能量代谢调控、衰老与衰老相关疾病

   

071003-生理学
100104-病理学与病理生理学
086000-生物与医药

生理学-能量代谢调控、衰老与衰老相关疾病
病理学与病理生理学-能量代谢调控、衰老与衰老相关疾病
生物与医药-能量代谢调控、衰老与衰老相关疾病

2006-09--2012-06   中国科学院研究生院   博士
2002-09--2006-06   南京大学   学士

   

2019-12~现在, 中科院上海营养与健康研究所, 研究员
2013-03~2019-12,哈佛医学院/麻省总医院, 博士后
2012-07~2013-02,中科院上海生命科学研究院, 助理研究员

营养与生理

   

（1） Harvard Chinese Life Science Distinguished Research Award, 研究所（学校）, 2019
（2） Tosteson & Fund for Medical Discovery (FMD) Fellowships, 研究所（学校）, 2017

   

[1] Alexander A Soukas, Ben Zhou. Surviving starvation simply without TFEB.. PLOS BIOLOGY[J]. 2019, 17(5): https://doaj.org/article/c20cc0d000694841ba4627948ed7e448.
[2] Zhou, Ben, Soukas, Alexander A. Suppressing the dark side of autophagy. AUTOPHAGYnull. 2019, 15(10): 1852-1853, [3] Zhou, Ben, Kreuzer, Johannes, Kumsta, Caroline, Wu, Lianfeng, Kamer, Kimberli J, Cedillo, Lucydalila, Zhang, Yuyao, Li, Sainan, Kacergis, Michael C, Webster, Christopher M, FejesToth, Geza, NarayFejesToth, Aniko, Das, Sudeshna, Hansen, Malene, Haas, Wilhelm, Soukas, Alexander A. Mitochondrial Permeability Uncouples Elevated Autophagy and Lifespan Extension. CELL[J]. 2019, 177(2): 299-+, http://dx.doi.org/10.1016/j.cell.2019.02.013.
[4] Webster Christopher M, Pino Elizabeth C, Carr Christopher E, Wu Lianfeng, Zhou Ben, Cedillo Lucydalila, Kacergis Michael C, Curran Sean P, Soukas Alexander A. Genome-wide RNAi Screen for Fat Regulatory Genes in C. elegans Identifies a Proteostasis-AMPK Axis Critical for Starvation Survival. CELL REPORTS[J]. 2017, [5] Liu, Jun, Zhou, Ben, Yan, Menghong, Huang, Rui, Wang, Yuangao, He, Zhishui, Yang, Yonggang, Dai, Changgui, Wang, Yiqian, Zhang, Fang, Zhai, Qiwei. CLOCK and BMAL1 Regulate Muscle Insulin Sensitivity via SIRT1 in Male Mice. ENDOCRINOLOGY[J]. 2016, 157(6): 2259-2269, [6] Wang, Yuangao, Hu, Yanan, Sun, Chenxia, Zhuo, Shu, He, Zhishui, Wang, Hui, Yan, Menghong, Liu, Jun, Luan, Yi, Dai, Changgui, Yang, Yonggang, Huang, Rui, Zhou, Ben, Zhang, Fang, Zhai, Qiwei. Down-regulation of Risa improves insulin sensitivity by enhancing autophagy. FASEB JOURNAL[J]. 2016, 30(9): 3133-3145, http://dx.doi.org/10.1096/fj.201500058R.
[7] Wu Lianfeng, Zhou Ben, OshiroRapley Noriko, Li Man, Paulo Joao A, Webster Christopher M, Mou Fan, Kacergis Michael C, Talkowski Michael E, Carr Christopher E, Gygi Steven P, Zheng Bin, Soukas Alexander A. An Ancient, Unified Mechanism for Metformin Growth Inhibition in C. elegans and Cancer. CELL[J]. 2016, [8] Zhou Ben. CLOCK/BMAL1 regulates circadian change of insuin sensitivity via SIRT1. Hepatology. 2014, [9] Yi Zhang, Ben Zhou, Bo Deng, Fang Zhang, Jingxia Wu, Yuangao Wang, Yingying Le, Qiwei Zhai. Amyloid-β Induces Hepatic Insulin Resistance In Vivo via JAK2. DIABETES. 2013, 62(4): 1159-1166, [10] Zhou, B, Li, C, Qi, W, Zhang, Y, Zhang, F, Wu, J X, Hu, Y N, Wu, D M, Liu, Y, Yan, T T, Jing, Q, Liu, M F, Zhai, Q W. Downregulation of miR-181a upregulates sirtuin-1 (SIRT1) and improves hepatic insulin sensitivity. DIABETOLOGIA[J]. 2012, 55(7): 2032-2043, https://www.webofscience.com/wos/woscc/full-record/WOS:000305215200022.

   

（ 1 ） 血清和糖皮质激素诱导激酶SGK3调控糖脂代谢的分子机理研究, 主持, 国家级, 2021-01--2024-12
（ 2 ） 线粒体膜通透性转换孔异常激活加速衰老的分子机理研究, 主持, 部委级, 2020-01--2024-12

现指导学生

陈启龙  博士研究生  071009-细胞生物学  

戴玉名  硕士研究生  0710Z2-计算生物学  

张绮阳  硕士研究生  0710Z2-计算生物学  

周子前  硕士研究生  071003-生理学  

王宝生  硕士研究生  071009-细胞生物学  

郭嘉璐  硕士研究生  071009-细胞生物学