015.12.08, 中国,授权ZL201510896226.9

(22) 周武,张丽娟,梁长虹等.一种CT影像体表提取方法及系统. 2016.06.20, 中国,ZL201610444521.5授权

(23) 周武,张丽娟,梁长虹等.一种外科手术中CT影像体表人工标记自动提取方法。2016.06.20, 中国,ZL 201610448693.x,授权

(24) 周武,张丽娟,谢耀钦.基于梯度直方图分布匹配确定三维旋转量的方法和系统。2014.11.27, 中国,ZL 201410708512.3, 授权

(25) 周武,张丽娟,梁长虹等.一种X光图像中人工圆形标记的自动检测和定位方法。2016.06.20, 中国,ZL 201610442687.3,授权


发表论文

1.   Siqi Cai, Zhifeng Shi, Chunxiang Jiang, Kai Wang, Liang Chen, Lin Ai, Lijuan Zhang. Hemispheric specific functional remodeling and its relevance to tumor malignancy of cerebral glioma based on resting-state functional network analysis. Front Neurosci 2021; 14: 611075.

2.  Wu Zhou, Wanwei Jian, Xiaoping Cen, Lijuan Zhang, Hui Guo, Zaiyi Liu, Changhong Liang, Guangyi Wang. Prediction of Microvascular invasion of hepatocellular carcinoma with Contrast-enhanced MR using 3D Convolutional Neural Networks. Front. Oncol. doi.org/10.3389/fonc.2021.588010.

3.   Lijuan Zhang. Glioma characterization based on magnetic resonance imaging:challenge overview and future perspective. Glioma 2020; 3: 61-66.

4.  Guangyi Wang, Wanwei Jian, Xiaoping Cen, Lijuan Zhang, Hui Guo, Zaiyi Liu, Changhong Liang, Wu Zhou. Prediction of microvascular invasion of HCC based on preoperative diffusion weighted MR using deep learning. Acad Radiology 2020; https://doi.org/10.1016/j.acra.2020.11.014.

5.    Chunxiang Jiang, Li Yi, Siqi Cai, Lijuan Zhang*. Ischemic stroke in Pontine and corona radiate: Location specific impairment of neural network investigated with Resting state Fmri. Frontiers in Neurology 2019; doi.org/10.3389/fneur.2019.00575

6.   Wu Zhou, Guangyi Wang, Guoxi Xie, Lijuan Zhang. Grading of hepatocellular carcinoma based on diffusion weighted images with multiple b-values using convolutional neural networks. Medical Physics 2019;46(9): 3951-3960.

7.   Xia J, Yang Y, Hu C, Meng R, Jiang Q, Liu R, Yu Y, Sheng Z, Yan F, Zhang L, Shi Z, Zheng H, Qiu W. Evaluation of Brain Tumor in Small Animals Using Plane Wave-Based Power Doppler Imaging. Ultrasound Med Biol. 2019 Mar;45(3):811-822.

8.  Shi Su, Na Lu, Lin Jia, Xiaojing Long, Chunxiang Jiang, Hang Zhang, Ye Li,  Kaibao Sun, Rong Xue, Dharmakumar R, Lijuan Zhang, Xin Liu, Guoxi Xie. High Spatial Resolution BOLD fMRI Using Simultaneous Multislice Excitation with Echo-Shifting Gradient Echo at 7 Tesla. MRI 2018; doi: 10.1016/j.mri.2018.08.019.

9.   Xiaojing Long, Chunxiang Jiang, Lijuan Zhang*. Morphological Biomarker Differentiating MCI Converters from Non-converters: Longitudinal Evidence Based on Hemispheric Asymmetry. Behavioural Neurology 2018; 3954101.

10.  LijXiaojing Long, Lifang Chen, Chunxiang Jiang, Lijuan Zhang*. Prediction and classification of Alzheimer disease based on quantification of MRI deformation. PloS One 2017; 12(3):e0173372.

11.  Wu ZhouLijuan Zhang*Kaixin WangShuting ChenGuangyi WangZaiyi LiuChanghong Liang. Malignancy Characterization of Hepatocellular Carcinomas Based on Texture Analysis of Contrast-Enhanced MR Images. JMRI 2017; 45:1476-1484.

12.  Chunxiang Jiang, Li Yi, Shi Su, Caiyun Shi, Guoxi Xie, Lijuan Zhang*. Diurnal variations in neural activity of healthy human brain decoded with resting state blood oxygen level dependent Fmri. Frontier Hum Neurosci 2016; 10:634.

13.   Lijuan Zhang, Xin Liu, Zhaoyang Fan, Na Zhang, Yiu-cho Chung, Weiqi Liao, Hairong Zheng, Debiao Li. Noncontrast MRA of Pedal arteries in Type II diabetes: effect of disease load on vessel visibility. Academic Radiology 2015; 22:513-519.

14.   Hang Zhang, Lijuan Zhang, Yufeng Zang. Fluctuation amplitude and local synchronization of brain activity in the ultra-low frequency band: an fMRI investigation of continuous feedback of finger force. Brain Research 2015; 1629104-112.

15.  Caiyun Shi, Guoxi Xie, Xiaoyong Zhang, Shi Su, Yongqin Zhang, Lijuan Zhang, Bensheng Qiu, Xin Liu. High spatiotemporal resolution fMRI using partial separability model. Bio-Medical Materials and Engineering 2015; 26: S1439-S1446.

16.   Lei Zhang, Na Zhang, Jun Wu, Lijuan Zhang, Yanyan Huang, Xin Liu, Yiu-Cho Chung. High resolution three dimensional intracranial arterial wall imaging at 3T using T1 weighted SPACE. MRI 2015; 33(9):1026-34.

17.  Wu Zhou, Lijuan Zhang*, Yaoqin Xie, Changhong Liang. A novel technique for prealignment in multimodality medical image registration. Biomed Res Int. 2014; 2014: 726852.

18.   Weiqi Liao, Xiaojing Long, Chunxiang Jiang, Yanjun Diao, Xin Liu, Hairong Zheng, Lijuan Zhang*. Discerning mild cognitive impairment and Alzheimer disease from normal aging: morphologic characterization based on univaritate and multivariate models. Academic Radiology 2014; 21:597-604.

19. Chunxiang Jiang, Lijuan Zhang*, Chao Zou, Xiaojing Long, Xin Liu, Hairong Zheng, Weiqi Liao, Yanjun Diao. Diurnal Microstructural variations of Healthy Adult Brain revealed by Diffusion tensor imaging. PLOS ONE 2014; DOI: 10.1371/journal.pone.0084822.

20.  Xiaojing Long, Lijuan Zhang*, Weiqi Liao, Chunxiang Jiang, Bensheng Qiu and Alzheimer’s disease neuroimaging initiative. Distinct laterality alterations distinguish mild cognitive impairment and Alzheimer’s disease from healthy aging: statistical parametric mapping with high resolution MRI. Human Brain Mapping 2013;34:3400-3410; 

21. Xiaojing Long, Weiqi Liao, Chunxiang Jiang, Dong Liang, Bensheng Qiu, Lijuan Zhang*. Healthy Aging: An automatic analysis of global and regional morphological alterations of human brain. Academic Radiology 2012; 19(7):785-793. 

22. Lijuan Zhang, David Yankelevitz, Claudia Henschke, Daryl Carter, Anthony P. Reeves, et al. Internal Growth of Non-solid Nodules: Radiologic-Pathologic Correlation. Radiology 2012; 263:279-286).

23. Na Zhang, Lijuan Zhang, Bensheng Qiu, Li Meng, Xiaoyi Wang, Bob Hou. Correlation of volume transfer coefficient K trans with histopathologic grades of gliomas. JMRI 2012; 36(2):355-363.

24.  AO Farooqi, M.Cham, Lijuan Zhang, MB. Beasley, JH. M. Austin , A.Miller , J. J Zulueta , H. Roberts, C. Enser, SJ. Kao, MK. Thorsen, JP. Smith, DM. Libby, R.Yip, DF. Yankelevitz, CI. Henschke. Lung Cancer Associated with Cystic Airspaces. AJR 2012; 199(4):781-786.

25. Chunxiang Jiang, Xiang Li, Fei Yan, Zhanhui Wang, Qiaofeng Jin, Feiyan Cai, Ming Qian, Xin Liu, Lijuan Zhang, Hairong Zheng.  Microfluidic Assisted Formation of Multifunctional Monodisperse Microbubbles for Diagnostics and Therapeutics. Micro & Nano Letters 2011; 6: 417-421.

26. Yao Huang, Dong ming Xu, Artit Jirapatnakul, Anthony P. Reeves, Ali Farooqi, Li juan Zhang, et al. CT- and computer-based features of small hamartomas. Clinical Imaging 2011; 35: 116-122. 

27. Yin Wu, Lijuan Zhang, Chao Zou, Hung-Fat Tse, Ed X. Wu. Transmural Heterogeneity of Left Ventricular Myocardium Remodeling in Postinfarct Porcine Model Revealed by MR Diffusion Tensor Imaging. JMRI 2011; 34(1): 43-49.

28.   Lijuan Zhang, David F. Yankelevitz MD,Claudia I. Henschke PhD, MD, Artit C. Jirapatnakul, PhD, Anthony P. Reeves PhD,  Darryl Carter MD. Zone of transition: A Potential Source of Error in Tumor Volume Estimation. Radiology 2010; 256: 633-639.

29.  Lijuan Zhang, David Yankelevitz, Claudia Henschke, Anthony Reeves, et al. Variations in Vascular Distribution in Small Lung Cancer. Lung Cancer 2010; 68: 389-393.

30. Madeline Vazquez, Darryl Carter, Elizabeth Brambilla, Lijuan Zhang, et al. Solitary and Multiple Resected Adenocarcinomas after CT Screening for Lung Cancer: Histopathologic Features and their Prognostic Implications. Lung Cancer 2009; 64: 148-154. 

31.  Rajbir K. Gill, Madeline F. Vazquez, Arin Kramer, Megan Hames, Lijuan Zhang, Kerstin Heselmeyer-Haddad, Thomas Ried, Konstantin Shilo, Claudia Henschke, David Yankelevitz, Jin Jen. The Use of Genetic Markers to Identify Lung Cancer in Fine Needle Aspiration Samples. Clinical Cancer Research 2008; 14, 7481-7487.

32. S. M. Hersch, S. Gevorkian, K. Marder, C. Moskowitz, A. Feigin, M. Cox, P. Como, C. Zimmerman, M. Lin, MD, Lijuan Zhang, A. M. Ulug, M. F. Beal, W. Matson, M. Bogdanov, E. Ebbel, A. Zaleta, Y. Kaneko, B. Jenkins, N. Hevelone, H. Zhang, H. Yu, D. Schoenfeld, R. Ferrante, H. D. Rosas. Creatine in Huntington disease is safe, tolerable, elevates brain NAA, and reduces serum 8OH2’dG. Neurology 2006; 66: 250-252.

33.  Lijuan Zhang, Melanie Harrison, Linda A. Heier, Robert D. Zimmerman, Lisa Ravdin, Michael Lockshin, Aziz M. Uluğ. Diffusion changes in patients with systemic lupus erythematosus. Magn Reson Imaging 2007; 3:399-405.

34.  Michael H. Chappell, Aziz M.Ulug, Lijuan Zhang, Marcus H. Heitger, Barry D. Jordan, Robert D. Zimmerman, Richard Watts. Distribution of microstructural damage in the brains of professional boxers: A diffusion MRI study. JMRI. 2006; 24(3):537-42.

35.  Lijuan Zhang, Linda A. Heier, Robert D. Zimmerman, et al. Diffusion anisotropy changes in the brains of professional boxers. AJNR 2006; 27(9):2000-4.

36.  Lijuan Zhang, Kathleen M. Thomas, Matthew C. Davidson, B.J. Casey, Linda A. Heier, Aziz M. Uluğ. MR Quantitation of Volume and Diffusion changes in the Developing Brain. AJNR 2005; 26:45-49.

37.   Lijuan Zhang, Lisa D. Ravdin, Norman Relkin, Robert D. Zimmerman, Aziz M.Ulug. Increased Diffusion in the Brain of Professional Boxers: A Preclinical Sign of Traumatic Brain Injury? AJNR 2003; 24: 52-57.     

38. Lijuan Zhang, Aziz M. Ulug, Robert D. Zimmerman, Michael Lin, Michael Rubin, M. Flint Beal. The diagnostic utility of FLAIR imaging in clinically verified amyotrophic lateral sclerosis. JMRI 2003; 17: 521-527.


发表著作
( 1 ) 临床磁共振神经影像:弥散,灌注及波谱, Clinical MR Neuroimaging:Diffusion, Perfusion and Spectroscopy, Cambridge University Press, 2004-07, 第 5 作者
( 2 ) 磁共振功能成像临床应用, Clinical Application of Functional MRI, 人民军医出版社, 2012-06, 第 5 作者

科研活动

学术会员
1. International Society for Magnetic Resonance in Medicine (ISMRM) 
2.  Radiological Society of North America (RSNA) 
3.  Organization of Human Brain Mapping (OHBM)
学术服务
1.  国际会议文章审稿人: ISMRM, OHBM, 生物医学工程与信息学会 BMEI 
2. 期刊文章审稿人: Neuroimage, AJNR, Neuroradiology,Frontiers of Human Neuroscience
3. 项目评审:  国家自然科学基金面上、青年、优青项目,广东省自然科学基金,深圳市科技创新委员会项目评阅人.

科研项目
( 1 ) 缺血性脑卒中氧代偿机制研究, 主持, 国家级, 2014-01--2017-12
( 2 ) 磁共振热成像引导肝癌射频消融的关键问题研究, 参与, 国家级, 2014-01--2017-12
( 3 ) 胶质瘤对脑功能影响的多模判定, 主持, 国家级, 2015-01--2019-08
( 4 ) 多核素同步一体化肿瘤分子成像仪器研制, 参与, 国家级, 2017-01--2021-12
参与会议
(1)Functional diaschisis of ischemic stroke investigated with R2' quantification   OHBM   Lijuan Zhang, Xiaojing Long, Chunxiang Jiang, Li Yi, Xiaoma Liu   2016-06-25
(2)Texture analysis of hepatocellular carcinomas in Contrast-enhanced MR images for malignant differentiation   2016-05-09
(3)Detection of imaging biomarkers between MCI converters and nonconverters using three different methods.   Xiaojing Long   2015-06-13
(4)Remote effect of ischemic stroke investigated with fMRI   Lijuan Zhang   2015-05-30
(5)Global Effect of Focal Ischemic Stroke Revealed by Regional Homogeneity with BOLD fMRI.   32. Lijuan Zhang,Xiaojing Long,Yanjun Diao, Li Yi,Chunxiang Jian   2014-05-11
(6)Gender-Specific Anatomical Alterations of Hemispheric Asymmetry during Healthy Aging of Human Brain   26. Xiaojing Long, Chunxiang Jiang, Weiqi Liao, and Lijuan Zhang*   2013-04-19
(7)Mapping the diurnal alterations of oxygen extraction fraction in basal ganglia and thalami.    Lijuan Zhang, Chunxiang Jiang, Weiqi Liao, Xiaojing Long, Mengyue He   2012-06-09
(8)Non-Contrast MRA of Pedal Arteries in Type II Diabetes: Effect of Disease Load on Vessel Visibility   Lijuan Zhang, Na Zhang, Weiqi Liao, Xin Liu, Yang Liu, Dehe Weng, Renate Jerecic, Fei Feng, Zhaoyang Fan, and Debiao Li   2012-05-08
(9)Transmural Heterogeneity of Left Ventricular Myocardium Remodeling in Postinfarct Porcine Model Revealed by MR Diffusion Tensor Imaging.   13. Yin Wu, Li-Juan Zhang,Chao Zou, Hung-Fat Tse, Ed X. Wu.   2011-05-09
(10)Effects of Artery Input Function on Dynamic Contrast Enhanced MRI for Determining Grades of Gliomas.   12. N. Zhang1, L. Zhang1, X. Liu1, H. Zheng1, J. Carpenter2, and B. L. Hou   2011-05-09
(11)Diffusion changes in patients with systemic lupus erythematosus   6. Lijuan Zhang, Melanie Harrison, Linda A. Heier, Robert D. Zimmerman, Michael Lockshin, Aziz M. Ulug   2005-05-13
(12)Distribution of microstructural damage in the brains of professional boxers: a diffusion MRI study   7. M. Chappell, A.M.Ulu?, L. Zhang, M. Heitger, B. Jordan, R.D.Zimmerman, R.Watts   2005-05-13
(13)Diffusion anisotropy changes in the brains of the professional boxers.   Lijuan Zhang, Linda A. Heier, Robert D. Zimmerman, Berry Jordan, Aziz M. Ulu?.    2005-05-13
(14)Diffusion and MRS Study of Huntington1s Disease   5. Lijuan Zhang, Michael T. Lin, Flint Beal, Aziz M. Ulug   2004-05-14
(15) Quantitative Evidence of Localized Brain Damage in Professional Boxers Using Diffusion Tensor Imaging   4. BM Hentel, L Zhang, CE Johnson, BD Jordan, AM Ulug, RD Zimmerman   2003-10-24
(16)Diffusion and volume changes during brain development   2. Lijuan Zhang, Kathleen M. Thomas, Matthew C. Davidson, BJ Casey, Linda A. Heier, Aziz M. Ulug.    2003-07-11
(17)Quantitative diffusion tensor imaging evidence of brain damage in professional boxers.   8. Lijuan Zhang, Lisa D. Ravdin, Norman Relkin, Robert D. Zimmerman, Aziz M. Ulug   2003-07-11
(18)Use of FLAIR imaging in diagnosing Amyotrophic Lateral Sclerosis   3. Lijuan Zhang, Robert D. Zimmerman, Michael Lin, Michael Rubin, M. Flint Beal, Aziz M. Ulug.   2003-07-11
(19)Experimental study ofmyocardial perfusion with contrast enhanced fast MRI.    中放   1. Lijuan Zhang, Youquan Cai, Jukun Chen, Yuangui Gao.    1998-09-28

合作情况

天坛医院,复旦大学附属华山医院,北京大学深圳医院, 香港大学滨海医院

指导学生

已指导学生

蔡思琦  硕士研究生  085208-电子与通信工程  

孟锐  硕士研究生  071010-生物化学与分子生物学  

现指导学生

姜春香  博士研究生  071010-生物化学与分子生物学  

周诗辉  硕士研究生  085210-控制工程  

蔡思琦  博士研究生  081104-模式识别与智能系统  

蒲尧  硕士研究生  085400-电子信息