基本信息
张许  男  博导  中国科学院精密测量科学与技术创新研究院
电子邮件: zhangxu@wipm.ac.cn
通信地址: 武昌小洪山西29栋2门1楼04号
邮政编码: 430071

研究领域

生物磁共振波谱

招生信息

   
招生专业
070302-分析化学
招生方向
核磁共振波谱学

教育背景

1999-09--2002-06   中国科学院武汉物理与数学研究所   博士学位
1993-09--1999-06   西北大学   硕士学位
学历
-- 研究生
学位
-- 博士

工作经历

   
工作简历
2010-10~现在, 中国科学院武汉物理与数学研究所, 研究员
2002-12~2010-09,中国科学院武汉物理与数学研究所, 副研究员
2002-08~2002-11,中国科学院武汉物理与数学研究所, 助理研究员

教授课程

磁共振前沿
液体核磁共振实验

专利与奖励

   
奖励信息
(1) 生物体系中分子间相互作用的核磁共振研究, 一等奖, 省级, 2006
专利成果
[1] 袁斌, 蒋滨, 张许, 刘买利. 核磁共振浓度排序谱的构建方法. CN: CN112986307A, 2021-06-18.

出版信息

   
发表论文
[1] 王远方, 王小花, 舒畅, 张许, 刘买利, 曾丹云. 溶液中 ATAD2 溴结构域聚集行为的研究. 波谱学杂志[J]. 2023, 40(2): 169-178, [2] Chen, Biying, Shi, Biru, Ge, Xiaoyan, Fu, Zhifei, Yu, Haiyang, Zhang, Xu, Liu, Caixiang, Han, Lifeng. Integrated metabolic and transcriptomic profiles reveal the germination-associated dynamic changes for the seeds of Cassia obtusifolia L.. PHYTOCHEMICAL ANALYSIS[J]. 2023, 34(2): 240-253, http://dx.doi.org/10.1002/pca.3200.
[3] Yang, Yuqi, Baolong Wang, Xu Zhang, Hongchuang Li, Sen Yue, Yifan Zhang, Yunhuang Yang, Maili Liu, Chaohui Ye, Peng Huang, Xin Zhou. Activatable Graphene Quantum-Dot-Based Nanotransformers for Long-Period Tumor Imaging and Repeated Photodynamic Therapy. Advanced Materials[J]. 2023, 35(23): 2211337-, https://onlinelibrary.wiley.com/doi/10.1002/adma.202211337.
[4] Caixiang Liu, Fangfang Chen, Laixing Liu, Xinyu Fan, Huili Liu, Danyun Zeng, Xu Zhang. The Different Metabolic Responses of Resistant and Susceptible Wheats to Fusarium graminearum Inoculation. METABOLITES[J]. 2022, 12(727): https://doaj.org/article/14dc65064fb4451e99dbc3b52a3028b0.
[5] Yu, Gangjin, Wang, Guan, Duan, Mojie, Jiang, Bin, Zhang, Xu, Li, Conggang, He, Lichun, Liu, Maili. Self-Assembled Oligopeptide (FK)(4) as a Chiral Alignment Medium for the Anisotropic NMR Analysis of Organic Compounds. ACS APPLIED MATERIALS & INTERFACES[J]. 2022, 14(25): 29223-29229, http://dx.doi.org/10.1021/acsami.2c05506.
[6] Jianhua Zhan, Guangqing Zhang, Xin Chai, Qinjun Zhu, Peng Sun, Bin Jiang, Xin Zhou, Xu Zhang, Maili Liu. NMR Reveals the Conformational Changes of Cytochrome C upon Interaction with Cardiolipin. LIFE[J]. 2021, 11(10): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8540660/.
[7] Yuan, Bin, Zhang, Xu, Kamal, Ghulam Mustafa, Jiang, Bin, Liu, Maili. Accurate estimation of diffusion coefficient for molecular identification in a complex background. ANALYTICAL AND BIOANALYTICAL CHEMISTRY[J]. 2020, 412(19): 4519-4525, https://www.webofscience.com/wos/woscc/full-record/WOS:000532642900001.
[8] Wang, Xiaohua, Zou, Wei, Kamal, Ghulam Mustafa, Wang, Jie, Zhou, Mi, Chen, Li, Jiang, Bin, Khalid, Muhammad, Zhang, Xu, Liu, Maili. An untargeted C-13 isotopic evaluation approach for the discrimination of fermented food matrices at natural abundance: Application to vinegar. TALANTA[J]. 2020, 210: http://dx.doi.org/10.1016/j.talanta.2019.120679.
[9] Hong Wan, Yafeng Tian, Haipeng Jiang, Xu Zhang, Xiulian Ju. A NMR-based drug screening strategy for discovering active substances from herbal medicines: Using Radix Polygoni Multiflori as example. JOURNAL OF ETHNOPHARMACOLOGY. 2020, 254: http://dx.doi.org/10.1016/j.jep.2020.112712.
[10] Yunyan Li, Wenping Mao, Chaoyang Liu, Xu Zhang, Junfeng Wang. Quantitative Determination of Fatty Acid Compositions in Edible Oils Using J-Selective 13C QDEPT. 2019, http://kns.cnki.net/KCMS/detail/detail.aspx?QueryID=0&CurRec=2&recid=&FileName=SSJD1DEBC013B96DBAB4ADC7E732682A19EC&DbName=SSJD_01&DbCode=SSJD&yx=&pr=&URLID=&bsm=.
[11] Zhang, Liang, Chai, Xin, Sun, Peng, Yuan, Bin, Jiang, Bin, Zhang, Xu, Liu, Maili. The Study of the Aggregated Pattern of TX100 Micelle by Using Solvent Paramagnetic Relaxation Enhancements. MOLECULES[J]. 2019, 24(9): https://doaj.org/article/16f467af2bfe4405a33ff27fd18f982d.
[12] Zhang, Liang, Chai, Xin, Sun, Peng, Zhu, Qinjun, Zhang, Xu, Liu, Maili. Characterization of the aggregated pattern of CHAPS using solvent paramagnetic relaxation enhancements. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS[J]. 2018, 555: 332-338, http://dx.doi.org/10.1016/j.colsurfa.2018.07.008.
[13] Sun, Peng, Wang, Qianwen, Yuan, Bin, Zhu, Qinjun, Jiang, Bin, Li, Conggang, Lan, Wenxian, Cao, Chunyang, Zhang, Xu, Liu, Maili. Monitoring alkaline transitions of yeast iso-1 cytochrome c at natural isotopic abundance using trimethyllysine as a native NMR probe. CHEMICAL COMMUNICATIONS[J]. 2018, 54(89): 12630-12633, http://ir.wipm.ac.cn/handle/112942/13200.
[14] Xiao, Xiongjie, Hu, Mary, Zhang, Xu, Hu, Jian Zhi. NMR-based Metabolomics Analysis of Liver from C57BL/6 Mouse Exposed to Ionizing Radiation. RADIATION RESEARCH[J]. 2017, 188(1): 44-55, http://dx.doi.org/10.1667/RR14602.1.
[15] Yuan, Bin, Ding, Yiming, Kamal, Ghulam M, Shao, Limin, Zhou, Zhiming, Jiang, Bin, Sun, Peng, Zhang, Xu, Liu, Maili. Reconstructing diffusion ordered NMR spectroscopy by simultaneous inversion of Laplace transform. JOURNALOFMAGNETICRESONANCE[J]. 2017, 278: 1-7, http://dx.doi.org/10.1016/j.jmr.2017.03.004.
[16] Wang, Xiaohua, Wang, Jie, Kamal, Ghulam Mustafa, Jiang, Bin, Sun, Peng, Zhang, Xu, Liu, Maili. Characterization and Comparison of Commercial Chinese Cereal and European Grape Vinegars Using H-1 NMR Spectroscopy Combined with Multivariate Analysis. CHINESE JOURNAL OF CHEMISTRY[J]. 2016, 34(11): 1183-1193, http://ir.wipm.ac.cn/handle/112942/9977.
[17] Feng Yitao, Zhang Lu, Wu Shaowen, Liu Zhijun, Gao Xin, Zhang Xu, Liu Maili, Liu Jianwei, Huang Xuhui, Wang Wenning. Conformational Dynamics of apo-GlnBP Revealed by Experimental and Computational Analysis.. ANGEWANDTE CHEMIE (INTERNATIONAL ED. IN ENGLISH). 2016, [18] Ghulam Mustafa Kamal, Xiaohua Wang, Bin Yuan, Jie Wang, Peng Sun, Xu Zhang, Maili Liu. Compositional differences among Chinese soy sauce types studied by 13 C NMR spectroscopy coupled with multivariate statistical analysis. TALANTA. 2016, 89-99, http://dx.doi.org/10.1016/j.talanta.2016.05.033.
[19] Guo, Qianni, Zeng, Qingbin, Jiang, Weiping, Zhang, Xiaoxiao, Luo, Qing, Zhang, Xu, Bouchard, LouisS, Liu, Maili, Zhou, Xin. A Molecular Imaging Approach to Mercury Sensing Based on Hyperpolarized Xe-129 Molecular Clamp Probe. CHEMISTRYAEUROPEANJOURNAL[J]. 2016, 22(12): 3967-3970, http://dx.doi.org/10.1002/chem.201600193.
[20] Ghulam Mustafa Kamal, Bin Yuan, Abdullah Ijaz Hussain, Jie Wang, Bin Jiang, Xu Zhang, Maili Liu. 13C-NMR-Based Metabolomic Profiling of Typical Asian Soy Sauces. MOLECULES. 2016, 21(9): https://doaj.org/article/03ff7f25da5944eda056ffcd398588de.
[21] Feng, Yue, Zhu, Hang, Zhang, Xu, Wang, Xuxia, Xu, Fuqiang, Tang, Huiru, Ye, Chaohui, Liu, Maili. NMR Based Cerebrum Metabonomic Analysis Reveals Simultaneous Interconnected Changes during Chick Embryo Incubation. PLOS ONE[J]. 2015, 10(10): http://ir.wipm.ac.cn/handle/112942/9031.
[22] Jiang, Bin, Yu, Binhan, Zhang, Xu, Liu, Maili, Yang, Daiwen. A N-15 CPMG relaxation dispersion experiment more resistant to resonance offset and pulse imperfection. JOURNAL OF MAGNETIC RESONANCE[J]. 2015, 257: 1-7, https://www.webofscience.com/wos/woscc/full-record/WOS:000358339700001.
[23] Wang, Guifang, Zhang, ZeTing, Jiang, Bin, Zhang, Xu, Li, Conggang, Liu, Maili. Recent advances in protein NMR spectroscopy and their implications in protein therapeutics research. ANALYTICAL AND BIOANALYTICAL CHEMISTRY[J]. 2014, 406(9-10): 2279-2288, http://dx.doi.org/10.1007/s00216-013-7518-5.
[24] 张许. 血浆与蛋白质-药物相互作用的个体差异的磁共振表征方法. Anal Chem. 2013, [25] 张许. Avr-Piz-t蛋白质的溶液结构. J Biomol NMR. 2013, [26] 张许. 生物分子配体识别的辐射阻尼waterLOGSY技术. J Biomol NMR. 2013, [27] 张许. NASA:NMR谱中噪音和伪峰同时抑制技术. Anal Chem. 2013, [28] 张许. 年龄和性别相关的大鼠皮层和小脑皮质的代谢变化. Brain Res. 2013, [29] 张许. 氯化钠浓度和温度度CHAPS胶束性质的影响. J. Phys. Chen. B. 2011, [30] 张许. 浓度相关的CHAPS胶束形态研究. J. Phys. Chen. B. 2010, [31] 张许. 非均匀采样快速多维谱的网格化重建技术. J Magn Reson. 2010, [32] 张许. 脉冲宽度对组合“水门”实验的影响. J Magn Reson. 2010, 

科研活动

   
科研项目
( 1 ) 14N核磁共振研究赖氨酸三甲基化蛋白质的相互作用动力学, 主持, 国家级, 2011-01--2013-12
( 2 ) 蛋白质动态学研究的新技术新方法, 参与, 国家级, 2013-01--2014-12
( 3 ) 高效药物初步筛选和毒性评估的磁共振波谱分析, 主持, 省级, 2015-08--2017-08
( 4 ) 甲基化生物大分子NMR检测新技术, 主持, 国家级, 2017-01--2020-12
( 5 ) 活体小动物磷脂特异性磁共振谱仪系统研制, 主持, 部委级, 2017-01--2018-12
( 6 ) 细胞内蛋白质结构和互作的原位NMR 分析新技术与新方法, 主持, 国家级, 2017-07--2022-06
( 7 ) 基于核磁共振的磷脂异常代谢药物高内涵筛选技术研究, 主持, 国家级, 2020-01--2023-12
参与会议
(1)Monitoring of Choline phosphorylation in Intact Cells by NMR   第十八届北京分析测试学术报告会暨展览会   2019-10-23
(2)The conformation of cytochome c - a ROS scavenger in mitochondria   第十八届北京分析测试学术报告会暨展览会   2019-10-23
(3)Study of the multiple conformation of yeast cytochrome c   第三届全国生物磁共振研讨会   2019-05-29
(4)白蛋白与棕榈酸相互作用的核磁共振研究   中国化学会第十三届全国分析化学年会   2018-06-14
(5)天然同位素丰度蛋白质核磁共振谱的简化   第二届全国生物磁共振研讨会   张许   2017-10-19
(6)Differentiation of Asian Soy Sauces by Multivariate Analysis of 13CNMR Profiles   第16届北京分析测试学术报告会暨展览会   Ghulam Mustafa Kamal   2015-10-27
(7)Using DOSY to Determine Chemical Exchange Rate Constants   第16届北京分析测试学术报告会暨展览会   Bin Yuan   2015-10-27

指导学生

已指导学生

李钊  硕士研究生  070208-无线电物理  

程鹏  硕士研究生  070208-无线电物理  

李雪  硕士研究生  070208-无线电物理  

王晶婧  硕士研究生  070302-分析化学  

孙鹏  博士研究生  070302-分析化学  

聂莉莎  硕士研究生  085238-生物工程  

王倩文  博士研究生  070302-分析化学  

李楠  硕士研究生  070208-无线电物理  

张亮  博士研究生  070302-分析化学  

肖雄杰  博士研究生  070302-分析化学  

汪旋  博士研究生  070302-分析化学  

陈瑶  硕士研究生  070302-分析化学  

方仲佩  硕士研究生  085238-生物工程  

现指导学生

张广庆  博士研究生  070302-分析化学  

王远方  硕士研究生  070302-分析化学  

占建华  博士研究生  070302-分析化学  

胡琴  硕士研究生  086000-生物与医药  

方仲佩  博士研究生  070302-分析化学