基本信息
联系电话：020-32015334
手机号码：
通信地址：广州市萝岗区开源大道190号
邮政编码：510530
郑辉博士于2001.09~2005.07在清华大学生物科学与技术系完成本科学习；本科毕业后于2005.08~2010.01在美国明尼苏达大学药理系攻读博士学位的科研训练，师从知名学者罗秉义教授和台湾中央研究院院士罗浩教授，获得博士学位后于2010.01~2010.09继续在同一实验室接受博士后训练。2010年09月作为全时研究员加入中国科学院广州生物医药与健康研究院，并开始建立自己的实验室。
郑辉博士一直聚焦在研究不同细胞命运转换过程涉及的细胞生物学机制: 1） 本科学习期间主要研究多能性转录因子对胚胎干细胞多能性维持的调控机制；2）博士研究生期间主要研究信号转导对神经干细胞分化的调控作用；3）回国后主要研究多能性转录因子以及细胞在不同状态（间充质及上皮）间的相互转化调控体细胞重编程具体机制。
郑辉博士目前承担包括国家自然科学基金以及中国科学院先导科技项目在内的多项国家以及省市级科研项目。申请人目前合计发表21篇论文。其中，在5年内（2009-2014）发表论文17篇。全部论文中包括：作为共同通讯作者在Nat Cell Biol上发表1篇论文，作为唯一通讯作者发表论文14篇（PNAS，Biol Psychiatry，Neuropsychopharmacol，J Neurosci等），作为唯一通讯作者发表论文13篇（Cell Res和13篇唯一通讯作者论文），作为共同作者发表论文5篇。合计影响因子超过120，合计他引次数超过400次。50%以上的论文是申请人在2010年9月回国后发表的。
郑辉博士现担任IUBMB Life, Cell Regeneration, Frontiers in Cellular Endocrinology等国际性学术杂志的编委。同时曾担任国际干细胞研究学会（ISSCR）2014年年会摘要评审，国家自然科学基金项目评审，香港研究资助局项目外部评审，科技部创新人才推进计划评审，广州市珠江新星等项目评审。
研究领域
干细胞生物学（诱导多能干细胞、细胞类型转换）
神经生物学（神经干细胞、学习记忆、成瘾机制、动物行为）
招生信息
招收对干细胞生物学和/或神经生物学有兴趣的博士、硕士
欢迎对干细胞生物学和/或神经生物学有兴趣的本科生来实验室实习
欢迎对干细胞生物学和/或神经生物学有兴趣的本科生来实验室实习
教育背景
2005-2009 美国明尼苏达大学 药理系 博士
2001-2005 清华大学 生物科学与技术系 学士
2001-2005 清华大学 生物科学与技术系 学士
工作经历
2010-至今 中国科学院广州生物医药与健康研究院 研究员
2010 美国明尼苏达大学药理系 博士后研究助理
2010 美国明尼苏达大学药理系 博士后研究助理
专利与奖励
2009.05 Beatrice Z. Milne and Theodore Brandenburg Awards for the excellent scientific achievement during the Ph.D. Study.
出版信息
01) Zheng H, Hutchins AP, Pan G, Li Y, Pei D*, & Pei G* Where cell fate conversions meet Chinese philosophy. Cell Res (2014) 24(10):1162-3.
02) Li W, He S, Zhou Y, Li Y, Hao J, Zhou X, Wang F, Zhang Y, Huang Z, Li Z, Loh HH, Law PY, & Zheng H* Neurod1 Modulates Opioid Antinociceptive Tolerance via Two Distinct Mechanisms. Biol Psychiatry (2014) 76(10):775-84.
03) Li X, Pei D, & Zheng H* Transitions between epithelial and mesenchymal states during cell fate conversions. Protein Cell (2014) 5(8):580-91.
04) Liu X, Sun H, Qi J, Wang L, He S, Liu J, Feng C, Chen C, Li W, Guo Y, Qin D, Pan G, Chen J, Pei D*, & Zheng H* Sequential introduction of reprogramming factors reveals a time-sensitive requirement for individual factors and a sequential EMT-MET mechanism for optimal reprogramming. Nat Cell Biol (2013) 15(7):829-838.
05) Zheng H*, Zhang Y, Li W, Loh HH, & Law PY NeuroD Modulates Opioid Agonist-Selective Regulation of Adult Neurogenesis and Contextual Memory Extinction. Neuropsychopharmacology (2013) 38(5):770-777.
06) Zheng H*, Loh HH, & Law PY Posttranslation modification of G protein-coupled receptor in relationship to biased agonism. Methods Enzymol (2013) 522:391-408.
07) Zheng H*, Zou H, Liu X, Chu J, Zhou Y, Loh HH, & Law PY Cholesterol level influences opioid signaling in cell models and analgesia in mice and humans. J Lipid Res (2012) 53(6):1153-1162.
08) Zheng H*, Pearsall EA, Hurst DP, Zhang Y, Chu J, Zhou Y, Reggio PH, Loh HH, & Law PY Palmitoylation and membrane cholesterol stabilize mu-opioid receptor homodimerization and G protein coupling. BMC Cell Biol (2012) 13:6.
09) Zheng H*, Law PY, & Loh HH Non-Coding RNAs Regulating Morphine Function: With Emphasis on the In vivo and In vitro Functions of miR-190. Front Genet (2012) 3:113.
10) Zheng H*, Chu J, Zhang Y, Loh HH, & Law PY Modulating micro-opioid receptor phosphorylation switches agonist-dependent signaling as reflected in PKCepsilon activation and dendritic spine stability. J Biol Chem (2011) 286(14):12724-12733.
11) Zheng H*, Zeng Y, Zhang X, Chu J, Loh HH, & Law PY mu-Opioid Receptor Agonists Differentially Regulate the Expression of miR-190 and NeuroD. Mol Pharmacol (2010) 77(1):102-109.
12) Zheng H*, Zeng Y, Chu J, Kam AY, Loh HH, & Law PY Modulations of NeuroD activity contribute to the differential effects of morphine and fentanyl on dendritic spine stability. J Neurosci (2010) 30(24):8102-8110.
13) Zheng H*, Loh HH, & Law PY Agonist-selective signaling of G protein-coupled receptor: Mechanisms and implications. IUBMB Life (2010) 62(2):112-119.
14) Zheng H*, Chu J, Zeng Y, Loh HH, & Law PY Yin Yang 1 phosphorylation contributes to the differential effects of mu-opioid receptor agonists on microRNA-190 expression. J Biol Chem (2010) 285(29):21994-22002.
15) Zheng H*, Loh HH, & Law PY beta-Arrestin-Dependent mu-Opioid Receptor-Activated Extracellular Signal-Regulated Kinases (ERKs) Translocate to Nucleus in Contrast to G Protein-Dependent ERK Activation. Mol Pharmacol (2008) 73(1):178-190.
16) Zheng H*, Chu J, Qiu Y, Loh HH, & Law PY Agonist-selective signaling is determined by the receptor location within the membrane domains. Proc Natl Acad Sci U S A (2008) 105(27):9421-9426.
其他论文
01) Xu C*, Zhang Y, Zheng H, Loh HH, & Law PY Morphine modulates mouse hippocampal progenitor cell lineages by up-regulating miR-181a level. Stem Cells (2014) 32(11):2961-72.
02) Wu Q*, Hwang CK, Zheng H, Wagley Y, Lin HY, Kim do K, Law PY, Loh HH, & Wei LN MicroRNA 339 down-regulates mu-opioid receptor at the post-transcriptional level in response to opioid treatment. FASEB J (2013) 27(2):522-535.
03) Chu J*, Zheng H, Zhang Y, Loh HH, & Law PY Agonist-dependent mu-opioid receptor signaling can lead to heterologous desensitization. Cell Signal (2010) 22(4):684-696.
04) Chu J*, Zheng H, Loh HH, & Law PY Morphine-induced mu-opioid receptor rapid desensitization is independent of receptor phosphorylation and beta-arrestins. Cell Signal (2008) 20(9):1616-1624.
05) Pan G, Li J, Zhou Y, Zheng H, & Pei D* A negative feedback loop of transcription factors that controls stem cell pluripotency and self-renewal. FASEB J (2006) 20(10):1730-1732.
02) Li W, He S, Zhou Y, Li Y, Hao J, Zhou X, Wang F, Zhang Y, Huang Z, Li Z, Loh HH, Law PY, & Zheng H* Neurod1 Modulates Opioid Antinociceptive Tolerance via Two Distinct Mechanisms. Biol Psychiatry (2014) 76(10):775-84.
03) Li X, Pei D, & Zheng H* Transitions between epithelial and mesenchymal states during cell fate conversions. Protein Cell (2014) 5(8):580-91.
04) Liu X, Sun H, Qi J, Wang L, He S, Liu J, Feng C, Chen C, Li W, Guo Y, Qin D, Pan G, Chen J, Pei D*, & Zheng H* Sequential introduction of reprogramming factors reveals a time-sensitive requirement for individual factors and a sequential EMT-MET mechanism for optimal reprogramming. Nat Cell Biol (2013) 15(7):829-838.
05) Zheng H*, Zhang Y, Li W, Loh HH, & Law PY NeuroD Modulates Opioid Agonist-Selective Regulation of Adult Neurogenesis and Contextual Memory Extinction. Neuropsychopharmacology (2013) 38(5):770-777.
06) Zheng H*, Loh HH, & Law PY Posttranslation modification of G protein-coupled receptor in relationship to biased agonism. Methods Enzymol (2013) 522:391-408.
07) Zheng H*, Zou H, Liu X, Chu J, Zhou Y, Loh HH, & Law PY Cholesterol level influences opioid signaling in cell models and analgesia in mice and humans. J Lipid Res (2012) 53(6):1153-1162.
08) Zheng H*, Pearsall EA, Hurst DP, Zhang Y, Chu J, Zhou Y, Reggio PH, Loh HH, & Law PY Palmitoylation and membrane cholesterol stabilize mu-opioid receptor homodimerization and G protein coupling. BMC Cell Biol (2012) 13:6.
09) Zheng H*, Law PY, & Loh HH Non-Coding RNAs Regulating Morphine Function: With Emphasis on the In vivo and In vitro Functions of miR-190. Front Genet (2012) 3:113.
10) Zheng H*, Chu J, Zhang Y, Loh HH, & Law PY Modulating micro-opioid receptor phosphorylation switches agonist-dependent signaling as reflected in PKCepsilon activation and dendritic spine stability. J Biol Chem (2011) 286(14):12724-12733.
11) Zheng H*, Zeng Y, Zhang X, Chu J, Loh HH, & Law PY mu-Opioid Receptor Agonists Differentially Regulate the Expression of miR-190 and NeuroD. Mol Pharmacol (2010) 77(1):102-109.
12) Zheng H*, Zeng Y, Chu J, Kam AY, Loh HH, & Law PY Modulations of NeuroD activity contribute to the differential effects of morphine and fentanyl on dendritic spine stability. J Neurosci (2010) 30(24):8102-8110.
13) Zheng H*, Loh HH, & Law PY Agonist-selective signaling of G protein-coupled receptor: Mechanisms and implications. IUBMB Life (2010) 62(2):112-119.
14) Zheng H*, Chu J, Zeng Y, Loh HH, & Law PY Yin Yang 1 phosphorylation contributes to the differential effects of mu-opioid receptor agonists on microRNA-190 expression. J Biol Chem (2010) 285(29):21994-22002.
15) Zheng H*, Loh HH, & Law PY beta-Arrestin-Dependent mu-Opioid Receptor-Activated Extracellular Signal-Regulated Kinases (ERKs) Translocate to Nucleus in Contrast to G Protein-Dependent ERK Activation. Mol Pharmacol (2008) 73(1):178-190.
16) Zheng H*, Chu J, Qiu Y, Loh HH, & Law PY Agonist-selective signaling is determined by the receptor location within the membrane domains. Proc Natl Acad Sci U S A (2008) 105(27):9421-9426.
其他论文
01) Xu C*, Zhang Y, Zheng H, Loh HH, & Law PY Morphine modulates mouse hippocampal progenitor cell lineages by up-regulating miR-181a level. Stem Cells (2014) 32(11):2961-72.
02) Wu Q*, Hwang CK, Zheng H, Wagley Y, Lin HY, Kim do K, Law PY, Loh HH, & Wei LN MicroRNA 339 down-regulates mu-opioid receptor at the post-transcriptional level in response to opioid treatment. FASEB J (2013) 27(2):522-535.
03) Chu J*, Zheng H, Zhang Y, Loh HH, & Law PY Agonist-dependent mu-opioid receptor signaling can lead to heterologous desensitization. Cell Signal (2010) 22(4):684-696.
04) Chu J*, Zheng H, Loh HH, & Law PY Morphine-induced mu-opioid receptor rapid desensitization is independent of receptor phosphorylation and beta-arrestins. Cell Signal (2008) 20(9):1616-1624.
05) Pan G, Li J, Zhou Y, Zheng H, & Pei D* A negative feedback loop of transcription factors that controls stem cell pluripotency and self-renewal. FASEB J (2006) 20(10):1730-1732.
科研活动
2010. 10 Beijing Forest University, Beijing,China
Oral Presentation in ASBMB. Title: “Opioid, NeuroD, Adult Neurogenesis and Memory”, Hui Zheng, Ji Chu, Horace H. Loh and Ping-Yee Law”
2010. 09 Cold Spring Harbor Asia Conference, Suzhou,China
Oral Presentation Titled “NeuroD, Adult Neurogenesis and Memory” in “Reprogramming and Plasticity” section, “Molecular Switches & Genome Function in Stem Cells & Development”, Hui Zheng, Ji Chu, Horace H. Loh and Ping-Yee Law”
2010. 04 Experimental Biology 2010, Anaheim, CA
Poster Presentation in ASBMB. Title: “Yin Yang 1 Phosphorylation contributes to the differential effects of µ-opioid receptor agonists on miR-190 expression”, Hui Zheng, Ji Chu, Yan Zeng, Horace H. Loh and Ping-Yee Law”
2009. 10 Society of neuroscience annual meeting in Chicago, IL.
Poster Presentation Title: μ-opioid receptor modulates the stability of dendritic spines by agonist-selective regulation on NeuroD activity. Hui Zheng, Yan Zeng, Xiaoxiao Zhang, Ji Chu, Horace H. Loh and Ping-Yee Law
2009. 05 2nd Annual Biomedical Sciences Graduate Programs, Minneapolis, MN
Oral Presentation. Title: “Agonist-selective signaling of MOR” Hui Zheng, Horace H. Loh and Ping-Yee Law
2008.08 236th American Chemical Society National Meeting, Philadelphia, PA
Oral Presentation in a symposium: “Pharmacology: The Forgotten Art of Drug Discovery”. Title: “Agonist-Selective Signaling On mu-Opioid Receptor, Hui Zheng, Horace H. Loh and Ping-Yee Law”
2008.05 1st Annual Biomedical Sciences Graduate Programs, Minneapolis, MN
Poster Presentation. Title: “Agonist-selective signaling of MOR agonists, morphine and fentanyl, Hui Zheng, Horace H. Loh and Ping-Yee Law
2008.04 Experimental Biology 2008, San Diego, CA
Poster Presentation in Program: “G Protein II”, ASPET. Title: “Morphine and Etorphine activate same G protein but exhibit distinct pathways in μ-opioid receptor-mediated ERK1/2 activation, Hui Zheng, Horace H. Loh and Ping-Yee Law”
Oral Presentation in ASBMB. Title: “Opioid, NeuroD, Adult Neurogenesis and Memory”, Hui Zheng, Ji Chu, Horace H. Loh and Ping-Yee Law”
2010. 09 Cold Spring Harbor Asia Conference, Suzhou,China
Oral Presentation Titled “NeuroD, Adult Neurogenesis and Memory” in “Reprogramming and Plasticity” section, “Molecular Switches & Genome Function in Stem Cells & Development”, Hui Zheng, Ji Chu, Horace H. Loh and Ping-Yee Law”
2010. 04 Experimental Biology 2010, Anaheim, CA
Poster Presentation in ASBMB. Title: “Yin Yang 1 Phosphorylation contributes to the differential effects of µ-opioid receptor agonists on miR-190 expression”, Hui Zheng, Ji Chu, Yan Zeng, Horace H. Loh and Ping-Yee Law”
2009. 10 Society of neuroscience annual meeting in Chicago, IL.
Poster Presentation Title: μ-opioid receptor modulates the stability of dendritic spines by agonist-selective regulation on NeuroD activity. Hui Zheng, Yan Zeng, Xiaoxiao Zhang, Ji Chu, Horace H. Loh and Ping-Yee Law
2009. 05 2nd Annual Biomedical Sciences Graduate Programs, Minneapolis, MN
Oral Presentation. Title: “Agonist-selective signaling of MOR” Hui Zheng, Horace H. Loh and Ping-Yee Law
2008.08 236th American Chemical Society National Meeting, Philadelphia, PA
Oral Presentation in a symposium: “Pharmacology: The Forgotten Art of Drug Discovery”. Title: “Agonist-Selective Signaling On mu-Opioid Receptor, Hui Zheng, Horace H. Loh and Ping-Yee Law”
2008.05 1st Annual Biomedical Sciences Graduate Programs, Minneapolis, MN
Poster Presentation. Title: “Agonist-selective signaling of MOR agonists, morphine and fentanyl, Hui Zheng, Horace H. Loh and Ping-Yee Law
2008.04 Experimental Biology 2008, San Diego, CA
Poster Presentation in Program: “G Protein II”, ASPET. Title: “Morphine and Etorphine activate same G protein but exhibit distinct pathways in μ-opioid receptor-mediated ERK1/2 activation, Hui Zheng, Horace H. Loh and Ping-Yee Law”
指导学生
已指导学生
李文 博士研究生 071010-生物化学与分子生物学
李响 硕士研究生 071010-生物化学与分子生物学
现指导学生
陈金龙 硕士研究生 071009-细胞生物学
杨肖 硕士研究生 085238-生物工程
张梦丹 硕士研究生 071009-细胞生物学
梁丽宁 博士研究生 071009-细胞生物学
林立龙 博士研究生 071009-细胞生物学