General
郑辉 男 博导 广州生物医药与健康研究院
Email: zheng_hui@gibh.ac.cn
Telephone: 020-32015334
Mobile phone:
Address: 广州市萝岗区开源大道190号
Postcode: 510530
Email: zheng_hui@gibh.ac.cn
Telephone: 020-32015334
Mobile phone:
Address: 广州市萝岗区开源大道190号
Postcode: 510530
Research Areas
Stem cell (iPS, reprogramming)
Neuroscience (NSC, learning and memory, addiction, behavior)
Neuroscience (NSC, learning and memory, addiction, behavior)
Education
2005-2010 Graduate Student, Pharmacology, University of Minnesota, Minneapolis, MN. USA
2001-2005 Undergraduate Student, Biology, Tsinghua University, Beijing, People’s Republic of China.
2001-2005 Undergraduate Student, Biology, Tsinghua University, Beijing, People’s Republic of China.
Experience
2010 –Current Researcher, Principle Investigator, Guangzhou Institutes of Biomedicine and Health, Chinese Academic of Science
2010 Postdoctoral Research Assistant, Pharmacology, University of Minnesota, Minneapolis, MN. USA
2010 Postdoctoral Research Assistant, Pharmacology, University of Minnesota, Minneapolis, MN. USA
Honors & Distinctions
2009.05 Beatrice Z. Milne and Theodore Brandenburg Awards for the excellent scientific achievement during the Ph.D. Study.
Publications
1. Zheng, H., Chu, J., Zhang, Y., Loh, H.H. & Law, P.Y. Modulating mu-Opioid Receptor Phosphorylation Switches Agonist-Dependent Signaling as Reflected in PKCε Activation and Dendritic Spine Stability. J Biol Chem (Published ahead of print).
2. Zheng, H., Chu, J., Zeng, Y., Loh, H. H. & Law, P. Y. (2010) Yin Yang 1 phosphorylation contributes to the differential effects of mu-opioid receptor agonists on microRNA-190 expression J Biol Chem 285, 21994-2002.
3. Zheng, H., Loh, H. H. & Law, P. Y. (2010) Agonist-selective signaling of G protein-coupled receptor: Mechanisms and implications IUBMB Life 62, 112-119.
4. Zheng, H., Zeng, Y., Chu, J., Kam, A. Y., Loh, H. H., et al. (2010) Modulations of NeuroD activity contribute to the differential effects of morphine and fentanyl on dendritic spine stability J Neurosci 30, 8102-10.
5. Zheng, H., Zeng, Y., Zhang, X., Chu, J., Loh, H. H., et al. (2010) {micro}-Opioid Receptor Agonists Differentially Regulate the Expression of miR-190 and NeuroD Mol Pharmacol 77, 102-109.
6. Zheng, H., Chu, J., Qiu, Y., Loh, H. H. & Law, P. Y. (2008) Agonist-selective signaling is determined by the receptor location within the membrane domains Proc Natl Acad Sci U S A 105, 9421-6.
7. Zheng, H., Loh, H. H. & Law, P. Y. (2008) {beta}-Arrestin-Dependent {micro}-Opioid Receptor-Activated Extracellular Signal-Regulated Kinases (ERKs) Translocate to Nucleus in Contrast to G Protein-Dependent ERK Activation Mol Pharmacol 73, 178-90.
8. Chu, J., Zheng, H., Loh, H. H. & Law, P. Y. (2008) Morphine-induced mu-opioid receptor rapid desensitization is independent of receptor phosphorylation and beta-arrestins Cell Signal 20, 1616-24.
9. Chu, J., Zheng, H., Zhang, Y., Loh, H. H. & Law, P. Y. (2010) Agonist-dependent mu-opioid receptor signaling can lead to heterologous desensitization Cell Signal 22, 684-96.
10. Pan, G., Li, J., Zhou, Y., Zheng, H. & Pei, D. (2006) A negative feedback loop of transcription factors that controls stem cell pluripotency and self-renewal Faseb J 20, 1730-2.
2. Zheng, H., Chu, J., Zeng, Y., Loh, H. H. & Law, P. Y. (2010) Yin Yang 1 phosphorylation contributes to the differential effects of mu-opioid receptor agonists on microRNA-190 expression J Biol Chem 285, 21994-2002.
3. Zheng, H., Loh, H. H. & Law, P. Y. (2010) Agonist-selective signaling of G protein-coupled receptor: Mechanisms and implications IUBMB Life 62, 112-119.
4. Zheng, H., Zeng, Y., Chu, J., Kam, A. Y., Loh, H. H., et al. (2010) Modulations of NeuroD activity contribute to the differential effects of morphine and fentanyl on dendritic spine stability J Neurosci 30, 8102-10.
5. Zheng, H., Zeng, Y., Zhang, X., Chu, J., Loh, H. H., et al. (2010) {micro}-Opioid Receptor Agonists Differentially Regulate the Expression of miR-190 and NeuroD Mol Pharmacol 77, 102-109.
6. Zheng, H., Chu, J., Qiu, Y., Loh, H. H. & Law, P. Y. (2008) Agonist-selective signaling is determined by the receptor location within the membrane domains Proc Natl Acad Sci U S A 105, 9421-6.
7. Zheng, H., Loh, H. H. & Law, P. Y. (2008) {beta}-Arrestin-Dependent {micro}-Opioid Receptor-Activated Extracellular Signal-Regulated Kinases (ERKs) Translocate to Nucleus in Contrast to G Protein-Dependent ERK Activation Mol Pharmacol 73, 178-90.
8. Chu, J., Zheng, H., Loh, H. H. & Law, P. Y. (2008) Morphine-induced mu-opioid receptor rapid desensitization is independent of receptor phosphorylation and beta-arrestins Cell Signal 20, 1616-24.
9. Chu, J., Zheng, H., Zhang, Y., Loh, H. H. & Law, P. Y. (2010) Agonist-dependent mu-opioid receptor signaling can lead to heterologous desensitization Cell Signal 22, 684-96.
10. Pan, G., Li, J., Zhou, Y., Zheng, H. & Pei, D. (2006) A negative feedback loop of transcription factors that controls stem cell pluripotency and self-renewal Faseb J 20, 1730-2.
Conferences
2010. 10 Beijing Forest University, Beijing,China
Oral Presentation in ASBMB. Title: “Opioid, NeuroD, Adult Neurogenesis and Memory”, Hui Zheng, Ji Chu, Horace H. Loh and Ping-Yee Law”
2010. 09 Cold Spring Harbor Asia Conference, Suzhou,China
Oral Presentation Titled “NeuroD, Adult Neurogenesis and Memory” in “Reprogramming and Plasticity” section, “Molecular Switches & Genome Function in Stem Cells & Development”, Hui Zheng, Ji Chu, Horace H. Loh and Ping-Yee Law”
2010. 04 Experimental Biology 2010, Anaheim, CA
Poster Presentation in ASBMB. Title: “Yin Yang 1 Phosphorylation contributes to the differential effects of µ-opioid receptor agonists on miR-190 expression”, Hui Zheng, Ji Chu, Yan Zeng, Horace H. Loh and Ping-Yee Law”
2009. 10 Society of neuroscience annual meeting in Chicago, IL.
Poster Presentation Title: μ-opioid receptor modulates the stability of dendritic spines by agonist-selective regulation on NeuroD activity. Hui Zheng, Yan Zeng, Xiaoxiao Zhang, Ji Chu, Horace H. Loh and Ping-Yee Law
2009. 05 2nd Annual Biomedical Sciences Graduate Programs, Minneapolis, MN
Oral Presentation. Title: “Agonist-selective signaling of MOR” Hui Zheng, Horace H. Loh and Ping-Yee Law
2008.08 236th American Chemical Society National Meeting, Philadelphia, PA
Oral Presentation in a symposium: “Pharmacology: The Forgotten Art of Drug Discovery”. Title: “Agonist-Selective Signaling On mu-Opioid Receptor, Hui Zheng, Horace H. Loh and Ping-Yee Law”
2008.05 1st Annual Biomedical Sciences Graduate Programs, Minneapolis, MN
Poster Presentation. Title: “Agonist-selective signaling of MOR agonists, morphine and fentanyl, Hui Zheng, Horace H. Loh and Ping-Yee Law
2008.04 Experimental Biology 2008, San Diego, CA
Poster Presentation in Program: “G Protein II”, ASPET. Title: “Morphine and Etorphine activate same G protein but exhibit distinct pathways in μ-opioid receptor-mediated ERK1/2 activation, Hui Zheng, Horace H. Loh and Ping-Yee Law”
Oral Presentation in ASBMB. Title: “Opioid, NeuroD, Adult Neurogenesis and Memory”, Hui Zheng, Ji Chu, Horace H. Loh and Ping-Yee Law”
2010. 09 Cold Spring Harbor Asia Conference, Suzhou,China
Oral Presentation Titled “NeuroD, Adult Neurogenesis and Memory” in “Reprogramming and Plasticity” section, “Molecular Switches & Genome Function in Stem Cells & Development”, Hui Zheng, Ji Chu, Horace H. Loh and Ping-Yee Law”
2010. 04 Experimental Biology 2010, Anaheim, CA
Poster Presentation in ASBMB. Title: “Yin Yang 1 Phosphorylation contributes to the differential effects of µ-opioid receptor agonists on miR-190 expression”, Hui Zheng, Ji Chu, Yan Zeng, Horace H. Loh and Ping-Yee Law”
2009. 10 Society of neuroscience annual meeting in Chicago, IL.
Poster Presentation Title: μ-opioid receptor modulates the stability of dendritic spines by agonist-selective regulation on NeuroD activity. Hui Zheng, Yan Zeng, Xiaoxiao Zhang, Ji Chu, Horace H. Loh and Ping-Yee Law
2009. 05 2nd Annual Biomedical Sciences Graduate Programs, Minneapolis, MN
Oral Presentation. Title: “Agonist-selective signaling of MOR” Hui Zheng, Horace H. Loh and Ping-Yee Law
2008.08 236th American Chemical Society National Meeting, Philadelphia, PA
Oral Presentation in a symposium: “Pharmacology: The Forgotten Art of Drug Discovery”. Title: “Agonist-Selective Signaling On mu-Opioid Receptor, Hui Zheng, Horace H. Loh and Ping-Yee Law”
2008.05 1st Annual Biomedical Sciences Graduate Programs, Minneapolis, MN
Poster Presentation. Title: “Agonist-selective signaling of MOR agonists, morphine and fentanyl, Hui Zheng, Horace H. Loh and Ping-Yee Law
2008.04 Experimental Biology 2008, San Diego, CA
Poster Presentation in Program: “G Protein II”, ASPET. Title: “Morphine and Etorphine activate same G protein but exhibit distinct pathways in μ-opioid receptor-mediated ERK1/2 activation, Hui Zheng, Horace H. Loh and Ping-Yee Law”
Students
已指导学生
李文 博士研究生 071010-生物化学与分子生物学
李响 硕士研究生 071010-生物化学与分子生物学
现指导学生
陈金龙 硕士研究生 071009-细胞生物学
杨肖 硕士研究生 085238-生物工程
张梦丹 硕士研究生 071009-细胞生物学
梁丽宁 博士研究生 071009-细胞生物学
林立龙 博士研究生 071009-细胞生物学