新型磁共振造影剂的研发及生物医学成像应用

   

070302-分析化学
0703J1-纳米科学与技术
0703Z1-化学生物学

化学

2012-08--2017-08   美国得克萨斯大学达拉斯分校 化学专业   博士
2007-09--2011-06   四川大学化学学院   学士

   

2021-08~现在, 中国科学院精密测量科学与技术创新研究院, 研究员
2018-01~2021-08,中国科学院长春应用化学研究所, 副研究员

   

[1] Zhu, Lijun, Li, Yu, Jiang, Mou, Ke, Changsheng, Long, Hanxiong, Qiu, Maosong, Zhang, Lei, Ye, Chaohui, Zhou, Xin, Jiang, ZhongXing, Chen, Shizhen. Self-Assembly of Precisely Fluorinated Albumin for Dual Imaging- Guided Synergistic Chemo-Photothermal-Photodynamic Cancer Therapy. ACS APPLIED MATERIALS & INTERFACES. 2023, [2] Chao Ma, Jing Sun, Bo Li, Yang Feng, Yao Sun, Li Xiang, Baiheng Wu, Lingling Xiao, Baimei Liu, Vladislav S Petrovskii, Bin Liu, Jinrui Zhang, Zili Wang, Hongyan Li, Lei Zhang, Jingjing Li, Fan Wang, Robert Gstl, Igor I Potemkin, Dong Chen, Hongbo Zeng, Hongjie Zhang, Kai Liu, Andreas Herrmann. Ultra-strong bio-glue from genetically engineered polypeptides. NATURE COMMUNICATIONS[J]. 2021, 12(1): http://dx.doi.org/10.1038/s41467-021-23117-9.
[3] Yu, Yibin, Cheng, Yi, Tong, Junye, Zhang, Lei, Wei, Yen, Tian, Mei. Recent advances in thermo-sensitive hydrogels for drug delivery. JOURNAL OF MATERIALS CHEMISTRY Bnull. 2021, 9(13): 2979-2992, https://www.webofscience.com/wos/woscc/full-record/WOS:000631591000001.
[4] Zhang, Yi, Zhao, Kelu, He, Haonan, Wan, Sikang, Martins, Andre F, Zhang, Lei, Liu, Kai. A T-2ex MRI Dy-based contrast agent for direct pH imaging using a ratiometric approach. DALTON TRANSACTIONS[J]. 2021, 50(6): 2014-2017, https://www.webofscience.com/wos/woscc/full-record/WOS:000618444900007.
[5] Wan, Sikang, Cui, Fengzhi, Li, Bo, Zhao, Kelu, He, Haonan, Zhang, Yi, Liu, Jianhua, Zhang, Lei, Liu, Kai. Dysprosium-Modified Gold Nanoparticles as T-2ex Contrast Agents for Magnetic Resonance Imaging. ACS APPLIED NANO MATERIALS[J]. 2020, 3(9): 9433-9439, https://www.webofscience.com/wos/woscc/full-record/WOS:000575846000091.
[6] He, Haonan, Zhao, Kelu, Xiao, Long, Zhang, Yi, Cheng, Yi, Wan, Sikang, Chen, Shizhen, Zhang, Lei, Zhou, Xin, Liu, Kai, Zhang, Hongjie. Detection and Chiral Recognition of alpha-Hydroxyl Acid through H-1 and CEST NMR Spectroscopy Using a Ytterbium Macrocyclic Complex. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2019, 58(50): 18286-18289, http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000493157400001.
[7] Liu, Yang, Zhen, Wenyao, Wang, Yinghui, Liu, Jianhua, Jin, Longhai, Zhang, Tianqi, Zhang, Songtao, Zhao, Ying, Yin, Na, Niu, Rui, Song, Shuyan, Zhang, Lei, Zhang, Hongjie. Double Switch Biodegradable Porous Hollow Trinickel Monophosphide Nanospheres for Multimodal Imaging Guided Photothermal Therapy. NANO LETTERS[J]. 2019, 19(8): 5093-5101, http://dx.doi.org/10.1021/acs.nanolett.9b01370.
[8] Zhang Lei, Li JingJing, Liu Kai. Recent advances in gadolinium-based MRI metal responsive agent. SCIENCE CHINA-TECHNOLOGICAL SCIENCES[J]. 2018, 61(9): 1329-1333, http://lib.cqvip.com/Qikan/Article/Detail?id=676287570.
[9] Zhang, Lei, Martins, Andre F, Zhao, Piyu, Tieu, Michael, EstebanGomez, David, McCandless, Gregory T, PlatasIglesias, Carlos, Sherry, A Dean. Enantiomeric Recognition of D- and L-Lactate by CEST with the Aid of a Paramagnetic Shift Reagent. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2017, 139(48): 17431-17437, https://www.webofscience.com/wos/woscc/full-record/WOS:000417669000040.
[10] Zhang, Lei, Martins, Andre F, Mai, Yuyan, Zhao, Piyu, Funk, Alexander M, Jordan, M Veronica Clavijo, Zhang, Shanrong, Chen, Wei, Wu, Yunkou, Sherry, A Dean. Imaging Extracellular Lactate In Vitro and In Vivo Using CEST MRI and a Paramagnetic Shift Reagent. CHEMISTRY-A EUROPEAN JOURNAL[J]. 2017, 23(8): 1752-1756, https://www.webofscience.com/wos/woscc/full-record/WOS:000395754800004.
[11] Lei Zhang, Andr F Martins, Piyu Zhao, Yunkou Wu, Gyula Tircs, A Dean Sherry. Lanthanide-based T 2ex and CEST complexes provide new insights into the design of pH sensitive MRI agents. ANGEWANDTECHEMIEINTERNATIONALEDINENGLISH. 2017, 56(52): 16626-16630, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5879776/.
[12] Dong, FengXia, Zhang, Lei, Tong, XiaoZuo, Chen, HongBing, Wang, XiuLi, Wang, YuZhong. Ionic liquid coated lipase: Green synthesis of high molecular weight poly(1,4-dioxan-2-one). JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC[J]. 2012, 77: 46-52, http://dx.doi.org/10.1016/j.molcatb.2012.01.006.
[13] Zhang Lei, Evbuomwan Osasere M., Tieu Michael, Zhao Piyu, Martins Andre F., Sherry A. Dean. Protonation of carboxyl groups in EuDOTA-tetraamide complexes results in catalytic prototropic exchange and quenching of the CEST signal. PHILOSOPHICAL TRANSACTIONS. SERIES A, MATHEMATICAL, PHYSICAL, AND ENGINEERING SCIENCES. 375(2107): https://www.webofscience.com/wos/woscc/full-record/WOS:000413121000007.

   

（ 1 ） 基于T2ex原理的新型镧系金属造影剂的设计及应用, 负责人, 国家任务, 2019-01--2021-12
（ 2 ） 基于T2ex原理的新型镧系金属造影剂活体应用研究, 负责人, 中国科学院计划, 2019-01--2021-12
（ 3 ） 超灵敏磁共振造影剂用于脑疾病的精准成像, 负责人, 研究所自选, 2021-08--2024-08
（ 4 ） 武汉英才项目, 负责人, 其他任务, 2022-04--2023-03