基本信息
于晓琳  女  硕导  中国科学院过程工程研究所
电子邮件: yuxiaolin@ipe.ac.cn
通信地址: 北京市海淀区中关村北二街1号
邮政编码: 100190

研究领域

治疗神经退行性疾病和糖尿病等重大疾病的基因工程抗体、疫苗、多肽和重组蛋白等生物技术药物。

招生信息

   
招生专业
081703-生物化工
085238-生物工程
招生方向
生物技术药物

教育背景

2001-09--2004-07   北京大学医学部   博士
1998-09--2001-07   中国药科大学   硕士
1994-09--1998-07   南京大学&中国药科大学   学士

工作经历

   
工作简历
2012-12~现在, 中国科学院过程工程研究所, 副研究员
2010-04~2012-12,清华大学, 药学教学
2005-12~2009-12,美国国立卫生研究院 (NIH), 博士后

专利与奖励

   
专利成果
[1] 刘瑞田, 于晓琳, 查君. 一种多肽及其应用. CN: CN106810603B, 2020-11-17.
[2] 刘瑞田, 刘小歌, 于晓琳, 卢帅. 一种具有寡聚体特异性的核磁造影剂及其制备方法与应用. CN: CN109364270A, 2019-02-22.
[3] 刘瑞田, 于晓琳, 查君. 一种多肽及其应用. 中国: CN106810603A, 2017-06-09.

出版信息

   
发表论文
[1] Xiao-ying Sun, Xiao-lin Yu, Jie Zhu, Ling-jie Li, Lun Zhang, Ya-ru Huang, Dong-qun Liu, Mei Ji, Xun Sun, Ling-xiao Zhang, Wei-wei Zhou, Dongming Zhang, Jianwei Jiao, Rui-tian Liu. Fc effector of anti-Aβ antibody induces synapse loss and cognitive deficits in Alzheimer’s disease-like mouse model. SIGNAL TRANSDUCTION AND TARGETED THERAPY[J]. 2023, 8(1): 1-14, http://dx.doi.org/10.1038/s41392-022-01273-8.
[2] Sun Xiaoying, Yu Xiaolin, Zhu Jie, Li Lingjie, Zhang Lun, Huang Yaru, Liu Dongqun, Ji Mei, Sun Xun, Zhang Lingxiao, Zhou Weiwei, Zhang Dongming, Jiao Jianwei, Liu Ruitian. Fc effector of anti-Aβ antibody induces synapse loss and cognitive deficits in Alzheimer's disease-like mouse model. SIGNAL TRANSDUCTION AND TARGETED THERAPY[J]. 2023, 8(2): 813-826, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=7412973&detailType=1.
[3] 李凌杰, 于晓琳, 刘瑞田. 胶质细胞介导的神经突触修剪在阿尔茨海默病中的作用. 药学学报[J]. 2021, 56(2): 383-390, http://lib.cqvip.com/Qikan/Article/Detail?id=7104429572.
[4] Sun, Xiaoying, Li, Lingjie, Dong, QuanXiu, Zhu, Jie, Huang, Yaru, Hou, Shengjie, Yu, Xiaolin, Liu, Ruitian. Rutin prevents tau pathology and neuroinflammation in a mouse model of Alzheimer's disease. JOURNALOFNEUROINFLAMMATION[J]. 2021, 18(1): 1-14, http://dx.doi.org/10.1186/s12974-021-02182-3.
[5] Lu, Shuai, Xie, Xixiu, Zhao, Lei, Wang, Bin, Zhu, Jie, Yang, Tingrui, Yang, Guangwen, Ji, Mei, Lv, Cuiping, Xue, Jian, Dai, Erhei, Fu, Ximing, Liu, Dongqun, Zhang, Lun, Hou, Shengjie, Yu, Xiaolin, Wang, Yuling, Gao, Huixia, Shi, Xuehan, Ke, Changwen, Ke, Bixia, Jiang, Chunguo, Liu, Ruitian. The immunodominant and neutralization linear epitopes for SARS-CoV-2. CELL REPORTS[J]. 2021, 34(4): 108666-108666, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7837128/.
[6] Zhang, Lun, Liu, Xiaoge, Liu, Dongqun, Yu, Xiaolin, Zhang, Lingxiao, Zhu, Jie, Lu, Shuai, Liu, Ruitian. A Conditionally Releasable "Do not Eat Me" CD47 Signal Facilitates Microglia-Targeted Drug Delivery for the Treatment of Alzheimer's Disease. ADVANCED FUNCTIONAL MATERIALS[J]. 2020, 30(24): https://www.webofscience.com/wos/woscc/full-record/WOS:000529145600001.
[7] Liu, Xiaoge, Zhang, Lun, Lu, Shuai, Liu, Dongqun, Huang, Yaru, Zhu, Jie, Zhou, Weiwei, Yu, Xiaolin, Liu, Ruitian. Superparamagnetic iron oxide nanoparticles conjugated with A beta oligomer-specific scFv antibody and class A scavenger receptor activator show therapeutic potentials for Alzheimer's Disease. JOURNAL OF NANOBIOTECHNOLOGY[J]. 2020, 18(1): https://www.webofscience.com/wos/woscc/full-record/WOS:000590702000001.
[8] 于晓琳. Vaccines targeting the primary amino acid sequence and conformational epitope of Aβ had distinct effects on neuropathology and cognitive deficits in EAE/AD mice. Br J Pharmacol. 2020, [9] Sun, Xun, Zhu, Jie, Sun, Xiaoying, Ji, Mei, Yu, Xiaolin, Liu, Ruitian. Ellagic acid rescues motor and cognitive deficits in the R6/2 mouse model of Huntington's disease by lowering mutant huntingtin protein. FOOD & FUNCTION[J]. 2020, 11(2): 1334-1348, https://www.webofscience.com/wos/woscc/full-record/WOS:000518566700012.
[10] Liu,Xiaoge, Zhang,Lun, Lu,Shuai, Liu,Dongqun, Huang,Yaru, Zhu,Jie, Zhou,Weiwei, Yu,Xiaolin, Liu,Ruitian. Superparamagnetic iron oxide nanoparticles conjugated with Aβ oligomer-specific scFv antibody and class A scavenger receptor activator show therapeutic potentials for Alzheimer’s Disease. JOURNAL OF NANOBIOTECHNOLOGY[J]. 2020, 18(1): 1-13, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7648289/.
[11] Liu XG, Zhang L, Lu S, Liu DQ, Zhang LX, Yu XL, Liu RT. Multifunctional Superparamagnetic Iron Oxide Nanoparticles Conjugated with Aβ Oligomer-Specific scFv Antibody and Class A Scavenger Receptor Activator Show Early Diagnostic Potentials for Alzheimer’s Disease. INTERNATIONAL JOURNAL OF NANOMEDICINE[J]. 2020, https://doaj.org/article/49836f48a7f140f5876909f0e95d06b1.
[12] Yu, XiaoLin, Zhu, Jie, Liu, Xiangmeng, Xu, Pengxin, Zhang, Yue, Liu, Ruitian. Vaccines targeting the primary amino acid sequence and conformational epitope of amyloid-beta had distinct effects on neuropathology and cognitive deficits in EAE/AD mice. BRITISH JOURNAL OF PHARMACOLOGY[J]. 2020, 177(12): 2860-2871, http://dx.doi.org/10.1111/bph.15015.
[13] Liu, XiaoGe, Zhang, Lun, Lu, Shuai, Liu, DongQun, Zhang, LingXiao, Yu, XiaoLin, Liu, RuiTian. Multifunctional Superparamagnetic Iron Oxide Nanoparticles Conjugated with A beta Oligomer-Specific scFv Antibody and Class A Scavenger Receptor Activator Show Early Diagnostic Potentials for Alzheimer's Disease. INTERNATIONAL JOURNAL OF NANOMEDICINE[J]. 2020, 15: 4919-4932, https://www.webofscience.com/wos/woscc/full-record/WOS:000548715400002.
[14] Liu, Xiaoge, Lu, Shuai, Liu, Dongqun, Zhang, Lun, Zhang, Lingxiao, Yu, Xiaolin, Liu, Ruitian. ScFv-conjugated superparamagnetic iron oxide nanoparticles for MRI-based diagnosis in transgenic mouse models of Parkinson's and Huntington's diseases. BRAIN RESEARCH[J]. 2019, 1707: 141-153, http://ir.ipe.ac.cn/handle/122111/28289.
[15] Huang, Yaru, Xie, Xixiu, Ji, Mei, Yu, Xiaolin, Zhu, Jie, Zhang, Lingxiao, Liu, Xiaoge, Wei, Chen, Li, Gang, Liu, Ruitian. Naturally occurring autoantibodies against alpha-synuclein rescues memory and motor deficits and attenuates alpha-synuclein pathology in mouse model of Parkinson's disease. NEUROBIOLOGY OF DISEASE[J]. 2019, 124: 202-217, http://ir.ipe.ac.cn/handle/122111/28086.
[16] Sun, XiaoYing, Dong, QuanXiu, Zhu, Jie, Sun, Xun, Zhang, LiFan, Qiu, Mandy, Yu, XiaoLin, Liu, RuiTian. Resveratrol Rescues Tau-Induced Cognitive Deficits and Neuropathology in a Mouse Model of Tauopathy. CURRENT ALZHEIMER RESEARCH[J]. 2019, 16(8): 710-722, http://dx.doi.org/10.2174/1567205016666190801153751.
[17] Ji, Mei, Xie, Xixiu, Liu, Dongqun, Yu, Xiaolin, Zhang, Yue, Zhang, Lingxiao, Wang, Shaowei, Huang, Yaru, Liu, Ruitian. Hepatitis B core VLP-based mis-disordered tau vaccine elicits strong immune response and alleviates cognitive deficits and neuropathology progression in Tau. P301S mouse model of Alzheimer's disease and frontotemporal dementia. ALZHEIMERS RESEARCH & THERAPY[J]. 2018, 10(1): http://ir.ipe.ac.cn/handle/122111/26690.
[18] 于晓琳. Intravenous immunoglobulin ameliorates motor and cognitive deficits and neuropathology in R6/2 mouse model of Huntington’s disease by decreasing mutant huntingtin protein level and normalizing NF-kB signaling pathway. Brain Research. 2018, [19] Shuying Liu, Xiaolin Yu, Jie Zhu, Xiangmeng Liu, Yue Zhang, Quanxiu Dong, Shan Ma, Ruitian Liu. Intravenous immunoglobulin ameliorates motor and cognitive deficits and neuropathology in R6/2 mouse model of Huntington’s disease by decreasing mutant huntingtin protein level and normalizing NF-κB signaling pathway. BRAIN RESEARCH. 2018, 1697: 21-33, http://dx.doi.org/10.1016/j.brainres.2018.06.009.
[20] Zhang, Yue, Yu, Xiaolin, Zhu, Jie, Liu, Shuying, Liu, Xiangmeng, Dong, Quanxiu, Chai, Jiaqian, Liu, Ruitian. Intravenous immunoglobulin improves glucose control and beta-cell function in human IAPP transgenic mice by attenuating islet inflammation and reducing IAPP oligomers. INTERNATIONAL IMMUNOPHARMACOLOGY[J]. 2018, 54: 145-152, http://dx.doi.org/10.1016/j.intimp.2017.11.012.
[21] Zhang, Lifan, Yu, Xiaolin, Ji, Mei, Liu, Shuying, Wu, Xiaoling, Wang, Yujiong, Liu, Ruitian. Resveratrol alleviates motor and cognitive deficits and neuropathology in the A53T-synuclein mouse model of Parkinson's disease. FOOD & FUNCTION[J]. 2018, 9(12): 6415-6427, http://ir.ipe.ac.cn/handle/122111/27592.
[22] Yue Zhang, Xiaolin Yu, Jun Zha, Lizhen Mao, Jiaqian Chai, Ruitian Liu. Therapeutic vaccine against IL-1β improved glucose control in a mouse model of type 2 diabetes. LIFE SCIENCES. 2018, 192: 68-74, http://dx.doi.org/10.1016/j.lfs.2017.11.021.
[23] Dong, Quanxiu, Zhu, Jie, Liu, Shuying, Yu, Xiaolin, Liu, Ruitian. An oligomer-specific antibody improved motor function and attenuated neuropathology in the SOD1-G93A transgenic mouse model of ALS. INTERNATIONAL IMMUNOPHARMACOLOGY[J]. 2018, 65: 413-421, http://dx.doi.org/10.1016/j.intimp.2018.10.032.
[24] 刘小歌, 张伦, 于晓琳. 小胶质细胞对阿尔兹海默病发生发展的影响作用. 过程工程学报[J]. 2018, 18(5): 900-907, http://lib.cqvip.com/Qikan/Article/Detail?id=676452467.
[25] Zhang, Yue, Yu, Xiaolin, Zha, Jun, Mao, Lizhen, Chai, Jiaqian, Liu, Ruitian. Therapeutic vaccine against IL-1 beta improved glucose control in a mouse model of type 2 diabetes. LIFE SCIENCES[J]. 2018, 192: 68-74, https://www.webofscience.com/wos/woscc/full-record/WOS:000418477800010.
[26] Liu, Shuying, Yu, Xiaolin, Zhu, Jie, Liu, Xiangmeng, Zhang, Yue, Dong, Quanxiu, Ma, Shan, Liu, Ruitian. Intravenous immunoglobulin ameliorates motor and cognitive deficits and neuropathology in R6/2 mouse model of Huntington's disease by decreasing mutant huntingtin protein level and normalizing NF-kappa B signaling pathway. BRAIN RESEARCH[J]. 2018, 1697: 21-33, http://ir.ipe.ac.cn/handle/122111/26697.
[27] Liu, ShuYing, Lu, Shuai, Yu, XiaoLin, Yang, ShiGao, Liu, Wen, Liu, XiangMeng, Wang, ShaoWei, Zhu, Jie, Ji, Mei, Liu, DongQun, Zhang, ZiPing, Liu, RuiTian. Fruitless Wolfberry-Sprout Extract Rescued Cognitive Deficits and Attenuated Neuropathology in Alzheimer's Disease Transgenic Mice. CURRENT ALZHEIMER RESEARCH[J]. 2018, 15(9): 856-868, http://ir.ipe.ac.cn/handle/122111/26816.
[28] Zhang, Lingxiao, Liu, Dongqun, Wang, Shaowei, Yu, Xiaolin, Ji, Mei, Xie, Xixiu, Liu, Shuying, Liu, Ruitian. MgAl-layered double hydroxide nanoparticles co-delivering siIDO and Trp2 peptide effectively reduce IDO expression and induce cytotoxic T-lymphocyte responses against melanoma tumor in mice. JOURNAL OF MATERIALS CHEMISTRY B[J]. 2017, 5(31): 6266-6276, http://www.irgrid.ac.cn/handle/1471x/1763716.
[29] Zha, Jun, Chi, Xiaowei, Yu, Xiaolin, Liu, Xiangmeng, Liu, Dongqun, Zhu, Jie, Ji, Hui, Liu, Ruitian. Interleukin-1 beta-Targeted Vaccine Improves Glucose Control and beta-Cell Function in a Diabetic KK-A(y) Mouse Model. PLOS ONE[J]. 2016, 11(5): http://ir.ipe.ac.cn/handle/122111/21056.
[30] Jun Zha, XiaoWei Chi, XiaoLin Yu, XiangMeng Liu, DongQun Liu, Jie Zhu, Hui Ji, RuiTian Liu. Interleukin-1β-Targeted Vaccine Improves Glucose Control and β-Cell Function in a Diabetic KK-Ay Mouse Model.. PLOS ONE[J]. 2016, 11(5): https://doaj.org/article/6988aa9205a84346aa546a0c2d6afc20.
[31] Wang, Teng, Xie, Xixiu, Ji, Mei, Wang, Shaowei, Zha, Jun, Zhou, Weiwei, Yu, Xiaolin, Wei, Chen, Ma, Shan, Xi, Zhiying, Pang, Guangli, Liu, Ruitian. Naturally occurring autoantibodies against A beta oligomers exhibited more beneficial effects in the treatment of mouse model of Alzheimer's disease than intravenous immunoglobulin. NEUROPHARMACOLOGY[J]. 2016, 105(JUNE): 561-576, http://dx.doi.org/10.1016/j.neuropharm.2016.02.015.
[32] Zha, Jun, Liu, Xiangmeng, Zhu, Jie, Liu, Shuying, Lu, Shuai, Xu, Pengxin, Yu, Xiaolin, Liu, Ruitian. A scFv antibody targeting common oligomeric epitope has potential for treating several amyloidoses. SCIENTIFIC REPORTS[J]. 2016, 6(NOV): http://ir.ipe.ac.cn/handle/122111/21654.
[33] Yu, XiaoLin, Li, YaNan, Zhang, He, Su, YaJing, Zhou, WeiWei, Zhang, ZiPing, Wang, ShaoWei, Xu, PengXin, Wang, YuJiong, Liu, RuiTian. Rutin inhibits amylin-induced neurocytotoxicity and oxidative stress. FOOD & FUNCTION[J]. 2015, 6(10): 3296-3306, http://www.irgrid.ac.cn/handle/1471x/1010242.
[34] Xu, Pengxin, Wang, Shaowei, Yu, Xiaolin, Su, Yajing, Wang, Teng, Zhou, Weiwei, Zhang, He, Wang, Yujiong, Liu, Ruitian. Rutin improves spatial memory in Alzheimer's disease transgenic mice by reducing A beta oligomer level and attenuating oxidative stress and neuroinflammation. BEHAVIOURAL BRAIN RESEARCH[J]. 2014, 264(1): 173-180, http://www.irgrid.ac.cn/handle/1471x/837097.
[35] Zhang, He, Su, Yajing, Zhou, Weiwei, Wang, Shaowei, Xu, Pengxin, Yu, Xiaolin, Liu, Ruitian. Activated Scavenger Receptor A Promotes Glial Internalization of A beta. PLOS ONE[J]. 2014, 9(4): http://www.irgrid.ac.cn/handle/1471x/857816.
[36] Zhao, Min, Wang, Shaowei, Wang, Yujiong, Zhang, Ran, Li, Yanan, Su, Yajing, Zhou, Weiwei, Yu, Xiaolin, Liu, Ruitian. Pan-Amyloid Oligomer Specific scFv Antibody Attenuates Memory Deficits and Brain Amyloid Burden in Mice with Alzheimer's Disease. CURRENT ALZHEIMER RESEARCH[J]. 2014, 11(1): 69-78, http://www.irgrid.ac.cn/handle/1471x/837058.
[37] Zhou, Weiwei, Lu, Shuai, Su, Yajing, Xue, Di, Yu, Xiaolin, Wang, Shaowei, Zhang, He, Xu, Pengxin, Xie, Xixiu, Liu, Ruitian. Decreasing oxidative stress and neuroinflammation with a multifunctional peptide rescues memory deficits in mice with Alzheimer disease. FREE RADICAL BIOLOGY AND MEDICINE[J]. 2014, 74(SEP.): 50-63, http://dx.doi.org/10.1016/j.freeradbiomed.2014.06.013.
[38] 周维维, 汪维云, 刘瑞田, 于晓琳. 抗淀粉样蛋白寡聚体单链抗体融合蛋白在真核细胞中表达的初步研究. 安徽农业大学学报[J]. 2013, 40(4): 685-689, http://www.irgrid.ac.cn/handle/1471x/857643.
[39] Yang, Shigao, Wang, Shaowei, Zhao, Min, Zhang, Ran, Zhou, Weiwei, Li, Yanan, Su, Yajing, Zhang, He, Yu, Xiaolin, Liu, Ruitian. A Peptide Binding to the beta-Site of APP Improves Spatial Memory and Attenuates A beta Burden in Alzheimer's Disease Transgenic Mice. PLOS ONE[J]. 2012, 7(11): http://www.irgrid.ac.cn/handle/1471x/725177.
[40] 于晓琳. A Peptide Binding to the b-Site of APP Improves Spatial Memory and Attenuates Ab Burden in Alzheimer’s Disease Transgenic Mice. Plos One. 2012, 
发表著作
( 1 ) 药物研究中的分子识别 (第2版), 北京大学医学出版社, 2015-08, 第 4 作者

科研活动

   
科研项目
( 1 ) 寡聚体特异性抗原表位疫苗, 主持, 国家级, 2014-01--2016-12
( 2 ) 纳微颗粒作为2型糖尿病疫苗佐剂的研究, 主持, 国家级, 2014-01--2016-12
( 3 ) 治疗2型糖尿病的新型多肽及其动物实验研究, 主持, 国家级, 2015-01--2017-12
( 4 ) 寡聚体特异性抗原表位疫苗, 主持, 省级, 2014-01--2017-06