鱼类生殖内分泌及分子遗传育种。主要从事鲤科模式鱼类-斑马鱼和养殖鱼类-鲤的生殖内分泌调控研究。通过在斑马鱼中阻断性类固醇激素的合成，构建了雄激素和雌激素缺乏、但孕激素积累的模型，针对其生殖发育和代谢等方面的研究获得了系列成果：①垂体Fshβ信号通路在精巢发育/精子发生中存在反馈补偿机制、②雌激素调控卵巢分化存在可塑性、③雄激素维持雄性的第二性征和生殖行为、④增强的孕激素通路可替代雄激素通路维持精巢发育和精子发生、⑤性类固醇激素调控代谢的机制等。将阻断性类固醇激素合成的策略在两性异形的鲤中进行应用，首创了可大规模连续生产的全雌鲤和高伪雄鲤群体，显著提升了养殖产量和效率。

另外，还针对胰岛素Insulin、垂体促泌乳素Prolactin、促甲状腺素Tshβ等内分泌激素进行了糖脂代谢、离子吸收、幼稚转化期发育等过程的研究。

招收水产养殖专业的硕士研究生。

090801-水产养殖

水产遗传育种

2015年3月-2018年12月 中国科学院水生生物研究所 助理研究员

2019年1月 至今 中国科学院水生生物研究所 副研究员

   

[1] 殷战, 石闯, 童金苟, 解绶启, 娄气永, 翟刚. 一种促进鱼类生长性状改良的方法. CN: CN111454992B, 2022-02-15.
[2] 殷战, 翟刚, 舒婷婷, 娄气永, 贺江燕, 姜冬火, 钱雪桥, 石闯, 黄建飞, 贾景怡. 规模化获得XX/XY性别决定的伪雄鱼亲本的育种方法及其应用. CN: CN113817779A, 2021-12-21.
[3] 殷战, 翟刚, 舒婷婷, 贺江燕, 娄气永, 姜冬火, 钱雪桥, 石闯, 黄建飞, 贾景怡, 金霞. 实现XX/XY性别遗传决定型鱼类性别控制育种的方法及应用. CN: CN113789352A, 2021-12-14.
[4] 殷战, 翟刚, 贾景怡, 舒婷婷, 贺江燕, 娄气永, 石闯. 鉴别黄河鲤遗传性别的分子标记、引物、试剂盒及应用. CN: CN113774122A, 2021-12-10.
[5] 殷战, 彭旭艳, 尚国辉, 贺江燕, 金霞, 翟刚, 娄气永, 刘若兰. 维生素D受体激动剂用于预防和/或治疗肥胖的用途. CN: CN108853503A, 2018-11-23.

以第一或通讯作者在Engineering、Elife、Endocrinology、Science Bulletin、American Journal of Physiology-Endocrinology and Metabolism、Molecular and Cellular Biology等SCI源刊发表论文14篇（含共同）。现任Frontiers in Marine Science、Genes、Aquaculture Nutrition、Aquaculture Research、水生生物学报等国内外多个杂志审稿人。

[1] Longwei Xi, Zhai, Gang, Yulong Liu, Gong, Yulong, Qisheng Lu, Zhimin Zhang, Liu, Haokun, Jin, Junyan, Xiaoming Zhu, Zhan Yin, Xie, Shouqi, Dong Han. Attenuated glucose uptake promotes catabolic metabolism through activated AMPK signaling and impaired insulin signaling in zebrafish. Frontiers in Nutrition[J]. 2023, 26: [2] Zhai, Gang, Jia, Jingyi, Bereketoglu, Ceyhun, Yin, Zhan, Pradhan, Ajay. Sex-specific differences in zebrafish brains. BIOLOGY OF SEX DIFFERENCES[J]. 2022, 13(1): http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000812519400001.
[3] 李天慧, 翟刚, 贺江燕, 娄气永, 金霞, 杜震宇, 肖武汉, 殷战. 雄激素受体缺乏抑制肝脏Vtg合成导致卵巢发育障碍. 水生生物学报. 2022, 46(9): 1277-1284, http://lib.cqvip.com/Qikan/Article/Detail?id=7107937761.
[4] Shengchi Shi, Shu, Tingting, Xi Li, Qiyong Lou, Jin, Xia, He, Jiangyan, Zhan Yin, 翟刚. Characterization of the interrenal gland and sexual traits development in cyp17a2-deficient zebrafish. Frontiers in Endocrinology[J]. 2022, [5] Gang Zhai, Tingting Shu, Guangqing Yu, Haipei Tang, Chuang Shi, Jingyi Jia, Qiyong Lou, Xiangyan Dai, Xia Jin, Jiangyan He, Wuhan Xiao, Xiaochun Liu, Zhan Yin, Cunming Duan, Didier YR Stainier. Augmentation of progestin signaling rescues testis organization and spermatogenesis in zebrafish with the depletion of androgen signaling. ELIFE[J]. 2022, 11: e66118-, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8912926/.
[6] Shi, Chuang, Lou, Qiyong, Fu, Beide, Jin, Junyan, Huang, Jianfei, Lu, Yao, Jin, Xia, He, Jiangyan, Zhai, Gang, Xie, Shouqi, Tong, Jingou, Gui, Jianfang, Yin, Zhan. Genomic polymorphisms at the crhr2 locus improve feed conversion efficiency through alleviation of hypothalamus-pituitary-interrenal axis activity in gibel carp (Carassius gibelio). SCIENCE CHINA-LIFE SCIENCES[J]. 2022, 65(1): 206-214, http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000647011600002.
[7] Zhai, Gang, Shu, Tingting, Chen, Kuangxin, Lou, Qiyong, Jia, Jingyi, Huang, Jianfei, Shi, Chuang, Jin, Xia, He, Jiangyan, Jiang, Donghuo, Qian, Xueqiao, Hu, Wei, Yin, Zhan. Successful Production of an All-female Common Carp (Cyprinus carpio L.) Population Using cyp17a1-deficient Neomale Carps. Engineering[J]. 2021, [8] Song, Jia, Lu, Yao, Cheng, Xiaoxia, Shi, Chuang, Lou, Qiyong, Jin, Xia, He, Jiangyan, Zhai, Gang, Yin, Zhan. Functions of the Thyroid-Stimulating Hormone on Key Developmental Features Revealed in a Series of Zebrafish Dyshormonogenesis Models. CELLS[J]. 2021, 10(8): http://dx.doi.org/10.3390/cells10081984.
[9] Dai, Xiangyan, Cheng, Xinkai, Huang, Jianfei, Gao, Yanping, Wang, Deshou, Feng, Zhi, Zhai, Gang, Lou, Qiyong, He, Jiangyan, Wang, Zhijian, Yin, Zhan. Rbm46, a novel germ cell-specific factor, modulates meiotic progression and spermatogenesis. BIOLOGY OF REPRODUCTION[J]. 2021, 104(5): 1139-1153, http://dx.doi.org/10.1093/biolre/ioab016.
[10] Luo, Jing, Zhang, Xiaokang, He, Siying, Lou, Qiyong, Zhai, Gang, Shi, Chuang, Yin, Zhan, Zheng, Fang. Deletion of narfl leads to increased oxidative stress mediated abnormal angiogenesis and digestive organ defects in zebrafish. REDOX BIOLOGY[J]. 2020, 28(1): http://dx.doi.org/10.1016/j.redox.2019.101355.
[11] Shu, Tingting, Zhai, Gang, Pradhan, Ajay, Olsson, PerErik, Yin, Zhan. Zebrafish cyp17a1 knockout reveals that androgen-mediated signaling is important for male brain sex differentiation. GENERAL AND COMPARATIVE ENDOCRINOLOGY[J]. 2020, 295: http://dx.doi.org/10.1016/j.ygcen.2020.113490.
[12] 李威, 贺江燕, 翟刚, 胡玉才, 殷战. 低温处理对异育银鲫腹部脂肪组织能量代谢相关基因表达的影响. 生物资源[J]. 2020, 42(6): 698-703, http://lib.cqvip.com/Qikan/Article/Detail?id=7103987807.
[13] Shi, Chuang, Lu, Yao, Zhai, Gang, Huang, Jianfei, Shang, Guohui, Lou, Qiyong, Li, Dongliang, Jin, Xia, He, Jiangyan, Du, Zhenyu, Gui, Jianfang, Yin, Zhan. Hyperandrogenism in POMCa-deficient zebrafish enhances somatic growth without increasing adiposity. JOURNAL OF MOLECULAR CELL BIOLOGY[J]. 2020, 12(4): 291-304, http://lib.cqvip.com/Qikan/Article/Detail?id=7102021277.
[14] Gao, Yanping, Dai, Ziru, Shi, Chuang, Zhai, Gang, Jin, Xia, He, Jiangyan, Lou, Qiyong, Yin, Zhan. Depletion of Myostatin b Promotes Somatic Growth and Lipid Metabolism in Zebra fish (vol 7, 88. 2016). FRONTIERS IN ENDOCRINOLOGY. 2019, 10(1): https://www.webofscience.com/wos/woscc/full-record/WOS:000468733700001.
[15] Shang, Guohui, Peng, Xuyan, Ji, Cheng, Zhai, Gang, Ruan, Yonglin, Lou, Qiyong, Jin, Xia, He, Jiangyan, Wang, Han, Yin, Zhan. Steroidogenic acute regulatory protein and luteinizing hormone are required for normal ovarian steroidogenesis and oocyte maturation in zebrafish. BIOLOGY OF REPRODUCTION[J]. 2019, 101(4): 760-770, [16] Zhai, Gang, Shu, Tingting, Xia, Yuguo, Lu, Yao, Shang, Guohui, Jin, Xia, He, Jiangyan, Nie, Pin, Yin, Zhan. Characterization of Sexual Trait Development in cyp17a1-Deficient Zebrafish. ENDOCRINOLOGY[J]. 2018, 159(10): 3549-3562, https://www.webofscience.com/wos/woscc/full-record/WOS:000446428300008.
[17] Shu, Tingting, Shu, Yuqin, Gao, Yanping, Jin, Xia, He, Jiangyan, Zhai, Gang, Yin, Zhan. Depletion of Tissue-Specific Ion Transporters Causes Differential Expression of PRL Targets in Response to Increased Levels of Endogenous PRL. FRONTIERS IN ENDOCRINOLOGY[J]. 2018, 9: http://202.127.146.157/handle/2RYDP1HH/6104.
[18] Gong, Yulong, Zhai, Gang, Su, Jingzhi, Yang, Binyuan, Jin, Junyan, Liu, Haokun, Yin, Zhan, Xie, Shouqi, Han, Dong. Different roles of insulin receptor a and b in maintaining blood glucose homeostasis in zebrafish. GENERAL AND COMPARATIVE ENDOCRINOLOGY[J]. 2018, 269: 33-45, http://dx.doi.org/10.1016/j.ygcen.2018.08.012.
[19] Yang, BinYuan, Zhai, Gang, Gong, YuLong, Su, JingZhi, Peng, XuYan, Shang, GuoHui, Han, Dong, Jin, JunYan, Liu, HaoKun, Du, ZhenYu, Yin, Zhan, Xie, ShouQi. Different physiological roles of insulin receptors in mediating nutrient metabolism in zebrafish. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM[J]. 2018, 315(1): E38-E51, https://www.webofscience.com/wos/woscc/full-record/WOS:000441172300005.
[20] Yang, Binyuan, Zhai, Gang, Gong, Yulong, Su, Jingzhi, Han, Dong, Yin, Zhan, Xie, Shouqi. Depletion of insulin receptors leads to beta-cell hyperplasia in zebrafish. SCIENCE BULLETIN[J]. 2017, 62(7): 486-492, [21] Binyuan Yang, Gang Zhai, Yulong Gong, Jingzhi Su, Dong Han, Zhan Yin, Shouqi Xie. Depletion of insulin receptors leads to β-cell hyperplasia in zebrafish. SCIENCE BULLETIN. 2017, 62(7): 486-492, http://dx.doi.org/10.1016/j.scib.2017.03.001.
[22] Peng, Xuyan, Shang, Guohui, Wang, Wenqing, Chen, Xiaowen, Lou, Qiyong, Zhai, Gang, Li, Dongliang, Du, Zhenyu, Ye, Yali, Jin, Xia, He, Jiangyan, Zhang, Yi, Yin, Zhan. Fatty Acid Oxidation in Zebrafish Adipose Tissue Is Promoted by 1 alpha,25(OH)(2)D-3. CELL REPORTS[J]. 2017, 19(7): 1444-1455, https://www.webofscience.com/wos/woscc/full-record/WOS:000402125100015.
[23] Zhai, Gang, Shu, Tingting, Xia, Yuguo, Jin, Xia, He, Jiangyan, Yin, Zhan. Androgen signaling regulates the transcription of anti-Mullerian hormone via synergy with SRY-related protein SOX9A. SCIENCE BULLETIN[J]. 2017, 62(3): 197-203, http://ir.ihb.ac.cn/handle/342005/28968.
[24] Zhai, Gang, Song, Jia, Shu, Tingting, Yan, Junjun, Jin, Xia, He, Jiangyan, Yin, Zhan. LRH-1 senses signaling from phosphatidylcholine to regulate the expansion growth of digestive organs via synergy with Wnt/beta-catenin signaling in zebrafish. JOURNAL OF GENETICS AND GENOMICS[J]. 2017, 44(6): 307-317, https://www.webofscience.com/wos/woscc/full-record/WOS:000404557900003.
[25] Yang Binyuan, Zhai Gang, Gong Yulong, Su Jingzhi, Han Dong, Yin Zhan, Xie Shouqi. Depletion of insulin receptors leads to b-cell hyperplasia in zebrafish. SCIENCE BULLETIN[J]. 2017, 62(7): 486-, [26] Dai, Xiangyan, Shu, Yuqin, Lou, Qiyong, Tian, Qiang, Zhai, Gang, Song, Jia, Lu, Suxiang, Yu, Hong, He, Jiangyan, Yin, Zhan. Tdrd12 Is Essential for Germ Cell Development and Maintenance in Zebrafish. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES[J]. 2017, 18(6): https://doaj.org/article/494c63ac378d444fac71d4a526028b49.
[27] Yang, Jie, Li, Zuhua, Gan, Xuedong, Zhai, Gang, Gao, Jiajia, Xiong, Chenling, Qiu, Xueping, Wang, Xuebin, Yin, Zhan, Zheng, Fang. Deletion of Pr130 Interrupts Cardiac Development in Zebrafish. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES[J]. 2016, 17(11): https://doaj.org/article/4e45d87ba2274597979390a2a40e34c8.
[28] Gao, Yanping, Dai, Ziru, Shi, Chuang, Zhai, Gang, Jin, Xia, He, Jiangyan, Lou, Qiyong, Yin, Zhan. Depletion of Myostatin b Promotes somatic Growth and Lipid Metabolism in Zebrafish. FRONTIERS IN ENDOCRINOLOGY[J]. 2016, 7(1): https://doaj.org/article/cef40e6ec23349b5a6e8e6dafa854189.
[29] Li, Dongliang, Lou, Qiyong, Zhai, Gang, Peng, Xuyan, Cheng, Xiaoxia, Dai, Xiangyan, Zhuo, Zijian, Shang, Guohui, Jin, Xia, Chen, Xiaowen, Han, Dong, He, Jiangyan, Yin, Zhan. Hyperplasia and Cellularity Changes in IGF-1-Overexpressing Skeletal Muscle of Crucian Carp. ENDOCRINOLOGY[J]. 2014, 155(6): 2199-2212, http://www.irgrid.ac.cn/handle/1471x/929276.
[30] Zhai, Gang, Gu, Qilin, He, Jiangyan, Lou, Qiyong, Chen, Xiaowen, Jin, Xia, Bi, Erfei, Yin, Zhan. Sept6 Is Required for Ciliogenesis in Kupffer's Vesicle, the Pronephros, and the Neural Tube during Early Embryonic Development. MOLECULAR AND CELLULAR BIOLOGY[J]. 2014, 34(7): 1310-1321, http://www.irgrid.ac.cn/handle/1471x/852670.

参加国际斑马鱼大会、比较内分泌大会等会议，并做了口头报告或海报展示。

与瑞典OREBRO UNIVERSITY的Ajay Prandial合作，进行类固醇激素-睾酮调控脑部基因表达的机制研究。

   

​指导硕博研究生多名。