Beijing 100101, China
Tel&Fax: +86-10-64806132
Research Areas
My research interests are in biotechnology, biodegradation & biotransformation, especially in the aspect of novel strain screening; functional gene identification and systems metabolic engineering of strains for bio-based products production:
- Understanding of microbially metabolizing persistent organic pollutants including heterocyclic aromatic compounds and hydrocarbon
- Screening of microbes and characterization of novel enzymes with potential in industrial use
- Reconstruction of novel metabolic pathway for bulk and high value-added fine chemicals production
Education
Ph.D., Microbiology June, 2006
Shandong University Jinan,
Bachelor of Sciences, Biotechnology June, 2001
Shandong University Jinan,
Experience
2016.10~ Professor/Group Leader, Institute of Microbiology, Chinese Academy of Sciences, China
2010.10~2016.9 Associate Professor/Group Leader, Institute of Microbiology, Chinese Academy of Sciences, China
2008.08~2010.07 German Alexander von Humboldt Fellowship for Post-doc Researcher
2008.08~2009.12 Helmholtz Centre for Infection Research
2010.01~2010.07 Hamburg University of Technology (TUHH), Germany
2008.01~2008.03 Senior Visiting Scholar, NIZO Food Research Institute, The Netherlands
2006.07~2008.07 Assistant Professor, Institute of Microbiology, Chinese Academy of Sciences,
Publications
Papers
1. Liu Y, Zhu LF, Qi WP, Yu B*. Biocatalytic production of D-p-hydroxyphenylglycine by optimizing protein expression and cell wall engineering in Escherichia coli. Appl. Microbiol. Biotechnol. 2019, 103(21), 8839-8851. PDF
2. Liu FX, Malaphan M, Xing FG, Yu B*. Biodetoxification of fungal mycotoxins zearalenone by engineered probiotic bacterium Lactobacillus reuteri with surface-displayed lactonohydrolase. Appl. Microbiol. Biotechnol. 2019, 103(21), 8813-8824. PDF
3. Zheng Y#, Meng FK#, Zhu ZH, Wei WJ, Sun Z, Chen JC, Yu B*, Lou CB*, Chen GQ*. A tight cold-inducible switch built by coupling thermosensitive transcriptional and proteolytic regulatory parts. Nucleic Acids Res., 2019, 47 (12), e137 (#Equal contributors) PDF
4. Wang Y, Zhang CL, Liu GX, Ju JS, Yu B*, Wang LM*. Elucidating the role and regulation of a lactate permease as lactate transporter in Bacillus coagulans DSM1. Appl. Environ. Microbiol. 2019, 85(14): e00672-19 PDF
5. Wang LM*, Yu B, Wang RX, Xie JC. Biotechnological routes for transglutaminase production: recent achievements, perspectives and limits. Trends Food Sci. Tech. 2018, 81: 116-120. PDF
6. Yang H, Liu FX, Li Y*, Yu B*. Reconstructing biosynthetic pathway of the plant-derived cancer chemopreventive-precursor glucoraphanin in Escherichia coli. ACS Synth. Biol. 2018, 7(1): 121-131. PDF
7. Zhang CL#, Zhou C#, Assavasirijinda N, Yu B, Wang LM*, Ma YH. Non-sterilized fermentation of high optically pure D-lactic acid by a genetically modified thermophilic Bacillus coagulans strain. Microb. Cell Fact. 2017, 16: 213. doi:10.1186/s12934-017-0827-1 (#Equal contributors) PDF
8. Sun LF#, Zhang CL#, Lyu PC, Wang YP, Wang LM*, Yu B*. Contributory roles of two L-lactate dehydrogenases for L-lactic acid production in thermotolerant Bacillus coagulans. Sci. Rep. 2016, 6: 37916, doi: 10.1038/srep37916 (#Equal contributors) PDF
9. Liu FX, Yang H, Wang LM, Yu B*. Biosynthesis of the high-value plant secondary product benzyl isothiocyanate via functional expression of multiple heterologous enzymes in E. coli. ACS Synth. Biol. 2016, 5(12): 1557-1565. PDF
10. Wang M#, Zhu LF#, Xu XL, Wang LM, Yin RC*, Yu B*. Efficient production of enantiomerically pure D-phenyllactate from phenylpyruvate by structure-guided design of an engineered D-lactate dehydrogenase. Appl. Microbiol. Biotechnol. 2016, 100(17): 7471-7478 (#Equal contributors) PDF
11. Sun LF, Li YF, Wang LM, Wang YP, Yu B*. Diammonium phosphate stimulates transcription of L-lactate dehydrogenase leading to increased L-lactate production in the thermotolerant Bacillus coagulans strain. Appl. Microbiol. Biotechnol. 2016, 100(15): 6653-6660 PDF
12. Hou JF, Liu FX, Wu N, Ju JS, Yu B*. Efficient biodegradation of chlorophenols in aqueous phase by magnetically immobilized aniline-degrading Rhodococcus rhodochrous strain. J. Nanobiotechnol. 2016, 14: 5. doi: 10.1186/s12951-016-0158-0 PDF
13. Assavasirijinda N, Ge DY, Yu B, Xue YF, Ma YH. Efficient fermentative production of polymer-grade D-lactate by an engineered alkaliphilic Bacillus sp. strain under non-sterile conditions. Microb. Cell Fact. 2016, 15: 3. doi: 10.1186/s12934-015-0408-0 PDF
14. You J, Wu G, Ren FP, Chang Q, Yu B*, Xue YF, Mu BZ*. Microbial community dynamics in Baolige oilfield during MEOR treatment, revealed by Illumina MiSeq sequencing. Appl. Microbiol. Biotechnol. 2016, 100(3): 1469-1478. PDF
15. Zhu LF#, Guan XC#, Xie NZ, Wang LM, Yu B*, Ma YH. Fermentative production of enantiomerically pure S-1,2-propanediol from glucose by engineered E. coli strain. Appl. Microbiol. Biotechnol. 2016, 100(3): 1241-1251. (#Equal contributors) PDF
16. Zhu LF, Xu XL, Wang LM, Dong H*, Yu B*. The D-lactate dehydrogenase from Sporolactobacillus inulinus also possessing reversible deamination activity. PLoS ONE 2015, 10(9): e0139066. doi: 10.1371/journal.pone.0139066 PDF
17. Wang HY#, Wang LM#, Yang H, Cai YM, Sun LF, Xue YF, Yu B*, Ma YH. Comparative proteomic insights into the lactate responses of halophilic Salinicoccus roseus W12. Sci. Rep. 2015, 5: 13776, doi: 10.1038/srep13776. (#Equal contributors) PDF
18. Yu B*, Tao F, Li FL, Hou JF, Tang HZ, Ma CQ, Xu P*. Complete genome sequence of Mycobacterium goodii X7B, a facultative thermophilic biodesulfurizing bacterium with industrial potential. J. Biotechnol. 2015, 212: 56-57. PDF
19. Zhu LF, Xu XL, Wang LM, Dong H*, Yu B*, Ma YH. NADP+-preferring D-lactate dehydrogenase from Sporolactobacillus inulinus. Appl. Environ. Microbiol. 2015, 81(18): 6294-6301. PDF
20. Peng LL, Song LF, Sun LF, Cai YM, Wang LM, Yu B*. Genome sequence of Bacillus coagulans P38, an efficient polymer-grade L-lactate producer from cellulosic substrates. Genome Announc. 2015, 3(3): e00495-15. PDF
21. Liu FX, Yu B*. Efficient production of reuterin from glycerol by magnetically immobilized Lactobacillus reuterin. Appl. Microbiol. Biotechnol. 2015, 99(11): 4659-4666. PDF
22. Liu XP, Yu HY, Jiang X, Ai GM, Yu B, Zhu K*. Biosynthesis of butenoic acid through fatty acid biosynthesis pathway in Escherichia coli. Appl. Microbiol. Biotechnol. 2015, 99(4): 1795-1804. PDF
23. Wang LM#, Cai YM#, Zhu LF, Guo HL, Yu B*. Major role of NAD-dependent lactate dehydrogenases in high optically pure L-lactic acid production by thermophilic Bacillus coagulans. Appl. Environ. Microbiol. 2014, 80(23): 7134-7141. (#Equal contributors) PDF
24. Peng LL#, Xie NZ#, Guo L, Wang LM, Yu B*, Ma YH. Efficient open fermentative production of polymer-grade L-lactate from sugarcane bagasse hydrolysate by thermotolerant Bacillus sp. strain P38. PLoS ONE 2014, 9(9): e107143 (#Equal contributors) PDF
25. Wang H, Wang LM, Ju JS, Yu B*, Ma YH. Genome sequence of Sporolactobacillus laevolacticus DSM442, an efficient polymer-grade D-lactate-producer from agricultural waste cottonseed as a nitrogen source. Genome Announc. 2013, 1(6): e01100-13. PDF
26. Jiang X, Wang LM, Zhang GM, Yu B*, Zeng QT*. Recent developments in L-lactate fermentation by genetically modified microorganisms. Chin. J. Biotech. 2013, 29(10): 1-13.
27. Peng LL, Wang LM, Che CC, Yang G, Yu B*, Ma YH. Bacillus sp. strain P38: an efficient producer of L-lactate from cellulosic hydrolysate, with high tolerance for 2-furfural. Bioresour. Technol. 2013, 149: 169-176. PDF
28. Jiang X, Xue YF, Wang LM, Yu B*, Ma YH. Genome sequence of a novel polymer-grade L-lactate-producing alkaliphile, Exiguobacterium sp. strain 8-11-1. Genome Announc. 2013; 1(4): e00616-13. PDF
29. Li K, Jiang TY, Yu B, Wang LM, Gao C, Ma CQ, Xu P*, Ma YH. Escherichia coli transcription termination factor NusA: heat-induced oligomerization and chaperone activity. Sci. Rep. 2013, 3: 2347. PDF
30. Yu D, Jiang YJ, Hou JF, Chen S, Zhang GF, Liu X, Dong H*, Yu B*. Crystallization and preliminary X-ray study of the deaminase AmnE from Pseudomonas sp. AP-3. Acta Cryst. 2013, F69: 812-814. PDF
31. Jiang X, Xue YF, Wang AY, Wang LM, Zhang GM, Zeng QT, Yu B*, Ma YH. Efficient production of polymer-grade L-lactate by an alkaliphilic Exiguobacterium sp. strain under nonsterile open fermentation conditions. Bioresour. Technol. 2013, 143: 665-668. PDF
32. Li Y, Wang LM, Ju JS, Yu B*, Ma YH. Efficient production of polymer-grade D-lactate by Sporolactobacillus laevolacticus DSM442 with agricultural waste cottonseed as the sole nitrogen source. Bioresour. Technol. 2013, 142: 186-191. PDF
33. Wang LM, Xue ZW, Zhao B, Yu B*, Xu P, Ma YH. Jerusalem artichoke powder: A useful material in producing high-optical-purity L-lactate using an efficient sugar-utilizing thermophilic Bacillus coagulans strain. Bioresour. Technol. 2013, 130: 174-180. PDF
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