周琪  男  研究员,博导,中国科学院院士  中国科学院动物研究所
电子邮件: zhouqi@ioz.ac.cn
通信地址: 北京市朝阳区大屯路甲3号院 中国科学院干细胞与再生医学创新研究院
邮政编码: 100101

研究领域

    生殖、发育、干细胞的基础研究与转化应用。

招生信息

   
招生专业
0710J6-再生医学
071008-发育生物学
招生方向
干细胞与再生医学

教育背景

1994-03--1996-12   东北农业大学   博士
1991-09--1994-03   东北农业大学   硕士
1987-09--1991-07   东北农业大学   学士
学历

研究生

学位

博士

工作经历

   
社会兼职
2021-01-01-今,Cell Stem Cell, 学术顾问委员会委员
2020-03-01-今,Cell, 学术顾问委员会委员
2019-08-26-今,中国动物学会第十八届理事会, 常务理事
2018-01-25-2019-09-01,中华医学会组织修复与再生分会, 常委
2018-01-01-今,Cell Proliferation, 主编
2017-10-31-2019-09-30,中国动物学会生殖生物学分会, 副主任委员
2017-01-01-2019-12-31,中国科学院院刊, 编委
2016-05-20-2018-06-23,国际干细胞研究学会(ISSCR)年会组委会, 委员
2016-05-17-2019-06-26,国际干细胞研究学会(ISSCR)会员委员会, 委员
2015-10-13-2018-10-31,中华医学会医学细胞生物学分会第五届委员会, 委员
2015-07-31-今,Signal Transduction and Targeted Therapy, 编委
2015-06-10-今,Nature partner journal Regenerative Medicine, 副编辑
2015-05-01-今,Protein & Cell, 编委
2015-04-01-今,中国细胞生物学学会, 副理事长
2014-06-18-2015-06-22,国际干细胞研究学会(ISSCR)年会组委会, 委员
2014-01-01-今,国际干细胞组织(ISCF), 主席
2014-01-01-2019-09-19,中国细胞生物学学会干细胞研究分会 会长, 会长
2013-06-16-今,中国实验动物学会学术工作委员会, 委员
2013-03-01-今,National Science Review, 编委
2011-06-29-2016-09-28,Journal of Biological Chemistry, 编委
2007-01-01-今,国际干细胞组织(ISCF), 中国代表
2004-01-01-今,国际转基因技术学会 终身荣誉会员, 荣誉会员

教授课程

干细胞生物学
科学前沿进展名家系列讲座I
科学前沿进展名家系列讲座Ⅱ
干细胞研究进展系列讲座

专利与奖励

   
奖励信息
(1) 全国妇幼健康科学技术奖 自然科学奖, 一等奖, 其他, 2019
(2) 中国科学院优秀导师奖, 院级, 2019
(3) 中国侨界杰出人物, 其他, 2018
(4) 第四届树兰医学奖, 其他, 2017
(5) 中国干细胞第六届年会“干细胞杰出贡献奖”, 其他, 2016
(6) 第六届中国侨界(创新成果)贡献奖, 其他, 2016
(7) 发展中国家科学院(TWAS)生物学奖, 其他, 2016
(8) 中国科学院“优秀研究生指导教师”奖, 院级, 2014
(9) 国家自然科学奖, 二等奖, 国家级, 2014
(10) 中国科学院青年科学家国际合作奖, 院级, 2013
(11) 谈家桢生命科学创新奖, , 其他, 2013
(12) 中国科学院杰出科技成就奖, , 院级, 2013
(13) 中华全国总工会工人先锋号, 部委级, 2013
(14) 中国科学院“优秀研究生指导教师”奖, 院级, 2012
(15) 周光召基金会杰出青年基础科学奖, , 其他, 2011
(16) 中国细胞生物学干细胞杰出贡献奖, , 其他, 2010
(17) 中国侨界(创新人才)贡献奖, , 其他, 2010
(18) 何梁何利基金科学与技术进步奖, , 其他, 2010
(19) 第十届中国科学院杰出青年, , 院级, 2010
(20) 第十一届“中国青年五四奖章”, , 国家级, 2007
(21) 第九届中国青年科技奖, , 其他, 2006
(22) 第三届genOway转基因科技奖, , 其他, 2004
(23) 法中科技促进会生物技术奖, , 其他, 2003
(24) 法国华人青年企业家协会年度科研奖, 一等奖, 其他, 2001

出版信息

   
发表论文
(1) Transcriptome and DNA Methylation Profiles of Mouse Fetus and Placenta Generated by Round Spermatid Injection, Front Cell Dev Biol. doi: 10.3389/fcell.2021.632183., 2021, 通讯作者
(2) Overcoming Intrinsic H3K27me3 Imprinting Barriers Improves Post-implantation Development after Somatic Cell Nuclear Transfer, Cell Stem Cell. S1934-5909(20)30212-5, 2020, 通讯作者
(3) SARS-CoV-2 detection with CRISPR diagnostics, Cell Discov., 6:34, 2020, 通讯作者
(4) Haploid pluripotent stem cells: twofold benefits with half the effort in genetic screening and reproduction, Curr Opin Genet Dev., 64:6-12, 2020, 通讯作者
(5) Generation of GGTA1-/-β2M-/-CIITA-/- Pigs Using CRISPR/Cas9 Technology to Alleviate Xenogeneic Immune Reactions, Transplantation, 104(8):1566-1573, 2020, 通讯作者
(6) Domesticated cynomolgus monkey embryonic stem cells allow the generation of neonatal interspecies chimeric pigs., Protein Cell.11(2):97-107, 2020, 通讯作者
(7) Ethical and Policy Considerations for Human Embryo and Stem Cell Research in China, Cell Stem Cell, 27(4):511-514, 2020, 通讯作者
(8) Rbm14 maintains the integrity of genomic DNA during early mouse embryogenesis via mediating alternative splicing, Cell Proliferation, 53:e12724, 2020, 通讯作者
(9) CDetection: CRISPR-Cas12b-based DNA detection with sub-attomolar sensitivity and single-base specificity, Genome Biol. 20(1):132, 2019, 通讯作者
(10) Reprogramming of fibroblasts to uterine glandular epithelium by a chemical cocktail induction, Cell Discov. 5:26, 2019, 通讯作者
(11) Generation of qualified clinical-grade functional hepatocytes from human embryonic stem cells in chemically defined conditions, Cell Death Dis. 10(10):763, 2019, 通讯作者
(12) Cyclin B3 is required for metaphase to anaphase transition in oocyte meiosis I, J Cell Biol. doi: 10.1083/jcb.201808088, 2019, 通讯作者
(13) Enhanced mammalian genome editing by new Cas12a orthologs with optimized crRNA scaffolds, Genome Biol. 20(1):15, 2019, 通讯作者
(14) Derivation of Mouse Haploid Trophoblast Stem Cells, Cell Rep. 26(2):407-414, 2019, 通讯作者
(15) The effect of clinical-grade retinal pigment epithelium derived from human embryonic stem cells using different transplantation strategies, Protein Cell. doi: 10.1007/s13238-018-0606-8, 2019, 通讯作者
(16) Artificial sgRNAs engineered for genomeediting with new Cas12b orthologs, Cell Discov. doi: 10.1038/s41421-019-0091-0, 2019, 通讯作者
(17) Precisely controlling endogenous protein dosage in hPSCs and derivatives to model FOXG1 syndrome, Nat Commun. 10(1):928, 2019, 通讯作者
(18) Synthetic chromosome evolves the yeast genome, Sci China Life Sci. doi: 10.1007/s11427-019-9516-2, 2019, 通讯作者
(19) Generation of Bimaternal and Bipaternal Mice from Hypomethylated Haploid ESCs with Imprinting Region Deletions, Cell Stem Cell 23(5):665-676, 2018, 通讯作者
(20) Human Clinical-Grade Parthenogenetic ESC-Derived Dopaminergic Neurons Recover Locomotive Defects of Nonhuman Primate Models of Parkinson's Disease, Stem Cell Reports 11(1):171-182, 2018, 通讯作者
(21) Dnmt2 mediates intergenerational transmission of paternally acquired metabolic disorders through sperm small non-coding RNAs, Nat Cell Biol. 20(5):535-540, 2018, 通讯作者
(22) Generation of Clinical-grade Functional Cardiomyocytes from Human Embryonic Stem Cells in Chemically Defined Conditions, J Tissue Eng Regen Med. 12(1):153-163, 2018, 通讯作者
(23) METTL3-mediated m6A modification is required for cerebellar development, PLoS Biol. 16(6):e2004880, 2018, 通讯作者
(24) MeCP2 deficiency promotes cell reprogramming by stimulating IGF1/AKT/mTOR signaling and activating ribosomal protein-mediated cell cycle gene translation, J Mol Cell Biol. doi: 10.1093/jmcb/mjy018, 2018, 通讯作者
(25) MicroRNA-494 promotes cancer progression and targets adenomatous polyposis coli in colorectal cancer, Mol Cancer. 17(1):1. doi: 10.1186/s12943-017-0753-1., 2018, 通讯作者
(26) Editing porcine IGF2 regulatory element improved meat production in Chinese Bama pigs, Cell Mol Life Sci. 75(24):4619-4628, 2018, 通讯作者
(27) Generation of rat-mouse chimeras by introducing single cells of rat inner cell masses into mouse blastocysts, J Genet Genomics. pii: S1673-8527(18)30082-1, 2018, 通讯作者
(28) A fully defined static suspension culture system for large-scale human embryonic stem cell production, Cell Death Dis. 9(9):892, 2018, 通讯作者
(29) Human embryonic stem cells contribute to embryonic and extraembryonic lineages in mouse embryos upon inhibition of apoptosis, Cell Research 28(1):126-129, 2018, 通讯作者
(30) Mitochondrially produced ATP affects stem cell pluripotency via Actl6a-mediated histone acetylation, FASEB J. 32(4):1891-1902, 2018, 通讯作者
(31) Accreditation of Biosafe Clinical-Grade Human Embryonic Stem Cells According to Chinese Regulations, Stem Cell Reports 9(1):366-380, 2017, 通讯作者
(32) Mettl3-mediated m6A regulates spermatogonial differentiation and meiosis initiation, Cell Res. 27(9):1100-1114, 2017, 通讯作者
(33) Generation of Mouse Haploid Somatic Cells by Small Molecules for Genome-wide Genetic Screening., Cell Rep. 20(9):2227-2237, 2017, 通讯作者
(34) Overexpression of Stella improves the efficiency of nuclear transfer reprogramming, J Genet Genomics. 44(7):363-366, 2017, 通讯作者
(35) Pilot study of large-scale production of mutant pigs by ENU mutagenesis, Elife. 6. pii: e26248. doi: 10.7554/eLife.26248, 2017, 通讯作者
(36) Rat embryonic stem cells produce fertile offspring through tetraploid complementation, Proc Natl Acad Sci U S A. 114(45):11974-11979, 2017, 通讯作者
(37) Generation and application of mouse-rat allodiploid embryonic stem cells, Cell 164(1-2):279–292, 2016, 通讯作者
(38) Birth of fertile bimaternal offspring following intracytoplasmic injection of parthenogenetic haploid embryonic stem cells, Cell Research 26(1):135-138, 2016, 通讯作者
(39) Complete Meiosis from Embryonic Stem Cell-Derived Germ Cells In Vitro, Cell Stem Cell 18(3):330-340, 2016, 通讯作者
(40) Sperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder, Science 351(6271):397-400, 2016, 通讯作者
(41) A non-invasive method to determine the pluripotent status of stem cells by culture medium microRNA expression detection, Scientific Reports 6:22380, 2016, 通讯作者
(42) Ubiquitously expressed genes participate in cell‐specific functions via alternative promoter usage, EMBO Reports 17: 1304–1313, 2016, 通讯作者
(43) ATG3-dependent autophagy mediates mitochondrial homeostasis in pluripotency acquirement and maintenance, Autophagy 12(11):2000-2008, 2016, 通讯作者
(44) Treatment of multiple sclerosis by transplantation of neural stem cells derived from induced pluripotent stem cells, Sci China Life Sci. 59(9):950-957, 2016, 通讯作者
(45) Efficient Production of Fluorescent Transgenic Rats using the piggyBac Transposon, Sci Rep. 6:33225, 2016, 通讯作者
(46) Co-participation of paternal and maternal genomes before the blastocyst stage is not required for full-term development of mouse embryos, J Mol Cell Biol. 7(5):486-488, 2015, 通讯作者
(47) Efficient CRISPR/Cas9-mediated biallelic gene disruption and site-specific knockin after rapid selection of highly active sgRNAs in pigs, Scientific Reports 5:13348, 2015, 通讯作者
(48) Durable pluripotency and haploidy in epiblast stem cells derived from haploid embryonic stem cells in vitro, J Mol Cell Biol. 7(4):326-337, 2015, 通讯作者
(49) Dynamic transcriptional symmetry-breaking in pre-implantation mammalian embryo development revealed by single-cell RNA-seq, Development 142(20):3468-3477, 2015, 通讯作者
(50) Generation of cynomolgus monkey chimeric fetuses using embryonic stem cells, Cell Stem Cell, 2015, 通讯作者
(51) Generation of fertile offspring from Kit(w)/Kit(wv) mice through differentiation of gene corrected nuclear transfer embryonic stem cells, Cell Research 25(7):851-863, 2015, 通讯作者
(52) Generation of cell-type-specific gene mutations by expressing the sgRNA of the CRISPR system from the RNA polymerase II promoters, Protein & Cell, 2015, 通讯作者
(53) Generation of an LncRNA Gtl2-GFP Reporter for Rapid Assessment of Pluripotency in Mouse Induced Pluripotent Stem Cells, Journal of Genetics and Genomics 42(3):125-128, 2015, 通讯作者
(54) One-step generation of p53 gene biallelic mutant Cynomolgus monkey via the CRISPR/Cas system, Cell Research 25(2):258-261, 2015, 通讯作者
(55) m6A RNA methylation is regulated by microRNAs and promotes reprogramming to pluripotency, Cell Stem Cell 16(3):289-301, 2015, 通讯作者
(56) Generation of tetraploid complementation mice from embryonic stem cells cultured with chemical defined medium, Chinese Science Bulletin 59(22):2743-2748, 2014, 通讯作者
(57) Epigenetic reprogramming, gene expression and in vitro development of porcine SCNT embryos are significantly improved by a histone deacetylase inhibitor -- m- carboxycinnamic acid bishydroxamide (CBHA), Protein and Cell 5(5):382-393, 2014, 通讯作者
(58) Efficient generation of mouse ESCs-like pig induced pluripotent stem cells, Protein and Cell, 2014, 通讯作者
(59) Balancing the welfare: the use of non-human primates in research, Trends in Genetics, 2014, 通讯作者
(60) One-step generation of knockout pigs by zygote injection of CRISPR/Cas system, Cell Research 24(3):372-375, 2014, 通讯作者
(61) Genetic modification and screening in the rat using haploid embryonic stem cells, Cell Stem Cell 14(3):404-414, 2014, 通讯作者
(62) Haploid embryonic stem cells serve as a new tool for mammalian genetic study, Stem Cell Research and Therapy, 2014, 通讯作者
(63) CRISPR/Cas technology: a revolutionary approach for genome engineering, Science China Life Sciences 57(6):639-640, 2014, 通讯作者
(64) Tex101 is essential for male fertility by affecting sperm migration into the oviduct in mice., Journal of Molecular Cell Biology, 2013, 通讯作者
(65) Simultaneous generation and germline transmission of multiple gene mutations in rat using CRISPR-Cas systems., Nature Biotechnology, 2013, 通讯作者
(66) Parthenogenetic haploid embryonic stem cells produce fertile mice, Cell Research, 2013, 通讯作者
(67) Evolutionary and Functional Analysis of the Key Pluripotency FactorOct4 and Its Family Proteins. , Journal of Genetics and Genomics , 2013, 通讯作者
(68) Derivation of androgenetic embryonic stem cells from m-carboxycinnamic acid bishydroxamide (CBHA) treated androgenetic embryos. , Chinese Science Bulletin, 2013, 通讯作者
(69) Blastomere biopsy influences epigenetic reprogramming during early embryo development, which impacts neural development and function in resulting mice. , Cellular and Molecular Life Sciences, 2013, 通讯作者
(70) Preimplantation genetic diagnosis (PGD) influences adrenal development and response to cold stress in resulting mice. , Cell Tissue Research, 2013, 通讯作者
(71) MicroRNA-323-3p Regulates the Activity of Polycomb Repressive Complex 2 (PRC2) via Targeting the mRNA of Embryonic Ectoderm Development (Eed) Gene in Mouse Embryonic Stem Cells. , Journal of Biological Chemistry, 2013, 通讯作者
(72) Generation of Transgenic Rats through Induced Pluripotent Stem Cells., Journal of Biological Chemistry, 2013, 通讯作者
(73) Direct reprogramming of setoli cells into multipotent neural stem cells by defined factors. , Cell Research, 2012, 通讯作者
(74) Rapid conversion of human ESCs into mouse ESC-like pluripotent state by optimizing culture conditions. , Protein and Cell, 2012, 通讯作者
(75) Generation of dopaminergic neurons directly from mouse fibroblasts and fibroblast-derived neural progenitors.,  Cell Research., 2012, 通讯作者
(76) PCBP1 is required for maintenance of the transcriptionally silent state in fully grown mouse oocytes., Cell Cycle, 2012, 通讯作者
(77) Androgenetic haploid embryonic stem cells produce live transgenic mice, Nature, 2012, 通讯作者
(78) Early patterning of cloned mouse embryos contributes to post-implantation development. , Developmental Biology, 2012, 通讯作者
(79) Generation of tripotent neural progenitor cells from rat embryonic stem cells. , Journal of Genetics and Genomics , 2012, 通讯作者
(80) Derivation of Germline Competent Rat Embryonic Stem Cells from DA Rats. , Journal of Genetics and Genomics, 2012, 通讯作者
(81) Induced pluripotent stem induced cells show better constitutive heterochromatin remodeling and developmental potential after nuclear transfer than their parental cells. , Stem Cell Development, 2012, 通讯作者
(82)  iPS cells generated without c-Myc have active Dlk1-Dio3 region and are capable of producing full-term mice through tetraploid complementation., Cell Research, 2011, 通讯作者
(83) Pluripotency maintenance in mouse somatic cell nuclear transfer embryos and its 3 improvement by treatment with the histone deacetylase inhibitor TSA., Cellular Reprogramming. , 2011, 通讯作者
(84) Microinjection manipulation resulted in the increased apoptosis of spermatocytes in testes from intracytoplasmic sperm injection (ICSI) derived mice. , PLoS ONE, 2011, 通讯作者
(85)  Mice generated from tetraploid complementation competent iPS cells show similar developmental features as those from ES cells but are prone to tumorigenesis. , Cell Research, 2011, 通讯作者
(86) Mouse cloning and somatic cell reprogramming using electrofused blastomeres, Cell Research , 2010, 通讯作者
(87) Viable Fertile Mice Generated from Fully Pluripotent iPS Cells Derived from Adult Somatic Cells., Stem Cell Rev., 2010, 通讯作者
(88) Successful generation of cloned mice using nuclear transfer from induced pluripotent stem cells.,  Cell Research, 2010, 通讯作者
(89) Somatic nucleus reprogramming is significantly improved by m- carboxycinnamic acid bishydroxamide (CBHA), a histone deacetylase inhibitor.,  J Biol Chem. , 2010, 通讯作者
(90) Activation of the imprinted Dlk1-Dio3 region correlates with pluripotency levels of mouse stem cells. , J Biol Chem., 2010, 通讯作者
(91) Nuclear transfer-derived epiblast stem cells are transcriptionally and epigenetically distinguishable from their fertilized-derived counterparts. , Stem Cells., 2010, 通讯作者
(92) Efficient and rapid generation of induced pluripotent stem cells using alternative culture medium. , Cell Research, 2010, 通讯作者
(93) HSPC117 deficiency in cloned embryos causes placental abnormality and fetal death. , Biochemical and Biophysical Research Communications, 2010, 通讯作者
(94) Transgenic rhesus monkeys produced by gene transfer into early-cleavage–stage embryos using a simian immunodeficiency virus-based vector. , ProcNatlAcadSci USA, 2010, 通讯作者
(95) Production of mice using iPS cells and tetraploid complementation. , Nat Protoc., 2010, 通讯作者
(96) Derivation of embryonic stem cells from Brown Norway rats blastocysts. , Journal of Genetics and Genomics, 2010, 通讯作者
(97)  , Derivation and long-term culture of human parthenogenetic embryonic stem cells using human foreskin feeders., J Assist Reprod Genet., 2010, 通讯作者
(98) Decreased cofilin1 expression is important for compaction during early mouse embryo development. , BiochimBiophysActa., 2010, 通讯作者
(99) iPS cells produce viable mice through tetraploid complementation. , Nature , 2009, 通讯作者
(100) Neural progenitors derived from monkey embryonic stem cells in a simple monoculture system. , Reprod Biomed Online, 2009, 通讯作者
(101) )Human parthenogenetic embryonic stem cells: one potential resource for cell therapy. , Sci China C Life Sci., 2009, 通讯作者
(102)  A modified culture method significantly improves the development of mouse somatic cell nuclear transfer embryos.,  Reproduction , 2009, 通讯作者
(103) Evaluation of blastomere biopsy using mouse model indicates the potential high-risk of neurodegenerative disorders in the offspring. , Mol Cell Proteomics, 2009, 通讯作者
(104) Isolation and characterization of liver epithelial progenitor cells from normal adult rhesus monkeys (Macacamulatta). , Cell Research, 2009, 通讯作者
(105) Assessment of the developmental competence of human somatic cell nuclear transfer embryos by oocyte morphology classification., Hum Reprod., 2009, 通讯作者
(106) Impairments in embryonic genome activation in rhesus monkey somatic cell nuclear transfer embryos. , Cloning Stem Cells, 2008, 通讯作者
(107) Protein expression profile of the mouse metaphase-II oocyte., J Proteome Res. , 2008, 通讯作者
(108) Dissecting Signaling Pathways That Govern Self-renewal of Rabbit Embryonic Stem Cells.,  J Biol Chem., 2008, 通讯作者
(109) Comparative pluripotency analysis of mouse embryonic stem cells derived from wild-type and infertile hermaphrodite somatic cell nuclear transfer blastocysts. , Chinese Science Bulletin , 2008, 通讯作者
(110) Effects of rhFSH regimen and time interval on ovarian responses to repeated stimulation cycles in rhesus monkeys during a physiologic breeding season. , Theriogenology, 2008, 通讯作者
(111) Derivation of human embryonic stem cell lines from parthenogenetic blastocysts. , Cell Research , 2007, 通讯作者
(112)  Superovulatory response to a low dose single-daily treatment of rhFSH dissolved in polyvinylpyrrolidone in rhesus monkeys. , Am J Primatol., 2007, 通讯作者
(113) Effects of rhFSH dose on ovarian follicular response, oocyte recovery and embryo development in rhesus monkeys. , Theriogenology , 2007, 通讯作者
(114) Epigenetic marks in cloned rhesus monkey embryos: comparison with counterparts produced in vitro., Biol Reprod. , 2007, 通讯作者
(115) A comparative approach to somatic cell nuclear transfer in the rhesus monkey.,  Hum Reprod. , 2006, 第 1 作者
(116) Transplantable neural progenitor populations derived from rhesus monkey embryonic stem cells. , Stem Cells , 2005, 通讯作者
(117) Homologous feeder cells support undifferentiated growth and pluripotency in monkey embryonic stem cells. , Stem Cells, 2005, 通讯作者
(118) Generation of fertile cloned rats by regulating oocyte activation. , Science, 2003, 第 1 作者
(119)  Nuclear Transfer: New Advances and Quandaries. , Reproductive Biology and Endocrinology, 2003, 通讯作者
(120) Developmental potential of mouse embryos reconstructed from metaphase embryonic stem cell nuclei. , Biol Reprod., 2001, 第 1 作者
(121) A simplified method for the reconstruction of fully competent mouse zygotes from adult somatic donor nuclei. , Cloning, 2000, 第 1 作者
发表著作
(1) 神秘的克隆, Clone, 中国教育科学出版社, 1997-08, 第 1 作者
(2) 干细胞实验指南, Handbook: Stem Cell Biology, 中央广播电视大学出版社, 2015-07, 第 1 作者

科研活动