生物医用材料，细胞工程

招生专业：生物化工 
招生方向：动物细胞规模化培养

081703-生物化工
083100-生物医学工程

   

研究生

博士

• 2007.6-2011.9 中国科学院大连化学物理研究所 生物技术部 助理研究员
• 2011.10-现在 中国科学院大连化学物理研究所 生物技术部 副研究员

   

生化分离工程

发表论文：

1 Ying Zhang, Wei Wang, etc. In vivo culture of encapsulated endostatin-CHO cells for systemic tumor inhibition. Human Gene Therapy. 18 (5): 474-481, 2007.

2 Ying Zhang, Wei Wang, etc. Tumor Anti-angiogenic Gene Therapy with Microencapsulated Recombinant CHO Cells. Annals of Biomedical Engineering. 35 (4): 605-614, 2007.

3 Ying Zhang, Wei Wang, etc. Optimization of Microencapsulated Recombinant CHO Cell Growth, Endostatin Production and Stability of Microcapsule in vivo. J Biomed Mater Res Part B: Appl Biomater 84B: 79-88, 2008.

4 Ying Zhang, Jing Zhou, etc. Optimization of the Seeding Density in Microencapsulated Recombinant CHO Cell Culture. Chem. Biochem. Eng. Q. 22 (1) : 105-111, 2008.

5 Qi Wen tao, Zhang Ying, etc. Optimization of the cell seeding density and modeling of cell growth and metabolism using themodified Gompertz model for microencapsulated animal cell culture. Biotechnology and Bioengineering. (93): 887-895, 2006.

6 Huaining Teng, Ying Zhang, etc. Inhibition of Tumor Growth in Mice by Endostatin Derived from Abdominal Transplanted Encapsulated Cell. Acta Biochim Biophys Sinica. 39 (4): 278-284, 2007.

7 Li N, Zhang Y*, Xiu ZL, Wang Y, Chen L, Wang SJ, Guo X, Ma XJ*.Thepreservation of islet with alginate encapsulation in the process of transportation. Biotechnology and Applied Biochemistry. 2015, 62 (4): 530-536.

8 Li N, Zhang Y*, Liu Y, Xiu ZL, Tan MQ, Li S, Guo X, Wang Y, Chen L, Song YZ, Yu WT, Lv GJ, Ma XJ*. Improvedislet purity by the hypertonic-hypotonic method. International Journal of Artificial Organs. 2015,37 (6): 477-485.

9 Li S, Zhang Y*, Chen L, Li N, Xie HG, Guo X, Zhao S, Yu WT, Lv Y, Lv GJ, Wu HJ*, Ma XJ. The relationship between the inflammatory response and cell adhesion on alginate-chitosan-alginate microcapsules after transplantation. Journal of biomedical materials research part A. 2015,103 (7): 2333-2343.

10 Deng F, Chen L, Zhang Y*, Zhao S, Wang Y, Li N, Li S, Guo X, Ma XJ. Development of a bioreactor based on magnetically stabilized fluidized bed for bioartificial liver. Bioprocess and biosystems engineering. 2015, 38 (12): 2369-2377.

11  Wang Y, Zhang Y*, Li N, Chen L, Zhang DM, Sun DS, Lv GJ, Yu WT, Guo X, Ma XJ*. Growth and Production of Microencapsulated recombinant CHO in a stirred tank bioreactor. Bioprocess and biosystems engineering. 2015,38 (7): 1303-1312.

12 Wang Y, Zhang Y*, Li N, Chen L, Zhang DM, Sun DS, Li S, Guo X, Ma XJ*. Stirring rate regulates the proliferation and metabolism of microencapsulated recombinant CHO cells. Biotechnology and  Applied Biochemistry.  2015, 62  (6): 833-839.

13 Huang PY, Zhang LD, Gao YM, He ZY, Yao D, Wu ZT, Cen J, Chen XT, Liu CC, Hu YP, Lai DM, Hu ZL, Chen L, Zhang Y, Cheng X, Ma XJ, Pan GY, Wang X, Hui LJ*. Direct Reprogramming of Human Fibroblasts to Functional and Expandable Hepatocytes. Cell Stem Cell. 2014,14: 370-384.

14 Chen L, Zhang Y*, Li S, Li N, Wang Y, Guo X, Zhao S, Yu WT, Sun GW, Liu Y, Ma XJ*. Effect of plasma components on the stability and permeability of microcapsule. Journal of Biomedical Materials Research: Part A. 2014, 102(7):  2408-2416.

15 Zhao W, Zhang Y*, Liu Y, Tan  MQ, Yu WT, Xie HG, Ma Ying, Sun GW, Lv  GJ, Zhao S, Ma XJ*. Oxygen diffusivity in alginate/chitosan microcapsules. Journal of Chemical Technology and Biotechnology. 2013, 88(3): 449-455.

16 Ma Y, Zhang Y*, Liu Y, Chen L, Zhao W, Sun GW, Li N, Wang Y, Guo X, Lv GJ, Ma XJ*. Investigation of alginate–ϵ-poly-L- lysine microcapsules for cell microencapsulation. Journal of Biomedical Materials Research Part A. 2013, 101A (5): 1265-1273.

17 Ma Y, Zhang Y*, Wang Y, Wang QY, Tan MQ, Liu Y, Chen L, Li N, Yu WT, Ma XJ*. Study of the effect of membrane thickness on microcapsule strength, permeability, and cell proliferation. Journal of Biomedical Materials Research PartA. 2013,101A (4): 1007-1015.

18 Ma Y, Zhang Y*, Zhao S, Wang Y, Wang SR, Zhou Y, Li N, Xie HG, Yu WT, Liu Y, Wang W, Ma XJ*. Modeling and optimization of membrane preparation conditions of the alginate-based microcapsules with response surface methodology. Journal of Biomedical Materials Research Part A. 2012, 100A (4): 989-998.

19 Yu WT，Song HY，Zheng GS，Liu XD，Zhang Y，Ma XJ*. Study on membrane characteristics of alginate-chitosan microcapsule with cell growth. Journal of Membrane Science. 2011,337: 214-220.

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发表著作：

1）Ying Zhang , Xiudong Liu, Weiting Yu, Guojun Lv, Jing Zhu, Wei Wang, Xiaojun Ma. “The Artificial Organ: Cell Encapsulation” Comprehensive Biotechnology, 2nd edition. Elsevier Press. 2011.

2）Sun GW, Xu XX, Li N, Zhang Y, Ma XJ. “Three-dimensional culture for expansion and differentiation of mouse embryonic stem cells”. Human Embryonic and Induced Pluripotent Stem Cells: Lineage-Specific Differentiation Protocols. Humana Press Inc., Totowa, NJ, 2011.

 3）王为，张英，马小军。 第35章《胰岛损伤与再生》。《再生医学原理与实践》第三版。上海科学技术出版社。2011年。

科研项目：
1. 国家自然科学基金面上项目：细胞间质体外模拟系统的构建及物质传递基本规律的研究
2. 辽宁省博士启动基金：新型流化床生物人工肝的研究
3. 大连市优秀青年科技人才基金：肿瘤治疗用重组蛋白药物递释系统的研究
4. 生物反应器工程国家重点实验室开放课题：基于微囊化肝细胞的新型流化床生物人工肝的研究