基本信息
赵欣捷  女  硕导  中国科学院大连化学物理研究所
电子邮件: xj_zhao1@126.com
通信地址: 大连市中山路457号
邮政编码:

招生信息

   
招生专业
070302-分析化学
招生方向
色谱,质谱,代谢组学

教育背景

2002-09--2009-01   中国科学院大连化学物理研究所   博士
1994-09--1998-07   大连理工大学   学士
学历
博士研究生
学位
博士学位

工作经历

   
工作简历
1998-08~现在, 中国科学院大连化学物理研究所, 副研究员

专利与奖励

   
专利成果
( 1 ) 用于诊断多囊卵巢综合征的联合标志物、试剂盒和系统, 发明, 2014, 第 3 作者, 专利号: 201410018414.7
( 2 ) 一种脂质代谢网络动态研究的方法, 发明, 2013, 第 3 作者, 专利号: 201310091384.8
( 3 ) 一种筛查糖尿病的联合型代谢标志物的应用及其试剂盒, 发明, 2019, 第 3 作者, 专利号: 201911218594.2
( 4 ) 一种血清代谢标志物的用途及检测试剂盒, 发明, 2019, 第 5 作者, 专利号: 201911004348.7
( 5 ) 用于糖尿病人群中视网膜病变诊断的联合标志物及试剂盒, 发明, 2019, 第 5 作者, 专利号: 20190609167.0

出版信息

   
发表论文
(1) Rapid lipidomic profiling based on ultra-high performance liquid chromatography-mass spectrometry and its application in diabetic retinopathy, ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2020, 第 5 作者
(2) Pseudotargeted Method Based on Parallel Column Two- Dimensional Liquid Chromatography-Mass Spectrometry for Broad Coverage of Metabolome and Lipidome, ANALYTICAL CHEMISTRY, 2020, 第 4 作者
(3) Muscle-Liver Substrate Fluxes in Exercising Humans and Potential Effects on Hepatic Metabolism, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2020, 第 5 作者
(4) Identification and regulation of the xenometabolite derivatives cis- and trans-3,4-methylene-heptanoylcarnitine in plasma and skeletal muscle of exercising humans, AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2020, 第 1 作者
(5) A multi-omics investigation of the molecular characteristics and classification of six metabolic syndrome relevant diseases, THERANOSTICS, 2020, 第 1 作者
(6) Removal of false positive features to generate authentic peak table for high-resolution mass spectrometry-based metabolomics study, ANALYTICA CHIMICA ACTA, 2019, 第 4 作者
(7) Metabolomics profiling of metformin-mediated metabolic reprogramming bypassing AMPK alpha, METABOLISM-CLINICAL AND EXPERIMENTAL, 2019, 第 4 作者
(8) Deep Annotation of Hydroxycinnamic Acid Amides in Plants Based on Ultra-High-Performance Liquid Chromatography-High-Resolution Mass Spectrometry and Its In Silico Database, ANALYTICAL CHEMISTRY, 2018, 第 3 作者
(9) Plasma bile acid changes in type 2 diabetes correlated with insulin secretion in two-step hyperglycemic clamp, JOURNAL OF DIABETES, 2018, 第 6 作者
(10) Ion-Pair Selection Method for Pseudotargeted Metabolomics Based on SWATH MS Acquisition and Its Application in Differential Metabolite Discovery of Type 2 Diabetes, ANALYTICAL CHEMISTRY, 2018, 第 5 作者
(11) Metabolomics and transcriptomics profiles reveal the dysregulation of the tricarboxylic acid cycle and related mechanisms in prostate cancer, INTERNATIONAL JOURNAL OF CANCER, 2018, 第 5 作者
(12) Development of a High Coverage Pseudotargeted Lipidomics Method Based on Ultra-High Performance Liquid Chromatography-Mass Spectrometry, ANALYTICAL CHEMISTRY, 2018, 第 6 作者
(13) Comprehensive Strategy to Construct In-House Database for Accurate and Batch Identification of Small Molecular Metabolites, ANALYTICAL CHEMISTRY, 2018, 第 1 作者
(14) Strategy for Comprehensive Identification of Acylcarnitines Based on Liquid Chromatography-High-Resolution Mass Spectrometry, ANALYTICAL CHEMISTRY, 2018, 第 5 作者
(15) Serum Metabolomics Study of Gliclazide-Modified-Release-Treated Type 2 Diabetes Mellitus Patients Using a Gas Chromatography-Mass Spectrometry Method, JOURNAL OF PROTEOME RESEARCH, 2018, 第 3 作者
(16) Development of Urinary Pseudotargeted LC-MS-Based Metabolomics Method and Its Application in Hepatocellular Carcinoma Biomarker Discovery, Journal of Proteome Research , 2015, 第 4 作者
(17) A data preprocessing strategy for metabolomics to reduce the mask effect in data analysis., Front Mol Biosci., 2015, 第 2 作者
(18) Discovery and validation of plasma biomarkers for major depressive disorder classification based on liquid chromatography-mass spectrometry., Journal of Proteome Research , 2015, 第 3 作者
(19) GC/MS-based metabolomic studies reveal key roles of glycine in regulating silk synthesis in silkworm, Bombyx mori., Insect Biochem Mol Biol. , 2015, 通讯作者
(20) Serum metabolomics study of polycystic ovary syndrome based on liquid chromatography-mass spectrometry, Journal of Proteome Research, 2014, 第 1 作者
(21) Serum metabolomics study of the acute graft rejection in human renal transplantation based on liquid chromatography-mass spectrometry, Journal of Proteome Research , 2014, 第 1 作者
(22)  Serum metabolomics study and eicosanoid analysis of childhood atopic dermatitis based on liquid chromatography-mass spectrometry, Journal of Proteome Research , 2014, 通讯作者
(23) Serum metabolic profiling study of lung cancer using ultra high performance liquid chromatography/quadrupole time-of-flight mass spectrometry., J Chromatogr B Analyt Technol Biomed Life Sci., 2014, 通讯作者
(24) Serum lipid profiling of patients with chronic hepatitis B, cirrhosis, and hepatocellular carcinoma by ultra fast LC/IT-TOF MS., Electrophoresis., 2013, 第 3 作者
(25) Large-scaled human serum sphingolipid profiling by using reversed-phase liquid chromatography coupled with dynamic multiple reaction monitoring of mass spectrometry: method development and application in hepatocellular carcinoma., J Chromatogr A., 2013, 第 3 作者
(26) Simultaneous extraction of metabolome and lipidome with methyl tert-butyl ether from a single small tissue sample for ultra-high performance liquid chromatography/mass spectrometry., J Chromatogr A., 2013, 通讯作者
(27) Production and release of acylcarnitines by primary myotubes reflect the differences in fasting fat oxidation of the donors., J Clin Endocrinol Metab. , 2013, 第 3 作者
(28) Stable isotope-assisted lipidomics combined with nontargeted isotopomer filtering, a tool to unravel the complex dynamics of lipid metabolism., Anal Chem. , 2013, 第 3 作者
(29) Preanalytical aspects and sample quality assessment in metabolomics studies of human blood., Clin Chem., 2013, 第 4 作者

科研活动

   
科研项目
( 1 ) 中德合作发展全脂及代谢组学平台用新代谢生物标志物的鉴定及其功能表征, 参与, 国家级, 2012-01--2015-12
( 2 ) 代谢小分子标志物筛选鉴定和应用, 参与, 国家级, 2012-01--2015-12
( 3 ) 大规模非靶向LC-MS代谢组学分析新策略研究, 主持, 国家级, 2020-01--2023-12
( 4 ) 基于LC-MSn的代谢物定性策略研究, 主持, 国家级, 2016-01--2019-12

指导学生

现指导学生

王鑫欣  硕士研究生  070302-分析化学