General

Dr. Yang Li, is a full professor and the lab head of Laboratory of Immunology and Nanomedicine, deputy director of Laboratory of Inflammation and Vaccines (LIV) at the Shenzhen Institute of Advanced Technology, Chinese Academy of Science.


Dr. Li obtained a Master degree in Physiology (molecular biology) in China, followed a PhD degree in Immunology/Nanoscience in Europe (Italian National Research Council and Salzburg University, Austria) with a Marie Curie Fellowship funded by EU FP7 programme. He studied immunology and focused on the activation of innate immunity and inflammatory mechanisms, with particular focus on monocytes and macrophages and IL-1 family cytokines and receptors, upon interaction with nanomaterials/nanomedicines. After his PhD in Europe, he moved to USA for his post-doctoral trainings on nano-immune interactions at the Nanotechnology Innovation Center of the Kansas State University, and on tumor immunology (inflammasome in tumor and PD-1/PD-L1 targeting tumor therapy) at the University of Colorado. He then moved back to China at the Shenzhen Institutes of Advanced Technology, Chinese Academy of Science. There, his research group is focusing on Nano-bio interactions, Nanomedicine, Immunology, Cancer immunology/Cancer therapy.


Lab page: https://www.lilaboratory.org/ 


Research Areas

1. Immunology

2. Cancer research

3. Nanomedicine

4. Nano-bio interation

Publications

2023

42. Zhengjiang Xu, Yuan Zhang, Danping Lu, Guofang Zhang, Yang Li, Zufu Lu, Fei Wang*, and Guocheng Wang*. Antisenescence ZIF-8/Resveratrol Nanoformulation with Potential for Enhancement of Bone Fracture Healing in the ElderlyACS Biomaterials Science & Engineering, 2023, Online. doi: doi.org/10.1021/acsbiomaterials.3c00090

41. Nahar Jannatun, Yuqian Zhang, Ben Wu, Qingle Song, Guoli Cao, Wenhe Luo, Feng Yuan, Qi Li, Yanqiao Zeng, Guofang Zhang*, Guocheng Wang*, Yang Li*. Tea Polyphenol Coordinated with Nanoparticles of ZIF-8 and Coated with Polydopamine and PEG for Immuno-OncotherapyACS Applied Nano Materials, 2023, 6(6), 4379–4389. doi: doi.org/10.1021/acsanm.2c05472

40. Wenjie Yang, Yang Li, Diana Boraschi*. Association between Microorganisms and Microplastics: How Does It Change the Host–Pathogen Interaction and Subsequent Immune Response?International Journal of Molecular Sciences, 2023, 24(4),4065. doi: doi.org/10.3390/ijms24044065

2022

39. Wenjie Yang, Nahar Jannatun, Yanqiao Zeng, Tinghao Liu, Guofang Zhang, Chunying Chen*, Yang Li*. Impacts of microplastics on immunityFrontiers in Toxicology2022, 4,956885doi: doi.org/10.3389/ftox.2022.956885

38. Della Camera, Giacomo, Tinghao Liu, Wenjie Yang, Yang Li, Victor F. Puntes, Sabrina Gioria, Paola Italiani, , Diana Boraschi*. Induction of Innate Memory in Human Monocytes Exposed to Mixtures of Bacterial Agents and NanoparticlesInternational Journal of Molecular Sciences2022, 23(23),14655. doi: doi.org/10.3390/ijms232314655

37. Guofang Zhang, Wenhe Luo, Wenjie Yang,Su Li, Dongjie Li, Yanqiao Zeng, Yang Li*. The importance of the IL-1 family of cytokines in nanoimmunosafety and nanotoxicologyWIREs Nanomedicine and Nanobiotechnology2022, 14(6),e1850doi: doi.org/10.1002/wnan.1850

36. Xuejin Li, Dongjie Li, Guofang Zhang*, Yanqiao Zeng, Nancy A Monteiro-Riviere, Yan-Zhong Chang* and Yang Li*. Biocorona modulates the inflammatory response induced by gold nanoparticles in human epidermal keratinocytesToxicology Letters2022, 369,34-42doi: doi.org/10.1016/j.toxlet.2022.08.009

35. Guofang Zhang, Yalin Cong, Feng-Liang Liu, Jiufeng Sun, Jiantian Zhang, Guoli Cao, Lingqiang Zhou, Wenjie Yang, Qingle Song, Fangjun Wang, Ke Liu, Jing Qu, Jing Wang, Min He, Shun Feng, Didar Baimanov, Wei Xu, Rong-Hua Luo, Xin-Yan Long, Shumin Liao, Yunping Fan, Yu-Feng Li, Bai Li, Ximing Shao, Guocheng Wang, Lijing Fang, Huaiyu Wang, Xue-Feng Yu, Yan-Zhong Chang, Yuliang Zhao, Liang Li, Peng Yu, Yong-Tang Zheng*, Diana Boraschi, Hongchang Li*, Chunying Chen*, Liming Wang* and Yang Li*. A nanomaterial targeting the spike protein captures SARS-CoV-2 variants and promotes viral elimination. Nature Nanotechnoloy2022, 17 (9), 993-1003doi: doi.org/10.1038/s41565-022-01177-2

34. Guofang Zhang, Guoli Cao, Rong-Hua Luo, Qingle Song, Yanqiao Zeng, Ke Liu, Jing Qu, Xian Lin, Feng-Liang Liu, Guocheng Wang, Hongchang Li, Liang Li, Yong-Tang Zheng, Diana Boraschi, Lidong Wu*, Yan-Zhong Chang* and Yang Li*. Microplastics interact with SARS-CoV-2 and facilitate host cell infection. Environmental Science: Nano2022, 9,2653-2664. doi: doi.org/10.1039/D2EN00019A

33. Yuange Chen, Longling Ouyang, Na Liu, Fang Li, Peiyi Li, Mengmeng Sun, Haiyang Qin, Yang Li, Xueping Xiang, Lidong Wu*. pH-responsive magnetic artificial melanin with tunable aggregation-induced stronger magnetism for rapid remediation of plastic fragments. Journal of Hazardous Materials, 2022, 435, 128962. doi: doi.org/10.1016/j.jhazmat.2022.128962

32. Yichuan Zhang, Quan Gao, Weishuo Li, Rongkun He, Liwei Zhu, Qianjin Lian, Liang Wang, Yang Li, Mark Bradley, Jin Geng*. Controlled Intracellular Polymerization for Cancer TreatmentJACS Au, 2022, 2(3), 579-589. doi: doi.org/10.1021/jacsau.1c00373

31. Yang Li*, Pengfei Zhang, Ben Zhong Tang, Diana Boraschi*. Editorial: Immunological Effects of Nano-Imaging MaterialsFrontiers in Immunology, 2022, 13,886415doi: 10.3389/fimmu.2022.886415

2021

30. Diana Boraschi*, Dongjie Li, Yang Li, Paola Italiani. In Vitro and In Vivo Models to Assess the Immune-Related Effects of Nanomaterials. International Journal of Environmental Research and Public Health2021, 18(22), 11769. doi: https://doi.org/10.3390/ijerph182211769

29. Dinoop Ravindran Menon, Yang Li, Takeshi Yamauchi, Douglas Grant Osborne, Prasanna Kumar Vaddi, Michael F Wempe, Zili Zhai, Mayumi Fujita. EGCG Inhibits Tumor Growth in Melanoma by Targeting JAK-STAT Signaling and Its Downstream PD-L1/PD-L2-PD1 Axis in Tumors and Enhancing Cytotoxic T-Cell Responses. Pharmaceuticals2021, 14(11), 1081. doi: https://doi.org/10.3390/ph14111081

28. Qingle Song, Amaneh Javid, Guofang Zhang, & Yang Li*. Applications of Magnetite-Nanoparticles in Cancer Immunotherapies: Present Hallmarks and Future PerspectivesFrontiers in Immunology, 2021, 12:701485. doi: https://doi.org/10.3389/fimmu.2021.701485

27. Zhenzhen Shi, Yang Li, & Majid Jaberi-Douraki*. Hybrid computational modeling demonstrates the utility of simulating complex cellular networks in type 1 diabetesPLoS computational biology2021, 17(9), e1009413. doi: https://doi.org/10.1371/journal.pcbi.1009413

26. Ximing Shao, Zhihao Ding, Wenhua Zhou, Yanyan Li, Zhibin Li, Haodong Cui, Xian Lin, Guoli Cao, Binghua Cheng, Haiyan Sun, Meiqing Li, Ke Liu, Danyi Lu, Shengyong Geng, Wenli Shi, Guofang Zhang, Qingle Song, Liang Chen, Guocheng Wang, Wu Su, Lintao Cai, Lijing Fang, David Tai Leong, Yang Li*, XueFeng Yu* & Hongchang Li*, Intrinsic bioactivity of black phosphorus nanomaterials on mitotic centrosome destabilization through suppression of PLK1 kinaseNature Nanotechnology, 2021, 16(10), 1150-1160. doi: https://doi.org/10.1038/s41565-021-00952-x

25.  Giacomo Della Camera,  Mariusz Madej, Anna M. Ferretti, Rita L. Spina,  Yang Li,  Annunziata Corteggio,  Tommaso Heinzl, Gergö Sipos,  Sabrina Gioria,  Alessandro Ponti,  Paola Italiani*, Diana Boraschi*,  Personalised Profiling of Immune Memory Induced by Nano-imaging Particles in Human MonocytesFrontiers in Immunology, 2021, 12, 692165. doi: 10.3389/fimmu.2021.692165

24. Qingle Song, Guofang Zhang, Bo Wang, Guoli Cao, Dongjie Li, Yu Wang, Yuqian Zhang, Jin Geng, Hongchang Li, Yang Li*, Reinforcing the Combinational Immuno-Oncotherapy of Switching “Cold” Tumor to “Hot” by Responsive Penetrating NanogelsACS Applied Materials and Interfaces2021, 13 (31), 36824-36838. doi: https://doi.org/10.1021/acsami.1c08201

23. Guofang Zhang, Yalin Cong, Guoli Cao, Liang Li, Peng Yu, Qingle Song, Ke Liu, Jing Qu, Jing Wang, Wei Xu, Shumin Liao, Yunping Fan, Yufeng Li, Guocheng Wang, Lijing Fang, Yanzhong Chang, Yuliang Zhao, Diana Boraschi, Hongchang Li*, Chunying Chen*, Liming Wang*, Yang Li*, Spike Protein Targeting “Nano-Glue” that Captures and Promotes SARS-CoV-2 EliminationbioRxiv 2021.04.13.439641. doi: https://doi.org/10.1101/2021.04.13.439641

22. Yuqian Zhang, Guofang Zhang, Guocheng Wang, Lidong Wu, Nancy A Monteiro-Riviere, Yang Li*, The synergistic strategies for the immuno-oncotherapy with photothermal nanoagentsWIREs: Nanomedicine and Nanobiotechnology, 2021, e1717. doi: https://doi.org/10.1002/wnan.1717

21. Lidong Wu, Qiang Cao, Na Liu, Yushi Xiao, Rong Huang, Yang Li*, Hybrid Magnetic Hydrogels Used as Artificial Marine Animals for Noncontact CleaningACS Applied Polymer Materials 3 (2), 2021, 1182-1189. doi: https://doi.org/10.1021/acsapm.1c00019

20. Anna M Ferretti, Sandro Usseglio, Sara Mondini, Carmelo Drago, Rosa La Mattina, Bice Chini, Claudia Verderio, Marianna Leonzino, Cinzia Cagnoli, Pooja Joshi, Diana Boraschi, Paola Italiani, Yang Li, Benjamin J Swartzwelter, Luigi Sironi, Paolo Gelosa, Laura Castiglioni, Uliano Guerrini, Alessandro Ponti*. Towards bio-compatible magnetic nanoparticles: Immune-related effects, in-vitro internalization, and in-vivo bio-distribution of zwitterionic ferrite nanoparticles with unexpected renal clearanceJournal of Colloid and Interface Science, 2021, 582, 678-700. doi: https://doi.org/10.1016/j.jcis.2020.08.026

19. Shi Qiu, Jiawen Ji, Wei Sun, Jia Pei, Jian He, Yang Li, Jiao Jiao Li*, Guocheng Wang*, Recent Advances in Surface Manipulation Using Micro-contact Printing for Biomedical ApplicationsSmart Materials in Medicine, 2021, 2, 65-73. doi: https://doi.org/10.1016/j.smaim.2020.12.002

2020

18. Jing Zhao, Danping Lu, Sergio Moya, Haoying Yan, Miaojuan Qiu, JunZong Chen, Xincheng Wang, Yang Li, Haobo Pan, Guochuang Chen*, Guocheng Wang*. Bispecific T-cell engager (BiTE) immunotherapy of ovarian cancer based on MIL-88A MOF/MC gene delivery systemApplied Materials Today. 2020, 20, 100701. doi: https://doi.org/10.1016/j.apmt.2020.100701

17. Guofang Zhang, Qingle Song, Yuqian Zhang, Ruijing Liang, Liang Chen, Nancy Monteiro-Riviere, Diana Boraschi, Yan-Zhong Chang, Hongchang Li, Yang Li*. Gold Nanoparticles Induce Cell Stress by Interfering with the Cellular Protein Quality Control SystemResearch Square. doi: https://doi.org/10.21203/rs.3.rs-84361/v1 

16. Shu Zhang, Ming Xiao, Yuqian Zhang, Yang Li, Huan Liu, Gang Han, Brijesh Rathi, Kaiyu Lyu, Lidong Wu*. Mimicking neuromelanin nanoparticles as a selective Pb2+ probeAnalytica Chimica Acta, 2020, 105, 208-213. doi: https://doi.org/10.1016/j.aca.2020.01.051

15. Yanfeng Liu, Shishi Tao, Lijuan Liao, Yang Li, Hongchang Li, Zhihuan Li, Lilong Lin, Xiaochun Wan, Xiaolu Yang*, Liang Chen*. TRIM25 promotes the cell survival and growth of hepatocellular carcinoma through targeting Keap1-Nrf2 pathwayNature communications, 2020, 11 (1), 1-13. doi: https://doi.org/10.1038/s41467-019-14190-2

14. Litian Zhang, Lukman O Afolabi, Xiaochun Wan, Yang Li*, Liang Chen*. Emerging Roles of Tripartite Motif-Containing Family Proteins (TRIMs) in Eliminating Misfolded ProteinsFrontiers in Cell and Developmental Biology, 2020, 8:802. doi: https://doi.org/10.3389/fcell.2020.00802

2019

13. Yuqian Zhang, Guofang Zhang, Liang Chen, Yang Li*. Modulation of the inflammatory tumor microenvironment - a new approach for photothermal-synergized cancer immunotherapyNanomedicine, 2019, 14(16), 2101–2104. doi: https://doi.org/10.2217/nnm-2019-0156

2017

12. Yang Li*, Zhenzhen Shi, Isabella Radauer-Preim, Ancuela Andosch, Eudald Casals, Ursula Luetz-Meindl, Jutta Horejs-Hoeck, Martin Himly, Nancy A. Monteiro-Riviere, Victor Puntus, Albert Duschl, Diana Boraschi. Bacterial endotoxin (lipopolysaccharide) binds to the surface of gold nanoparticles, interferes with biocorona formation and induces human monocyte inflammatory activationNanotoxicology, 2017, 11(9-10): 1157-1175. doi: https://doi.org/10.1080/17435390.2017.1401142

Before SIAT

11. Dinoop Ravindran Menon, Yuchun Luo, John Arcaroli, Sucai Liu, Lekha KrishnanKutty, Douglas Osborne, Yang Li, Jenny Mae Samson, Stacey Bagby, Aik-Choon Tan, William Robinson, Wells Messersmith, and Mayumi Fujita. CDK1 interacts with Sox2 and promotes tumor initiation in human melanomaCancer Research, 2018, 78(23):6561-6574. doi: 10.1158/2F0008-5472.CAN-18-0330

10. Yang Li*, Mayumi Fujita, Diana Boraschi. Endotoxin contamination in nanomaterials leads to the misinterpretation of immunosafety results. Front. Immunol. 2017, 8: 472. doi: https://doi.org/10.3389/fimmu.2017.00472

9. Yang Li, Nancy A. Monteiro-Riviere. Mechanisms of cell uptake, inflammatory potential and protein corona effects with gold nanoparticlesNanomedicine, 2016. 11(24): 3185-3203. doi: https://doi.org/10.2217/nnm-2016-0303

8. Yang Li*, Paola Italiani, Eudald Casals, Dirk Valkenborg, Inge Mertens, Geert Baggerman, Inge Nelissen, Victor F. Puntes, Diana Boraschi. Assessing the immunosafety of engineered nanoparticles with a novel in vitro model based on human primary monocytesACS Appl. Mater. Interfaces. 2016, 8(42): 28437–28447. doi: https://doi.org/10.1021/acsami.6b06278

7. Yang Li*, Diana Boraschi. Endotoxin contamination: a key element for interpretation of nanosafety studiesNanomedicine, 2016 11(3): 269-287. (2016-2018, most read paper in Nanomedicine)  doi: https://doi.org/10.2217/nnm.15.196

6. Yang Li*, Paola Italiani, Eudald Casals, Ngoc Tran, Victor Puntes, Diana Boraschi. Optimising the use of commercial LAL assays for the analysis of endotoxin contamination in metal colloids and metal oxide nanoparticlesNanotoxicology, 2015, 9(4): 462-473. doi: https://doi.org/10.3109/17435390.2014.948090

5. Murali Kumarasamy, Kata Kenesei, Yang Li, Kornél Demeter, Zsuzsanna Környei, Emilia Madarász. Uptake and bio-reactivity of polystyrene nanoparticles is affected by surface modifications, ageing and LPS adsorption: in vitro studies on neural tissue cellsNanoscale, 2015, 7(9): 4199-4210. doi: https://doi.org/10.1039/C4NR06849A

4. Peng Wang, Xin Nie, Yue Wang, Yang Li, Cuicui Ge, Lili Zhang, Liming Wang, Ru Bai, Zhiyun Chen, Yuliang Zhao, Chunying Chen. Multiwall carbon nanotubes mediate macrophage activation and promote pulmonary fibrosis through TGF-β/Smad signaling pathwaySmall, 2013, 9(22): 3799-3811. doi: https://doi.org/10.1002/smll.201300607

3. Cuicui Ge, Yang Li, Jun-Jie Yin, Ying Liu, Liming Wang, Yuliang Zhao, Chunying Chen*. The contributions of metal impurities and tube structure to the toxicity of carbon nanotube materialsNPG Asia Materials, 2012, 4(12): e32. doi: https://doi.org/10.1038/am.2012.60

2. Yang Li, Ying Liu, Yujian Fu, Taotao Wei, Laurent Le Guyader, Ge Gao, Ru-Shi Liu, Yanzhong Chang, Chunying Chen*. The triggering of apoptosis in macrophages by pristine graphene through the MAPK and TGF-beta signaling pathwaysBiomaterials, 2012, 33(2), 402-411. (ISI web of knowledge-Essential Science Indicators, Highly cited papers). doi: https://doi.org/10.1016/j.biomaterials.2011.09.091

1. Cuicui Ge, Li Meng, Ligeng Xu, Ru Bai, Jiangfeng Du, Lili Zhang, Yang Li, Yanzhong Chang, Yuliang Zhao, Chunying Chen. Acute pulmonary and moderate cardiovascular responses of spontaneously hypertensive rats after exposure to single-wall carbon nanotubesNanotoxicology, 2012, 6(5), 526-542. doi: https://doi.org/10.3109/17435390.2011.587905

Research Interests

Innate immunity, IL-1 cytokines, Macrophages/monocytes, Apoptosis, Nanomedicine, Nanotoxicology and nanosafety, Drug delivery and cancer therapy, Lung fibrosis, Tumor immunology.



Honors & Distinctions

​Marie Curie Fellowship, 2011