基本信息
张丽娟  女  博导  中国科学院深圳先进技术研究院
电子邮件: lj.zhang@siat.ac.cn
通信地址: 中国科学院深圳先进技术研究院
邮政编码:
部门/实验室:医工所

研究领域

使用包括DTI, MRS, RS-fMRI, SWI, parametric mapping 等功能磁共振和定量磁共振技术, 从结构, 功能, 代谢等方面深入探讨大脑发育, 衰老, 肿瘤, 缺血, 退行性改变等生理及病理机制.

招生信息

生物医学工程, 医学影像学

招生专业
100207-影像医学与核医学
083100-生物医学工程
100204-神经病学
招生方向
神经影像学, 磁共振成像
神经科学,脑疾病
定量磁共振成像技术及应用

教育背景

1995-07--1998-07   中国解放军总医院研究生院   硕士
1990-07--1995-07   哈尔滨医科大学   医学学士
学历
研究生

学位
硕士

工作经历

2013-10~今, 中国科学院深圳先进技术研究院, 研究员
2010-10~2013-10,中国科学院深圳先进技术研究院, 副研究员
2010-01~2010-10,Mount Sinai Medical College, 助理教授
2007-09~2009-12,Weill Cornell Medical College, 助理研究员
2002-01~2007-08,Weill Cornell Medical College, 博士后
1998-08~2002-01,南方医院, 放射科执业医师

工作简历
2013-10~2017-06,中国科学院深圳先进技术研究院, 研究员
2010-10~2013-10,中国科学院深圳先进技术研究院, 副研究员
2010-01~2010-10,Mount Sinai Medical College, 助理教授
2007-09~2009-12,Weill Cornell Medical College, 助理研究员
2002-01~2007-08,Weill Cornell Medical College, 博士后
1998-08~2002-01,南方医院, 放射科执业医师
社会兼职
   

教授课程

医学影像学基础
教授课程
博士生选修--放射诊断学基础

专利与奖励

   
奖励信息
   
专利成果
( 1 ) 基于弹性成像的图像处理方法及系统, 发明, 2012, 第 1 作者, 专利号: 201110350385.0
( 2 ) 激励装置及其系统, 发明, 2012, 第 2 作者, 专利号: 201120257733.5
( 3 ) 磁共振弹性成像的三维可视化成像方法, 发明, 2011, 第 5 作者, 专利号: 201110406350.4
( 4 ) 一种基于贝叶斯通用回归模型的形态学分析法, 发明, 2012, 第 4 作者, 专利号: 201110403723.2
( 5 ) 使用数学方法的MRE仿真, 发明, 2011, 第 4 作者, 专利号: 201110412326.1
( 6 ) 脑功能磁共振成像方法和系统, 发明, 2014, 第 2 作者, 专利号: 201310514492.1
( 7 ) 磁共振弹性模量重建方法和系统, 发明, 2012, 第 3 作者, 专利号: 201210572449.6
( 8 ) 磁共振弹性成像三维可视化 , 发明, 2012, 第 3 作者, 专利号: 201210110880.9
( 9 ) 脑部图像处理方法和系统, 发明, 2013, 第 1 作者, 专利号: 201310289449.X
( 10 ) 磁共振弹性成像精度检测方法, 发明, 2012, 第 4 作者, 专利号: 201210460717.5
( 11 ) 氧代谢参数估测方法和系统, 发明, 2014, 第 2 作者, 专利号: 201310501061.1

出版信息

   
发表论文
(1) Ischemic Stroke in Pontine and Corona Radiata: Location Specific Impairment of Neural Network Investigated With Resting State fMRI, Front. Neurol., 2019, 通讯作者
(2) Evaluation of Brain Tumor in Small Animals Using Plane Wave-Based Power Doppler Imaging, Ultrasound Med Biol, 2019, 第 10 作者
(3) High Spatial Resolution BOLD fMRI Using Simultaneous Multislice Excitation with Echo-Shifting Gradient Echo at 7 Tesla, MRI, 2018, 其他(合作组作者)
(4) Morphological Biomarker Differentiating MCI Converters from Non-converters: Longitudinal Evidence Based on Hemispheric Asymmetry, Behavioural Neurology, 2018, 通讯作者
(5) Prediction and classification of Alzheimer disease based on quantification of MRI deformation, PloS One, 2017, 通讯作者
(6) Malignancy Characterization of Hepatocellular Carcinomas Based on Texture Analysis of Contrast-Enhanced MR Images, JMRI, 2016, 通讯作者
(7) Diurnal variations in neural activity of healthy human brain decoded with resting state blood oxygen level dependent Fmri., Frontier Hum Neurosci, 2016, 通讯作者
(8) Noncontrast MRA of Pedal arteries in Type II diabetes: effect of disease load on vessel visibility., Academic Radiology, 2015, 第 1 作者
(9) Fluctuation amplitude and local synchronization of brain activity in the ultra-low frequency band: an fMRI investigation of continuous feedback of finger force, Brain Research, 2015, 第 2 作者
(10) High resolution three dimensional intracranial arterial wall imaging at 3T using T1 weighted SPACE, MRI, 2015, 第 4 作者
(11) Diurnal Microstructural variations of Healthy Adult Brain revealed by Diffusion tensor imaging., PLOS one, 2014, 通讯作者
(12) Discerning mild cognitive impairment and Alzheimer disease from normal aging: morphologic characterization based on univaritate and multivariate models, Academic Radiology, 2014, 通讯作者
(13) A novel technique for prealignment in multimodality medical imaging registration, Biomed Research International , 2014, 通讯作者
(14) Internal Growth of Non-solid Nodules: Radiologic-Pathologic Correlation., Radiology , 2012, 第 1 作者
(15) An automatic analysis of global and regional morphological alterations of human brain during healthy aging., Academic Radiology , 2012, 通讯作者
(16) Distinct Laterality Alterations Distinguish Mild Cognitive Impairment and Alzheimer’s disease From Healthy Aging: Statistical Parametric Mapping with High Resolution MRI, Human Brain Mapping, 2012, 通讯作者
(17) Correlation of volume transfer coefficient K trans with histopathologic grades of gliomas. , JMRI, 2012, 第 2 作者
(18) Lung Cancer Associated with Cystic Airspaces, AJR, 2012, 第 3 作者
(19) CT- and computer-based features of small hamartomas., Clinical Imaging , 2011, 通讯作者
(20) Transmural Heterogeneity of Left Ventricular Myocardium Remodeling in Postinfarct Porcine Model Revealed by MR Diffusion Tensor Imaging., JMRI, 2011, 第 2 作者
(21) Variations in Vascular Distribution in Small Lung Cancer., Lung Cancer, 2010, 第 1 作者
(22) Zone of transition: A Potential Source of Error in Tumor Volume Estimation, Radiology, 2010, 第 1 作者
(23) Zone of transition: A Potential Source of Error in Tumor Volume Estimation. , Radiology, 2010, 第 1 作者
(24) Solitary and Multiple Resected Adenocarcinomas after CT Screening for Lung Cancer: Histopathologic Features and their Prognostic Implications. , Lung Cancer, 2009, 第 4 作者
(25) The Use of Genetic Markers to Identify Lung Cancer in Fine Needle Aspiration Samples, Clinical Cancer Research, 2008, 第 4 作者
(26) Diffusion changes in patients with systemic lupus erythematosus. , MRI, 2007, 第 1 作者
(27) Distribution of microstructural damage in the brains of professional boxers: A diffusion MRI study., JMRI, 2006, 第 3 作者
(28) Diffusion anisotropy changes in the brains of professional boxers, AJNR, 2006, 第 1 作者
(29) Creatine in HD is safe, tolerable, elevates brain NAA, and reduces serum 8OH2’dG., Neurology, 2006, 通讯作者
(30) The MR Quantitation of Volume and Diffusion changes in the Developing Brain., AJNR, 2005, 第 1 作者
(31) FLAIR signature of Amyotrophic Lateral Sclerosis, JMRI, 2003, 第 1 作者
(32) Increased Diffusion in the Brain of Professional Boxers: A Preclinical Sign of Traumatic Brain Injury , AJNR, 2003, 第 1 作者
发表著作
( 1 ) 临床磁共振神经影像:弥散,灌注及波谱, Clinical MR Neuroimaging:Diffusion, Perfusion and Spectroscopy, Cambridge University Press, 2004-07, 第 5 作者
( 2 ) 磁共振功能成像临床应用, Clinical Application of Functional MRI, 人民军医出版社, 2012-06, 第 5 作者

科研活动

学术会员
1. International Society for Magnetic Resonance in Medicine (ISMRM) 
2.  Radiological Society of North America (RSNA) 
3.  Organization of Human Brain Mapping (OHBM)
学术服务
1.  国际会议文章审稿人: ISMRM, OHBM, 生物医学工程与信息学会 BMEI 
2. 期刊文章审稿人: Neuroimage, AJNR, Neuroradiology,Frontiers of Human Neuroscience
3. 项目评审:  国家自然科学基金面上、青年、优青项目,广东省自然科学基金,深圳市科技创新委员会项目评阅人.

科研项目
( 1 ) 缺血性脑卒中氧代偿机制研究, 主持, 国家级, 2014-01--2017-12
( 2 ) 磁共振热成像引导肝癌射频消融的关键问题研究, 参与, 国家级, 2014-01--2017-12
( 3 ) 胶质瘤对脑功能影响的多模判定, 主持, 国家级, 2015-01--2019-08
( 4 ) 多核素同步一体化肿瘤分子成像仪器研制, 参与, 国家级, 2017-01--2021-12
参与会议
(1)Functional diaschisis of ischemic stroke investigated with R2' quantification   OHBM   Lijuan Zhang, Xiaojing Long, Chunxiang Jiang, Li Yi, Xiaoma Liu   2016-06-25
(2)Texture analysis of hepatocellular carcinomas in Contrast-enhanced MR images for malignant differentiation   2016-05-09
(3)Detection of imaging biomarkers between MCI converters and nonconverters using three different methods.   Xiaojing Long   2015-06-13
(4)Remote effect of ischemic stroke investigated with fMRI   Lijuan Zhang   2015-05-30
(5)Global Effect of Focal Ischemic Stroke Revealed by Regional Homogeneity with BOLD fMRI.   32. Lijuan Zhang,Xiaojing Long,Yanjun Diao, Li Yi,Chunxiang Jian   2014-05-11
(6)Gender-Specific Anatomical Alterations of Hemispheric Asymmetry during Healthy Aging of Human Brain   26. Xiaojing Long, Chunxiang Jiang, Weiqi Liao, and Lijuan Zhang*   2013-04-19
(7)Mapping the diurnal alterations of oxygen extraction fraction in basal ganglia and thalami.    Lijuan Zhang, Chunxiang Jiang, Weiqi Liao, Xiaojing Long, Mengyue He   2012-06-09
(8)Non-Contrast MRA of Pedal Arteries in Type II Diabetes: Effect of Disease Load on Vessel Visibility   Lijuan Zhang, Na Zhang, Weiqi Liao, Xin Liu, Yang Liu, Dehe Weng, Renate Jerecic, Fei Feng, Zhaoyang Fan, and Debiao Li   2012-05-08
(9)Transmural Heterogeneity of Left Ventricular Myocardium Remodeling in Postinfarct Porcine Model Revealed by MR Diffusion Tensor Imaging.   13. Yin Wu, Li-Juan Zhang,Chao Zou, Hung-Fat Tse, Ed X. Wu.   2011-05-09
(10)Effects of Artery Input Function on Dynamic Contrast Enhanced MRI for Determining Grades of Gliomas.   12. N. Zhang1, L. Zhang1, X. Liu1, H. Zheng1, J. Carpenter2, and B. L. Hou   2011-05-09
(11)Diffusion changes in patients with systemic lupus erythematosus   6. Lijuan Zhang, Melanie Harrison, Linda A. Heier, Robert D. Zimmerman, Michael Lockshin, Aziz M. Ulug   2005-05-13
(12)Distribution of microstructural damage in the brains of professional boxers: a diffusion MRI study   7. M. Chappell, A.M.Ulu?, L. Zhang, M. Heitger, B. Jordan, R.D.Zimmerman, R.Watts   2005-05-13
(13)Diffusion anisotropy changes in the brains of the professional boxers.   Lijuan Zhang, Linda A. Heier, Robert D. Zimmerman, Berry Jordan, Aziz M. Ulu?.    2005-05-13
(14)Diffusion and MRS Study of Huntington1s Disease   5. Lijuan Zhang, Michael T. Lin, Flint Beal, Aziz M. Ulug   2004-05-14
(15) Quantitative Evidence of Localized Brain Damage in Professional Boxers Using Diffusion Tensor Imaging   4. BM Hentel, L Zhang, CE Johnson, BD Jordan, AM Ulug, RD Zimmerman   2003-10-24
(16)Diffusion and volume changes during brain development   2. Lijuan Zhang, Kathleen M. Thomas, Matthew C. Davidson, BJ Casey, Linda A. Heier, Aziz M. Ulug.    2003-07-11
(17)Quantitative diffusion tensor imaging evidence of brain damage in professional boxers.   8. Lijuan Zhang, Lisa D. Ravdin, Norman Relkin, Robert D. Zimmerman, Aziz M. Ulug   2003-07-11
(18)Use of FLAIR imaging in diagnosing Amyotrophic Lateral Sclerosis   3. Lijuan Zhang, Robert D. Zimmerman, Michael Lin, Michael Rubin, M. Flint Beal, Aziz M. Ulug.   2003-07-11
(19)Experimental study ofmyocardial perfusion with contrast enhanced fast MRI.    中放   1. Lijuan Zhang, Youquan Cai, Jukun Chen, Yuangui Gao.    1998-09-28

合作情况

北京大学深圳医院, 香港大学滨海医院
项目协作单位