基本信息

杨军丽  男 研究员 博导  中国科学院兰州化学物理研究所
电子邮件: yangjl@licp.cas.cn
通信地址: 兰州市天水中路18号
邮政编码: 730000

研究领域

1. 中草药活性成分的定向发现与制备方法学研究;

2. 中草药活性成分的分子结构、构效关系、作用机制研究

3. 基于天然产物的新药研究


招生信息

热忱欢迎对天然药物化学/药物化学、有机合成、分析化学等领域感兴趣的学生报考本课题组研究生和联合培养学生。


招生专业
070302-分析化学
招生方向
药物分析化学
制药工程化学

教育背景

2007-09--2012-06   兰州大学   硕博连读研究生/理学博士
2003-09--2007-06   山东大学   本科生/理学学士
学历

20079-20126                  博士(有机化学)

                                                       化学化工学院/功能有机分子化学国家重点实验室

                                                       兰州大学


20039-20076                  学士(化学)

                                                       化学与化工学院

                                                       山东大学

学位
有机化学 博士

工作经历

2018年12月 至今:研究员,中科院兰州化物所

201511 2018年12月:副研究员,****,中科院兰州化物所

201412-20159月:Postdoctoral Research Associate North Carolina A&T State University/North Carolina Research CampusUSA

20133-201411月:Postdoctoral Research FellowSeoul National UniversityKorea

20129-20132月:Postdoctoral ResearcherChosun UniversityKorea


工作简历
2014-12~2015-09,North Carolina A&T State University (USA), Postdoctoral Research Associate
2013-03~2014-11,Seoul National University(South Korea), Postdoctoral Research Fellow
2012-09~2013-02,Chosun University(South Korea), Postdoctoral Researcher

专利与奖励

荣誉与奖励:

1.        2015年度甘肃省自然科学奖二等奖:重要中草药化学成分和生物活性研究(排名第二)

专利:

1.         杨军丽,师彦平,从中药千年健中制备具有抑制COX-2mRNA表达活性倍半萜的方法,2017,申请号:201710078369.8

2.        杨军丽,王伟峰,师彦平,一种快速、高选择性检测鸟氨酸的分析方法,2017,申请号:201710078829.7

3.         Oh, W.K.; Yang, J.L.; Kim, E.; Lee, S.C. Composition comprising extract of Camellia japonica or oleanane triterpenes derivatives isolated therefrom for treating or preventing Corona virus related diseases. Korea government application number 10-2014-0109981. 

4.        Oh, W.K.; Yang, J.L.; Kim, E. Composition comprising ginsenosides for treating or preventing Cold, Avian influenza, or Swine influenza. Korea government application number 10-2013-0137867.


奖励信息
(1) 重要中草药化学成分和生物活性研究, 二等奖, 省级, 2015
专利成果
( 1 ) 一种检测鸟氨酸的比色分析方法, 发明, 2017, 第 1 作者, 专利号: 201710078829.7
( 2 ) 一种枸杞中具有的抗阿尔茨海默病的酰胺类化合物及酰胺类化合物组分, 发明, 2018, 第 1 作者, 专利号: 201810340462.6
( 3 ) 一种枸杞中的酰胺类化合物及酰胺类化合物组分及其制备方法, 发明, 2018, 第 1 作者, 专利号: 201810340746.5
( 4 ) 具有SIRT1抑制活性的糖苷类化合物及其制备方法, 发明, 2017, 第 1 作者, 专利号: 201711215932.8
( 5 ) 一种利用花椒根枝提取物制备的足浴粉及其制备方法, 发明, 2017, 第 1 作者, 专利号: 201710526565.7
( 6 ) 一种花椒叶总黄酮提取物的用途, 发明, 2018, 第 1 作者, 专利号: 201811247205.4
( 7 ) 一种花椒叶中具有保健功能的总黄酮提取物的制备方法及用途, 发明, 2018, 第 1 作者, 专利号: 201811244878.4
( 8 ) 一种绞股蓝中具有抗阿尔兹海默病的达玛烷型三萜皂苷, 发明, 2018, 第 1 作者, 专利号: 201810812434.X

出版信息

1.        Xian-Hua Meng, Kai Wang, Tian Chai, Zhi-Ying Guo, Ming Zhao, Jun-Li Yang*. Ingenane and jatrophane diterpenoids from Euphorbia kansui and their antiproliferative effects, Phytochemistry, 2020, 172, 112257.

2.        Wei-Feng Wang, Jun-Li Yang*. Advances in Screening Enzyme Inhibitors by Capillary Electrophoresis. Electrophoresis, 2019, 40(16-17), 2075–2083.

3.        Yu-Zhu Ding, Wei-Feng Wang, Tian Chai, Yin Qiang, Yan-Ping Shi, Jun-Li Yang*. Ratiometric Target-Triggered Fluorescence Silicon Nanoparticles Probe for Quantitative Visulization of Tyrosinase Activity. Talanta, 2019, 197, 113-121.

4.        Wei-Feng Wang, Jun-Li Yang*, Yan-Ping Shi. Quality Evaluation of Six Bioactive Constituents in Goji Berry based on Capillary Electrophoresis Field Amplified Sample Stacking. Electrophoresis, 2018, 39(16), 2117-2124.

5.        Wei-Feng Wang, Yin Qiang, Xian-Hua Meng, Jun-Li Yang*, Yan-Ping Shi. Ultrasensitive Colorimetric Assay Melamine based on in situ Reduction to Formation of CQDs-Silver Nanocomposite. Sensors and Actuators B: Chemical, 2018, 260, 808-815.

6.        Jun Wang, Jun-Li Yang,* Pan-Pan Zhou, Xian-Hua Meng, Yan-Ping Shi. Further New Gypenosides from Jiaogulan (Gynostemma pentaphyllum). Journal of Agricultural and Food Chemistry, 2017, 65(29), 5926–5934.

7.        Yin Qiang, Wei-Feng Wang, Basanta Dhodary, Jun-Li Yang*. Zeolitic Imidazolate Framework 8 (Zif-8) Reinforced Macroporous Resin D101 for Selective Solid-Phase Extraction of 1-Naphthol and 2-Naphthol from Phenol Compounds. Electrophoresis, 2017, 38(13-14), 1685–1692.

8.        Jun Wang, Ming Zhao, Xiang Cheng, Ying Han, Tong Zhao, Ming Fan, Lingling Zhu,* Jun-Li Yang,* Dammarane-Type Saponins from Gynostemma pentaphyllum prevent hypoxia-induced neural injury through activation of ERK, Akt and CREB pathways, Journal of Agricultural and Food Chemistry, 2020, 68, 1, 193-205.

9.        Jun Wang, Thi Kim Quy Ha, Yan-Ping Shi, Won Keun Oh*, Jun-Li Yang*, Hypoglycemic Triterpenes from Gynostemma pentaphyllum. Phytochemistry, 2018, 155, 171-181.

10.    Xuan Qi, Wei-Feng Wang, Jun Wang, Jun-Li Yang *, Yan-Ping Shi *. Highly Selective Colorimetric Detection of Putrescine in Fish Products Using O-Phthalaldehyde Derivatization Reaction. Food Chemistry, 2018, 259, 245-250.

11.    Xian-Fei Zhang, Juan Chen, Jun-Li Yang*, Yan-Ping Shi*. UPLC-MS/MS Analysis for Antioxidant Components of Lycii Fructus based on Spectrum-effect Relationship. Talanta, 2018, 180, 389-395.

12.    Lei-Lei Liu, Thi Kim Quy Ha, Wei Ha, Won Keun Oh, Jun-Li Yang*, Yan-Ping Shi*. Sesquiterpenoids with Various Carbocyclic Skeletons from the Flowers of Chrysanthemum indicum. Journal of Natural Products, 2017, 80 (2), 298–307.

13.    Junli Yang, Pei Wang, Wenbin Wu, Yantao Zhao, Emmanuel Idehen, Shengmin Sang*. Steroidal Saponins in Oat Bran. Journal of Agricultural and Food Chemistry, 2016, 64(7), 1549-1556.

14.    Jun-Li Yang, Thi Kim Quy Ha, Basanta Dhodary, Kuk-Hwa Kim, Junsoo Park, Chul-Ho Lee, Young-Choong Kim, Won Keun Oh*. Dammarane Triterpenes as Potential SIRT1 Activators from the Leaves of Panax Ginseng. Journal of Natural Products, 2014, 77(7), 1615-1623.

15.    Jun-Li Yang, Yan-Ping Shi*. Cycloartane-type Triterpenoids and Sesquiterpenoids from the Resinous Eudates of Commiphora opobalsamum. Phytochemistry, 2012, 76, 124-132.

16.    Jun-Li Yang, Thi Kim Quy Ha, Basanta Dhodary, Euisun Pyo, Ngoc Hieu Nguyen, Hyomoon Cho, Eunhee Kim, Won Keun Oh*. Oleanane Triterpenes from the Flowers of Camellia japonica Inhibit Porcine Epidemic Diarrhea Virus (PEDV) Replication. Journal of Medicinal Chemistry, 2015, 58(3), 1268-1280.

发表论文
(1) Dammarane-type Saponins from Gynostemma pentaphyllum and Their Potential anti-AD Activity, Phytochemistry Letters, 2019, 通讯作者
(2) Advances in Screening Enzyme Inhibitors by Capillary Electrophoresis, Electrophoresis, 2019, 通讯作者
(3) Further sesquiterpenoids from the rhizomes of Homalomena occulta and their anti-inflammatory activity, Bioorganic & Medicinal Chemistry Letters, 2019, 第 1 作者
(4) Two New Eudesmane Sesquiterpenoids from the Flowers of Chrysanthemum indicum, Natural Products and Bioprospecting, 2019, 第 1 作者
(5) Ratiometric Target-Triggered Fluorescence Silicon Nanoparticles Probe for Quantitative Visulization of Tyrosinase Activity, Talanta, 2019, 通讯作者
(6) Quality Evaluation of Six Bioactive Constituents in Goji Berry based on Capillary Electrophoresis Field Amplified Sample Stacking, Electrophoresis, 2018, 通讯作者
(7) Ultrasensitive Colorimetric Assay Melamine based on in situ Reduction to Formation of CQDs-Silver Nanocomposite, Sensors and Actuators B: Chemical, 2018, 通讯作者
(8) UPLC-MS/MS Analysis for Antioxidant Components of Lycii Fructus based on Spectrum-effect Relationship, Talanta, 2018, 通讯作者
(9) Highly Selective Colorimetric Detection of Putrescine in Fish Products Using O-Phthalaldehyde Derivatization Reaction, Food Chemistry, 2018, 通讯作者
(10) Optimization of a Decoction Process for an Herbal Formula Using a Response Surface Methodology, Journal of AOAC International, 2017, 第 2 作者
(11) Anthraquinones from Morinda longissima and Their Insulin Mimetic Activities via AMP-activated Protein Kinase (AMPK) Activation, Bioorganic & Medicinal Chemistry Letters, 2017, 第 5 作者
(12) Sesquiterpenoids with Various Carbocyclic Skeletons from the Flowers of Chrysanthemum indicum, Journal of Natural Products, 2017, 通讯作者
(13) Further New Gypenosides from Jiaogulan (Gynostemma pentaphyllum), Journal of Agricultural and Food Chemistry, 2017, 通讯作者
(14) Zeolitic imidazolate framework 8 (ZIF-8) reinforced macroporous resin D101 for selective solid-phase extraction of 1-naphthol and 2-naphthol from phenol compounds, Electrophoresis, 2017, 通讯作者
(15) Antiviral escin derivatives from the seeds of Aesculus turbinata Blume (Japanese horse chestnut), Bioorganic & Medicinal Chemistry Letters, 2017, 第 6 作者
(16) Avenacosides: Metabolism, and potential use as exposure biomarkers of oat intake, Molecular Nutrition & Food Research, 2017, 第 2 作者
(17) Chemical constituents from Ligularia purdomii (Turrill) Chittenden, Biochemical Systematics and Ecology, 2017, 第 3 作者
(18) Efficient synthesis of camptothecin propargylamine derivatives in water catalyzed by macroporous adsorption resin-supported gold nanoparticles, Green Chemistry, 2017, 第 5 作者
(19) Kinetics and inhibition study of tyrosinase by pressure mediated microanalysis, Analytical Biochemistry, 2017, 第 2 作者
(20) Separation of antioxidant and α-glucosidase inhibitory flavonoids from the aerial parts of Asterothamnus centrali-asiaticus, Natural Product Research, 2017, 第 3 作者
(21) Optimization of ultrasonic cell grinder extraction of anthocyanins from blueberry using response surface methodology, Ultrasonics Sonochemistry, 2016, 通讯作者
(22) New sesquiterpene polyol esters from the root barks of Pseudolarix kaempferi, Phytochemistry Letters, 2016, 通讯作者
(23) Steroidal Saponins in Oat Bran, Journal of Agricultural and Food Chemistry, 2016, 第 1 作者
(24) 3, 4-seco-28-Noroleanane Triterpenes from Camellia japonica Protect from Neurotoxicity in a Rotenone Model of Parkinson’s Disease, Tetrahedron, 2016, 第 1 作者
(25) Three new coumarins from Saposhnikovia divaricata and their porcine epidemic diarrhea virus (PEDV) inhibitory activity, Tetrahedron, 2016, 第 1 作者
(26) Oleanane Triterpenes from the Flowers of Camellia japonica Inhibit Porcine Epidemic Diarrhea Virus (PEDV) Replication, Journal of Medicinal Chemistry, 2015, 第 1 作者
(27) Dammarane Triterpenes as Potential SIRT1 Activators from the Leaves of Panax Ginseng, Journal of Natural Products, 2014, 第 1 作者

科研活动

1.     国家重点研发计划基于中伊传统草药的抗AD药物候选化合物研究(主持,2018YFE0182500

2.    中国科学院率先行动****人才项目:植物源活性天然产物的快速发现与应用(主持)

3.    国家自然科学基金面上项目基于超滤质谱和超低温探头NMR技术的三种花椒属植物中SIRT1抑制剂的快速发现及其抗肿瘤活性研究 主持,81673325


科研项目
( 1 ) 中国科学院率先行动“****”项目, 主持, 部委级, 2015-11--2018-12
( 2 ) 基于超滤质谱和超低温探头NMR技术的三种花椒属植物中SIRT1抑制剂的快速发现及其抗肿瘤活性研究, 主持, 国家级, 2017-01--2020-12
( 3 ) "一带一路”民族药研发与产业化合作, 参与, 部委级, 2016-01--2020-12
( 4 ) 中韩药用植物抗衰老活性分子研究, 主持, 国家级, 2017-07--2019-06
( 5 ) 甘肃花椒活性成分发现与宏量制备关键技术一带一路国际科技合作研究, 参与, 省级, 2018-07--2020-06
( 6 ) 中科院2019年度特别交流计划项目“中亚植物药研究(A类)”, 主持, 部委级, 2019-01--2020-12
( 7 ) 基于西北特色植物资源的改善认知损伤的药物筛选与评价, 主持, 研究所(学校), 2019-01--2021-12
参与会议
(1)Bioactive Natural Compounds from Plants in Northwestern China   天然药物活性成分结构与功能国际研讨会   2019-06-06
(2)中药萜类化学成分发现与活性评价   中国化学会第十届全国有机化学学术会议   杨军丽   2017-12-19
(3)Chemical Constitutes and Biological Activities of TCMs   第十二届天然化合物化学国际研讨会   2017-09-06
(4)Chemical Constitutes and Biological Activities on TCMs    第五届可食和药用植物资源及功能成分国际学术研讨会   2016-11-04
(5)Bioactive Natural Products from Medicinal Plants   天然产物分离分析新技术国际学术研讨会   2016-11-04
(6)植物源天然化合物的发现与生物活性研究   中国化学会第十一届全国天然有机化学学术会议   2016-09-25

指导学生

已指导学生

祁轩  硕士研究生  070303-有机化学  

王君  博士研究生  070302-分析化学  

现指导学生

李彩虹  硕士研究生  070302-分析化学  

马丽梅  硕士研究生  070302-分析化学  

陶璐瑶  硕士研究生  085235-制药工程  

丁玉竹  博士研究生  070302-分析化学  

马丽  硕士研究生  070302-分析化学  

王凯  博士研究生  070302-分析化学  

张瑛  博士研究生  070302-分析化学