General
刘志华 女 汉族 博导 生物物理研究所
Principal Investigator
Key Laboratory of Infection and Immunity of CAS, Institute of Biophysics, Chinese Academy of Sciences
Email: zhihualiu@ibp.ac.cn
Telephone: 10-64888004
Address: 15 Datun Road, Chaoyang District, Beijing, China
Postcode: 100101
Principal Investigator
Key Laboratory of Infection and Immunity of CAS, Institute of Biophysics, Chinese Academy of Sciences
Email: zhihualiu@ibp.ac.cn
Telephone: 10-64888004
Address: 15 Datun Road, Chaoyang District, Beijing, China
Postcode: 100101
Research Areas
1. Intestinal macrophage and T/B cell differentiation, migration and expansion
2. Microbiota recognition and control by intestinal macrophage
3. In inflammatory bowel disease (IBD), the mechanism of macrophage regulating T cell differentiation
4. The mechanistic studies of IBD susceptible genes
5. The role of macrophage in colon cancer
2. Microbiota recognition and control by intestinal macrophage
3. In inflammatory bowel disease (IBD), the mechanism of macrophage regulating T cell differentiation
4. The mechanistic studies of IBD susceptible genes
5. The role of macrophage in colon cancer
Education
1995-1999 Beijing University, B.S
1999-2005 Harvard University, Ph.D
1999-2005 Harvard University, Ph.D
Experience
Work Experience
2006-2011 National Institutes of Health, USA
2012- Institute of Biophysics, Chinese Academy of Sciences
2012- Institute of Biophysics, Chinese Academy of Sciences
Honors & Distinctions
2012 “Thousand People Plan”
2012 Chinese Academy of Sciences - Novo Nordisk Great Wall Professorship
2012 Chinese Academy of Sciences - Novo Nordisk Great Wall Professorship
Publications
Papers
1.Zhang Q, Pan Y, Yan R, Zeng B, Wang H, Zhang X, Li W, Wei H, Liu Z. Commensal bacteria direct selective cargo sorting to promote symbiosis. Nature Immunology. 2015 Aug 3. doi: 10.1038/ni.3233.
2. Cho HJ, Yu J, Xie C, Rudrabhatla P, Chen X, Wu J, Parisiadou L, Liu G, Sun L, Ma B, Ding J, Liu Z*, Cai H*.Leucine-rich repeat kinase 2 regulates Sec16A at ER exit sites to allow ER-Golgi export. EMBO J. 2014 Sep. (*Co-corresponding author)
3. Xing S., Luo Y., Liu Z., Bu P., Duan H., Liu D., Wang P., Yang J., Song L., Feng J., Yang D., Qin Z., Yan X. Targeting endothelial CD146 attenuates colitis and prevents colitis-associated carcinogenesis. Am J Pathol. 2014 May; 184 (5), 1604-16.
4. Liu Z, Lenardo MJ. The role of LRRk2 in inflammatory bowel disease. Cell Research. 2012 Jul; 22(7):1092-4.
5. Liu Z, Lee J, Krummey S, Lu W, Cai H, Lenardo MJ. LRRK2 is a regulator of NFAT that modulates the severity of inflammatory bowel disease. Nature Immunology. 2011 Oct 11; 12(11):1063. (Cover story in Nature Immunology 2011, issue 11)
6. Yu L, McPhee CK, Zheng L, Mardones GA, Rong Y, Peng J, Mi N, Zhao Y, Liu Z, Wan F, Hailey DW, Oorschot V, Klumperman J, Baehrecke EH, Lenardo MJ. Termination of autophagy and reformation of lysosomes regulated by mTOR. Nature. 2010 Jun 17; 465(7300): 942-6.
7. Liu Z, Meray RK, Grammatopoulos TN, Fredenburg RA, Cookson MR, Liu Y, Logan T, Lansbury PT Jr. Membrane-associated farnesylated UCH-L1 promotes alpah-synuclein neurotoxicity and is a therapeutic target for Parkinson’s disease. PNAS. 2009 Mar 24; 106(12): 4635-40.
8. Liu Z, Lenardo MJ. Reactive oxygen species regulate autophagy through redox-sensitive proteases. Dev Cell. 2007 Apr; 12(4): 484-5
9. Yu L, Wan F, Dutta S, Welsh S, Liu Z, Freundt E, Baehrecke EH, Lenardo M. Autophagic cell death by selective catalase degradation. PNAS 2006 Mar, 103(13): 4952-7.
10. Liu Y, Fallon L, Lashuel HA, Liu Z, Lansbury PT Jr. The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility. Cell. 2002 Oct 18; 111(2): 209-18.
11. Ge H, Liu Z, Church GM, Vidal M. Correlation between transcriptome and interactome mapping data from Saccharomyces cerevisiae. Nat Genet. 2001 Dec; 29(4): 482-6.
2. Cho HJ, Yu J, Xie C, Rudrabhatla P, Chen X, Wu J, Parisiadou L, Liu G, Sun L, Ma B, Ding J, Liu Z*, Cai H*.Leucine-rich repeat kinase 2 regulates Sec16A at ER exit sites to allow ER-Golgi export. EMBO J. 2014 Sep. (*Co-corresponding author)
3. Xing S., Luo Y., Liu Z., Bu P., Duan H., Liu D., Wang P., Yang J., Song L., Feng J., Yang D., Qin Z., Yan X. Targeting endothelial CD146 attenuates colitis and prevents colitis-associated carcinogenesis. Am J Pathol. 2014 May; 184 (5), 1604-16.
4. Liu Z, Lenardo MJ. The role of LRRk2 in inflammatory bowel disease. Cell Research. 2012 Jul; 22(7):1092-4.
5. Liu Z, Lee J, Krummey S, Lu W, Cai H, Lenardo MJ. LRRK2 is a regulator of NFAT that modulates the severity of inflammatory bowel disease. Nature Immunology. 2011 Oct 11; 12(11):1063. (Cover story in Nature Immunology 2011, issue 11)
6. Yu L, McPhee CK, Zheng L, Mardones GA, Rong Y, Peng J, Mi N, Zhao Y, Liu Z, Wan F, Hailey DW, Oorschot V, Klumperman J, Baehrecke EH, Lenardo MJ. Termination of autophagy and reformation of lysosomes regulated by mTOR. Nature. 2010 Jun 17; 465(7300): 942-6.
7. Liu Z, Meray RK, Grammatopoulos TN, Fredenburg RA, Cookson MR, Liu Y, Logan T, Lansbury PT Jr. Membrane-associated farnesylated UCH-L1 promotes alpah-synuclein neurotoxicity and is a therapeutic target for Parkinson’s disease. PNAS. 2009 Mar 24; 106(12): 4635-40.
8. Liu Z, Lenardo MJ. Reactive oxygen species regulate autophagy through redox-sensitive proteases. Dev Cell. 2007 Apr; 12(4): 484-5
9. Yu L, Wan F, Dutta S, Welsh S, Liu Z, Freundt E, Baehrecke EH, Lenardo M. Autophagic cell death by selective catalase degradation. PNAS 2006 Mar, 103(13): 4952-7.
10. Liu Y, Fallon L, Lashuel HA, Liu Z, Lansbury PT Jr. The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility. Cell. 2002 Oct 18; 111(2): 209-18.
11. Ge H, Liu Z, Church GM, Vidal M. Correlation between transcriptome and interactome mapping data from Saccharomyces cerevisiae. Nat Genet. 2001 Dec; 29(4): 482-6.
Patents
1. Methods for the treatment of synucleinopathies, US 20050277629 2005-12-15
2. Treatment of proteinophathies using a farnesyl transferase inhibitor, US 20100160372 2010-6-24
3. Treatment of lysosomal storage diseases, US 20100184803 2010-7-22
4. Treatment of mitochondrial disorders using a farnesyl tranferase inhibitor, US 20110060005 2011-3-10
2. Treatment of proteinophathies using a farnesyl transferase inhibitor, US 20100160372 2010-6-24
3. Treatment of lysosomal storage diseases, US 20100184803 2010-7-22
4. Treatment of mitochondrial disorders using a farnesyl tranferase inhibitor, US 20110060005 2011-3-10
Students
已指导学生
赵永亮 硕士研究生 071010-生物化学与分子生物学
张馨文 硕士研究生 085238-生物工程
现指导学生
颜瑞清 博士研究生 071010-生物化学与分子生物学
方传雷 硕士研究生 085238-生物工程
王海方 博士研究生 071010-生物化学与分子生物学
俞昊男 硕士研究生 071010-生物化学与分子生物学
向琛 硕士研究生 071006-神经生物学
李慧 硕士研究生 071009-细胞生物学
沈雪莹 博士研究生 071010-生物化学与分子生物学