General

Bo Yu, Ph.D
Professor, CAS Key Laboratory of Microbial Physiological and Metabolic Engineering &
Deputy director, CAS-TWAS Centre of Excellence for Biotechnology
Institute of Microbiology, Chinese Academy of Sciences
NO.1 Beichen West Road, Chaoyang District
Beijing 100101, China
Tel&Fax: +86-10-64806132
E-mail: yub@im.ac.cn 

Research Areas

My research interests are in biotechnology, biodegradation & biotransformation, especially in the aspect of novel strain screening; functional gene identification and systems metabolic engineering of strains for bio-based products production:

-            Understanding of microbially metabolizing persistent organic pollutants including heterocyclic aromatic compounds and hydrocarbon

-            Screening of microbes and characterization of novel enzymes with potential in industrial use

-            Reconstruction of novel metabolic pathway for bulk and high value-added fine chemicals production


Education

Ph.D., Microbiology                            June, 2006

Shandong University                            Jinan,China


Bachelor of Sciences, Biotechnology               June, 2001

Shandong University                            Jinan,China


Experience

2016.10~   Professor/Group Leader,  Institute of Microbiology, Chinese Academy of Sciences, China

2010.10~2016.9  Associate Professor/Group Leader,  Institute of Microbiology, Chinese Academy of Sciences, China

2008.08~2010.07 German Alexander von Humboldt Fellowship for Post-doc Researcher

        2008.08~2009.12   Helmholtz Centre for Infection Research

        2010.01~2010.07   Hamburg University of Technology (TUHH), Germany

2008.01~2008.03   Senior Visiting Scholar, NIZO Food Research Institute, The Netherlands

2006.07~2008.07   Assistant Professor, Institute of Microbiology, Chinese Academy of Sciences,China


Publications

   
Papers

1.        Liu Y, Zhu LF, Qi WP, Yu B*. Biocatalytic production of D-p-hydroxyphenylglycine by optimizing protein expression and cell wall engineering in Escherichia coli. Appl. Microbiol. Biotechnol. 2019, 103(21), 8839-8851. PDF

2.        Liu FX, Malaphan M, Xing FG, Yu B*. Biodetoxification of fungal mycotoxins zearalenone by engineered probiotic bacterium Lactobacillus reuteri with surface-displayed lactonohydrolase. Appl. Microbiol. Biotechnol. 2019, 103(21), 8813-8824. PDF

3.        Zheng Y#, Meng FK#, Zhu ZH, Wei WJ, Sun Z, Chen JC, Yu B*, Lou CB*, Chen GQ*. A tight cold-inducible switch built by coupling thermosensitive transcriptional and proteolytic regulatory parts. Nucleic Acids Res., 2019, 47 (12), e137 (#Equal contributors) PDF

4.        Wang Y, Zhang CL, Liu GX, Ju JS, Yu B*, Wang LM*. Elucidating the role and regulation of a lactate permease as lactate transporter in Bacillus coagulans DSM1. Appl. Environ. Microbiol. 2019, 85(14): e00672-19 PDF

5.        Wang LM*, Yu B, Wang RX, Xie JC. Biotechnological routes for transglutaminase production: recent achievements, perspectives and limits. Trends Food Sci. Tech. 2018, 81: 116-120. PDF

6.        Yang H, Liu FX, Li Y*, Yu B*. Reconstructing biosynthetic pathway of the plant-derived cancer chemopreventive-precursor glucoraphanin in Escherichia coli. ACS Synth. Biol. 2018, 7(1): 121-131. PDF

7.        Zhang CL#, Zhou C#, Assavasirijinda N, Yu B, Wang LM*, Ma YH. Non-sterilized fermentation of high optically pure D-lactic acid by a genetically modified thermophilic Bacillus coagulans strain. Microb. Cell Fact. 2017, 16: 213. doi:10.1186/s12934-017-0827-1 (#Equal contributors) PDF

8.        Sun LF#, Zhang CL#, Lyu PC, Wang YP, Wang LM*, Yu B*. Contributory roles of two L-lactate dehydrogenases for L-lactic acid production in thermotolerant Bacillus coagulans. Sci. Rep. 2016, 6: 37916, doi: 10.1038/srep37916 (#Equal contributors) PDF

9.        Liu FX, Yang H, Wang LM, Yu B*. Biosynthesis of the high-value plant secondary product benzyl isothiocyanate via functional expression of multiple heterologous enzymes in E. coli. ACS Synth. Biol. 2016, 5(12): 1557-1565. PDF

10.    Wang M#, Zhu LF#, Xu XL, Wang LM, Yin RC*, Yu B*. Efficient production of enantiomerically pure D-phenyllactate from phenylpyruvate by structure-guided design of an engineered D-lactate dehydrogenase. Appl. Microbiol. Biotechnol. 2016, 100(17): 7471-7478 (#Equal contributors) PDF

11.    Sun LF, Li YF, Wang LM, Wang YP, Yu B*. Diammonium phosphate stimulates transcription of L-lactate dehydrogenase leading to increased L-lactate production in the thermotolerant Bacillus coagulans strain. Appl. Microbiol. Biotechnol. 2016, 100(15): 6653-6660 PDF

12.    Hou JF, Liu FX, Wu N, Ju JS, Yu B*. Efficient biodegradation of chlorophenols in aqueous phase by magnetically immobilized aniline-degrading Rhodococcus rhodochrous strain. J. Nanobiotechnol. 2016, 14: 5. doi: 10.1186/s12951-016-0158-0 PDF

13.    Assavasirijinda N, Ge DY, Yu B, Xue YF, Ma YH. Efficient fermentative production of polymer-grade D-lactate by an engineered alkaliphilic Bacillus sp. strain under non-sterile conditions. Microb. Cell Fact. 2016, 15: 3. doi: 10.1186/s12934-015-0408-0 PDF

14.    You J, Wu G, Ren FP, Chang Q, Yu B*, Xue YF, Mu BZ*. Microbial community dynamics in Baolige oilfield during MEOR treatment, revealed by Illumina MiSeq sequencing. Appl. Microbiol. Biotechnol. 2016, 100(3): 1469-1478. PDF

15.    Zhu LF#, Guan XC#, Xie NZ, Wang LM, Yu B*, Ma YH. Fermentative production of enantiomerically pure S-1,2-propanediol from glucose by engineered E. coli strain. Appl. Microbiol. Biotechnol. 2016, 100(3): 1241-1251. (#Equal contributors) PDF

16.    Zhu LF, Xu XL, Wang LM, Dong H*, Yu B*. The D-lactate dehydrogenase from Sporolactobacillus inulinus also possessing reversible deamination activity. PLoS ONE 2015, 10(9): e0139066. doi: 10.1371/journal.pone.0139066 PDF

17.    Wang HY#, Wang LM#, Yang H, Cai YM, Sun LF, Xue YF, Yu B*, Ma YH. Comparative proteomic insights into the lactate responses of halophilic Salinicoccus roseus W12. Sci. Rep. 2015, 5: 13776, doi: 10.1038/srep13776. (#Equal contributors) PDF

18.    Yu B*, Tao F, Li FL, Hou JF, Tang HZ, Ma CQ, Xu P*. Complete genome sequence of Mycobacterium goodii X7B, a facultative thermophilic biodesulfurizing bacterium with industrial potential. J. Biotechnol. 2015, 212: 56-57. PDF

19.    Zhu LF, Xu XL, Wang LM, Dong H*, Yu B*, Ma YH. NADP+-preferring D-lactate dehydrogenase from Sporolactobacillus inulinus. Appl. Environ. Microbiol. 2015, 81(18): 6294-6301. PDF

20.    Peng LL, Song LF, Sun LF, Cai YM, Wang LM, Yu B*. Genome sequence of Bacillus coagulans P38, an efficient polymer-grade L-lactate producer from cellulosic substrates. Genome Announc. 2015, 3(3): e00495-15. PDF

21.    Liu FX, Yu B*. Efficient production of reuterin from glycerol by magnetically immobilized Lactobacillus reuterin. Appl. Microbiol. Biotechnol. 2015, 99(11): 4659-4666. PDF

22.    Liu XP, Yu HY, Jiang X, Ai GM, Yu B, Zhu K*. Biosynthesis of butenoic acid through fatty acid biosynthesis pathway in Escherichia coli. Appl. Microbiol. Biotechnol. 2015, 99(4): 1795-1804. PDF

23.    Wang LM#, Cai YM#, Zhu LF, Guo HL, Yu B*. Major role of NAD-dependent lactate dehydrogenases in high optically pure L-lactic acid production by thermophilic Bacillus coagulans. Appl. Environ. Microbiol. 2014, 80(23): 7134-7141. (#Equal contributors) PDF

24.    Peng LL#, Xie NZ#, Guo L, Wang LM, Yu B*, Ma YH. Efficient open fermentative production of polymer-grade L-lactate from sugarcane bagasse hydrolysate by thermotolerant Bacillus sp. strain P38. PLoS ONE 2014, 9(9): e107143 (#Equal contributors) PDF

25.    Wang H, Wang LM, Ju JS, Yu B*, Ma YH. Genome sequence of Sporolactobacillus laevolacticus DSM442, an efficient polymer-grade D-lactate-producer from agricultural waste cottonseed as a nitrogen source. Genome Announc. 2013, 1(6): e01100-13. PDF

26.    Jiang X, Wang LM, Zhang GM, Yu B*, Zeng QT*. Recent developments in L-lactate fermentation by genetically modified microorganisms. Chin. J. Biotech. 2013, 29(10): 1-13.

27.    Peng LL, Wang LM, Che CC, Yang G, Yu B*, Ma YH. Bacillus sp. strain P38: an efficient producer of L-lactate from cellulosic hydrolysate, with high tolerance for 2-furfural. Bioresour. Technol. 2013, 149: 169-176. PDF

28.    Jiang X, Xue YF, Wang LM, Yu B*, Ma YH. Genome sequence of a novel polymer-grade L-lactate-producing alkaliphile, Exiguobacterium sp. strain 8-11-1. Genome Announc. 2013; 1(4): e00616-13. PDF

29.    Li K, Jiang TY, Yu B, Wang LM, Gao C, Ma CQ, Xu P*, Ma YH. Escherichia coli transcription termination factor NusA: heat-induced oligomerization and chaperone activity. Sci. Rep. 2013, 3: 2347. PDF

30.    Yu D, Jiang YJ, Hou JF, Chen S, Zhang GF, Liu X, Dong H*, Yu B*. Crystallization and preliminary X-ray study of the deaminase AmnE from Pseudomonas sp. AP-3. Acta Cryst. 2013, F69: 812-814. PDF

31.    Jiang X, Xue YF, Wang AY, Wang LM, Zhang GM, Zeng QT, Yu B*, Ma YH. Efficient production of polymer-grade L-lactate by an alkaliphilic Exiguobacterium sp. strain under nonsterile open fermentation conditions. Bioresour. Technol. 2013, 143: 665-668. PDF

32.    Li Y, Wang LM, Ju JS, Yu B*, Ma YH. Efficient production of polymer-grade D-lactate by Sporolactobacillus laevolacticus DSM442 with agricultural waste cottonseed as the sole nitrogen source. Bioresour. Technol. 2013, 142: 186-191. PDF

33.    Wang LM, Xue ZW, Zhao B, Yu B*, Xu P, Ma YH. Jerusalem artichoke powder: A useful material in producing high-optical-purity L-lactate using an efficient sugar-utilizing thermophilic Bacillus coagulans strain. Bioresour. Technol. 2013, 130: 174-180. PDF


Students

已指导学生

管祥辰  硕士研究生  085238-生物工程  

朱凌峰  硕士研究生  085238-生物工程  

刘菲霞  硕士研究生  085238-生物工程  

张彩丽  硕士研究生  071010-生物化学与分子生物学  

李衍峰  硕士研究生  085238-生物工程  

刘洋  硕士研究生  085238-生物工程  

杨寒  博士研究生  071005-微生物学  

现指导学生

薛宇斌  硕士研究生  071005-微生物学  

孙智  博士研究生  071010-生物化学与分子生物学  

石雅南  硕士研究生  071005-微生物学  

牟庆璇  博士研究生  071005-微生物学  

刘洋  博士研究生  071010-生物化学与分子生物学  

孟凡康  硕士研究生  071007-遗传学