基本信息
张鹏飞  男  硕导  中国科学院深圳先进技术研究院
电子邮件: pf.zhang@siat.ac.cn
通信地址: 深圳市南山区学苑大道1068号
邮政编码:

研究领域

1)  聚集诱导发光

2)  纳米生物分析

3)  纳米医学

4) 生物材料


招生信息

1)  分析化学

2)  功能材料

3)  化学生物学/纳米生物学

招生专业
0703Z1-化学生物学
070305-高分子化学与物理
083100-生物医学工程
招生方向
聚集发光材料
核酸纳米技术
微纳机器人

教育背景

2015-08--2018-11   香港科技大学   博士研究生
2002-09--2009-07   湖南大学   硕士研究生
学历
博士


工作经历

工作简历
2018-12~现在, 中国科学院深圳先进技术研究院, 副研究员
2011-07~2015-08,中国科学院深圳先进技术研究院, 助理研究员
2009-07~2011-07,中国科学院深圳先进技术研究院, 研究助理

教授课程

化学生物学

专利与奖励


奖励信息
(1) 纳米智能材料的化学标记与生物示踪研究, 二等奖, 省级, 2016
(2) 纳米生物智能材料的肿瘤诊疗一体化研究, 二等奖, 市地级, 2015
专利成果
( 1 ) LUMINOGENS FOR BIOLOGICAL APPLICATIONS, 发明, 2017, 第 5 作者, 专利号: WO2018108070
( 2 ) NIR-II Emissive Luminogens, 发明, 2019, 第 2 作者, 专利号: WO2019238121A1
( 3 ) AIEGENS FOR CANCER CELL IMAGING, 发明, 2017, 第 5 作者, 专利号: WO2018014865.

出版信息

长期从事多功能发光纳米材料合成、修饰及其生物分析及医学相关应用研究,已在J.Am.Chem.Soc.(化学顶级期刊), Angewandte Chemie International Edition, (化学顶级期刊), Analytical Chemistry (分析化学顶级期刊), Advanced Materials(材料科学顶级期刊), Advanced Functional Materials, ACS NANO, Biomaterials等国际期刊发表发表论文50 余篇(第一作者/通讯作者文章15篇,其中影响因子大于10的论文4篇)


发表论文
(1) Fluorescence Self‐Reporting Precipitation Polymerization Based on Aggregation‐Induced Emission for Constructing Optical Nanoagents, Angewandte Chemie International Edition, 2020, 第 1 作者
(2) Ratiometric Photoacoustic Chemical Sensor for Pd2+ Ion, Analytical Chemistry, 2020, 通讯作者
(3) Highly Stable and Bright NIR-II AIE Dots for Intraoperative Identification of Ureter, ACS Appl. Mater. Interfaces, 2020, 第 1 作者
(4) Development of AIEgen–montmorillonite nanocomposite powders for computer-assisted visualization of latent fingermarks, Materials Chemistry Frontiers, 2020, 通讯作者
(5) On-site visual discrimination of transgenic food by water-soluble DNA-binding AIEgens, Materials Chemistry Frontiers, 2019, 通讯作者
(6) Mitochondria-Localized Self-Reporting Small-Molecule-Decorated Theranostic Agents for Cancer-Organelle Transporting and Imaging, ACS Applied Bio Materials, 2019, 通讯作者
(7) Lysosome-Targeting Red-Emitting Aggregation-Induced Emission Probe with Large Stokes Shift for Light-Up in Situ Visualization of β-N-Acetylhexosaminidase, Analytical Chemistry, 2019, 第 4 作者
(8) An Easily Available Ratiometric Reaction-Based AIE Probe for Carbon Monoxide Light-up Imaging, Analytical Chemistry, 2019, 通讯作者
(9) Monitorable Mitochondria-Targeting DNAtrain for Image-Guided Synergistic Cancer Therap, Analytical Chemistry, 2019, 通讯作者
(10) Scaffolds biomimicking macrophages for a glioblastoma NIR-Ib imaging guided photothermal therapeutic strategy by crossing Blood-Brain Barrier, Biomaterials, 2019, 通讯作者
(11) Rational Design of Perylenediimide-Substituted Triphenylethylene to Electron Transporting Aggregation-Induced Emission Luminogens (AIEgens) with High Mobility and Near-Infrared Emission, Advanced Functional Materials, 2018, 第 4 作者
(12) Protein-modified conjugated polymer nanoparticles with strong near-infrared absorption: a novel nanoplatform to design multifunctional nanoprobes for dual-modal photoacoustic and fluorescence imaging, Nanoscale, 2018, 第 1 作者
(13) Red/NIR‐Emissive Benzo[d]imidazole‐Cored AIEgens: Facile Molecular Design for Wavelength Extending and In Vivo Tumor Metabolic Imaging, Advanced Materials, 2018, 第 1 作者
(14) Recombina nt-fully-human-antibody decorated highly-stable far-red AIEdots for in vivo HER-2 receptor-targeted imaging, Chemical Communications, 2018, 通讯作者
(15) Ultrabright red AIEgens for two-photon vascular imaging with high resolution and deep penetration, Chemical Science, 2018, 第 1 作者
(16) Polyyne bridged AIE luminogens with red emission: design, synthesis, properties and applications, Journal of Materials Chemistry B, 2017, 第 3 作者
(17) Aptamer-Decorated Self-Assembled Aggregation-Induced Emission Organic Dots for Cancer Cell Targeting and Imaging, Analytical Chemistry, 2017, 第 1 作者
(18) Ionization and Anion−π+ Interaction: A New Strategy for Structural Design of Aggregation-Induced Emission Luminogens, Journal of the American Chemical Society, 2017, 第 3 作者
(19) Observation of Metal Nanoparticles for Acoustic Manipulation, Advanced Science, 2017, 第 7 作者
(20) The synthesis of novel AIE emitters with the triphenylethene-carbazole skeleton and para-/meta-substituted arylboron groups and their application in efficient non-doped OLEDs, Journal of Materials Chemistry C, 2016, 第 4 作者
(21) Iron oxide nanoparticles protected by NIR-active multidentate-polymers as multifunctional nanoprobes for NIRF/PA/MR trimodal imaging, Nanoscale, 2016, 通讯作者
(22) Long-decay near-infrared-emitting doped quantum dots for lifetime-based in vivo pH imaging, Chemical Communications, 2015, 第 1 作者
(23) Compact chelator-free Ni-integrated CuS nanoparticles with tunable near-infrared absorption and enhanced relaxivity for in vivo dual-modal photoacoustic/MR imaging, Nanoscale, 2015, 第 1 作者
(24) Robust ICG Theranostic Nanoparticles for Folate Targeted Cancer Imaging and Highly Effective Photothermal Therapy, ACS Applied Materials & Interfaces, 2014, 第 6 作者
(25) Aptamer-mediated indirect quantum dot labeling and fluorescent imaging of target proteins in living cells, Nanotechnology, 2014, 第 1 作者
(26) Near-Infrared-Emitting Two-Dimensional Codes Based on Lattice-Strained Core/(Doped) Shell Quantum Dots with Long Fluorescence Lifetime, Advanced Materials, 2014, 第 1 作者
(27) Smart Human Serum Albumin-Indocyanine Green Nanoparticles Generated by Programmed Assembly for Dual-Modal Imaging-Guided Cancer Synergistic Phototherapy, ACS NANO, 2014, 第 9 作者
(28) Noninvasive Visualization of Respiratory Viral Infection Using Bioorthogonal Conjugated Near-Infrared-Emitting Quantum Dots, ACS NANO, 2014, 第 1 作者
(29) Highly Bright and Compact Alloyed Quantum Rods with Near Infrared Emitting: a Potential Multifunctional Nanoplatform for Multimodal Imaging In Vivo, Advanced Functional Materials, 2014, 第 1 作者
(30) Folate Receptor-Targeting Gold Nanoclusters as Fluorescence Enzyme Mimetic Nanoprobes for Tumor Molecular Colocalization Diagnosis, Theranostics, 2014, 第 6 作者
(31) Near infrared fluorescence resonance energy transfer based aptamer biosensor for insulin detection in human plasma, Chemical Communications, 2014, 第 3 作者
(32) Functionalized quantum dots induce proinflammatory responses in vitro: the role of terminal functional group-associated endocytic pathways, Nanoscale, 2013, 第 3 作者
(33) Hybrid gold–gadolinium nanoclusters for tumor-targeted NIRF/CT/MRI triple-modal imaging in vivo, Nanoscale, 2013, 第 3 作者
(34) One-step synthesis of peptide-programmed QDs as ready-to-use nanoprobes, Chemical Communications, 2013, 通讯作者
(35) Single-Step Assembly of DOX/ICG Loaded Lipid–Polymer Nanoparticles for Highly Effective Chemo-photothermal Combination Therapy, ACS NANO, 2013, 第 8 作者
(36) Protein-assisted fabrication of nano-reduced graphene oxide for combined in vivo photoacoustic imaging and photothermal therapy, Biomaterials, 2013, 第 9 作者
(37) Polypeptide cationic micelles mediated co-delivery of docetaxel and siRNA for synergistic tumor therapy, Biomaterials, 2013, 第 6 作者
(38) DNase-activatable fluorescence probes visualizing the degradation of exogenous DNA in living cells, Nanoscale, 2012, 第 3 作者
(39) Click-Functionalized Compact Quantum Dots Protected by Multidentate-Imidazole Ligands: Conjugation-Ready Nanotags for Living-Virus Labeling and Imaging, Journal of the American Chemical Society, 2012, 第 1 作者
(40) PEI protected aptamer molecular probes for contrast-enhanced in vivo cancer imaging, Biomaterials, 2012, 第 5 作者
(41) Indocyanine green-loaded biodegradable tumor targeting nanoprobes for in vitro and in vivo imaging, Biomaterials, 2012, 第 5 作者
(42) Cation exchange in aptamer-conjugated CdSe nanoclusters: a novel fluorescence signal amplification for cancer cell detection, Chemical Communications, 2012, 第 3 作者
(43) A fast synthesis of near-infrared emitting CdTe/CdSe quantum dots with small hydrodynamic diameter for in vivo imaging probes, Nanoscale, 2011, 第 1 作者
(44) Planar AIEgens with Enhanced Solid‐State Luminescence and ROS Generation for Multidrug‐Resistant Bacteria Treatment, Angewandte Chemie International Edition, 2002, 第 5 作者

科研活动

   
科研项目
( 1 ) 基于体内点击化学的光学纳米探针的构建及 其活体成像研究, 主持, 国家级, 2016-01--2018-12
( 2 ) “点击化学”纳米探针用于病毒活体示踪研究, 主持, 省级, 2015-01--2016-12
( 3 ) 基于点击化学的量子点原位生物标记新方法研究, 主持, 市地级, 2014-01--2015-12
( 4 ) 王宽诚率先人才计划-卢嘉锡国际团队-纳米免疫与诊疗一体化国际团队, 参与, 部委级, 2019-01--2021-12
( 5 ) 智能响应AIE-DNA 纳米火车载药系统用于精准纳米医学研究, 主持, 部委级, 2020-01--2021-12
( 6 ) 仿生纳米/聚集态可视化诊疗一体化技术, 主持, 市地级, 2020-01--2021-12
参与会议
(1)AIE新材料在生物医疗技术方面的发展趋势   第十二届中国生物产业大会   2019-06-10
(2)AIEgens-Based Photophysical Tools for Biomedical Research    第十六次中国暨国际生物物理大会   2018-08-24
(3)Aptamer-AIE Dots: A Promising Tumor-Targeting Nanoprobe for Translational Medicine   2017-06-21

合作情况

中国香港-香港科技大学/香港大学/香港城市大学

中国澳门-澳门大学/澳门科技大学

澳大利亚-新南威尔士大学

意大利-米兰大学