基本信息
朱强 男 汉族 博导 广州生物医药与健康研究院
电子邮件:zhu_qiang@gibh.ac.cn
联系电话:020-32015287
手机号码:
通信地址:广州市萝岗区开源大道190号
邮政编码:510530

研究领域

(1)  过渡金属参与的 C-H 键官能化反应用于合成杂环化合物的方法研究;
(2)  Cu/O体系对小分子的选择性氧化;
(3)  多组分、多反应中心、串联反应等一步形成多个碳碳键或碳杂键的高效的杂环化合物合成方法研究;
(4)  抗肺癌和抗 TB 活性先导化合物的发现与结构修饰;

招生信息

   
招生专业
100701-药物化学
070303-有机化学
招生方向
抗肺癌、抗 TB 药物设计与合成

教育背景

1、1995.9 ~ 2000.6  中国科学院上海有机化学研究所,有机化学,博士
2、1991.9 ~ 1995.6  南京大学化学化工学院,有机化学,本科
学历
-- 研究生
学位
-- 博士
出国学习工作

  2000.8 ~ 2001.4  美国科罗拉多州立大学 (CSU) 化学系博士后.

工作经历

   
工作简历

1、2008.5  至今      中科院广州生物医药与健康研究院,研究员;
2、2005.9 ~ 2008.2  美国 XTL Biopharmaceuticals Inc., 研究员;
3、2001.4 ~ 2005.9  美国 Vivoquest, Inc., 研究员.

专利与奖励

   
专利成果
[1] 涂正超, 朱强, 张天宇, 黄金波, 徐晓冰, 万军庭, 黎敏科, 李登科, 周亚丽, 刘志永, 王邦兴, 米琦.托特雷拉. 吲哚-2-酮-3-螺噻嗪酮或噻唑酮化合物及其应用. CN: CN107722044B, 2020-11-03.

[2] 朱强, 赵昕, 涂正超, 彭江灵, 贺益苗, 毛婷婷, 罗爽. 多取代吲哚类化合物及其应用. CN: CN109665985A, 2019-04-23.

[3] 朱强, 张天宇, 刘兰英, 鲁明辉, 毛婷婷, 黄金波. 吲哚3,2-c喹啉类化合物或其药学上可接受的盐及其制备方法和应用. 中国: CN103554103A, 2014-02-05.

[4] 朱强, 王洪根, 王勇, 梁冬冬, 刘兰英, 张健存. 咪唑1,2-a吡啶和咪唑醛类化合物的合成方法. CN: CN102358739A, 2012-02-22.

[5] 吴东海, 朱强, 杨松, 刘兰英, 彭长兰. 青蒿素衍生物的新应用. CN: CN101879158A, 2010-11-10.

出版信息

   
发表论文
[1] Teng, Fan, Yu, Ting, Peng, Yan, Hu, Weiming, Hu, Huaanzi, He, Yimiao, Luo, Shuang, Zhu, Qiang. Palladium-Catalyzed Atroposelective Coupling-Cyclization of 2-Isocyanobenzamides to Construct Axially Chiral 2-Aryl- and 2,3-Diarylquinazolinones. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2021, 143(7): 2722-2728, https://www.webofscience.com/wos/woscc/full-record/WOS:000623246000017.

[2] Hu, Huaanzi, Peng, Yan, Yu, Ting, Cheng, Sidi, Luo, Shuang, Zhu, Qiang. Palladium-Catalyzed Enantioselective 7-exo-Trig Carbopalladation/Carbonylation: Cascade Reactions To Achieve Atropisomeric Dibenzob,dazepin-6-ones. ORGANIC LETTERS[J]. 2021, 23(9): 3636-3640, http://dx.doi.org/10.1021/acs.orglett.1c01036.

[3] Ting Yu, Qiang Zhu, Shuang Luo. Pd-catalyzed imine-directed intramolecular CsbndN bond formation through C(sp3)sbndH activation: An efficient approach to multisubstituted pyrroles. Tetrahedron Letters[J]. 2020, 61(21): http://dx.doi.org/10.1016/j.tetlet.2020.151887.

[4] Yu, Ting, Zhu, Qiang, Luo, Shuang. Pd-catalyzed imine-directed intramolecular C-N bond formation through C(sp(3))-H activation: An efficient approach to multisubstituted pyrroles. TETRAHEDRON LETTERS[J]. 2020, 61(21): https://www.webofscience.com/wos/woscc/full-record/WOS:000531102800007.

[5] Teng, Fan, Peng, Yan, Wang, Xilong, Hu, Weiming, Hu, Huaanzi, He, Yimiao, Luo, Shuang, Zhu, Qiang. Pd-Catalyzed Domino Imidoylation/Heck/C(sp(2))-H Cyclization: Isocyanide Relay Strategy toward Tricyclic-Fused Heterocycles Containing an All-Carbon Quaternary Center. ORGANIC LETTERS[J]. 2020, 22(21): 8188-8192, http://dx.doi.org/10.1021/acs.orglett.0c02503.

[6] Hu, Huaanzi, Teng, Fan, Liu, Jian, Hu, Weiming, Luo, Shuang, Zhu, Qiang. Enantioselective Synthesis of 2-Oxindole Spirofused Lactones and Lactams by Heck/Carbonylative Cylization Sequences: Method Development and Applications. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2019, 58(27): 9225-9229, https://www.webofscience.com/wos/woscc/full-record/WOS:000476691200047.

[7] Teng, Fan, Hu, Weiming, Hu, Huaanzi, Luo, Shuang, Zhu, Qiang. Selective C-H or N-H Imidoylative Annulation of 2-(2-Isocyanophenyl)-1H-indoles Leading to Diverse Indole-fused Scaffolds. ADVANCED SYNTHESIS & CATALYSIS[J]. 2019, 361(6): 1414-1418, 
[8] Hu, Weiming, Teng, Fan, Hu, Huaanzi, Luo, Shuang, Zhu, Qiang. Pd-Catalyzed C(sp(2))-H Imidoylative Annulation: A General Approach To Construct Dibenzoox(di)azepines. JOURNAL OF ORGANIC CHEMISTRY[J]. 2019, 84(10): 6524-6535, https://www.webofscience.com/wos/woscc/full-record/WOS:000468696400050.

[9] Makafe, Gaelle G, Hussain, Muzammal, Surineni, Goverdhan, Tan, Yaoju, Wong, NaiKei, Julius, Mugweru, Liu, Lanying, Gift, Chiwala, Jiang, Huofeng, Tang, Yunxiang, Liu, Jianxiong, Tan, Shouyong, Yu, Zhijun, Liu, Zhiyong, Lu, Zhili, Fang, Cuiting, Zhou, Yang, Zhang, Jiancun, Zhu, Qiang, Liu, Jinsong, Zhang, Tianyu. Quinoline Derivatives Kill Mycobacterium tuberculosis by Activating Glutamate Kinase. CELL CHEMICAL BIOLOGY[J]. 2019, 26(8): 1187-+, http://dx.doi.org/10.1016/j.chembiol.2019.05.003.

[10] 朱强. Pd-Catalzed Divergent C(sp2)–H Activation/Cycloimidlylation of 2-Isocyano-2,3-diarylpropanoates. Org. Lett.. 2018, 
[11] Luo, Shuang, Xiong, Zhuang, Lu, Yongzhi, Zhu, Qiang. Enantioselective Synthesis of Planar Chiral Pyridoferrocenes via Palladium-Catalyzed Imidoylative Cyclization Reactions. ORGANIC LETTERS[J]. 2018, 20(7): 1837-1840, https://www.webofscience.com/wos/woscc/full-record/WOS:000429886900034.

[12] Sun, Hongwei, Tang, Shi, Li, Dengke, Zhou, Yali, Huang, Jinbo, Zhu, Qiang. Cascade double isocyanide insertion and C-N coupling of 2-iodo-2-isocyano-1,1-biphenyls. ORGANIC & BIOMOLECULAR CHEMISTRY[J]. 2018, 16(21): 3893-3896, https://www.webofscience.com/wos/woscc/full-record/WOS:000434260600007.

[13] Zhou, Yali, Li, Dengke, Tang, Shi, Sun, Hongwei, Huang, Jinbo, Zhu, Qiang. PhI(OAc)(2)-mediated dearomative C-N coupling: facile construction of the spiroindoline-3,2 '-pyrrolidine skeleton. ORGANIC & BIOMOLECULAR CHEMISTRY[J]. 2018, 16(12): 2039-2042, https://www.webofscience.com/wos/woscc/full-record/WOS:000428808500004.

[14] Hu, Huaanzi, Xie, Zeqiang, Luo, Shuang, Zhu, Qiang. Stirring-controlled mono or double aminocarbonylation of 1,3-bis(2-iodoaryl)propan-2-amines. TETRAHEDRON LETTERS[J]. 2018, 59(11): 1034-1037, http://dx.doi.org/10.1016/j.tetlet.2018.01.092.

[15] Li, Dengke, Mao, Tingting, Huang, Jinbo, Zhu, Qiang. Copper-Catalyzed Bromodifluoroacetylation of Alkenes with Ethyl Bromodifluoroacetate. JOURNAL OF ORGANIC CHEMISTRY[J]. 2018, 83(17): 10445-10452, https://www.webofscience.com/wos/woscc/full-record/WOS:000444364600077.

[16] 朱强. Palladium-Catalyzed Enantioselective C(sp2 )−H Imidoylation by Desymmetrization. ACS Catal.. 2017, 
[17] Li, Dengke, Mao, Tingting, Huang, Jinbo, Zhu, Qiang. A one-pot synthesis of 1,2,3triazolo1,5-aquinoxalines from 1-azido-2-isocyanoarenes with high bond-forming efficiency. CHEMICAL COMMUNICATIONS[J]. 2017, 53(7): 1305-1308, https://www.webofscience.com/wos/woscc/full-record/WOS:000394244000022.

[18] Li, Dengke, Mao, Tingting, Huang, Jinbo, Zhu, Qiang. Denitrogenative Imidoyl Radical Cyclization: Synthesis of 2-Substituted Benzoimidazoles from 1-Azido-2-isocyanoarenes. ORGANIC LETTERS[J]. 2017, 19(12): 3223-3226, https://www.webofscience.com/wos/woscc/full-record/WOS:000403854300047.

[19] Wang, Jian, Gao, DeWei, Huang, Jinbo, Tang, Shi, Xiong, Zhuang, Hu, Huaanzi, You, ShuLi, Zhu, Qiang. Palladium-Catalyzed Enantioselective C(sp(2))-H lmidoylation by Desymmetrization. ACS CATALYSIS[J]. 2017, 7(6): 3832-3836, 
[20] Xiong, Zhuang, Wang, Jian, Wang, Yanbo, Luo, Shuang, Zhu, Qiang. Palladium-catalyzed C(sp(2))-H aminoimidoylation of isocyano-containing arenes: synthesis of amino substituted N-heterocycles. ORGANIC CHEMISTRY FRONTIERS[J]. 2017, 4(9): 1768-1771, https://www.webofscience.com/wos/woscc/full-record/WOS:000408263400009.

[21] 朱强. A one-pot synthesis of [1,2,3]triazolo[1,5- a]quinoxalines from 1-azido-2-isocyanoarenes with high bond-forming efficiency. Chem. Commun.. 2017, 
[22] Li, Dengke, Mao, Tingting, Huang, Jinbo, Zhu, Qiang. Copper-catalyzed regioselective 1,2-thioamidation of alkenes. CHEMICAL COMMUNICATIONS[J]. 2017, 53(24): 3450-3453, https://www.webofscience.com/wos/woscc/full-record/WOS:000398999600012.

[23] Xie, Zeqiang, Peng, Jiangling, Zhu, Qiang. Copper-mediated C(sp(3))-H amination in a multiple C-N bond-forming strategy for the synthesis of N-heterocycles. ORGANIC CHEMISTRY FRONTIERS[J]. 2016, 3(1): 82-86, http://ir.gibh.ac.cn/handle/344009/926.

[24] Xie, Zeqiang, Luo, Shuang, Zhu, Qiang. Pd-Catalyzed C(sp(2))-H carbonylation of 2-benzylpyridines for the synthesis of pyridoisoquinolinones. CHEMICAL COMMUNICATIONS[J]. 2016, 52(87): 12873-12876, http://ir.foo.ac.cn/handle/2SETSVCV/570.

[25] Wang, Jian, Tang, Shi, Zhu, Bang. Intramolecular Imidoylative Heck Reaction: Synthesis of Cyclic Ketoimines from Functionalized Isocyanide. ORGANIC LETTERS[J]. 2016, 18(13): 3074-3077, http://ir.foo.ac.cn/handle/2SETSVCV/403.

[26] 朱强. Recent progress in imydoyl radical-involved reactions. Org. Biomol. Chem. 2016, 14, 2593-2602.. 2016, 
[27] Xie, Zeqiang, Deng, Jiaojiao, Qiu, Zhiping, Li, Juan, Zhu, Qiang. Copper-mediated C(sp(3))-H azidation with Me3SiN3: synthesis of imidazoles from ketones and aldehydes. CHEMICAL COMMUNICATIONS[J]. 2016, 52(38): 6467-6470, http://ir.foo.ac.cn/handle/2SETSVCV/389.

[28] Lei, Jian, Huang, Jinbo, Zhu, Qiang. Recent progress in imidoyl radical-involved reactions. ORGANIC & BIOMOLECULAR CHEMISTRY[J]. 2016, 14(9): 2593-2602, http://ir.gibh.ac.cn/handle/344009/175.

[29] Luo, Shuang, Hu, Ziwei, Zhu, Qiang. Dearomative C-C and C-N bond cleavage of 2-arylindoles: transition-metal-free access to 2-aminoarylphenones. ORGANIC CHEMISTRY FRONTIERS[J]. 2016, 3(3): 364-367, http://ir.gibh.ac.cn/handle/344009/922.

[30] Wang, Jian, Li, Jing, Huang, Jinbo, Zhu, Qiang. Transition Metal-Free Amidoalkylation of Benzothiazoles and Amidoalkylarylation of Activated Alkenes with N,N-Dialkylamides. JOURNAL OF ORGANIC CHEMISTRY[J]. 2016, 81(7): 3017-3022, http://ir.gibh.ac.cn/handle/344009/872.

[31] He, Yimiao, Li, Jing, Luo, Shuang, Huang, Jinbo, Zhu, Qiang. A metal-free synthesis of 2-aminobenzothiazoles through aminyl radical addition to aryl isothiocyanates. CHEMICAL COMMUNICATIONS[J]. 2016, 52(54): 8444-8447, http://ir.foo.ac.cn/handle/2SETSVCV/425.

[32] Hu, Ziwei, Luo, Shuang, Zhu, Qiang. Aminopalladation-Triggered Carbene Insertion Reaction: Synthesis of 2-(1H-Indol-3-yl)acetates. ADVANCED SYNTHESIS & CATALYSIS[J]. 2015, 357(5): 1060-1064, http://dx.doi.org/10.1002/adsc.201400799.

[33] Lei, Jian, Wu, Xiaoxing, Zhu, Qiang. Copper-Catalyzed Trifluoromethylalkynylation of Isocyanides. ORGANIC LETTERS[J]. 2015, 17(10): 2322-2325, http://ir.gibh.ac.cn/handle/344009/544.

[34] Lei, Jian, Liu, Xiaowu, Zhang, Shaolin, Jiang, Shuang, Huang, Minhao, Wu, Xiaoxing, Zhu, Qiang. Copper-Catalyzed Trifluoromethylation of Trisubstituted Allylic and Homoallylic Alcohols. CHEMISTRY-A EUROPEAN JOURNAL[J]. 2015, 21(18): 6700-6703, http://ir.gibh.ac.cn/handle/344009/554.

[35] Liang, Dongdong, Zhu, Qiang. A Facile Synthesis of Pyrazoles through Metal-Free Oxidative C(sp(2))-H Cycloamination of Vinyl Hydrazones. ASIAN JOURNAL OF ORGANIC CHEMISTRY[J]. 2015, 4(1): 42-45, http://ir.foo.ac.cn/handle/2SETSVCV/366.

[36] Hu, Ziwei, Luo, Shuang, Zhu, Qiang. Palladium-catalyzed intermolecular C-H amidation of indoles with sulfonyl azides. SCIENCE CHINA-CHEMISTRY[J]. 2015, 58(8): 1349-1353, http://ir.foo.ac.cn/handle/2SETSVCV/105.

[37] Lyu, Beier, Cha, Wenli, Mao, Tingting, Wu, Yuanzi, Qian, Hujun, Zhou, Yitian, Chen, Xiuli, Zhang, Shen, Liu, Lanying, Yang, Guang, Lu, Zhongyuan, Zhu, Qiang, Ma, Hongwei. Surface Confined Retro Diels-Alder Reaction Driven by the Swelling of Weak Polyelectrolytes. ACS APPLIED MATERIALS & INTERFACES[J]. 2015, 7(11): 6254-6259, http://ir.sinano.ac.cn/handle/332007/3409.

[38] Wang, Jian, Li, Jing, Zhu, Qiang. Copper-Promoted Cycloaddition of alpha-Methylenyl Isocyanides with Benzothiazoles: Tunable Access to Benzodimidazothiazoles. ORGANIC LETTERS[J]. 2015, 17(21): 5336-5339, http://ir.gibh.ac.cn/handle/344009/459.

[39] 朱强. Copper-Catalyzed Trifluoromethylalkynylation of Isocyanides. Org. Lett.. 2015, 
[40] Li, Jing, He, Yimiao, Luo, Shuang, Lei, Jian, Wang, Jian, Xie, Zeqiang, Zhu, Qiang. Palladium-Catalyzed Intramolecular C(sp(2))-H Imidoylation for the Synthesis of Six-Membered N-Heterocycles. JOURNAL OF ORGANIC CHEMISTRY[J]. 2015, 80(4): 2223-2230, http://ir.foo.ac.cn/handle/2SETSVCV/224.

[41] 朱强. Surface Confined Retro Diels-Alder Reaction Driven by the Swelling of Weak Polyelectrolytes. ACS Appl. Mater. Interfaces. 2015, 
[42] Wang, Jian, Luo, Shuang, Li, Jing, Zhu, Qiang. A room-temperature synthesis of 2,2 '-bisoxazoles through palladium-catalyzed oxidative coupling of alpha-isocyanoacetamides. ORGANIC CHEMISTRY FRONTIERS[J]. 2014, 1(11): 1285-1288, http://ir.gibh.ac.cn/handle/344009/390.

[43] Peng, Jiangling, Chen, Ming, Xie, Zeqiang, Luo, Shuang, Zhu, Qiang. Copper-mediated C(sp(2))-H amination using TMSN3 as a nitrogen source: redox-neutral access to primary anilines. ORGANIC CHEMISTRY FRONTIERS[J]. 2014, 1(7): 777-781, http://ir.gibh.ac.cn/handle/344009/389.

[44] Xia, Zhonghua, Huang, Jinbo, He, Yimiao, Zhao, Jiaji, Lei, Jian, Zhu, Qiang. Arylative Cyclization of 2-Isocyanobiphenyls with Anilines: One-Pot Synthesis of 6-Arylphenanthridines via Competitive Reaction Pathways. ORGANIC LETTERS[J]. 2014, 16(9): 2546-2549, http://ir.foo.ac.cn/handle/2SETSVCV/243.

[45] 朱强. A Facile Synthesis of Pyrazoles through Metal-Free Oxidative C(sp2)-H Cycloamination of Vinyl Hydrazones. Asian J. Org. Chem.. 2014, 
[46] Peng, Jiangling, Xie, Zeqiang, Chen, Ming, Wang, Jian, Zhu, Qiang. Copper-Catalyzed C(sp(2))-H Amidation with Azides as Amino Sources. ORGANIC LETTERS[J]. 2014, 16(18): 4702-4705, http://ir.gibh.ac.cn/handle/344009/287.

[47] Huang, Jinbo, Mao, Tingting, Zhu, Qiang. Copper-Catalyzed Intramolecular Oxidative C(sp(3))- H Amidation of 2-Aminoacetophenones: Efficient Synthesis of Indoline-2,3-diones. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY[J]. 2014, 2014(14): 2878-2882, http://ir.foo.ac.cn/handle/2SETSVCV/378.

[48] Wang, Jian, Luo, Shuang, Huang, Jinbo, Mao, Tingting, Zhu, Qiang. Palladium-Catalyzed Imidoylative Cyclization of alpha-Isocyanoacetamides: Efficient Access to C2-Diversified Oxazoles. CHEMISTRY-A EUROPEAN JOURNAL[J]. 2014, 20(35): 11220-11224, http://dx.doi.org/10.1002/chem.201403033.

[49] Liang, Dongdong, He, Yimiao, Zhu, Qiang. Palladium-Catalyzed C(sp(2))-H Pyridocarbonylation of N-Aryl-2-aminopyridines: Dual Function of the Pyridyl Moiety. ORGANIC LETTERS[J]. 2014, 16(10): 2748-2751, http://ir.foo.ac.cn/handle/2SETSVCV/640.

[50] 罗爽. Palladium-Catalyzed Imidoylative Cyclization of a- Isocyanoacetamides: Efficient Access to C2-Diversified Oxazoles. Chem. Eur. J.. 2014, 
[51] 朱强. A Metal-Free Tandem Demethylenation/C(sp2)-H Cycloamination Process of N‑Benzyl-2-aminopyridines via C−C and C−N Bond Cleavage. Org. Lett.. 2013, 
[52] Liang, Dongdong, Hu, Ziwei, Peng, Jiangling, Huang, Jinbo, Zhu, Qiang. Synthesis of phenanthridinones via palladium-catalyzed C(sp(2))-H aminocarbonylation of unprotected o-arylanilines. CHEMICAL COMMUNICATIONS[J]. 2013, 49(2): 173-175, http://ir.gibh.ac.cn/handle/344009/794.

[53] Huang, Jinbo, Wan, Congqing, Xu, MingFang, Zhu, Qiang. Synthesis of 10-Methylacridin-9(10H)-ones through Cu-Catalyzed Intramolecular Oxidative C(sp(2))-H Amination of 2-(Methylamino)benzophenones. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY[J]. 2013, 2013(10): 1876-1880, http://ir.gibh.ac.cn/handle/344009/755.

[54] 朱强. Synthesis of 10-Methylacridin-9(10H)-ones through Cu-Catalyzed Intramolecular Oxidative C(sp2)-H Amination of o-N-Methylaminobenzophenones. Eur. J. Org. Chem.. 2013, 
[55] He, Yimiao, Huang, Jinbo, Liang, Dongdong, Liu, Lanying, Zhu, Qiang. C-H cycloamination of N-aryl-2-aminopyridines and N-arylamidines catalyzed by an in situ generated hypervalent iodine(III) reagent. CHEMICAL COMMUNICATIONS[J]. 2013, 49(66): 7352-7354, http://ir.foo.ac.cn/handle/2SETSVCV/257.

[56] Xia, Zhonghua, Zhu, Qiang. A Transition-Metal-Free Synthesis of Arylcarboxyamides from Aryl Diazonium Salts and Isocyanides. ORGANIC LETTERS[J]. 2013, 15(16): 4110-4113, http://ir.gibh.ac.cn/handle/344009/704.

[57] Hu, Ziwei, Wang, Jian, Liang, Dongdong, Zhu, Qiang. Synthesis of 1H-Indole-3-carboxamidines through a Palladium-Catalyzed Three-Component Reaction Involving Isocyanide Insertion as a Key Step. ADVANCED SYNTHESIS & CATALYSIS[J]. 2013, 355(16): 3290-3294, http://ir.foo.ac.cn/handle/2SETSVCV/133.

[58] Liang, Dongdong, He, Yimiao, Liu, Lanying, Zhu, Qiang. A Metal-Free Tandem Demethylenation/C(sp )-H Cycloamination Process of N-Benzyl-2-aminopyridines via C-C and C-N Bond Cleavage. ORGANIC LETTERS[J]. 2013, 15(13): 3476-3479, http://ir.gibh.ac.cn/handle/344009/721.

[59] Zhao, Jiaji, Wang, Yong, Zhu, Qiang. Copper-Catalyzed Regioselective C-H Aerobic Oxidative Cycloetherification of o-Arylphenols Bearing an Additional Directing Group. SYNTHESIS-STUTTGART[J]. 2012, 44(10): 1551-1555, 
[60] Wang, Yong, Zhu, Qiang. Palladium(II)-Catalyzed Cycloamidination via C(sp(2))-H Activation and Isocyanide Insertion. ADVANCED SYNTHESIS & CATALYSIS[J]. 2012, 354(10): 1902-1908, 
[61] Peng, Jiangling, Liu, Lanying, Hu, Ziwei, Huang, Jinbo, Zhu, Qiang. Direct carboxamidation of indoles by palladium-catalyzed C-H activation and isocyanide insertion. CHEMICAL COMMUNICATIONS[J]. 2012, 48(31): 3772-3774, https://www.webofscience.com/wos/woscc/full-record/WOS:000301673200026.

[62] Zhao, Jiaji, Zhang, Qi, Liu, Lanying, He, Yimiao, Li, Jing, Li, Juan, Zhu, Qiang. Cul-Mediated Sequential Iodination/Cycloetherification of o-Arylphenols: Synthesis of 2-or 4-Iododibenzofurans and Mechanistic Studies. ORGANIC LETTERS[J]. 2012, 14(20): 5362-5365, http://dx.doi.org/10.1021/ol302562a.

[63] Huang, Jinbo, He, Yimiao, Wang, Yong, Zhu, Qiang. Synthesis of Benzimidazoles by PIDA-Promoted Direct C(sp(2))-H Imidation of N-Arylamidines. CHEMISTRY-A EUROPEAN JOURNAL[J]. 2012, 18(44): 13964-13967, https://www.webofscience.com/wos/woscc/full-record/WOS:000310473900008.

[64] 朱强. CuI-Mediated Sequential Iodination/Cycloetherification of o-Arylphenols: Synthesis of 2- or 4-Iododibenzofurans and Mechanistic Studies. Org. Lett.. 2012, 
[65] 朱强. Cu-Catalyzed Regioselective C-H Aerobic Oxidative Cycloetherification of o-Arylphenols Bearing an Additional Directing Group. Synthesis. 2012, 
[66] Zhao, Jiaji, Wang, Yong, He, Yimiao, Liu, Lanying, Zhu, Qiang. Cu-Catalyzed Oxidative C(sp(2))-H Cycloetherification of o-Arylphenols for the Preparation of Dibenzofurans. ORGANIC LETTERS[J]. 2012, 14(4): 1078-1081, https://www.webofscience.com/wos/woscc/full-record/WOS:000300339800032.

[67] Hu, Ziwei, Liang, Dongdong, Zhao, Jiaji, Huang, Jinbo, Zhu, Qiang. Palladium-catalyzed cyclization of o-alkynyltrifluoroacetanilides followed by isocyanide insertion: synthesis of 2-substituted 1H-indole-3-carboxamides. CHEMICAL COMMUNICATIONS[J]. 2012, 48(59): 7371-7373, https://www.webofscience.com/wos/woscc/full-record/WOS:000305792800011.

[68] Peng, Jiangling, Zhao, Jiaji, Hu, Ziwei, Liang, Dongdong, Huang, Jinbo, Zhu, Qiang. Palladium-Catalyzed C(sp(2))-H Cyanation Using Tertiary Amine Derived Isocyanide as a Cyano Source. ORGANIC LETTERS[J]. 2012, 14(18): 4966-4969, https://www.webofscience.com/wos/woscc/full-record/WOS:000308958500067.

[69] 朱强. Sequential Hydration–Condensation–Double Cyclization of Pyridine-Substituted 2-Alkynylanilines: An Efficient Approach to Quinoline-Based Heterocycles. synthesis[J]. 2011, http://ir.foo.ac.cn/handle/2SETSVCV/675.

[70] Wang, Honggen, Zhao, Jiaji, Zhang, Jiancun, Zhu, Qiang. Bronsted Acid-Promoted Sequential Hydroarylation-Hydroamidation of Arene-Tethered 1-(2-Alkynylphenyl)ureas: Direct Access to 4,4-Spiro-3,4-dihydro-2-(1H)-quinazolinones. ADVANCED SYNTHESIS & CATALYSIS[J]. 2011, 353(14-15): 2653-2658, https://www.webofscience.com/wos/woscc/full-record/WOS:000296901800016.

[71] Wang, Honggen, Wang, Yong, Liang, Dongdong, Liu, Lanying, Zhang, Jiancun, Zhu, Qiang. Copper-Catalyzed Intramolecular Dehydrogenative Aminooxygenation: Direct Access to Formyl-Substituted Aromatic N-Heterocycles. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2011, 50(25): 5677-5680, http://ir.gibh.ac.cn/handle/344009/140.

[72] Peng, Lijie, Wang, Honggen, Peng, Changlan, Ding, Ke, Zhu, Qiang. Sequential Hydration-Condensation-Double Cyclization of Pyridine-Substituted 2-Alkynylanilines: An Efficient Approach to Quinoline-Based Heterocycles. SYNTHESIS-STUTTGART[J]. 2011, 1723-1732, https://www.webofscience.com/wos/woscc/full-record/WOS:000290787100010.

[73] Ma, Bin, Wang, Yong, Peng, Jiangling, Zhu, Qiang. Synthesis of Quinazolin-4(3H)-ones via Pd(II)-Catalyzed Intramolecular C(sp(2))-H Carboxamidation of N-arylamidines. JOURNAL OF ORGANIC CHEMISTRY[J]. 2011, 76(15): 6362-6366, https://www.webofscience.com/wos/woscc/full-record/WOS:000293252600054.

[74] 朱强. Palladium-Catalyzed Intramolecular C(sp2)–H Amidination by Isonitrile Insertion Provides Direct Access to 4-Aminoquinazolines from N-Arylamidines. Org.Lett.[J]. 2011, 353(14): 2653-2658, http://ir.foo.ac.cn/handle/2SETSVCV/766.

[75] 朱强. Copper-catalyzed intramolecular dehydrogenative aminooxygenation: direct access to formyl-substituted aromatic N-heteroxyxles. Angewandte Chemie International Edition. 2011, 
[76] 朱强. Sequential Hydration-Condensation-Double Cycloaddition of Pyridine-Substituted 2-Alkynylanilines: an Efficient Approach to Quinoline-Based Heterocycles. synthesis. 2011, 
[77] Wang, Yong, Wang, Honggen, Peng, Jiangling, Zhu, Qiang. Palladium-Catalyzed Intramolecular C(sp(2))-H Amidination by Isonitrile Insertion Provides Direct Access to 4-Aminoquinazolines from N-Arylamidines. ORGANIC LETTERS[J]. 2011, 13(17): 4604-4607, https://www.webofscience.com/wos/woscc/full-record/WOS:000294242600033.

[78] 朱强. Quinazolin-4(3H)-ones via Pd(II)-Catalyzed Intramolecular C(sp2)-H Carboxamidation of N-arylamidines. J. Org. Chem.[J]. 2011, 15(76): 6362-6366, http://ir.foo.ac.cn/handle/2SETSVCV/589.

[79] Zhang jiancun, Zhu qiang. Bronsted Acid-Promoted Sequential Hydroarylation-Hydroamidation of Arene Tethered 1-(2-Alkynylphenyl)ureas: Direct Access to 4,4-spiro-3,4-dihydro-2-(1H)-quinazolinones.. Adv. Synth. Catal.[J]. 2011, http://ir.foo.ac.cn/handle/2SETSVCV/567.

[80] Zhao, Jiaji, Peng, Changlan, Liu, Lanying, Wang, Yong, Zhu, Qiang. Synthesis of 2-Alkoxy(aroxy)-3-substituted Quinolines by DABCO-Promoted Cyclization of o-Alkynylaryl Isocyanides. JOURNAL OF ORGANIC CHEMISTRY[J]. 2010, 75(21): 7502-7504, https://www.webofscience.com/wos/woscc/full-record/WOS:000283531100068.

[81] 朱强. A direct intramolecular C-H amination reaction Co-catalyzed bu Copper(II) and Iron(III) as part of an efficient route for the synthesis of pyrido[1,2-a]benzimidazoles from N-aryl-2-aminopyridines. 2010, 
[82] Wang, Honggen, Wang, Yong, Peng, Changlan, Zhang, Jiancun, Zhu, Qiang. Direct Intramolecular C-H Amination Reaction Cocatalyzed by Copper(II) and Iron(III) as Part of an Efficient Route for the Synthesis of Pyrido1,2-abenzimidazoles from N-Aryl-2-aminopyridines. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2010, 132(38): 13217-13219, https://www.webofscience.com/wos/woscc/full-record/WOS:000282304000044.

[83] Peng, Changlan, Wang, Yong, Liu, Lanying, Wang, Honggen, Zhao, Jiaji, Zhu, Qiang. p-Toluenesulfonic Acid Promoted Annulation of 2-Alkynylanilines with Activated Ketones: Efficient Synthesis of 4-Alkyl-2,3-Disubstituted Quinolines. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY[J]. 2010, 2010(5): 818-822, https://www.webofscience.com/wos/woscc/full-record/WOS:000274843100003.

[84] Wang, Yong, Lu, Hong, Zhu, Qiang, Jiang, Shibo, Liao, Yun. Structure-based design, synthesis and biological evaluation of new N-carboxyphenylpyrrole derivatives as HIV fusion inhibitors targeting gp41. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS[J]. 2010, 20(1): 189-192, http://dx.doi.org/10.1016/j.bmcl.2009.10.139.

[85] 朱强. Synthesis of 2-alkoxy(aroxy)-3-substitued quinolines by DABCO-promoted cyclization of ortho-alkynylaryl isocyanides. Journal of Organic Chemistry. 2010, 
[86] Zhou, Yi, Wang, Dongye, Zhu, Qiang, Gao, Xuefei, Yang, Song, Xu, Aimin, Wu, Donghai. Inhibitory Effects of A-769662, a Novel Activator of AMP-Activated Protein Kinase, on 3T3-L1 Adipogenesis. BIOLOGICAL & PHARMACEUTICAL BULLETIN[J]. 2009, 32(6): 993-998, http://ir.gibh.ac.cn/handle/344009/209.

[87] Liu, Lanying, Wang, Yong, Wang, Honggen, Peng, Changlan, Zhao, Jiaji, Zhu, Qiang. Tetrabutylammonium chloride-triggered 6-endo cyclization of o-alkynylisocyanobenzenes: an efficient synthesis of 2-chloro-3-substituted quinolines. TETRAHEDRON LETTERS[J]. 2009, 50(48): 6715-6719, http://dx.doi.org/10.1016/j.tetlet.2009.09.096.

[88] Wang, Honggen, Liu, Lanying, Wang, Yong, Peng, Changlan, Zhang, Jiancun, Zhu, Qiang. An efficient synthesis of 4-alkyl-2(1H)-quinazolinones and 4-alkyl-2-chloroquinazolines from 1-(2-alkynylphenyl)ureas. TETRAHEDRON LETTERS[J]. 2009, 50(49): 6841-6843, http://dx.doi.org/10.1016/j.tetlet.2009.09.130.

[89] Wang, Yong, Peng, Changlan, Liu, Lanying, Zhao, Jiaji, Su, Li, Zhu, Qiang. Sulfuric acid promoted condensation cyclization of 2-(2-(trimethylsilyl) ethynyl)anilines with arylaldehydes in alcoholic solvents: an efficient one-pot synthesis of 4-alkoxy-2-arylquinolines. TETRAHEDRON LETTERS[J]. 2009, 50(19): 2261-2265, http://dx.doi.org/10.1016/j.tetlet.2009.02.206.

[90] 朱强. Sulfuric acid promoted condesation cyclization of 2-(2-(trimethylsilyl)ethynyl)anilines with arylaldehydes in alcoholic solvents: an efficient one-pot synthesis of 4-alkoxy-2-arylquinolines. Tetrahedron Letters. 2009, 
[91] Wu, J, Zhu, Q, Wang, LS, Fathi, R, Yang, Z. Palladium-catalyzed cross-coupling reactions of 4-tosyl-2(5H)-furanone with boronic acids: A facile and efficient route to generate 4-substituted 2(5H)-furanones. JOURNAL OF ORGANIC CHEMISTRY[J]. 2003, 68(2): 670-673, https://www.webofscience.com/wos/woscc/full-record/WOS:000180540500070.

[92] Liao, Y, Hu, YH, Wu, H, Zhu, Q, Donovan, M, Fathi, R, Yang, Z. Diversity oriented synthesis and branching reaction pathway to generate natural product-like compounds. CURRENT MEDICINAL CHEMISTRY[J]. 2003, 10(21): 2285-2316, https://www.webofscience.com/wos/woscc/full-record/WOS:000185946900006.

[93] 朱强. Phenyliodonium Zwitterion as an Efficient Electrophile in the Palladium-Catalyzed Suzuki-type Reaction: a Novel Method for the Synthesis of 3-Aryl-4-ydroxycoumarins. Organic Letters. 2002, 
[94] 朱强. Observation and Elimination of N-Acetylation of Oligonucleotides Prepared Using Fast-Deprotection Phosphoramidites and Ultra-Mild Deprotection. Bioorganic Medicinal Chemistry Letters. 2001, 
[95] Zhu, Q, Qiao, LX, Wu, YK, Wu, YL. Studies toward the total synthesis of clavulactone. JOURNAL OF ORGANIC CHEMISTRY[J]. 2001, 66(8): 2692-2699, http://www.irgrid.ac.cn/handle/1471x/583080.

[96] Zhu, Q, Fan, KY, Ma, HW, Qiao, LX, Wu, YL, Wu, YK. Radical-mediated diastereoselective construction of a chiral synthon for synthesis of dolabellanes. ORGANIC LETTERS[J]. 1999, 1(5): 757-759, http://www.irgrid.ac.cn/handle/1471x/583052.

[97] Zhu, Q, Qiao, LX, Wu, YK, Wu, YL. Radical-mediated construction of cyclopentane with concurrent formation of a well-defined quaternary center. JOURNAL OF ORGANIC CHEMISTRY[J]. 1999, 64(7): 2428-2432, http://www.irgrid.ac.cn/handle/1471x/583050.

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科研活动

   
科研项目
1、2008年自然科学基金主任基金 ( 20942001 ) 1项,“异腈参与的多取代喹啉的合成研究”,8万元,2009年已顺利结题。
 
2、2010自然科学基金面上项目“通过分子内C-H键官能化合成几类杂环化合物的新方法研究”( 21072190 ),36万元,2011年至2013年。 

3、2010广州市科技计划项目“以邻炔基苯胺为原料合成几类重要的含氮杂环”( 2010Y1-C241 ),6万元,2011年。
参与会议
1、2009.8,参加中国化学会第六届有机化学学术会议
2、2009.11,参加第一届岭南有机化学论坛
3、2009.11,参加广东省药学会药物化学专业委员会
4、2010.10,参加第十六届全国金属有机化学学术讨论会

指导学生

现指导学生

彭江灵  硕士研究生  077901-药物化学  

赵家冀  博士研究生  100701-药物化学