基本信息
于海军  男  硕导  中国科学院上海药物研究所
电子邮件: hjyu@simm.ac.cn
通信地址: 上海市浦东新区海科路501号
邮政编码:

研究领域

1. 智能药物递送系统
2. 纳米药物载体的体内过程和生物安全性
3. 耐药和转移性肿瘤的诊疗一体化

招生信息

招生专业:药剂学
招生方向:纳米药物制剂,分子药剂学。
招生专业
100702-药剂学
100703-生药学
招生方向
药剂学
纳米递药系统

教育背景

2001-09--2006-12   中科院长春应用化学研究所   博士生,研究生学历/博士学位
1997-09--2001-07   内蒙古大学   本科学习,学士学位
学历

1.2001.09-2006.12 硕博连读研究生,中国科学院长春应用化学研究所高分子物理与化学国家重点实验室
专业: 高分子化学; 导师:景遐斌研究员,陈学思研究员
2. 1997.09-2001.07:本科,内蒙古大学化学化工学院
专业: 化学; 指导教师:边占喜教授

学位
理学博士

工作经历

2016.10~ 现在,中科院上海药物研究所,研究员

2012.05~2016.09,中科院上海药物研究所,副研究员
2011.02~2012.04,日本东北大学原子分子材料研究所,博士后
2009.02~2011.01,美国得州大学西南医学中心,博士后
2007.02-2009.01,德国慕尼黑大学药学系,博士后

工作简历
2016-10~现在, 中科院上海药物所, 研究员
2012-05~2016-09,中科院上海药物所, 副研究员
2011-01~2012-05,日本东北大学, 博士后
2009-02~2011-01,美国西南医学中心, 博士后
2007-02~2009-02,德国慕尼黑大学, 博士后
社会兼职
2017-01-01-今,药学学报编委会, 青年编委
2016-10-01-今,中国毒理学会纳米毒理学专业委员会, 青年委员

专利与奖励


奖励与荣誉:获得2016年度国家基金委优青项目资助,2014年度中国药学会-中恒青年药剂学奖,入选2013年度中科院青年人才促进会,2013年度赛诺菲-上海生科院优秀青年人才奖,2013年度上海市药学科技一等奖等奖励。
专利成果:共申请中国发明专利6项,授权3项。

奖励信息
(1) 中国药学会青年药剂学奖, 一等奖, 部委级, 2014
(2) 上海生科院赛诺菲-安万特青年人才奖, 一等奖, 其他, 2013
(3) 中科院青促会, 一等奖, 部委级, 2013
专利成果
( 1 ) 光控温敏脂质体,其制备及用途, 发明, 2016, 第 1 作者, 专利号: 201610128545.X

出版信息

共发表SCI论文80余篇,第一/通讯作者论文包括Nano Letters, ACS NanoAdv Funct MaterBiomaterialsSmallTheranostics等国际权威期刊。论文他引共2000余次。申报中国发明专利10项,授权3项。


  1. Dangge Wang, Tingting Wang, Jianping Liu, Haijun Yu,* Shi Jiao, Bing Feng, Fangyuan Zhou, Yuanlei Fu, Qi Yin, Pengcheng Zhang, Zhiwen Zhang, Zhaocai Zhou, Yaping Li,* Acid-Activatable Versatile Micelleplexes for PD-L1 Blockade-Enhanced Cancer Photodynamic Immunotherapy. Nano Letters, 2016, 16, 5503−5513.

  2. Bing Feng, Fangyuan Zhou, Zhiai Xu, Tingting Wang, Dangge Wang, Jianping Liu, Qi Yin, Zhiwen Zhang, Haijun Yu*, Yaping Li*. Versatile Prodrug Nanoparticles for Acid-Triggered Precise Imaging and Organelle-Specific Combination Cancer Therapy. Adv. Funct. Mater. 2016, 26, 7431–7442.

  3. Jianping Liu, Tingting Wang, Dangge Wang, Anjie Dong*, Yaping Li, Haijun Yu*, Smart Nanoparticles for Therapy of the Drug-Resistant Tumors by Overcoming the Pathophysiological Barriers. Acta Pharmacologica Sinica (Review Article). 2017, 38, 1-8.

  4. Tingting Wang, Dangge Wang, Haijun Yu*, Mingwei Wang, Jianping Liu, Bing Feng, Fangyuan Zhou, Qi Yin, Zhiwen Zhang, Yaping Li* Intracellularly Acid-Switchable Multifunctional Micelles for Combinational Photo/ Chemotherapy of the Drug Resistant Tumor. ACS Nano. 2016, 10, 3496−3508.

  5. Fangyuan Zhou, Bing Feng, Haijun Yu*, Dangge Wang, Tingting Wang, Jianping Liu, Qingshuo Meng, Siling Wang,*, Pengcheng Zhang, Zhiwen Zhang, Yaping Li*, Cisplatin Prodrug-Conjugated Gold Nanocluster: A Theranostic Platform for Treatment of Metastatic Breast Cancer. Theranostics. 2016, 6, 679-687.

  6. Lijuan Zeng, Lili Zou, Haijun Yu#, Xinyu He, Haiqiang Cao, Zhiwen Zhang,* Qi Yin, Pengcheng Zhang, Wangwen Gu, Lingli Chen, and Yaping Li. Treatment of Malignant Brain Tumor by Tumor-Triggered Programmed Wormlike Micelles with Precise Targeting and Deep Penetration. Adv. Funct. Mater. 2016, 26, 4201– 4212.

  7. Dangge Wang, Tingting Wang, Zhiai Xu, Haijun Yu*, Bing Feng, Junying Zhang, Chengyue Guo, Qi Yin, Zhiwen Zhang, Yaping Li* Cooperative Treatment of Metastatic Breast Cancer Using Host-Guest Nanoplatform Loading Docetaxel and siRNA. Small. 2016, 12, 488-498.

  8. Haijun Yu*, Chengyue Guo, Xianzhi Chen, Bing Feng, Jianping Liu, Tingting Wang, Dangge Wang, Zhirui Cui, Qi Yin, Zhiwen Zhang, Yaping Li* Triple-Layered pH-Responsive Micelleplexes Loaded with siRNA and Cisplatin Prodrug for NF-Kappa B Targeted Treatment of Metastatic Breast Cancer. Theranostic, 2016, 6, 14-27.

  9. Bing Feng, Zhiai Xu, Fangyuan Zhou, Haijun Yu*, Qianqian Sun, Dangge Wang, Zhaohui Tang, Haiyang Yu, Qi Yin, Zhiwen Zhang, Yaping Li,* Polypeptide-Wrapped Gold Nanorods as a Dual-modal Nanoplatform for Combinational Photothermal and Chemo-therapy of Metastatic Breast Cancer. Nanoscale, 2015, 7, 14854–14864.

  10. Haijun Yu*, Zhirui Cui, Pengcheng Yu, Chengyue Guo, Bing Feng, Tongying Jiang, Siling Wang, Qi Yin, Dafang Zhong, Xiangliang Yang, Zhiwen Zhang, Yaping Li*. pH and near-infrared light-responsive micelles with hyperthermia-triggered tumor penetration and cytoplasm drug release reverse doxorubicin resistance in breast cancer. Adv Funct Mater (Front Cover) 2015, 25, 2489-2500.

  11. Chongsheng Guo, Haijun Yu,*, Bing Feng, Weidong Gao, Mei Yan, Zhiwen Zhang, Yaping Li*, Shaoqing Liu*. Highly efficient ablation of metastatic breast cancer using ammonium-tungsten-bronze nanocube as a novel 1064 nm-laser-driven photothermal agent. Biomaterials 2015, 52, 407-416.

  12. Pengcheng Yu, Haijun Yu*, Chengyue Guo, Zhirui Cui, Xianzhi Chen, Qi Yin, Zhiwen Zhang, Xiangliang Yang, Yaping Li*. Reversal of Doxorubicin Resistance in Breast Cancer by Mitochondria-Targeted pH-Responsive Micelles. Acta Biomater 2015, 14,115-124.

  13. Dangge Wang, Zhiai Xu, Haijun Yu*, Xianzhi Chen, Bing Feng, Zhirui Cui, Bin LinQi Yin, Zhiwen Zhang, Chunying Chen, Jun Wang, Wen Zhang, Yaping Li. Treatment of metastatic breast cancer by combination of chemotherapy and photothermal ablation using doxorubicin-loaded DNA wrapped gold nanorods. Biomaterials. 2014, 35, 8374–8384.

  14. Haijun Yu, Yonglong Zou, Lei Jiang, Qi Yin, Xinyu He, Lingli Chen, Zhiwen Zhang, Wangwen Gu, Yaping Li.* Induction of Apoptosis in Non-Small Cell Lung Cancer by Downregulation of MDM2 Using pH-Responsive PMPC-b-PDPA/siRNA Complex Nanoparticles. Biomaterials, 2013, 34, 2738-2747.




发表论文
(1) Programmed Multi-Responsive Vesicles for Enhanced Tumor Penetration and Combination Therapy of Triple-Negative Breast Cancer., Adv. Funct. Mater., 2017, 通讯作者
(2) Acid-Activatable Versatile Micelleplexes for PD-L1 Blockade-Enhanced Cancer Photodynamic Immunotherapy., Nano Letters, 2016, 通讯作者
(3) Versatile Prodrug Nanoparticles for Acid-Triggered Precise Imaging and Organelle-Specific Combination Cancer Therapy., Adv. Funct. Mater., 2016, 通讯作者
(4) Intracellularly Acid-Switchable Multifunctional Micelles for Combinational Photo/ Chemotherapy of the Drug Resistant Tumor., ACS Nano., 2016, 通讯作者
(5) Cooperative Treatment of Metastatic Breast Cancer Using Host-Guest Nanoplatform Loading Docetaxel and siRNA, Small, 2016, 通讯作者
(6) pH and near-infrared light-responsive micelles with hyperthermia-triggered tumor penetration and cytoplasm drug release reverse doxorubicin resistance in breast cancer. , Adv Funct Mater , 2015, 第 1 作者
(7) Reversal of Doxorubicin Resistance in Breast Cancer by Mitochondria-Targeted pH-Responsive Micelles. , Acta Biomater , 2015, 第 2 作者
(8) Treatment of metastatic breast cancer by combination of chemotherapy and photothermal ablation using doxorubicin-loaded DNA wrapped gold nanorods., Biomaterials, 2014, 第 3 作者
(9) Intracellular pH-Activatable PEG-b-PDPA Wormlike Micelles for Hydrophobic Drug Delivery. , Polymer Chemistry, 2013, 第 1 作者
(10) Ductile Biodegradable Mg-based Metallic Glasses with Excellent Biocompatibility. , Adv. Funct. Mater, 2013, 第 1 作者
(11) Reversing Lung Cancer Multidrug Resistance Via Dual pH-Responsive Micelleplexes Mediated siRNA and Paclitaxel Co-Delivery, Macromolecular Bioscience, 2013, 第 1 作者

科研活动

以课题负责人身份承担了科技部973计划和国家自然科学基金重点项目和面上项目等多项基金项目。

科研项目
( 1 ) 双重酸敏感多层阳离子胶束/RNA复合纳米粒的构建及其用于转移性乳腺癌分子靶向治疗的研究, 主持, 国家级, 2014-01--2017-12
( 2 ) 生物医用纳米材料的代谢过程及其分析方法研究, 主持, 国家级, 2013-01--2017-08
( 3 ) 肿瘤微环境自适性纳米载药系统抗乳腺癌转移及其作用机制研究, 主持, 国家级, 2017-01--2020-12
( 4 ) 纳米载药系统, 主持, 国家级, 2017-01--2019-12
参与会议
(1)细胞内刺激响应纳米载药系统的研究   细胞内刺激响应纳米载药系统的研究,第三届全国纳米科技前沿论坛   2017-04-08