​本团队的研究目标是 解析阿尔茨海默病等老年期复杂疾病发生发展的分子机制，构建合适的体内、体外研究体系和模型，以探索阿尔茨海默病等疾病的早期、精准干预策略。

团队主要研究方向与策略为：基于病例对照人群、队列人群的样本和数据，开展遗传学、基因组学与分子流行病学分析，鉴定阿尔茨海默病发生发展相关的核心分子；随后在细胞、类器官等体外水平开展分子、生化与功能基因组学分析，解析其分子机制；并基于小鼠、树鼩、猕猴等实验动物构建疾病动物模型，开展认知行为、神经病理等表型分析，探索基于特定基因型和特定发病机制的基因治疗与药物干预策略。团队将基于对阿尔茨海默病发生发展的生物学基础的理解，为促进阿尔茨海默病的认识、预测、预防、诊断、治疗提供基础数据。

具有遗传学、生物信息学、生物统计学、分子生物学、生物化学、神经生物学、细胞生物学等相关专业背景的硕士生与博士生；以及大三、大四的相关专业本科实习生。

071007-遗传学

医学遗传学

2010-09--2016-01   中国科学院大学   遗传学博士
2006-09--2010-06   华中科技大学生命科学与技术学院   理学学士

   

2021-01~现在, 中国科学院昆明动物研究所, 研究员
2018-01~2020-12,中国科学院昆明动物研究所, 副研究员
2016-01~2017-12,中国科学院昆明动物研究所, 助理研究员

2019-01-01-今,Associate Editor of Journal of Alzheimer's disease,

   

（1） 中国人群血液肿瘤患者IDH1、IDH2、DNMT3A基因突变发现及其机理研究与应用, 三等奖, 省级, 2019

   

[1] Xiao Li, Min Xu, Rui Bi, LiWen Tan, YongGang Yao, DengFeng Zhang. Common and rare variants of EGF increase the genetic risk of Alzheimer's disease as revealed by targeted sequencing of growth factors in Han Chinese. NEUROBIOLOGY OF AGING[J]. 2023, 123: 170-181, http://dx.doi.org/10.1016/j.neurobiolaging.2022.10.009.
[2] Zhang, Deng-Feng, Li, Ming. Toward a Full Understanding of Causal and Modifiable Risk Factors for Alzheimer’s Disease by Integrative Phenome-wide Association Studies. Biol Psychiatry[J]. 2023, [3] Xiao Li, Deng-Feng Zhang, Rui Bi, Li-Wen Tan, Xiaogang Chen, Min Xu, Yong-Gang Yao. Convergent transcriptomic and genomic evidence supporting a dysregulation of CXCL16 and CCL5 in Alzheimer’s disease. ALZHEIMER'S RESEARCH & THERAPY[J]. 2023, 15(1): 1-14, http://dx.doi.org/10.1186/s13195-022-01159-5.
[4] Guanqin Ma, DengFeng Zhang, QingCui Zou, Xiaochun Xie, Ling Xu, XiaoLi Feng, Xiaohong Li, JianBao Han, Dandan Yu, ZhongHua Deng, Wang Qu, Junyi Long, MingHua Li, YongGang Yao, Jianxiong Zeng. SARS-CoV-2 Spike protein S2 subunit modulates γ-secretase and enhances amyloid-β production in COVID-19 neuropathy. CELL DISCOVERY[J]. 2022, 8(1): 1-5, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9524330/.
[5] Zheng, Quanzhen, Bi, Rui, Xu, Min, Zhang, DengFeng, Tan, LiWen, Lu, YaPing, Yao, YongGang. Exploring the Genetic Association of the ABAT Gene with Alzheimer's Disease. MOLECULAR NEUROBIOLOGY[J]. 2021, 58(5): 1894-1903, http://dx.doi.org/10.1007/s12035-020-02271-z.
[6] Zhang, DengFeng, Li, HuiLong, Zheng, Quanzhen, Bi, Rui, Xu, Min, Wang, Dong, Zhu, GuoPing, Li, YuYe, Yao, YongGang. Mapping leprosy-associated coding variants of interleukin genes by targeted sequencing. CLINICAL GENETICS[J]. 2021, 99(6): 802-811, http://dx.doi.org/10.1111/cge.13945.
[7] Zhang, DengFeng, Bu, XianLe, Aliev, Gjumrakch, Zhu, Feiqi. Editorial: Infection, Inflammation, Cardiovascular Diseases, and Neurodegeneration. FRONTIERS IN NEUROSCIENCE[J]. 2021, 15: http://dx.doi.org/10.3389/fnins.2021.750172.
[8] Luo, Rongcan, Su, LingYan, Li, Guiyu, Yang, Jing, Liu, Qianjin, Yang, LuXiu, Zhang, DengFeng, Zhou, Hejiang, Xu, Min, Fan, Yu, Li, Jiali, Yao, YongGang. Activation of PPARA-mediated autophagy reduces Alzheimer disease-like pathology and cognitive decline in a murine model. AUTOPHAGY[J]. 2020, 16(1): 52-69, https://www.tandfonline.com/doi/full/10.1080/15548627.2019.1596488.
[9] Zhang, DengFeng, Wang, Dong, Li, YuYe, Yao, YongGang. Is there an antagonistic pleiotropic effect of a LRRK2 mutation on leprosy and Parkinson's disease?. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICAnull. 2020, 117(19): 10122-10123, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229648/.
[10] Weidao Zhang, Zhongliang Chen, Dengfeng Zhang, Bo Zhao, Lu Liu, Zhengyuan Xie, Yonggang Yao, Ping Zheng. KHDC3L mutation causes recurrent pregnancy loss by inducing genomic instability of human early embryonic cells.. PLOS BIOLOGY[J]. 2019, 17(10): https://doaj.org/article/8568c646525c4cbfaaf43c07cd7cf22c.
[11] 方新宇, 卢卫红, 王慧珍, 倪建良, 张江涛, 蔡军, 李涛, 张登峰, 张晨. EGR1基因与中国汉族人群阿尔茨海默病发病风险的关联研究. 上海交通大学学报:医学版[J]. 2019, 39(2): 153-159, http://lib.cqvip.com/Qikan/Article/Detail?id=7001431253.
[12] 陈艳, 方新宇, 汪也微, 倪建良, 张江涛, 卢卫红, 李涛, 张登峰, 张晨. 中国汉族FOS基因rs1063169多态性与阿尔茨海默病的关联性研究. 上海交通大学学报:医学版[J]. 2019, 39(1): 47-51, http://lib.cqvip.com/Qikan/Article/Detail?id=7001263845.
[13] Wang, Guihong, Zhang, DengFeng, Jiang, HongYan, Fan, Yu, Ma, Lingyan, Shen, Zonglin, Bi, Rui, Xu, Min, Tan, Liwen, Shan, Baoci, Yao, YongGang, Feng, Tao. Mutation and association analyses of dementia-causal genes in Han Chinese patients with early-onset and familial Alzheimer's disease. JOURNAL OF PSYCHIATRIC RESEARCH[J]. 2019, 113: 141-147, http://ir.kiz.ac.cn:8080/handle/152453/12407.
[14] Zhang, DengFeng, Fan, Yu, Xu, Min, Wang, Guihong, Wang, Dong, Li, Jin, Kong, LiLi, Zhou, Hejiang, Luo, Rongcan, Bi, Rui, Wu, Yong, Li, GuoDong, Li, Ming, Luo, XiongJian, Jiang, HongYan, Tan, Liwen, Zhong, Chunjiu, Fang, Yiru, Zhang, Chen, Sheng, Nengyin, Jiang, Tianzi, Yao, YongGang. Complement C7 is a novel risk gene for Alzheimer's disease in Han Chinese. NATIONAL SCIENCE REVIEW[J]. 2019, 6(2): 257-274, [15] Zhang, DengFeng, Xu, Min, Bi, Rui, Yao, YongGang. Genetic Analyses of Alzheimer's Disease in China: Achievements and Perspectives. ACS CHEMICAL NEUROSCIENCEnull. 2019, 10(2): 890-901, http://dx.doi.org/10.1021/acschemneuro.8b00435.
[16] Fang, Xinyu, Tang, Wei, Yang, Fuyin, Lu, Weihong, Cai, Jun, Ni, Jianliang, Zhang, Jiangtao, Tang, Wenxin, Li, Tao, Zhang, DengFeng, Zhang, Chen. A Comprehensive Analysis of the CaMK2A Gene and Susceptibility to Alzheimer's Disease in the Han Chinese Population. FRONTIERS IN AGING NEUROSCIENCE[J]. 2019, 11: https://doaj.org/article/4bb8844282274f5fa2d5935b57ce6ff5.
[17] DengFeng Zhang, Dong Wang, YongGang Yao, Mahadev Malhi, Rui Bi, Yong Wu, Min Xu, XiuFeng Yu, Heng Long, YuYe Li. Missense Variants in HIF1A and LACC1 Contribute to Leprosy Risk in Han Chinese. THE AMERICAN JOURNAL OF HUMAN GENETICS[J]. 2018, 102(102): 794–805-, http://159.226.149.26:8080/handle/152453/12340.
[18] Bi, Rui, Zhang, Wen, Zhang, DengFeng, Xu, Min, Fan, Yu, Hu, QiuXiang, Jiang, HongYan, Tan, Liwen, Li, Tao, Fang, Yiru, Zhang, Chen, Yao, YongGang. Genetic association of the cytochrome c oxidase-related genes with Alzheimer's disease in Han Chinese. NEUROPSYCHOPHARMACOLOGY[J]. 2018, 43(11): 2264-2276, https://www.webofscience.com/wos/woscc/full-record/WOS:000444406700014.
[19] Xu M, Zhang DF, Luo R, Wu Y, Zhou H, Kong LL, Bi R, Yao YG. A systematic integrated analysis of brain expression profiles reveals yap1 and other prioritized hub genes as important upstream regulators in alzheimer\'s disease(article). ALZHEIMER\'S AND DEMENTIA[J]. 2018, Vol.14 no.2: 215-229, http://www.corc.org.cn/handle/1471x/2204329.
[20] Ni, Hua, Xu, Min, Zhan, GuiLai, Fan, Yu, Zhou, Hejiang, Jiang, HongYan, Lu, WeiHong, Tan, Liwen, Zhang, DengFeng, Yao, YongGang, Zhang, Chen. The GWAS Risk Genes for Depression May Be Actively Involved in Alzheimer's Disease. JOURNAL OF ALZHEIMERS DISEASE[J]. 2018, 64(4): 1149-1161, http://dx.doi.org/10.3233/JAD-180276.
[21] Wang, Dong, Fan, Yu, Malhi, Mahadev, Bi, Rui, Wu, Yong, Xu, Min, Yu, XiuFeng, Long, Heng, Li, YuYe, Zhang, DengFeng, Yao, YongGang. Missense Variants in HIF1A and LACC1 Contribute to Leprosy Risk in Han Chinese. AMERICAN JOURNAL OF HUMAN GENETICS[J]. 2018, 102(5): 794-805, http://dx.doi.org/10.1016/j.ajhg.2018.03.006.
[22] Zhang DF, changchenmoonibpaccn, Wang P, Chang C, Liu LM, Su WT, Zhang C, Liu GH, Yao YG, Yuan ZQ, Yao Q, Qiao XH, Wu KY, Zhang YY. Increased GSNOR expression during aging impairs cognitive function and decreases S-nitrosation of CaMKIIα. JOURNAL OF NEUROSCIENCE[J]. 2017, **(**): Epub ahead of print-, http://159.226.149.26:8080/handle/152453/12039.
[23] Xiang, Qun, Bi, Rui, Xu, Min, Zhang, DengFeng, Tan, Liwen, Zhang, Chen, Fang, Yiru, Yao, YongGang. Rare Genetic Variants of the Transthyretin Gene Are Associated with Alzheimer's Disease in Han Chinese. MOLECULAR NEUROBIOLOGY[J]. 2017, 54(7): 5192-5200, http://dx.doi.org/10.1007/s12035-016-0065-2.
[24] Li, GuoDong, Wang, Dong, Zhang, DengFeng, Xiang, Qun, Feng, JiaQi, Li, XiaoAn, Li, YuYe, Yao, YongGang. Fine mapping of the GWAS loci identifies SLC35D1 and IL23R as potential risk genes for leprosy. JOURNAL OF DERMATOLOGICAL SCIENCE[J]. 2016, 84(3): 322-329, http://dx.doi.org/10.1016/j.jdermsci.2016.09.018.
[25] Zhang DengFeng, Fan Yu, Wang Dong, Bi Rui, Zhang Chen, Fang Yiru, Yao YongGang. PLD3 in Alzheimer’s Disease: a Modest Effect as Revealed by Updated Association and Expression Analyses. MOLECULAR NEUROBIOLOGY[J]. 2016, [26] Zhang, DengFeng, Wang, Dong, Li, Yu Ye, Yao, YongGang. Integrative analyses of leprosy susceptibility genes indicate a common autoimmune profile. JOURNAL OF DERMATOLOGICAL SCIENCE[J]. 2016, 82(1): 18-27, http://dx.doi.org/10.1016/j.jdermsci.2016.01.001.
[27] Zhang, DengFeng, Li, Jin, Wu, Huan, Cui, Yue, Bi, Rui, Zhou, HeJiang, Wang, HuiZhen, Zhang, Chen, Wang, Dong, Kong, QingPeng, Li, Tao, Fang, Yiru, Jiang, Tianzi, Yao, YongGang, ADNI. CFH Variants Affect Structural and Functional Brain Changes and Genetic Risk of Alzheimer's Disease. NEUROPSYCHOPHARMACOLOGY[J]. 2016, 41(4): 1034-1045, http://dx.doi.org/10.1038/npp.2015.232.
[28] Huo, YongXia, Huang, Liang, Zhang, DengFeng, Yao, YongGang, Fang, YiRu, Zhang, Chen, Luo, XiongJian. Identification of SLC25A37 as a major depressive disorder risk gene. JOURNAL OF PSYCHIATRIC RESEARCH[J]. 2016, 83(X): 168-175, http://dx.doi.org/10.1016/j.jpsychires.2016.09.011.
[29] Zhang, DengFeng, Fan, Yu, Wang, Dong, Bi, Rui, Zhang, Chen, Fang, Yiru, Yao, YongGang. PLD3 in Alzheimer's Disease: a Modest Effect as Revealed by Updated Association and Expression Analyses. MOLECULAR NEUROBIOLOGY[J]. 2016, 53(6): 4034-4045, http://www.corc.org.cn/handle/1471x/2374523.
[30] Xiang, YangLin, Zhang, DengFeng, Wang, Dong, Li, YuYe, Yao, YongGang. Common variants of OPA1 conferring genetic susceptibility to leprosy in Han Chinese from Southwest China. JOURNAL OF DERMATOLOGICAL SCIENCE[J]. 2015, 80(2): 133-141, http://dx.doi.org/10.1016/j.jdermsci.2015.09.001.
[31] 张登峰. 阿尔兹海默病遗传风险相关基因的整合分析. 2015, [32] Li, Xiao, Zhang, Wen, Zhang, Chen, Yi, Zhenghui, Zhang, DengFeng, Gong, Wei, Tang, Jinsong, Wang, Dong, Lu, Weihong, Chen, Xiaogang, Fang, Yiru, Yao, YongGang. Common variants of the PINK1 and PARL genes do not confer genetic susceptibility to schizophrenia in Han Chinese. MOLECULAR GENETICS AND GENOMICS[J]. 2015, 290(2): 585-592, http://dx.doi.org/10.1007/s00438-014-0942-1.
[33] Zhang, DengFeng, Huang, XianQiong, Wang, Dong, Li, YuYe, Yao, YongGang. Genetic variants of complement genes Ficolin-2, Mannose-binding lectin and Complement factor H are associated with leprosy in Han Chinese from Southwest China. HUMAN GENETICS[J]. 2013, 132(6): 629-640, http://www.irgrid.ac.cn/handle/1471x/1154465.
[34] Wang, Dong, Feng, JiaQi, Li, YuYe, Zhang, DengFeng, Li, XiaoAn, Li, QingWei, Yao, YongGang. Genetic variants of the MRC1 gene and the IFNG gene are associated with leprosy in Han Chinese from Southwest China. HUMAN GENETICS[J]. 2012, 131(7): 1251-1260, http://www.irgrid.ac.cn/handle/1471x/490565.

   

（ 1 ） 补体组分C7基因突变增加阿尔茨海默病遗传风险的机制解析, 主持, 国家级, 2020-01--2023-12
（ 2 ） 西部青年学者, 主持, 部委级, 2017-01--2020-12
（ 3 ） 青年创新促进会, 主持, 部委级, 2019-01--2022-12
（ 4 ） 云南麻风人群基因组编码区易感变异的发现与功能分析, 主持, 省级, 2019-06--2022-05
（ 5 ） 云南省优秀青年基金, 主持, 省级, 2019-06--2022-05
（ 6 ） 云南省“万人计划”青年拔尖人才, 主持, 省级, 2019-01--2023-12
（ 7 ） 阿尔茨海默病的功能基因组学, 主持, 国家级, 2021-01--2023-12

现指导学生

曾春华  硕士研究生  071007-遗传学