基本信息
周晗  女  硕导  中国科学院大连化学物理研究所
电子邮件: zhouhan418@dicp.ac.cn
通信地址: 辽宁大连沙河口区中山路457号大连化学物理研究所生物技术部
邮政编码: 116023

研究领域

1. 基于GPCR的药物筛选与发现

2. 基于大数据与人工智能的药物-靶点的作用机理

3. 天然产物的抗肿瘤机制


招生信息

   
招生专业
070302-分析化学
招生方向
分析化学
生物化学

教育背景

2007-09--2014-01   Northeastern University   研究生学历 博士学位
2003-09--2007-07   中国科学技术大学   本科学历 学士学位

工作经历

   
工作简历
2019-05~2020-06,Columbia University, 访问学者
2018-06~现在, 中国科学院大连化学物理研究所, 副研究员
2016-09~2018-06,中国科学院大连化学物理研究所, 助理研究员
2014-02~2016-06,Northeastern University, 博士后

出版信息

   
发表论文
(1) Oxa-adamantyl cannabinoids, Bioorganic & Medicinal Chemistry Letters, 2021, 第 6 作者
(2) Structure−Activity Relationship Studies of Coumarin-like Diacid Derivatives as Human G Protein-Coupled Receptor-35 (hGPR35) Agonists and a Consequent New Design Principle, Journal of Medicinal Chemistry, 2021, 第 5 作者
(3) Discovery of eight alkaloids with D1 and D2 antagonist activity in leaves of Nelumbo nucifera Gaertn. Using FLIPR assays, Journal of Ethnopharmacology, 2021, 第 1 作者
(4) Label-free cell phenotypic study of opioid receptors and discovery of novel mu opioid ligands from natural products, Journal of Ethnopharmacology, 2021, 第 4 作者
(5) Integration of micro-fractionation, high-performance liquid chromatography-ultraviolet detector-charged aerosol detector-mass spectrometry analysis and cellular dynamic mass redistribution assay to accelerate alkaloid drug discovery, Journal of Chromatography A, 2020, 第 3 作者
(6) Phenotypic assessment and ligand screening of ETA/ETB receptors with label-free dynamic mass redistribution assay, Naunyn-Schmiedeberg's Archives of Pharmacology, 2020, 第 4 作者
(7) An offline two-dimensional supercritical fluid chromatography × reversed phase liquid chromatography tandem quadrupole time-of-flight mass spectrometry system for comprehensive gangliosides profiling in swine brain extract, Talanta, 2020, 第 8 作者
(8) Identification of novel phytocannabinoids from Ganoderma by label-free dynamic mass redistribution assay, Journal of ethnopharmacology, 2020, 第 1 作者
(9) Systematic characterization of AT1 receptor antagonists with label-free dynamic mass redistribution assays, Journal of Pharmacological and Toxicological Methods, 2020, 第 4 作者
(10) Production of 1,2-Cyclohexanedicarboxylates from Diacetone Alcohol and Fumarates, ACS Sustainable Chemistry & Engineering, 2019, 第 4 作者
(11) Label-free cell phenotypic study of FFA4 and FFA1 and discovery of novel agonists of FFA4 from natural products, RSC advances, 2019, 第 2 作者
(12) Profiling of Human Milk Oligosaccharides for Lewis Epitopes and Secretor Status by Electrostatic Repulsion Hydrophilic Interaction Chromatography Coupled with Negative-Ion Electrospray Tandem Mass Spectrometry, Analytical chemistry, 2019, 第 7 作者
(13) Discovery of β2- adrenoceptor agonists in Curcuma zedoaria Roscusing label-free cell phenotypic assay combined withtwo-dimensional liquid chromatography, Journal of Chromatography A, 2018, 第 7 作者
(14) Saikosaponin D from Radix Bupleuri suppresses triple-negative breast cancer cell growth by targeting β-catenin signaling, Biomedicine & Pharmacotherapy, 2018, 第 7 作者
(15) Oximes short-acting CB1 receptor agonists, Bioorganic & medicinal chemistry, 2018, 第 7 作者
(16) (R)‑N‑(1-Methyl-2-hydroxyethyl)-13‑(S)‑methyl-arachidonamide (AMG315): A Novel Chiral Potent Endocannabinoid Ligand with Stability to Metabolizing Enzymes, Journal of Medicinal Chemistry, 2018, 第 10 作者
(17) Discovery of novel antagonists on β2-adrenoceptor from natural products using a label-free cell phenotypic assay, Naunyn-Schmiedeberg's Archives of Pharmacology, 2018, 第 10 作者
(18) Human Cannabinoid Receptor 2 Ligand-interaction Motif: Transmembrane Helix 2 Cysteine, C2.59(89), as Determinant of Classical Cannabinoid Agonist Activity and Binding Pose, ACS Chemical Neuroscience, 2017, 第 1 作者
(19) Discovery of new muscarinic acetylcholine receptor antagonists from Scopolia tangutica, Scientific Reports, 2017, 第 7 作者
(20) Crystal Structure of the Human Cannabinoid Receptor CB1, Cell, 2016, 其他(合作组作者)

科研活动

   
参与会议
(1)AM994-Binding Architecture of Human Cannabinoid Receptor 2 Using Ligand-Assisted Protein Structure Followed by Molecular Dynamics   2011-07-05