代谢工程

合成生物学

工业微生物

   

081703-生物化工

生物化工
代谢工程
合成生物学

2008-09--2012-07   中国科学院大连化学物理研究所   博士学位
2006-09--2008-07   天津大学   硕士学位
2002-09--2006-06   江南大学   学士学位

博士研究生

博士

   

2018-02~现在, 中国科学院大连化学物理研究所, 研究组组长，研究员
2017-01~2018-02,中国科学院大连化学物理研究所, 研究组组长、副研究员
2012-06~2016-12,Chalmers University of Technology, 博士后

2018-01-01-今,中国分子生药学专业委员会, 常务委员
2017-05-07-今,中国化工学会生物化工专业委员会青年工作委员会, 委员

   

（1） 丹参酮生物合成途径解析及其合成, 一等奖, 部委级, 2015

[1] 周雍进, 蔡鹏, 纪璐璐. 一种重组巴斯德毕赤酵母菌株、其构建方法和应用. CN: CN113774078A, 2021-12-10.
[2] 周雍进, 高教琪, 高宁. 多形汉逊酵母基因编辑系统、其应用以及基因编辑方法. CN: CN113265383A, 2021-08-17.
[3] 周雍进, 高教琪, 李云霞. 一种重组多形汉逊酵母的构建方法及其应用. CN: CN113265343A, 2021-08-17.
[4] 周雍进, 杨珊, 曹选. 一种基因突变表达盒及其应用. CN: CN113151339A, 2021-07-23.
[5] 赵宗保, 周雍进, 林心萍, 张素芳. 烟酰胺腺嘌呤二核苷酸营养缺陷型大肠杆菌的构建及其应用. CN: CN102925398A, 2013-02-13.

   

[1] Cai, Peng, Wu, Xiaoyan, Deng, Jun, Gao, Linhui, Shen, Yiwei, Yao, Lun, Zhou, Yongjin J. Methanol biotransformation toward high-level production of fatty acid derivatives by engineering the industrial yeast Pichia pastoris. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2022, 119(29): http://dx.doi.org/10.1073/pnas.2201711119.
[2] Chen Ruibing, Gao Jiaoqi, Yu Wei, Chen Xianghui, Zhai Xiaoxin, Chen Yu, Zhang Lei, Zhou Yongjin J.. Engineering cofactor supply and recycling to drive phenolic acid biosynthesis in yeast. NATURECHEMICALBIOLOGY[J]. 2022, [3] 冯叨, 高教琪, 龚志伟, 周雍进. 多形汉逊酵母代谢改造生产脂肪酸及发酵条件优化. 生物工程学报[J]. 2022, 38(2): 760-771, http://lib.cqvip.com/Qikan/Article/Detail?id=7106678263.
[4] Gao, Jiaoqi, Li, Yunxia, Yu, Wei, Zhou, Yongjin J. Rescuing yeast from cell death enables overproduction of fatty acids from sole methanol. NATURE METABOLISM[J]. 2022, 4(7): 932-+, http://dx.doi.org/10.1038/s42255-022-00601-0.
[5] Gao, Jiaoqi, Gao, Ning, Zhai, Xiaoxin, Zhou, Yongjin J. Recombination machinery engineering for precise genome editing in methylotrophic yeast Ogataea polymorpha. ISCIENCE[J]. 2021, 24(3): http://dx.doi.org/10.1016/j.isci.2021.102168.
[6] 高琳惠, 蔡鹏, 周雍进. 甲醇酵母代谢工程研究进展. 生物工程学报[J]. 2021, 37(3): 966-979, http://lib.cqvip.com/Qikan/Article/Detail?id=7105044199.
[7] Cai, Peng, Duan, Xingpeng, Wu, Xiaoyan, Gao, Linhui, Ye, Min, Zhou, Yongjin J. Recombination machinery engineering facilitates metabolic engineering of the industrial yeast Pichia pastoris. NUCLEIC ACIDS RESEARCH[J]. 2021, 49(13): 7791-7805, http://dx.doi.org/10.1093/nar/gkab535.
[8] Yang, Shan, Cao, Xuan, Yu, Wei, Li, Shengying, Zhou, Yongjin J. Efficient targeted mutation of genomic essential genes in yeast Saccharomyces cerevisiae. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2020, 104(7): 3037-3047, https://www.webofscience.com/wos/woscc/full-record/WOS:000520095900001.
[9] 高教琪, 周雍进. 甲醇生物转化的机遇与挑战. 合成生物学[J]. 2020, 1(2): 158-173, http://lib.cqvip.com/Qikan/Article/Detail?id=7102383133.
[10] Chen, Ruibing, Yang, Shan, Zhang, Lei, Zhou, Yongjin J. Advanced Strategies for Production of Natural Products in Yeast. ISCIENCE[J]. 2020, 23(3): https://doaj.org/article/8587bee70b924b829125d3c8274eda27.
[11] 刘爽, 高教琪, 薛闯, 周雍进. 多形汉逊酵母提高生长性能的培养基优化. 生物加工过程[J]. 2020, 18(1): 117-126, https://kns.cnki.net/KCMS/detail/detail.aspx?dbcode=CJFQ&dbname=CJFDLAST2020&filename=SWJG202001014&v=MTM2MTF1RnlIaFZML0JOanJCYWJHNEhOSE1ybzlFWUlSOGVYMUx1eFlTN0RoMVQzcVRyV00xRnJDVVI3cWVadWQ=.
[12] 禹伟, 高教琪, 周雍进. 蛋白质组学和代谢组学在微生物代谢工程中的应用. 色谱[J]. 2019, 37(8): 798-805, http://lib.cqvip.com/Qikan/Article/Detail?id=7002627631.
[13] Ding, Mingzhu, Chen, Biqiang, Ji, Xiaojun, Zhou, Jingwen, Wang, Huiyuan, Tian, Xiwei, Feng, Xudong, Yue, Hua, Zhou, Yongjin, Wang, Hailong, Wu, Jianping, Yang, Pengpeng, Jiang, Yu, Mao, Xuming, Xiao, Gang, Zhong, Cheng, Xiao, Wenhai, Li, Bingzhi, Qin, Lei, Cheng, Jingsheng, Yao, Mingdong, Wang, Ying, Liu, Hong, Zhang, Lin, Yu, Linling, Chen, Tao, Dong, Xiaoyan, Jia, Xiaoqiang, Zhang, Songping, Liu, Yanfeng, Chen, Yong, Chen, Kequan, Wu, Jinglan, Zhu, Chenjie, Zhuang, Wei, Xu, Sheng, Jiao, Pengfei, Zhang, Lei, Song, Hao, Yang, Sheng, Xiong, Yan, Li, Yongquan, Zhang, Youming, Zhuang, Yingping, Su, Haijia, Fu, Weiping, Huang, Yingming, Li, Chun, Zhao, Zongbao K, Sun, Yan, Chen, GuoQiang, Zhao, Xueming, Huang, He, Zheng, Yuguo, Yang, Lirong, Su, Zhiguo, Ma, Guanghui, Ying, Hanjie, Chen, Jian, Tan, Tianwei, Yuan, Yingjin. Biochemical engineering in China. REVIEWS IN CHEMICAL ENGINEERINGnull. 2019, 35(8): 929-993, http://dx.doi.org/10.1515/revce-2017-0035.
[14] Cai, Peng, Gao, Jiaoqi, Zhou, Yongjin. CRISPR-mediated genome editing in non-conventional yeasts for biotechnological applications. MICROBIAL CELL FACTORIES[J]. 2019, 18(1): http://cas-ir.dicp.ac.cn/handle/321008/165686.
[15] Zhou, Yongjin J, Kerkhoven, Eduard J, Nielsen, Jens. Barriers and opportunities in bio-based production of hydrocarbons. NATURE ENERGY[J]. 2018, 3(11): 925-935, http://www.corc.org.cn/handle/1471x/2373119.
[16] Yu, Tao, Zhou, Yongjin J, Huang, Mingtao, Liu, Quanli, Pereira, Rui, David, Florian, Nielsen, Jens. Reprogramming Yeast Metabolism from Alcoholic Fermentation to Lipogenesis. CELL[J]. 2018, 174(6): 1549-+, http://dx.doi.org/10.1016/j.cell.2018.07.013.
[17] Zhou, Yongjin J, Hu, Yating, Zhu, Zhiwei, Siewers, Verena, Nielsen, Jens. Engineering 1-Alkene Biosynthesis and Secretion by Dynamic Regulation in Yeast. ACS SYNTHETIC BIOLOGY[J]. 2018, 7(2): 584-590, http://cas-ir.dicp.ac.cn/handle/321008/168798.
[18] 高教琪, 段兴鹏, 周雍进. 酵母细胞工厂生产脂肪酸及其衍生物. 生物加工过程[J]. 2018, 16(1): 19-30, http://lib.cqvip.com/Qikan/Article/Detail?id=674353287.
[19] Zhou, Yongjin J. Expanding the terpenoid kingdom. NATURE CHEMICAL BIOLOGY. 2018, 14(12): 1069-1070, http://www.corc.org.cn/handle/1471x/2373076.
[20] Tao Yu, Yongjin J Zhou, Leonie Wenning, Quanli Liu, Anastasia Krivoruchko, Verena Siewers, Jens Nielsen, Florian David. Metabolic engineering of Saccharomyces cerevisiae for production of very long chain fatty acid-derived chemicals. NATURE COMMUNICATIONS[J]. 2017, 8(1): https://doaj.org/article/36f3a67ebbcd46798748b17bc28b8b18.
[21] Zhu, Zhiwei, Zhou, Yongjin J, Krivoruchko, Anastasia, Grininger, Martin, Zhao, Zongbao K, Nielsen, Jens. Expanding the product portfolio of fungal type I fatty acid synthases. NATURE CHEMICAL BIOLOGY[J]. 2017, 13(4): 360-+, http://cas-ir.dicp.ac.cn/handle/321008/169530.
[22] Zhou, Yongjin J, Buijs, Nicolaas A, Zhu, Zhiwei, Gomez, Diego Orol, Boonsombuti, Akarin, Siewers, Verena, Nielsen, Jens. Harnessing Yeast Peroxisomes for Biosynthesis of Fatty-Acid-Derived Biofuels and Chemicals with Relieved Side-Pathway Competition. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2016, 138(47): 15368-15377, http://dx.doi.org/10.1021/jacs.6b07394.
[23] Yongjin J Zhou, Nicolaas A Buijs, Zhiwei Zhu, Jiufu Qin, Verena Siewers, Jens Nielsen. Production of fatty acid-derived oleochemicals and biofuels by synthetic yeast cell factories. NATURE COMMUNICATIONS[J]. 2016, 7(1): https://doaj.org/article/2beb07a6bc024743839aa5b405664535.
[24] 赵宗保, 周雍进, 高伟, 杨薇, 靳国杰, 刘武军, 黄璐琦. Modular pathway engineering for the construction of diterpene cell factory. COPENHAGEN BIOSCIENCE CONFERENCESnull. 2013, 137-, http://159.226.238.44/handle/321008/116926.
[25] 杨薇, 周雍进, 赵宗保. Production of dihydroxyacetone from glycerol by engineered Escherichia coli cells co-expressing gldA and nox genes. AFRICAN JOURNAL OF BIOTECHNOLOGY[J]. 2013, 12(27): 4387-, http://159.226.238.44/handle/321008/119298.
[26] 蔡媛, 郭娟, 周雍进, 朱志伟, 吴文燕, 黄璐琦, 陈敏, 赵宗保. 转化次丹参酮二烯酿酒酵母全细胞催化体系的构建. 药学学报[J]. 2013, 48(10): 1618-, http://159.226.238.44/handle/321008/119299.
[27] 周雍进, 赵宗保. 植物源活性萜类化合物“细胞工厂”的构建及优化. 2013工业生物技术发展报告[J]. 2013, 278-, http://159.226.238.44/handle/321008/119605.
[28] 杨薇, 周雍进, 刘武军, 沈宏伟, 赵宗保. 构建酿酒酵母工程菌合成香紫苏醇. 生物工程学报[J]. 2013, 29(8): 1185-, http://159.226.238.44/handle/321008/119279.
[29] 周雍进, 杨薇, 靳国杰, 刘武军, 赵宗保. Modular pathway engineering in yeast for diterpenoids production. THE GORDON RESEARCH CONFERENCE ON BIOCATALYSISnull. 2012, 0-, http://159.226.238.44/handle/321008/117122.
[30] 纪德彬, 王磊, 周雍进, 杨薇, 王倩, 赵宗保. 利用人工氧还酶体系催化L-苹果酸氧化脱羧反应. 催化学报[J]. 2012, 33(3): 530-535, http://lib.cqvip.com/Qikan/Article/Detail?id=41460045.
[31] Lin, Xinping, Yang, Fan, Zhou, Yongjin, Zhu, Zhiwei, Jin, Guojie, Zhang, Sufang, Zhao, Zongbao Kent. Highly-efficient colony PCR method for red yeasts and its application to identify mutations within two leucine auxotroph mutants. YEAST[J]. 2012, 29(11): 467-474, http://www.irgrid.ac.cn/handle/1471x/721291.
[32] Ji Debin, Wang Lei, Zhou Yongjin, Yang Wei, Wang Qian, Zhao Zongbao. Oxidative Decarboxylation of L-Malate by Using a Synthetic Bioredox System. CHINESE JOURNAL OF CATALYSIS[J]. 2012, 33(3): 530-535, http://159.226.238.44/handle/321008/143134.
[33] 周雍进, 赵宗保. 先进生物燃料导向的脂肪酸途径合成生物学改造. 生物工程学报[J]. 2011, 27(9): 1261-1267, http://lib.cqvip.com/Qikan/Article/Detail?id=39404171.
[34] 周雍进, 侯淑华, 张素芳, 赵宗保. Construction of E. coli NAD+ auxotrophic strains and the biotechnological application thereof. BOOK OF ABSTRACTSnull. 2011, 26-0, http://159.226.238.44/handle/321008/116038.
[35] Yang, Fan, Tan, Haidong, Zhou, Yongjin, Lin, Xinping, Zhang, Sufang. High-Quality RNA Preparation from Rhodosporidium toruloides and cDNA Library Construction Therewith. MOLECULAR BIOTECHNOLOGY[J]. 2011, 47(2): 144-151, http://www.irgrid.ac.cn/handle/1471x/456952.
[36] 周雍进, 高伟, 荣齐仙, 靳国杰, 刘武军, 杨薇, 朱志伟, 黄璐琦, 赵宗保. Modular Pathway Engineering (MOPE) in Yeast for Diterpenoids. 2011 COLD SPRING HARBOR ASIA SYMPOSIUMnull. 2011, 62-, http://159.226.238.44/handle/321008/117372.
[37] 周雍进, 高伟, 荣齐仙, 靳国杰, 刘武军, 杨薇, 朱志伟, 黄璐琦, 赵宗保. Modular Pathway Engineering (MOPE) in Yeast for Diterpenoids. ABSTRACTS OF PAPERS PRESENTED AT THE 2011 COLD SPRING HARBOR ASIA SYMPOSIUMnull. 2011, 62-0, http://159.226.238.44/handle/321008/116042.
[38] Zhou, Yongjin, Wang, Lei, Yang, Fan, Lin, Xinping, Zhang, Sufang, Zhao, Zongbao K. Determining the Extremes of the Cellular NAD(H) Level by Using an Escherichia coli NAD(+)-Auxotrophic Mutant. APPLIED AND ENVIRONMENTAL MICROBIOLOGY[J]. 2011, 77(17): 6133-6140, http://159.226.238.44/handle/321008/142672.
[39] 周雍进, 王磊, 杨帆, 林心萍, 张素芳, 赵宗保. Questing the extremes of the cellular NAD(H) level using an Escherichia coli NAD+ auxotrophic mutant. GORDON RESEARCH CONFERENCES ON BIOORGANIC CHEMISTRYnull. 2011, 1-, http://159.226.238.44/handle/321008/117316.
[40] 周雍进, 侯淑华, 张素芳, 赵宗保. Construction of E. coli NAD+ auxotrophic strains and the biotechnological application thereof. ASIAN CONGRESS ON BIOTECHNOLOGYnull. 2011, 26-, http://159.226.238.44/handle/321008/117375.
[41] 周雍进, 王磊, 杨帆, 林心萍, 张素芳, 赵宗保. Determining the Extremes of the Cellular NAD(H) Level by Using an Escherichia coli NAD -Auxotrophic Mutant. APPLIED AND ENVIRONMENT MICROBIOLOGY[J]. 2011, 17(待补充): 6133-, http://www.irgrid.ac.cn/handle/1471x/456956.
[42] Zhao, GuangRong, Luo, Ting, Zhou, YongJin, Jiang, Xin, Qiao, Bin, Yu, FengMing, Yuan, YingJin. fabC of Streptomyces lydicus involvement in the biosynthesis of streptolydigin. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2009, 83(2): 305-313, https://www.webofscience.com/wos/woscc/full-record/WOS:000265684900012.

（1） 植物源活性萜类化合物“细胞工厂”的构建及优化, 科学出版社, 2014-06, 第 1 作者

   

（ 1 ） 毕赤巴斯德酵母中乙酰辅酶A代谢调控, 主持, 国家级, 2018-01--2020-12
（ 2 ） 国家项目, 主持, 国家级, 2018-02--2022-12
（ 3 ） 酿酒酵母过氧化物酶体脂肪酸代谢调控高效合成脂肪醇, 主持, 国家级, 2019-01--2022-12
（ 4 ） 生物催化导向的合成生物学研究, 主持, 市地级, 2017-01--2020-12

（1）Engineering biosynthesis and secretion of 1-alkenes in yeast   2017-10-15
（2）Harnessing yeast peroxisomes for production of fatty acid-derived chemicals and biofuels   2017-05-21

现指导学生

吴晓燕  硕士研究生  081703-生物化工  

叶敏  硕士研究生  081703-生物化工  

申益维  硕士研究生  081703-生物化工  

禹伟  博士研究生  081703-生物化工