色谱分离 蛋白质组学

   

070302-分析化学

2005-09--2011-07   中国科学院大连化学物理研究所   博士
2001-09--2005-07   武汉大学   学士

   

2018-10~现在, 中国科学院大连化学物理研究所, 副研究员
2017-10~2018-10,美国威斯康辛大学麦迪逊分校, 访问学者
2014-07~2017-10,中国科学院大连化学物理研究所, 副研究员
2011-07~2014-07,中国科学院大连化学物理研究所, 助理研究员

   

   

（1） Capillary electrophoresis.mass spectrometry and its application to proteomic analysis, CHINESE JOURNAL OF CHROMATOGRAPHY, 2020, 第 1 作者
（2） 毛细管电泳-质谱联用技术及其在蛋白质组学中的应用, Capillary electrophoresis-mass spectrometry and its application to proteomic analysis, 色谱, 2020, 第 1 作者
（3） Comprehensive Analysis of Protein N-Terminome by Guanidination of Terminal Amines, ANALYTICAL CHEMISTRY, 2020, 第 2 作者
（4） Well-Defined Materials for High-Performance Chromatographic Separation, ANNUAL REVIEW OF ANALYTICAL CHEMISTRY, VOL 12, 2019, 第 1 作者
（5） Bridged Hybrid Monolithic Column Coupled to High-Resolution Mass Spectrometry for Top-down Proteomics, ANALYTICAL CHEMISTRY, 2019, 第 1 作者
（6） Macro-mesoporous organosilica monoliths with bridged-ethylene and terminal-vinyl: High-density click functionalization for chromatographic separation, ANALYTICA CHIMICA ACTA, 2018, 第 2 作者
（7） N-糖基化蛋白质组样品富集策略的研究进展, Research Advances of Enrichment Approaches in N-glycoproteomics, 分析测试学报, 2018, 第 2 作者
（8） "Thiol-ene" grafting of silica particles with three-dimensional branched copolymer for HILIC/cation-exchange chromatographic separation and N-glycopeptide enrichment, ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2018, 第 3 作者
（9） Ethane-bridged hybrid monoliths with well-defined mesoporosity and great stability for high-performance peptide separation, ANALYTICA CHIMICA ACTA, 2018, 第 2 作者
（10） Aptamer-immobilized open tubular capillary column to capture circulating tumor cells for proteome analysis, TALANTA, 2017, 第 4 作者
（11） Aptamer functionalized hydrophilic polymer monolith with gold nanoparticles modification for the sensitive detection of human alpha-thrombin, TALANTA, 2016, 第 4 作者
（12） Hydrogen-bond interaction assisted branched copolymer HILIC material for separation and N-glycopeptides enrichment, TALANTA, 2016, 第 4 作者
（13） Clickable Periodic Mesoporous Organosilica Monolith for Highly Efficient Capillary Chromatographic Separation., ANALYTICAL CHEMISTRY, 2016, 第 2 作者
（14） Preparation of Hydrophilic Monolithic Capillary Column by in Situ Photo-polymerization of N-vinyl-2-pyrrolidinone and Acrylamide for Highly Selective and Sensitive Enrichment of N-linked Glycopeptides, TALANTA, 2016, 第 4 作者
（15） 整体材料的研制及其在蛋白质组色谱分离中的应用, Preparation of monolithic materials and applications in proteomic chromatographic separation, 轻工学报, 2016, 第 2 作者
（16） imFASP: An Integrated Approach Combining In-situ filter-aided Sample Pretreatment with Microwave-assisted Protein Digestion for Fast and Efficient Proteome Sample Preparation, ANALYTICA CHIMICA ACTA, 2016, 第 5 作者
（17） Aptamer-conjugated gold functionalized graphene oxide nanocomposites for human α-thrombin specific recognition, JOURNAL OF CHROMATOGRAPHY A, 2016, 第 6 作者
（18） Aptamer-conjugated Gold Functionalized Graphene Oxide Nanocomposites for Human Alpha-thrombin Specific Recognition, JOURNAL OF CHROMATOGRAPHY A, 2016, 第 6 作者
（19） Glycan Moieties as Bait to Fish Plasma Membrane Proteins., ANALYTICAL CHEMISTRY, 2016, 第 4 作者
（20） Surface Protein Imprinted Core−Shell Particles for High Selective, ACS APPLIED MATERIALS & INTERFACES, 2016, 第 3 作者
（21） Gold-Coated Nanoelectrospray Emitters Fabricated by Gravity-Assisted Etching Self-Termination and Electroless Deposition, ANALYTICAL CHEMISTRY, 2016, 第 2 作者
（22） Aptamer Functionalized Hydrophilic Polymer Monolith with Gold Nanoparticles Modification for Zhodification for the Sensitive Detection of Human Alpha-thrombin, TALANTA, 2016, 第 4 作者
（23） 有机溶剂辅助封闭式电喷雾离子源的设计及其在痕量蛋白质组样品分析中的应用, CHINESE JOURNAL OF ANALYTICAL CHEMISTRY分析化学, 2015, 第 4 作者
（24） Gold nanoparticles immobilized hydrophilic monoliths with variable functional modification for highly selective enrichment and on-line deglycosylation of glycopeptides, ANALYTICA CHIMICA ACTA, 2015, 第 1 作者
（25） Design of organic vapor assisted tight ion source and its application in trace analysis of proteomic samples, CHINESE JOURNAL OF ANALYTICAL CHEMISTRY, 2015, 第 4 作者
（26） 有机溶剂辅助封闭式电喷雾离子源的设计及其在痕量蛋白质组样品分析中的应用, Design of Organic Vapor Assisted Tight Ion Source and Its Application in Trace Analysis of Proteomic Samples, 分析化学, 2015, 第 4 作者
（27） New Materials for Selctive Enrichment of Glycoproteins/peptides for Proteome Analysis, the 41th international symposium on high performance liquid phase separations and related techniques, 2014, 第 5 作者
（28） Surface protein imprinted core-shell particles for high selective lysozyme recognition prepared by reversible addition-fragmentation chain transfer strategy., ACS APPLIED MATERIALS & INTERFACES, 2014, 第 3 作者
（29） Ethylene-bridged hybrid silica monoliths with versatility, good stability, high surface area for high performance liquid chromatography, 2014 iternational conference on microfluidic chip and micro/nanoscale bioseparation analysis, 2014, 第 2 作者
（30） Boronate affinity materials for selective enrichment of glycoproteins for Proteome Analysis, the 5th asia oceania mass spectrometry conference & the 33rd chinese mass spectrometry society annual conference, 2014, 第 3 作者
（31） 1-Dodecyl-3-methylimidazolium chloride-assisted sample preparation method for efficient integral membrane proteome analysis., ANALYTICAL CHEMISTRY, 2014, 第 3 作者
（32） Novel organic-silica hybrid monoliths based on bridged organo-silane precursors for HPLC separation of proteins and peptides, 2014 iternational conference on microfluidic chip and micro/nanoscale bioseparation analysis, 2014, 第 1 作者
（33） New GO-PEI-Au-L-Cys ZIC-HILIC composites: synthesis and selective enrichment of glycopeptides, NANOSCALE, 2014, 第 2 作者
（34） Differential expression of GATA-3 in urothelial carcinoma variants, HUMAN PATHOLOGY, 2014, 第 1 作者
（35） PHENYL-FUNCTIONALIZED ETHYL-BRIDGED HYBRID ORGANIC-INORGANIC MONOLITHIC CAPILLARY COLUMN FOR LIQUID CHROMATOGRAPHY, the 15th beijing conference and exhibition on instrumental analysis (bceia2013), 2013, 第 2 作者
（36） Recent advances in monolithic columns for protein and peptide separation by capillary liquid chromatography, ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2013, 第 1 作者
（37） HIGHY EFFICIENT AND SELECTIVE ENRICHMENT OF GLYCOPROTEINS AND GLYCOPEPTIDES BY FUNCTIONALIZED GOLD NANOPARTICLES MODIFIED HYDROPHILIC MONOLITHS, the 15th beijing conference and exhibition on instrumental analysis (bceia2013), 2013, 第 1 作者
（38） Biphasic microreactor for efficient membrane protein pretreatment with a combination of formic acid assisted solubilization, on-column pH adjustment, reduction, alkylation, and tryptic digestion., ANALYTICAL CHEMISTRY, 2013, 第 2 作者
（39） Gold nanoparticles modified hydrophilic polymer monoliths functionalized with boronate acid for specific capture of glycoproteins, 22nd international symposium on glycoconjugates, 2013, 第 2 作者
（40） Gold nanoparticles modified hydrophilic monoliths for high selective enrichment of glycoproteins and glycopeptides, 39th international symposium on high performance liquid phase separations and related techniques, 2013, 第 1 作者
（41） DECREASE OF DYNAMIC RANGE OF PROTEINS IN HUMAN PLASMA BY AMPHOLINE IMMOBILIZED POLYMER MICROSPHERES, The 15th beijing conference and exhibition on instrumental analysis (bceia2013), 2013, 第 5 作者
（42） Preparation of amide functionalized hydrophilic monolith by in situ photo-polymerization for highly selective enrichment of glycopeptides, 22nd international symposium on glycoconjugates, 2013, 第 3 作者
（43） Aptamer Modified Organic-Inorganic Hybrid Silica Monolithic Capillary Columns for Highly Selective Recognition of Thrombin, ANALYTICAL CHEMISTRY, 2012, 第 3 作者
（44） Prefractionation and separation by C8 stationary phase: Effective strategies for integral membrane proteins analysis, TALANTA, 2012, 第 3 作者
（45） Development of Hydrophilic Immobilized Enzymatic Reactors and Applications in High Throughput Proteome Digestion, ASIA OCEANIA HUMAN PROTEOME ORGANIZATION 6TH CONGRESS, 2012, 第 5 作者
（46） A hydrophilic immobilized trypsin reactor with N-vinyl-2-pyrrolidinone modified polymer microparticles as matrix for highly efficient protein digestion with low peptide residue, JOURNAL OF CHROMATOGRAPHY A, 2012, 第 3 作者
（47） 新型整体材料的制备及其在蛋白质组学中的应用, Preparation of monolithic materials and their applications in proteomic analysis, 色谱, 2011, 第 1 作者
（48） Monolithic Materials for Sample Preparation and Separation in Proteome Study, 37TH INTERNATIONAL SYMPOSIUM ON HIGH-PERFORMANCE LIQUID PHASE SEPARATIONS AND RELATED TECHNIQUES, 2011, 第 2 作者
（49） Hydrophilic monolith based immobilized enzyme reactors in capillary and on microchip for high-throughput proteomic analysis, JOURNAL OF CHROMATOGRAPHY A, 2011, 第 1 作者
（50） 基于整体材料的微流控芯片反相液相色谱-串联质谱平台用于蛋白质分析, Microchip-based reversed-phase liquid chromatography-tandem mass spectrometry platform for protein analysis, 色谱, 2011, 第 1 作者
（51） Integrated Microfluidic System Containing Two Dimensional Separation and MS Identification for Proteomics Analysis, PITTSBURGH CONFERENCE ON ANALYTICAL CHEMISTRY AND APPLIED SPECTROSCOPY, 2011, 第 1 作者
（52） Integrated microfluidic system for proteomic analysis consisting of on-line protein digestion, peptides separation and identification, INTEGRATED MICROFLUIDIC SYSTEM FOR PROTEOMIC ANALYSIS CONSISTING OF ON-LINE PROTEIN DIGESTION, PEPTIDES SEPARATION AND IDENTIFICATION, 2011, 第 1 作者
（53） Fast preparation of monolithic immobilized pH gradient column by photopolymerization and photografting techniques for isoelectric focusing separation of proteins, ELECTROPHORESIS, 2011, 第 1 作者
（54） Efficient proteolysis using a regenerable metal-ion chelate immobilized enzyme reactor supported on organic-inorganic hybrid silica monolith, PROTEOMICS, 2011, 第 3 作者
（55） Oxygen reduction reaction mechanism on nitrogen-doped graphene: A density functional theory study, JOURNAL OF CATALYSIS, 2011, 第 1 作者
（56） Hydrophilic Monolith Based Frits for Preparation of lin-exchange Packed Capillary Column, 37TH INTERNATIONAL SYMPOSIUM ON HIGH-PERFORMANCE LIQUID PHASE SEPARATIONS AND RELATED TECHNIQUES, 2011, 第 1 作者
（57） Monoliths with immobilized zirconium ions for selective enrichment of phosphopeptides, JOURNAL OF SEPARATION SCIENCE, 2011, 第 5 作者
（58） 新型整体材料的制备及其在蛋白质组学中的应用, Preparation of monolithic materials and their applications in proteomic analysis, 色谱, 2011, 第 1 作者
（59） Highly efficient proteome analysis with combination of protein pre-fractionation by preparative microscale solution isoelectric focusing and identification by mu RPLC-MS/MS with serially coupled long microcolumn, JOURNAL OF SEPARATION SCIENCE, 2011, 第 4 作者
（60） High sensitive protein detection by hollow fiber membrane interface based protein enrichment and in situ fluorescence derivatization, JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2011, 第 4 作者
（61） Integrated microfluidic system for proteomic analysis consisting of on-line protein digestion, peptides separation and identification, 35TH INTERNATIONAL SYMPOSIUM ON HIGH PERFORMANCE LIQUID PHASE SEPARATIONS AND RELATED TECHNIQUES, 2010, 第 1 作者
（62） Integrated Device for Online Sample Buffer Exchange, Protein Enrichment, and Digestion, ANALYTICAL CHEMISTRY, 2010, 第 4 作者
（63） Protein separation using free-flow electrophoresis microchip etched in a single step, JOURNAL OF SEPARATION SCIENCE, 2010, 第 5 作者
（64） Integrated microfluidic system for proteomic analysis consisting of on-line protein digestion, peptides separation and identification, 35TH INTERNATIONAL SYMPOSIUM ON HIGH PERFORMANCE LIQUID PHASE SEPARATIONS AND RELATED TECHNIQUES, 2010, 第 1 作者
（65） Improved protein separation by microchip isoelectric focusing with stepwise gradient of electric field strength, JOURNAL OF SEPARATION SCIENCE, 2009, 第 2 作者
（66） Novel capillary and microchip based enzymatic reactors with hydrophilic monolithic polymer as matrix, the 24th msb 2009, 2009, 第 1 作者
（67） Preparation of Monolithic Immobilized pH Gradient Materials in Capillaries and Microchannels by Photopolymerization and Photografting for Isoelectric Focusing of Proteins, 34th international symposium on high-performance liquid phase separations and related techniques, 2009, 第 1 作者
（68） Miniaturized two-dimensional capillary electrophoresis on a microchip for analysis of the tryptic digest of proteins, JOURNAL OF SEPARATION SCIENCE, 2008, 第 4 作者
（69） Miniaturized two dimensional capillary electrophoresis on microchip for protein analysis, 7th annual world congress hupo2008, 2008, 第 3 作者
（70） Microchip-based monolithic immobilized pH gradient isoelectric focusing for protein analysis, 7th annual world congress hupo2008, 2008, 第 1 作者
（71） Monoliths with immobilized pH gradient for chip-based IEF, dalian international symposia and exhibitoon on chromatography, 2007, 第 1 作者

   

（ 1 ） 基于有机桥联硅氧烷的杂化整体柱制备及其在蛋白质组定性定量分析中的应用, 主持, 国家级, 2016-01--2019-12
（ 2 ） 基于表面引发原子转移自由基聚合技术的超长超细内径毛细管开管柱的制备及其在蛋白质组分析中的应用, 主持, 国家级, 2013-01--2015-12
（ 3 ） 基于酶解策略的修饰蛋白质集成化分析系统研究, 主持, 国家级, 2013-01--2017-08
（ 4 ） 基于可控组装的胶体晶体毛细管柱的制备及其在蛋白质组学中的应用, 主持, 国家级, 2021-01--2024-12