General

Huashan Zhao

Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences

E-mail: hs.zhao@siat.ac.cn

Address: 1068 Xueyuan Avenue, Shenzhen University Town, Shenzhen 518055, China

Department: Institute of Biomedicine and Biotechnology

Research Areas

1) Neuroendocrine diseases and peptide molecular targeting
2) Skin wound healing and drug screening


Education

2009-2015 Ph.D. in University of Chinese Academy of Sciences 


Experience


Work Experience

2020-present, Senior Engineer (Associate professor), Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, China

2017-2019, Assistant professor, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, China

2015-2016, Postdoctor, University of Wisconsin-Madison, USA



Publications


(1) Zhang Q, Lee CL, Yang T, Li J, Zeng Q, Liu X, Liu Z, Ruan D, Li Z, Kan ASY, Cheung KW, Mak ASL, Ng VWY, Zhao H, Fan X, Duan YG, Zhong L, Chen M, Du M, Li RHW, Liu P, Ng EHY, Yeung WSB, Gao Y, Yao Y, Chiu PCN. Adrenomedullin has a pivotal role in trophoblast differentiation: A promising nanotechnology-based therapeutic target for early-onset preeclampsia. Sci Adv. 2023 Nov 3;9(44):eadi4777. doi: 10.1126/sciadv.adi4777.

(2) Xiong Y, Ma C, Li Q, Zhang W, Zhao H, Ren P, Zhang K, Lei X. Melatonin ameliorates simulated-microgravity-induced mitochondrial dysfunction and lipid metabolism dysregulation in hepatocytes. FASEB J. 2023 Sep;37(9):e23132. doi: 10.1096/fj.202301137R.

(3) Lin J, Li Q, Lei X, Zhao H*. The emerging roles of GPR158 in the regulation of the endocrine system. Front Cell Dev Biol. 2022 Nov 18;10:1034348. doi: 10.3389/fcell.2022.1034348.(*corresponding author)

(4) Yu M, Yang Y, Zhao H, Li M, Chen J, Wang B, Xiao T, Huang C, Zhao H, Zhou W, Zhang JV. Targeting the chemerin/CMKLR1 axis by small molecule antagonist α-NETA mitigates endometriosis progression. Front Pharmacol. 2022 Nov 29;13:985618. doi: 10.3389/fphar.2022.985618.

(5) Yu M, Yang Y, Huang C, Ge L, Xue L, Xiao Z, Xiao T, Zhao H, Ren P, Zhang JV. Chemerin: A Functional Adipokine in Reproductive Health and Diseases. Biomedicines. 2022 Aug 7;10(8):1910. doi: 10.3390/biomedicines10081910.

(6) Ma C.; Xiong Y.; Han P.; Zhang X.; Cao Y.; Wang B.; Zhao H.; Duan E.; Zhang J.V.; Lei X. Simulated Microgravity Potentiates Hematopoietic Differentiation of Human Pluripotent Stem Cells and Supports Formation of 3D Hematopoietic Cluster. Front Cell Dev Biol 2021, 9, 797060, doi:10.3389/fcell.2021.797060.

(7) Li R., Ma C., Xiong Y., Zhao H., Yang Y., Xue L., Wang B., Xiao T., Chen J., Lei X., Ma B., Zhang J. An Antagonistic Peptide of Gpr1 Ameliorates LPS-Induced Depression through the Hypothalamic-Pituitary-Ovarian Axis. Biomolecules. 2021, 11, p857. DOI 10.3390/biom11060857.

(8) Sun L.; Yang Y.; Wang M.; Zhao H.; Xiao T.; Li M.; Wang B. ; Huang C.; Ren P.; Zhang J. Inhibition of Col6a5 Improve Lipid Metabolism Disorder in Dihydrotestosterone-Induced Hyperandrogeni. Front Cell Dev Biol. 2021, 9, 669189. DOI 10.3389/fcell.2021.669189.

(9) Huang B.#, Zhu W.#, Zhao H.#, Zeng F., Wang E., Wang H., Chen J., Li M., Huang C., Ren L., Niu J., Zhang J. Placenta-derived Osteoprotegerin is Required for Glucose Homeostasis in Gestational Diabetes Mellitus [J]. Front Cell Dev Biol. 2020: 8. doi: 10.3389/fcell.2020.563509. (#co-first author)

(10) Zhang H., Zhao H., Wang X., Cui X., Jin L. Keratin 86 is up-regulated in the uterus during implantation, induced by oestradiol [J]. BMC developmental biology. 2020: 3.

(11) Huang B.#, Zhao H.#, Huang C.#, Wu L., Xiang L., Chen J., Wang B., Xiao T., Li M., Ren L., Niu J., Zhang J. V. CMKLR1 deficiency attenuates androgen-induced lipid accumulation in mice [J]. American journal of physiology Endocrinology and metabolism. 2020: E371-E80. (#co-first author)

(12) Chen Z., Zhang J., Yuan A., Han J., Tan L., Zhou Z., Zhao H., Su R., Huang B., Wang B., Sun B., Fan X., Yang Q. R-spondin3 promotes the tumor growth of choriocarcinoma JEG-3 cells [J]. Am J Physiol Cell Physiol. 2020: C664-C74.

(13) Zhao H., Yan D., Xiang L., Huang C., Li J., Yu X., Huang B., Wang B., Chen J., Xiao T., Ren P. G., Zhang J. V. Chemokine-like receptor 1 deficiency leads to lower bone mass in male mice [J]. Cellular and molecular life sciences: CMLS. 2019: 355-67.

(14) Huang B.#, Huang C.#, Zhao H.#, Zhu W., Wang B., Wang H., Chen J., Xiao T., Niu J., Zhang J. Impact of GPR1 signaling on maternal high-fat feeding and placenta metabolism in mice [J]. American journal of physiology Endocrinology and metabolism. 2019: E987-E97. (#co-first author)

(15) Qiao J.#, Zhao H.#, Zhang Y., Peng H., Chen Q., Zhang H., Zheng X., Jin Y., Ni H., Duan E., Guo Y. GPR39 is region-specifically expressed in mouse oviduct correlating with the Zn(2+) distribution [J]. Theriogenology. 2017: 98-105. (#co-first author)

(16) Li M., Zhao H., Ananiev G. E., Musser M. T., Ness K. H., Maglaque D. L., Saha K., Bhattacharyya A., Zhao X. Establishment of Reporter Lines for Detecting Fragile X Mental Retardation (FMR1) Gene Reactivation in Human Neural Cells [J]. Stem cells. 2017: 158-69.

(17) Zhang H.#, Zhao H.#, Qiao J.#, Zhang S., Liu S., Li N., Lei X., Ning L., Cao Y., Duan E. Expansion of Hair Follicle Stem Cells Sticking to Isolated Sebaceous Glands to Generate in Vivo Epidermal Structures [J]. Cell transplantation. 2016: 2071-82. (#co-first author)

(18) Li N., Liu S., Zhang H., Deng Z., Zhao H., Zhao Q., Lei X., Ning L., Cao Y. J., Wang H., Liu S., Duan E. Exogenous R-Spondin1 Induces Precocious Telogen-to-Anagen Transition in Mouse Hair Follicles [J]. Int J Mol Sci. 2016: 582.

(19) Zhao H., Qiao J., Zhang S., Zhang H., Lei X., Wang X., Deng Z., Ning L., Cao Y., Guo Y., Liu S., Duan E. GPR39 marks specific cells within the sebaceous gland and contributes to skin wound healing [J]. Scientific reports. 2015: 7913.

(20) Zhang H., Zhang S., Zhao H., Qiao J., Liu S., Deng Z., Lei X., Ning L., Cao Y., Zhao Y., Duan E. Ovine Hair Follicle Stem Cells Derived from Single Vibrissae Reconstitute Haired Skin [J]. Int J Mol Sci. 2015: 17779-97.

(21) Wang F., Tidei J. J., Polich E. D., Gao Y., Zhao H., Perrone-Bizzozero N. I., Guo W., Zhao X. Positive feedback between RNA-binding protein HuD and transcription factor SATB1 promotes neurogenesis [J]. Proceedings of the National Academy of Sciences of the United States of America. 2015: E4995-5004.

(22) Liu S., Wang X., Zhao Q., Liu S., Zhang H., Shi J., Li N., Lei X., Zhao H., Deng Z., Cao Y., Ning L., Xia G., Duan E. Senescence of human skin-derived precursors regulated by Akt-FOXO3-p27(KIP(1))/p15(INK(4)b) signaling [J]. Cellular and molecular life sciences: CMLS. 2015: 2949-60.

(23) Wang X., Liu S., Zhao Q., Li N., Zhang H., Zhang X., Lei X., Zhao H., Deng Z., Qiao J., Cao Y., Ning L., Liu S., Duan E. Three-dimensional hydrogel scaffolds facilitate in vitro self-renewal of human skin-derived precursors [J]. Acta biomaterialia. 2014: 3177-87.

(24) Lei X., Deng Z., Zhang H., Zhao H., Zhou J., Liu S., Chen Q., Ning L., Cao Y., Wang X., Zhang X., Duan E. Rotary suspension culture enhances mesendoderm differentiation of embryonic stem cells through modulation of Wnt/beta-catenin pathway [J]. Stem cell reviews. 2014: 526-38.

(25) Zhang H., Zhang Y., Zhao H., Zhang Y., Chen Q., Peng H., Lei L., Qiao J., Shi J., Cao Z., Duan E., Jin Y. Hormonal regulation of ovarian bursa fluid in mice and involvement of aquaporins [J]. PloS one. 2013: e63823.

(26) Zhang Y., Zhao H., Peng H., Hu Z., Ning L., Cao Y., Tan Y., Duan E. GPR39, a putative receptor of Zn2+, is region specifically localized in different lobes of the mouse prostate [J]. Urology. 2011: 1010 e1-6.