基本信息
朱强 男 汉族 博导 广州生物医药与健康研究院
电子邮件:zhu_qiang@gibh.ac.cn
联系电话:020-32015287
手机号码:
通信地址:广州市萝岗区开源大道190号
邮政编码:510530

研究领域

(1)  过渡金属参与的 C-H 键官能化反应用于合成杂环化合物的方法研究;
(2)  Cu/O体系对小分子的选择性氧化;
(3)  多组分、多反应中心、串联反应等一步形成多个碳碳键或碳杂键的高效的杂环化合物合成方法研究;
(4)  抗肺癌和抗 TB 活性先导化合物的发现与结构修饰;

招生信息

   
招生专业
100701-药物化学
070303-有机化学
招生方向
抗肺癌、抗 TB 药物设计与合成

教育背景

1、1995.9 ~ 2000.6  中国科学院上海有机化学研究所,有机化学,博士
2、1991.9 ~ 1995.6  南京大学化学化工学院,有机化学,本科
学历
-- 研究生
学位
-- 博士
出国学习工作

  2000.8 ~ 2001.4  美国科罗拉多州立大学 (CSU) 化学系博士后.

工作经历

   
工作简历

1、2008.5  至今      中科院广州生物医药与健康研究院,研究员;
2、2005.9 ~ 2008.2  美国 XTL Biopharmaceuticals Inc., 研究员;
3、2001.4 ~ 2005.9  美国 Vivoquest, Inc., 研究员.

专利与奖励

   
专利成果
1. Jie Wu, Zhen Yang, Reza Fathi, Qiang Zhu, Lisha Wang “4-Thio-Coumarins" US Patent 6 703 514, 2004.

2. Jie Wu, Zhen Yang, Reza Fathi, Qiang Zhu “4-Thio-Coumarins" US Patent 7 148 253 2006.

3. Bin Xu, Qiang Zhu, Hyun-Joon Cho, Reza Fathi, Zhen Yang, Anthony Sandrasagra, Yixin Liu “3,4-Disubstituted Coumarin and Quinolone Compounds” Wipo Patent WO/2007/133211.

4. Zhen Yang, Reza Fathi, Qiang Zhu, Hyun Joon Cho, Yixin Liu, Anthony Sandrasagra, Richard Wobbe “4-Thio Substituted Quinoline and Naphthyridine Compounds” Wipo Patent WO/2008/024423

5. Guolin Li, Reza Fathi, Zhen Yang, Yun Liao, Qiang Zhu, Angela Lam, Anthony Sandrasagra, Kenneth Nawoschik, Hyun Joon Cho, Jie Cao, Ruoqiu Wu, Richard Wobbe “Compounds and Methods for Treatment of HCV” Wipo Patent WO/2008/048589 A2.

出版信息

   
发表论文

  2008年5月独立工作后:

1. Sequential Hydration-Condensation-Double Cycloaddition of Pyridine-Substituted 2-Alkynylanilines: an Efficient Approach to Quinoline-Based Heterocycles
Peng Lijie, Wang Honggen, Peng Changlan, Ding ke*, Zhu Qiang*
Synthesis, 2011, accepted.

2. Copper-catalyzed intramolecular dehydrogenative aminooxygenation: direct access to formyl-substituted aromatic N-heteroxyxles
Honggen Wang, Yong Wang, Dongdong Liang, Lanying Liu, Jiancun Zhang*, Qiang Zhu*
Angew. Chem. Int. Ed., 2011, In press. (Selected as a "Hot Paper") 

3. Synthesis of 2-alkoxy(aroxy)-3-substitued quinolines by DABCO-promoted cyclization of ortho-alkynylaryl isocyanides
Jiaji Zhao, Changlan Peng, Lanying Liu, Yong Wang, Qiang Zhu*
J. Org. Chem., 2010, 75, 7502 - 7504. 

4. A direct intramolecular C-H amination reaction Co-catalyzed bu Copper(II) and Iron(III) as part of an efficient route for the synthesis of pyrido[1,2-a]benzimidazoles from N-aryl-2-aminopyridines
Honggen Wang, Yong Wang, Changlan Peng, Jiancun Zhang*, Qiang Zhu*
J. Am. Chem. Soc., 2010, 132, 13217 - 13219. 

5. p-Toluenesulfonic acid promoted annulation of 2-alkynylanilines with activated ketones: efficient synthesis of 4-alkyl-2,3-disubstituted quinolines
Changlan Peng, Yong Wang, Lanying Liu, Honggen Wang, Jiaji Zhao, Qiang Zhu*
Eur. J. Org. Chem., 2010, 818 - 822. 

6. Structure-based design, synthesis and biological evaluation of new N-carboxyphenylpyrrole derivatives as HIV fusion inhibitors targeting gp41
Yong Wang, Hong Lu, Qiang Zhu*, Shibo Jiang*, Yun LIao*
Bioorg. Med. Chem. Lett., 2010, 20, 189 - 192.

7. Sulfuric acid promoted condesation cyclization of 2-(2-(trimethylsilyl)ethynyl)anilines with arylaldehydes in alcoholic solvents: an efficient one-pot synthesis of 4-alkoxy-2-arylquinolines
Yong Wang, Changlan Peng, Lanying Liu, Jiaji Zhao, Li Su, Qiang Zhu*
Tetrahedron Lett., 2009, 50, 2261 - 2265. 

8. An efficient synthesis of 4-alkyl-2(1H)-quinazolinones and 4-alkyl-2-chloroquinazolines from 1-(2-alkynylphenyl)ureas
Honggen Wang, Lanying Liu, Yong Wang, Changlan Peng, Jiancun Zhang*, Qiang Zhu*
Tetrahedron Lett., 2009, 50, 6841 - 6843. 

9. Tetrabutylammonium chloride-triggered 6-endo cyclization of o-alkynylisocyanobenzenes: an efficient synthesis of 2-chloro-3-substituted quinolines
Lanying Liu, Yong Wang, Honggen Wang, Changlan Peng, Jiaji Zhao, Qiang Zhu*
Tetrahedron Lett., 2009, 50, 6715 - 6719. 

  2008年5月独立工作前:

1. Diversity Oriented Synthesis and Branching reaction Pathway to Generate Natural Product-like compounds
Yun Liao, Youhong Hu, Jie Wu, Qiang Zhu, Maryann Donovan, Reza Fathi, Zhen Yang*
Curr. Med. Chem. 2003, 10, 2285 - 2316. 

2. Palladium-catalyzed Cross-Coupling Reactions of 4-Tosyl-2(5H)-furanone with Boronic Acids: A Facile and Efficient Route to Generate Substituted 2(5H)-furanones
Jie Wu,* Qiang Zhu, Lisha Wang, Reza Fathi, and Zhen Yang*
J. Org. Chem. 2003, 68, 670. 

3. Phenyliodonium Zwitterion as an Efficient Electrophile in the Palladium-Catalyzed Suzuki-type Reaction: a Novel Method for the Synthesis of 3-Aryl-4-ydroxycoumarins
Qiang Zhu*, Jie Wu, Reza Fathi, and Zhen Yang*
Org. Lett. 2002, 4, 3333 - 3336. 

4. Observation and Elimination of N-Acetylation of Oligonucleotides Prepared Using Fast-Deprotection Phosphoramidites and Ultra-Mild Deprotection
Qiang Zhu, Michael O. Delaney, and Marc M. Greenberg*
Bioorg. Med. Chem. Lett. 2001, 11, 1105 - 1107. 

5. Studies toward the Total Synthesis of Clavulactone
Qiang Zhu, Lixin Qiao, Yikang Wu, and Yu-Lin Wu*
J. Org. Chem. 2001, 66, 2692 - 2699.

6. Radical-Mediated Diastereoselective Construction of a Chiral Synthon for Synthesis of Dolabellanes
Qiang Zhu, Kai-Yi Fan, Hong-Wei Ma, Li-Xin Qiao, Yu-Lin Wu,* and Yikang Wu*
Org. Lett. 1999, 1, 757 - 759. 

7. Radical-Mediated Construction of Cyclopentane with Concurrent Formation of a Well-Defined Quaternary Center
Qiang Zhu, Li-Xin Qiao, Yikang Wu, and Yu-Lin Wu*
J. Org. Chem. 1999, 64, 2428 - 2432.
 

科研活动

   
科研项目
1、2008年自然科学基金主任基金 ( 20942001 ) 1项,“异腈参与的多取代喹啉的合成研究”,8万元,2009年已顺利结题。
 
2、2010自然科学基金面上项目“通过分子内C-H键官能化合成几类杂环化合物的新方法研究”( 21072190 ),36万元,2011年至2013年。 

3、2010广州市科技计划项目“以邻炔基苯胺为原料合成几类重要的含氮杂环”( 2010Y1-C241 ),6万元,2011年。
参与会议
1、2009.8,参加中国化学会第六届有机化学学术会议
2、2009.11,参加第一届岭南有机化学论坛
3、2009.11,参加广东省药学会药物化学专业委员会
4、2010.10,参加第十六届全国金属有机化学学术讨论会

指导学生

现指导学生

彭江灵  硕士研究生  077901-药物化学  

赵家冀  博士研究生  100701-药物化学