抗微生物耐药与治疗；新型抗菌分子发现与改造；噬菌体与宿主免疫；

071005-微生物学

抗微生物耐药与治疗
新型抗菌分子发现与改造
噬菌体与宿主免疫

2010-09--2013-06   中国科学院武汉病毒研究所   博士
2007-09--2010-06   华中农业大学   硕士
2003-09--2007-06   武汉轻工大学   学士

   

2021-10~现在, 中国科学院武汉病毒研究所, 研究员
2018-04~2019-04,马里兰大学帕克分校, 访问学者
2018-01~2021-10,中国科学院武汉病毒研究所, 青年研究员
2015-08~2017-12,中国科学院武汉病毒研究所, 副研究员
2013-07~2015-08,中国科学院武汉病毒研究所, 助理研究员

2016-06-29-今,中国生物工程学会噬菌体技术专业委员会, 委员

微生物学前沿

   

（1） 武汉市青年科技朝阳计划, 市地级, 2016
（2） 武汉市黄鹤英才（科技）计划, 专项, 2016
（3） 第四届中国科学院水生生物研究所“青年科学家”论坛奖, 三等奖, 研究所（学校）, 2013
（4） 湖北省优秀硕士学位论文, 省级, 2012
（5） 保罗生物科技奖优秀学生特别奖, 特等奖, 院级, 2012

[1] 危宏平, 杨航, 李唱唱, 余军平, 蒋梦薇. 一种具有广谱裂解活性的抗菌肽P104、裂解酶LysP53及其应用. CN: CN113549610A, 2021-10-26.

[2] 位灯国, 杨航, 罗德华, 危宏平, 刘思思, 余军平, 沈薇, 李小红, 高超, 洪伟. 卟啉类化合物在制备抗冠状病毒药物中的应用. CN: CN112315959A, 2021-02-05.

[3] 危宏平, 李小红, 杨航. 一种葡萄球菌裂解酶及其保存方法和应用. CN: CN110117587A, 2019-08-13.

[4] 危宏平, 李小红, 杨航. V12CBD蛋白的新用途及含V12CBD蛋白的金黄色葡萄球菌疫苗. CN: CN109999193A, 2019-07-12.

[5] 危宏平, 杨航. 一种高效肺炎链球菌嵌合裂解酶及其突变体与应用. CN: CN108823193A, 2018-11-16.

[6] 危宏平, 杨航. V12CBD蛋白及其编码基因的一种新用途. CN: CN107670023A, 2018-02-09.

[7] 危宏平, 滕铁山, 杨航, 余军平. 一株能够产生细菌素的分散泛菌及其筛选方法和应用. CN: CN104531572A, 2015-04-22.

[8] 危宏平, 胡伟, 杨航, 余军平. 基于金黄色葡萄球菌的生物探针、制备方法及其应用. CN: CN104198737A, 2014-12-10.

[9] 危宏平, 杨航, 张云, 余军平, 张先恩. 一种杀灭葡萄球菌的裂解酶及其应用. CN: CN103122347A, 2013-05-29.

[10] 危宏平, 杨航, 王殿冰, 张先恩. 识别炭疽芽胞杆菌芽孢的多肽序列及其应用. CN: CN102586214A, 2012-07-18.

   

（1） Calcium-binding motif-mediated binding of redundant calcium offers a chimeolysin enhanced bactericidal activity and extended host range under physiological conditions, JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2023, 通讯作者
（2） Design, Synthesis, and Biological Evaluation of Peptidomimetic Aldehydes as Broad-Spectrum Inhibitors against Enterovirus and SARS-CoV-2, JOURNAL OF MEDICINAL CHEMISTRY, 2022, 第 4 作者
（3） Effects of simeprevir on the replication of SARS-CoV-2 in vitro and in transgenic hACE2 mice, INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2022, 通讯作者
（4） Natural triterpenoids from licorice potently inhibit SARS-CoV-2 infection, JOURNAL OF ADVANCED RESEARCH, 2022, 通讯作者
（5） Schaftoside inhibits 3CL^(pro)and PL^(pro)of SARS-CoV-2 virus and regulates immune response and inflammation of host cells for the treatment of COVID-19, Schaftoside inhibits 3CLpro and PLpro of SARS-CoV-2 virus and regulates immune response and inflammation of host cells for the treatment of COVID-19, ACTA PHARMACEUTICA SINICA B, 2022, 通讯作者
（6） Enriched Opportunistic Pathogens Revealed by Metagenomic Sequencing Hint Potential Linkages between Pharyngeal Microbiota and COVID-19, Enriched Opportunistic Pathogens Revealed by Metagenomic Sequencing Hint Potential Linkages between Pharyngeal Microbiota and COVID-19, VIROLOGICA SINICA, 2021, 第 6 作者
（7） A Novel Acinetobacter baumannii Bacteriophage Endolysin LysAB54 With High Antibacterial Activity Against Multiple Gram-Negative Microbes, FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 2021, 通讯作者
（8） Internal cell-penetrating peptide-mediated internalization enables a chimeric lysin to target intracellular pathogens, INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2021, 第 1 作者
（9） Intrinsic Antimicrobial Peptide Facilitates a New Broad-Spectrum Lysin LysP53 to Kill Acinetobacter baumannii In Vitro and in a Mouse Burn Infection Model, ACS INFECTIOUS DISEASES, 2021, 通讯作者
（10） Encapsulation and Delivery of Therapeutic Phages, APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2021, 第 5 作者
（11） Genetic Polymorphism Drives Susceptibility Between Bacteria and Bacteriophages, FRONTIERS IN MICROBIOLOGY, 2021, 第 4 作者
（12） A Highly Active Chimeric Lysin with a Calcium-Enhanced Bactericidal Activity against Staphylococcus aureus In Vitro and In Vivo, ANTIBIOTICS-BASEL, 2021, 通讯作者
（13） Linker Editing of Pneumococcal Lysin ClyJ Conveys Improved Bactericidal Activity, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2020, 通讯作者
（14） Construction and characterization of a chimeric lysin ClyV with improved bactericidal activity against Streptococcus agalactiae in vitro and in vivo, APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2020, 通讯作者
（15） Can bacteriophage endolysins be nebulised for inhalation delivery against Streptococcus pneumoniae?, INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2020, 第 5 作者
（16） A Choline-Recognizing Monomeric Lysin, ClyJ-3m, Shows Elevated Activity against Streptococcus pneumoniae, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2020, 通讯作者
（17） A Novel Double Core-Shell Bionanoparticle Formed by Ferritin and Baculoviral Polyhedrin, JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, 2019, 第 2 作者
（18） Construction of Lentivirus-Based Reference Material for RT-PCR Detection of Middle East Respiratory Syndrome Coronavirus and Its Application in External Quality Assessment, JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, 2019, 第 5 作者
（19） ClyJ Is a Novel Pneumococcal Chimeric Lysin with a Cysteine- and Histidine-Dependent Amidohydrolase/Peptidase Catalytic Domain, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2019, 第 1 作者
（20） Activity of the Chimeric Lysin ClyR against Common Gram-Positive Oral Microbes and Its Anticaries Efficacy in Rat Models, VIRUSES, 2018, 第 2 作者
（21） Activity of the chimeric lysin clyr against common gram-positive oral microbes and its anticaries efficacy in rat models, VIRUSES-BASEL, 2018, 第 2 作者
（22） Effects of a Chimeric Lysin against Planktonic and Sessile Enterococcus faecalis Hint at Potential Application in Endodontic Therapy, VIRUSES-BASEL, 2018, 通讯作者
（23） Effects of a Chimeric Lysin against Planktonic and Sessile Enterococcus faecalis Hint at Potential Application in Endodontic Therapy, VIRUSES, 2018, 第 2 作者
（24） Staphylococcus aureus virulence attenuation and immune clearance mediated by a phage lysin‐derived protein, EMBO JOURNAL, 2018, 第 1 作者
（25） Parallel susceptibility testing of bacteria through culture-quantitative pcr in 96-well plates, INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 2018, 第 3 作者
（26） Accurate Detection of Methicillin-Resistant Staphylococcus aureus in Mixtures by Use of Single-Bacterium Duplex Droplet Digital PCR, JOURNAL OF CLINICAL MICROBIOLOGY, 2017, 第 3 作者
（27） Rapid and selective detection of E. coli O157:H7 combining phagomagnetic separation with enzymatic colorimetry, FOOD CHEMISTRY, 2017, 第 3 作者
（28） Combining phagomagnetic separation with immunoassay for specific, fast and sensitive detection of Staphylococcus aureus, TALANTA, 2017, 第 3 作者
（29） A novel chimeric lysin with robust antibacterial activity against planktonic and biofilm methicillin-resistant Staphylococcus aureus, SCIENTIFIC REPORTS, 2017, 第 1 作者
（30） Antibiofilm Activities of a Novel Chimeolysin against Streptococcus mutans under Physiological and Cariogenic Conditions, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2016, 第 1 作者
（31） Comparison between a chimeric lysin ClyH and other enzymes for extracting DNA to detect methicillin resistant Staphylococcus aureus by quantitative PCR, WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY, 2016, 第 2 作者
（32） Sensitive and rapid detection of staphylococcus aureus in milk via cell binding domain of lysin, BIOSENSORS AND BIOELECTRONICS, 2016, 第 5 作者
（33） Rapid detection of viral antibodies based on multifunctional Staphylococcus aureus nanobioprobes, ENZYME AND MICROBIAL TECHNOLOGY, 2016, 第 4 作者
（34） Sensitive and rapid detection of staphylococcus aureus in milk via cell binding domain of lysin, BIOSENSORS & BIOELECTRONICS, 2016, 第 5 作者
（35） Rapid and sensitive detection of hiv-1 p24 antigen by immunomagnetic separation coupled with catalytic fluorescent immunoassay, ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2016, 第 2 作者
（36） Anti-biofilm activities of a novel chimeolysin against S. mutans in physiological and cariogenic conditions, Antimicrob Agents Chemother, 2016, 第 1 作者
（37） Molecular dissection of phage lysin PlySs2: integrity of the catalytic and cell wall binding domains is essential for its broad lytic activity, VIROLOGICA SINICA, 2015, 第 2 作者
（38） Study of the interactions between endolysin and bacterial peptidoglycan on S. aureus by dynamic force spectroscopy, NANOSCALE, 2015, 第 3 作者
（39） 裂解酶治疗的研究进展与应用前景, Research progress in lysin therapy, 微生物学通报, 2015, 第 1 作者
（40） Molecular dissection of phage lysin PlySs2: integrity of the catalytic and cell wall binding domains is essential for its broad lytic activity, Molecular dissection of phage lysin PlySs2: integrity of the catalytic and cell wall binding domains is essential for its broad lytic activity, 中国病毒学：英文版, 2015, 第 2 作者
（41） Isolation and complete genome sequence of a novel virulent mycobacteriophage, CASbig, Isolation and complete genome sequence of a novel virulent mycobacteriophage, CASbig, 中国病毒学：英文版, 2015, 第 3 作者
（42） Construction of a chimeric lysin Ply187N-V12C with extended lytic activity against staphylococci and streptococci, MICROBIAL BIOTECHNOLOGY, 2015, 第 3 作者
（43） Aspartate inhibits Staphylococcus aureus biofilm formation, FEMS MICROBIOLOGY LETTERS, 2015, 第 1 作者
（44） Antibacterial Activity of a Novel Peptide-Modified Lysin Against Acinetobacter baumannii and Pseudomonas aeruginosa, FRONTIERS IN MICROBIOLOGY, 2015, 第 1 作者
（45） Isolation and complete genome sequence of a novel virulent mycobacteriophage, CASbig, VIROLOGICA SINICA, 2015, 第 3 作者
（46） Simple and rapid preparation of red fluorescence and red color S. aureus derived nanobioparticles for pathogen detection, JOURNAL OF MICROBIOLOGICAL METHODS, 2015, 第 3 作者
（47） A chimeolysin with extended-spectrum streptococcal host range found by an induced lysis-based rapid screening method, SCIENTIFIC REPORTS, 2015, 第 1 作者
（48） PCR-Based In Vitro Synthesis of Hepatitis C Virus NS3 Protease for Rapid Phenotypic Resistance Testing of Protease Inhibitors, JOURNAL OF CLINICAL MICROBIOLOGY, 2014, 第 3 作者
（49） Engineered bacteriophage lysins as novel anti-infectives, FRONTIERS IN MICROBIOLOGY, 2014, 第 1 作者
（50） Degradation of methicillin-resistant Staphylococcus aureus biofilms using a chimeric lysin, BIOFOULING, 2014, 第 1 作者
（51） Novel Chimeric Lysin with High-Level Antimicrobial Activity against Methicillin-Resistant Staphylococcus aureus In Vitro and In Vivo, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2014, 第 1 作者
（52） Existence of Separate Domains in Lysin PlyG for Recognizing Bacillus anthracis Spores and Vegetative Cells, ANTIMICROBIALAGENTSANDCHEMOTHERAPY, 2012, 第 1 作者
（53） Detection of Escherichia coli Enoyl-ACP Reductase Using Biarsenical-Tetracysteine Motif, BIOCONJUGATECHEMISTRY, 2010, 第 1 作者

   

（ 1 ） 高效筛选嵌合裂解酶的平台及其应用, 参与, 国家任务, 2016-01--2019-12
（ 2 ） 噬菌体裂解酶细胞壁结合域抑制金黄色葡萄球菌生物膜形成的机理与应用, 负责人, 国家任务, 2015-01--2017-12
（ 3 ） 噬菌体裂解酶治疗奶牛乳腺炎的研究, 参与, 研究所自选, 2014-01--2015-12
（ 4 ） 噬菌体裂解酶的理性设计与改造, 参与, 国家任务, 2012-01--2016-12
（ 5 ） 杀多菌广谱裂解酶的结构基础与作用机制研究, 负责人, 国家任务, 2018-01--2021-12
（ 6 ） 中国科学院青年创新促进会, 负责人, 中国科学院计划, 2018-01--2021-12
（ 7 ） 武汉市黄鹤英才科技计划, 负责人, 地方任务, 2017-01--2019-12
（ 8 ） 噬菌体裂解酶细胞壁结合域V12CBD竞争结合自溶素的识别底物免疫保护金黄色葡萄球菌感染的分子机制, 负责人, 国家任务, 2021-01--2024-12
（ 9 ） ShaCoVacc mRNA疫苗在转基因小鼠上对新冠病毒的保护效果评价, 负责人, 企业委托, 2021-05--2021-12
（ 10 ） Rhodomyrtone抗SARS-CoV-2作用机制及构效关系研究, 负责人, 国家任务, 2021-01--2024-12
（ 11 ） 噬菌体“暗物质”与哺乳动物宿主免疫互作的分子机制研究, 负责人, 国家任务, 2022-01--2024-12

（1）Challenge antimicrobial resistance: from lysin therapy to lysin immunity   第四届国际噬菌体研讨会   2020-11-09
（2）Facing antimicrobial resistance: from phage therapy to lysin therapy   2019年川鄂微生物学学术年会   2019-08-26
（3）Using bacteriophage lysin as non-traditional therapeutic to combat bacterial infection   第十四届（2019）生物毒素毒理学术大会暨第一届生物毒素-从生存适应到转化医学专题学术会议   2019-08-16
（4）Bacteriophage lysin as non-traditional therapeutic   中国科学院青年创新促进会第一届《青年生命科学论坛》   2019-07-12
（5）Designing of chimeric lysins as non-traditional therapeutics against bacterial infections   青年科学家论坛病原微生物与生物安全   2019-06-20
（6）Designing of chimeric lysins as non-traditional therapeutics against Streptococcal infections   细菌感染与宿主免疫   2019-04-08
（7）Designing and engineering of chimeric lysins specific for Streptococcus pneumoniae   第二届裂解酶国际会议   2018-11-16
（8） Intervention of the cell-wall binding domain of a bacteriophage lysin in Staphylococcus aureus biofilm formation   第一届噬菌体裂解酶国际学术研讨会   2016-11-17
（9）Engineered bacteriophage lysins as novel anti-infectives   第一届噬菌体国际学术研讨会（南京2014）   Hang Yang, Jing Wang, Junping Yu, Hongping Wei   2014-11-17
（10）Chimeolysin as novel anti-infectives   2014年鄂湘微生物学基础与应用学术研讨会   Hang Yang, Jing Wang, Junping Yu, Hongping Wei   2014-10-17

已指导学生

李小红  硕士研究生  085238-生物工程  

王淑娟  硕士研究生  071005-微生物学  

周万里  硕士研究生  085238-生物工程  

王冠华  硕士研究生  085238-生物工程  

现指导学生

王奕尧  硕士研究生  071005-微生物学  

呼岳锋  硕士研究生  086000-生物与医药  

薛恒  博士研究生  071005-微生物学