基本信息
王宇辉  男  硕导  中国科学院宁波材料技术与工程研究所
电子邮件: wangyuhui@nimte.ac.cn
通信地址: 浙江省宁波市镇海区中官西路1219号
邮政编码:

研究领域

荧光探针;快速检测技术与试剂;生物分析;食品安全

招生信息

1名
招生专业
083100-生物医学工程
招生方向
体外快速诊断
荧光探针
生物传感

教育背景

2007-09--2012-06   武汉大学   博士
2003-09--2007-06   河北师范大学   学士

工作经历

   
工作简历
2014-11~现在, 中国科学院宁波材料技术与工程研究所, 副研究员
2012-07~2014-10,中国科学院深圳先进技术研究院, 助理研究员
社会兼职
2023-05-01-2026-04-30,中国抗癌学会纳米肿瘤学分会, 青年委员会委员
2023-03-31-2026-02-28,中国生物医学工程学会, 高级会员

专利与奖励

   
奖励信息
(1) Biosensors and Bioelectronics 最佳审稿人奖, 三等奖, 其他, 2018
(2) Journal of Luminescence 最佳审稿贡献奖, 三等奖, 其他, 2018
专利成果
( 1 ) 一种碳荧光微球侧流层析高灵敏定量检测方法及应用, 发明专利, 2022, 第 1 作者, 专利号: CN114167053A

( 2 ) 非金属硼、氮共掺杂的磷光碳量子点材料及其制法与应用, 发明专利, 2022, 第 1 作者, 专利号: CN113930241A

( 3 ) 一种稀土上转换能量转移纳米传感平台、构建方法及应用, 发明专利, 2021, 第 1 作者, 专利号: CN113640269A

( 4 ) 铜掺杂血红蛋白-聚多巴胺纳米材料及其制备方法与应用, 发明专利, 2021, 第 2 作者, 专利号: CN113289008A

( 5 ) 一种铜掺杂碳点于抗菌产品中的用途, 发明专利, 2021, 第 1 作者, 专利号: CN112998030A

( 6 ) 长余辉分子信标探针、其构建方法及应用, 发明专利, 2021, 第 1 作者, 专利号: CN112725414A

( 7 ) 一种蛋白纳米药物及其制备方法与应用, 发明专利, 2020, 第 1 作者, 专利号: CN111558032A

( 8 ) 近红外抗生素荧光探针检测试剂、其制备方法与应用, 发明专利, 2019, 第 1 作者, 专利号: CN110117488A

( 9 ) 荧光指示剂组合、荧光阵列传感器、其制备方法与应用, 发明专利, 2019, 第 4 作者, 专利号: CN109975253A

( 10 ) 用于检测农药残留物的阵列传感器及其制备方法与应用, 发明专利, 2019, 第 3 作者, 专利号: CN109900685A

( 11 ) 过氧亚硝酸根离子检测探针、其制备方法及应用, 专利授权, 2016, 第 1 作者, 专利号: CN105866083A

出版信息

   
发表论文
(1) An ultrasensitive lateral flow immunoassay platform for foodborne biotoxins and pathogenic bacteria based on carbon-dots embedded mesoporous silicon nanoparticles fluorescent reporter probes, FOOD CHEMISTRY, 2023, 通讯作者
(2) DNA Nanoribbon for Efficient Anti-miRNA Peptide Nucleic Acid Delivery and Synergistic Enhancement of Cancer Cell Apoptosis, ANALYTICAL CHEMISTRY, 2023, 第 5 作者
(3) Emerging and Versatile Platforms of Metal-Ion-Doped Carbon Dots for Biosensing, Bioimaging, and Disease Therapy, CHEMMEDCHEM, 2023, 通讯作者
(4) Biomolecule-based stimuli-responsive nanohybrids for tumor-specific and cascade-enhanced synergistic therapy, ACTA BIOMATERIALIA, 2022, 第 7 作者
(5) Multi-omics analyses revealed key factors involved in fluorescent carbon-dots-regulated secondary metabolism in Tetrastigma hemsleyanum, JOURNAL OF NANOBIOTECHNOLOGY, 2022, 通讯作者
(6) An Emerging Fluorescent Carbon Nanobead Label Probe for Lateral Flow Assays and Highly Sensitive Screening of Foodborne Toxins and Pathogenic Bacteria, ANALYTICAL CHEMISTRY, 2022, 通讯作者
(7) Single-cell RNA-seq of UVB-radiated skin reveals landscape of photoaging-related inflammation and protection by vitamin D, GENE, 2022, 通讯作者
(8) A persistent luminescence resonance energy transfer-based molecular beacon probe for the highly sensitive detection of microRNA in biological samples, BIOSENSORS AND BIOELECTRONICS, 2022, 通讯作者
(9) Peroxidase-Mimetic Copper-Doped Carbon-Dots for Oxidative Stress-Mediated Broad-Spectrum and Efficient Antibacterial Activity, CHEMISTRY-A EUROPEAN JOURNAL, 2022, 通讯作者
(10) Fluorescent carbon-dots enhance light harvesting and photosynthesis by overexpressing PsbP and PsiK genes, JOURNAL OF NANOBIOTECHNOLOGY, 2021, 第 1 作者
(11) 新一代测序技术的文库制备方法研究进展, Recent Progress of Library Construction for Next-generation Sequencing, 应用化学, 2021, 第 4 作者
(12) Carbon Dots with Dual-Emissive, Robust, and Aggregation-Induced Room-Temperature Phosphorescence Characteristics, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2020, 第 4 作者
(13) A persistent luminescence-based label-free probe for the ultrasensitive detection of hemoglobin in human serum, TALANTA, 2020, 通讯作者
(14) Improving the performance of upconversion nanoprobe-based lateral flow immunoassays by supramolecular self-assembly core/shell strategies, SENSORS AND ACTUATORS B-CHEMICAL, 2020, 通讯作者
(15) Disulfide bond-based self-crosslinked carbon-dots for turn-on fluorescence imaging of GSH in living cells, Analyst, 2020, 通讯作者
(16) A Facile Approach to Carbon Dots-Mesoporous Silica Nanohybrids and Their Applications for Multicolor and Two-Photon Imaging Guided Chemo-/Photothermal Synergistic Oncotherapy, CHEMNANOMAT, 2020, 第 4 作者
(17) Improving the performance of upconversion nanoprobe-based lateral flow immunoassays by supramolecular self-assembly core/shell strategies, Sensors and Actuators B: Chemical, 2020, 通讯作者
(18) Disulfide bond-based self-crosslinked carbon-dots for turn-on fluorescence imaging of GSH in living cells, ANALYST, 2020, 通讯作者
(19) A conjugated carbon-dot-tyrosinase bioprobe for highly selective and sensitive detection of dopamine, ANALYST, 2019, 通讯作者
(20) An inner filter effect-based near-infrared probe for the ultrasensitive detection of tetracyclines and quinolones, TALANTA, 2019, 通讯作者
(21) Ce6-Modified Carbon Dots for Multimodal-Imaging-Guided and Single-NIR-Laser-Triggered Photothermal/Photodynamic Synergistic Cancer Therapy by Reduced Irradiation Power, ACS APPLIED MATERIALS & INTERFACES, 2019, 第 5 作者
(22) An inner flter effect-based near-infrared probe for the ultrasensitive detection of tetracyclines and quinolones, Talanta, 2019, 通讯作者
(23) Preparation of Multicolor Photoluminescent Carbon Dots by Tuning Surface States, NANOMATERIALS, 2019, 第 4 作者
(24) Recent advances of multidimensional sensing:from design to applications, Recent advances of multidimensional sensing:from design to applications, SCIENCE CHINA. CHEMISTRY, 2019, 通讯作者
(25) In Situ Synthesis of Fluorescent Mesoporous Silica–Carbon Dot Nanohybrids Featuring Folate Receptor‑Overexpressing Cancer Cell Targeting and Drug Delivery, NANO-MICRO LETTERS, 2019, 第 4 作者
(26) In Situ Synthesis of Fluorescent Mesoporous Silica–Carbon Dot Nanohybrids Featuring Folate Receptor-Overexpressing Cancer Cell Targeting and Drug Delivery, In Situ Synthesis of Fluorescent Mesoporous Silica–Carbon Dot Nanohybrids Featuring Folate Receptor-Overexpressing Cancer Cell Targeting and Drug Delivery, 纳微快报:英文版, 2019, 第 4 作者
(27) Conversion of Carbon Dots from Fluorescence to Ultralong Room-Temperature Phosphorescence by Heating for Security Applications, ADVANCED MATERIALS, 2018, 第 2 作者
(28) Facile, Quick, and Gram-Scale Synthesis of Ultralong-Lifetime Room-Temperature-Phosphorescent Carbon Dots by Microwave Irradiation, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2018, 第 2 作者
(29) Fluorescent and photoacoustic bifunctional probe for the detection of ascorbic acid in biological fluids, living cells and in vivo, NANOSCALE, 2018, 通讯作者
(30) Carbon-dots-based lab-on-a-nanoparticle approach for the detection and differentiation of antibiotics, CHEMISTRY-A EUROPEAN JOURNAL, 2018, 通讯作者
(31) A colorimetric sensor array based on sulfuric acid assisted KMnO4 fading for the detection and identification of pesticides, TALANTA, 2018, 第 3 作者
(32) A versatile platform for the highly efficient preparation of graphene quantum dots: photoluminescence emission and hydrophilicity-hydrophobicity regulation and organelle imaging, NANOSCALE, 2018, 通讯作者
(33) Activating Room Temperature Long Afterglow of Carbon Dots via Covalent Fixation, CHEMISTRY OF MATERIALS, 2017, 第 2 作者
(34) A highly sensitive and selective fluorimetric probe for intracellular peroxynitrite based on photoinduced electron transfer from ferrocene to carbon dots, BIOSENSORS & BIOELECTRONICS, 2017, 通讯作者
(35) A fluorescent carbon-dots-based mitochondria-targetable nanoprobe for peroxynitrite sensing in living cells, BIOSENSORS AND BIOELECTRONICS, 2017, 第 3 作者
(36) A graphene quantum dot-based fluorescent nanoprobe for hypochlorite detection in water and in living cells, MICROCHIMICA ACTA, 2017, 通讯作者
(37) Synthesis of Gold Nanoparticles from Au(I) Ions That Shuttle To Solidify: Application on the Sensor Array Design, LANGMUIR, 2017, 第 4 作者
(38) Applying Carbon Dots-Metal Ions Ensembles as a Multichannel Fluorescent Sensor Array: Detection and Discrimination of Phosphate Anions, ANALYTICALCHEMISTRY, 2017, 第 4 作者
(39) A highly sensitive and selective fluorimetric probe for intracellular peroxynitrite based on photoinduced electron transfer from ferrocene to carbon dots, BIOSENSORS AND BIOELECTRONICS, 2017, 第 4 作者
(40) A graphene quantum dot-based fluorescent nanoprobe for hypochlorite detection in tap w ater and liv ing cells, Microchim. Acta, 2017, 通讯作者
(41) Single-indicator-based Multidimensional Sensing: Detection and Identification of Heavy Metal Ions and Understanding the Foundations from Experiment to Simulation, SCIENTIFIC REPORTS, 2016, 第 3 作者
(42) A label-free fluorescence turn-on sensor for rapid detection of cysteine, TALANTA, 2015, 第 5 作者
(43) A fret-based carbon dot-mno2 nanosheet architecture for glutathione sensing in human whole blood samples, CHEMICAL COMMUNICATIONS, 2015, 第 1 作者
(44) Bright-Yellow-Emissive N-Doped Carbon Dots: Preparation, Cellular Imaging, and Bifunctional Sensing, ACS APPLIED MATERIALS & INTERFACES, 2015, 通讯作者
(45) NIR-Emitting Two-Dimensional Codes Based on Lattice-Strained Core/(Doped) Shell Quantum Dots with Long Fluorescence Lifetime., Adv. Mater, 2014, 第 1 作者
(46) A near infrared fluorescence resonance energy transfer based aptamer biosensor for insulin detection in human plasma, CHEMICAL COMMUNICATIONS, 2014, 第 1 作者
(47) Upconversion Fluorescence Resonance Energy Transfer Biosensor with Aromatic Polymer Nanospheres as The Lable-Tree Energy Acceptor, Analytical Chemistry, 2013, 第 1 作者
(48) Upconversion Fluorescence Resonance Energy Transfer Based Biosensor for Ultrasensitive Detection of Matrix Metalloproteinase-2 in Blood, ANALYTICAL CHEMISTRY, 2012, 第 1 作者
(49) Highly selective and sensitive method for cysteine detection based on fluorescence resonance energy transfer between FAM-tagged ssDNA and graphene oxide, TALANTA, 2012, 第 2 作者
(50) Biosensing Platform Based on Fluorescence Resonance Energy Transfer from Upconverting Nanocrystals to Graphene Oxide, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2011, 第 4 作者
(51) Aptamer Biosensor Based on Fluorescence Resonance Energy Transfer from Upconverting Phosphors to Carbon Nanoparticles for Thrombin Detection in Human Plasma, ANALYTICAL CHEMISTRY, 2011, 第 1 作者
(52) Controlled synthesis of NaYF4: Yb, Er nanocrystals with upconversion fluorescence via a facile hydrothermal procedure in aqueous solution, CRYSTENGCOMM, 2011, 第 1 作者
(53) A new biosensor for glucose determination in serum based on up-converting fluorescence resonance energy transfer, BIOSENSORS AND BIOELECTRONICS, 2011, 第 2 作者
发表著作
(1) 先进碳材料科学与功能应用技术, 科学出版社, 2016-09, 第 5 作者

科研活动

   
科研项目
( 1 ) 基于NIR-QDs 的受体免标记 FRET 新方法及其临床血样分析, 负责人, 国家任务, 2014-01--2016-12
( 2 ) 受体免标记近红外FRET及其血样分析, 负责人, 地方任务, 2013-10--2015-09
( 3 ) 基于连接酶激活型探针的信号放大技术分析血液中循环癌细胞的新方法研究 , 参与, 国家任务, 2014-01--2017-12
( 4 ) pH敏感变构聚合物载体FRET模型构建及其肿瘤诊疗一体化研究 , 参与, 国家任务, 2014-01--2016-12
( 5 ) 基于贵金属杂化二硫化钼/氧化石墨烯插层纳米复合物的可控合成与光催化性能研究 , 参与, 国家任务, 2015-01--2017-12
( 6 ) 智能化葡聚糖纳米药物载体的构建及其在肿瘤诊疗一体化中的应用, 参与, 国家任务, 2015-01--2017-12
( 7 ) 基于荧光碳点的新型双光子激发FRET探针设计,合成与生物分析应用, 负责人, 地方任务, 2015-03--2017-08
( 8 ) 基于荧光碳点的双光子激发FRET新方法及其血样分析应用研究, 负责人, 地方任务, 2016-01--2018-12
( 9 ) 抗基质干扰的抗生素现场快速检测技术开发与应用研究, 负责人, 地方任务, 2016-09--2019-08
( 10 ) 先进纳米碳材料及应用, 负责人, 地方任务, 2019-01--2021-12
( 11 ) 基于近红外碳点的肿瘤微环 境刺激-响应型诊疗探针的构筑与生物应用, 负责人, 地方任务, 2020-01--2022-12
( 12 ) 膀胱癌的液体活检多组学标志物的筛查研究, 负责人, 企业委托, 2022-01--2022-12
( 13 ) 新型荧光微球的小批量制备与表面改性, 负责人, 企业委托, 2022-07--2022-12
( 14 ) 单分子长读长基因测序文库制备技术及其试剂盒研发, 参与, 研究所自选, 2022-01--2023-12
( 15 ) 新型荧光微球及免疫层析技术与试剂开发, 负责人, 地方任务, 2023-01--2025-12
( 16 ) 肠道菌群高灵敏荧光成像技术及其应用, 负责人, 企业委托, 2023-07--2026-07
( 17 ) 金属掺杂碳点的构筑及其抗菌机制研究, 负责人, 地方任务, 2023-01--2025-12
参与会议
(1)高信背比光学标记探针及其食品快检分析应用   第二届中国(南昌)食品安全快速检测高峰论坛   2023-07-10
(2)碳基荧光微球标记探针及POCT应用   第六届荧光探针与成像青年论坛   2023-05-26
(3)近红外碳点增强农作物光合作用及其分子机制研究   中国化学会第17届光化学学术研讨会   2021-10-10
(4)碳基发光纳米探针构筑及其分析检测应用   中国化学会第13届分析化学年会   2018-06-15
(5)基于荧光碳点的线粒体靶向ONOO-探针设计   2016全国生命分析化学大会   2016-12-16
(6)基于受体免标记的上转换/近红外FRET及其生物分析应用   中国化学会第十二届分析化学年会   王宇辉,林恒伟   2015-05-08
(7)基于FRET的碳点-层状MnO2复合物用于GSH高灵敏分析   中国化学会第十二届分析化学年会   王宇辉,林恒伟   2015-05-08
(8)受体免标记近红外FRET传感器设计及其生物分析应用   中国化学会第29届学术年会   王宇辉,高笃阳,张鹏飞,陈驰,蔡林涛   2014-08-04