神经退行性疾病生物技术药物、病原体亚单位疫苗等

   

081703-生物化工

神经退行性疾病生物技术药物

2008-08--2013-07   北京协和医学院   博士
2004-09--2008-07   首都师范大学   学士

研究生

博士

   

2017-07~现在, 中国科学院过程工程研究所, 副研究员
2013-08~2017-07,中国科学院过程工程研究所, 助理研究员

   

[1] 刘瑞田, 卢帅, 谢喜秀. 新型冠状病毒抗原表位及其应用. CN: CN111848753B, 2022-03-15.

[2] 刘瑞田, 季梅, 谢喜秀. 一种重组蛋白及其制备方法和应用. CN: CN108314737B, 2021-03-16.

[3] 刘瑞田, 季梅, 谢喜秀. 疫苗通用载体及其制备方法和应用. CN: CN112062862A, 2020-12-11.

[4] 刘瑞田, 黄亚茹, 谢喜秀. 一种天然α-syn寡聚体抗体的制备方法及其产品和应用. CN: CN109293770A, 2019-02-01.

[5] 宋佃卫, 谢喜秀, 马山, 刘瑞田, 菅长永, 朱孟沼, 席智赢, 刘坤, 范克明. 一种Aβ寡聚体抗体的制备工艺. CN: CN106519029A, 2017-03-22.

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[1] Ya-ru Huang, Xi-xiu Xie, Jing Yang, Xiao-ying Sun, Xiao-yun Niu, Cheng-gang Yang, ling-jie Li, Lun Zhang, Dan Wang, Chun-yu Liu, Sheng-jie Hou, Chen-yang Jiang, Yu-ming Xu, Rui-tian Liu. ArhGAP11A mediates amyloid-b generation and neuropathology in an Alzheimer’s disease-like mouse model. Cell Reports[J]. 2023, 42(112624): [2] Lu, Shuai, Xie, Xixiu, Zhao, Lei, Wang, Bin, Zhu, Jie, Yang, Tingrui, Yang, Guangwen, Ji, Mei, Lv, Cuiping, Xue, Jian, Dai, Erhei, Fu, Ximing, Liu, Dongqun, Zhang, Lun, Hou, Shengjie, Yu, Xiaolin, Wang, Yuling, Gao, Huixia, Shi, Xuehan, Ke, Changwen, Ke, Bixia, Jiang, Chunguo, Liu, Ruitian. The immunodominant and neutralization linear epitopes for SARS-CoV-2. CELL REPORTS[J]. 2021, 34(4): 108666-108666, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7837128/.
[3] Ji, Mei, Xie, Xixiu, Liu, Dongqun, Lu, Shuai, Zhang, Lingxiao, Huang, Yaru, Liu, Ruitian. Engineered hepatitis B core virus-like particle carrier for precise and personalized Alzheimer's disease vaccine preparation via fixed-point coupling. APPLIED MATERIALS TODAY[J]. 2020, 19: http://dx.doi.org/10.1016/j.apmt.2020.100575.
[4] Xiaoyu Du, Xixiu Xie, Ruitian Liu. The Role of α-Synuclein Oligomers in Parkinson’s Disease. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES[J]. 2020, 21(22): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7697105/.
[5] Ji, Mei, Zhu, Jie, Xie, Xixiu, Liu, Dongqun, Wang, Bin, Yu, Zhuo, Liu, Ruitian. A novel rapid modularized hepatitis B core virus-like particle-based platform for personalized cancer vaccine preparation via fixed-point coupling. NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE[J]. 2020, 28: http://dx.doi.org/10.1016/j.nano.2020.102223.
[6] Du, Xiaoyu, Xie, Xixiu, Liu, Ruitian. The Role of alpha-Synuclein Oligomers in Parkinson's Disease. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES[J]. 2020, 21(22): https://www.webofscience.com/wos/woscc/full-record/WOS:000594886400001.
[7] Huang, Yaru, Xie, Xixiu, Ji, Mei, Yu, Xiaolin, Zhu, Jie, Zhang, Lingxiao, Liu, Xiaoge, Wei, Chen, Li, Gang, Liu, Ruitian. Naturally occurring autoantibodies against alpha-synuclein rescues memory and motor deficits and attenuates alpha-synuclein pathology in mouse model of Parkinson's disease. NEUROBIOLOGY OF DISEASE[J]. 2019, 124: 202-217, http://ir.ipe.ac.cn/handle/122111/28086.
[8] Zhang, Lingxiao, Xie, Xixiu, Liu, Dongqun, Xu, Zhi Ping, Liu, Ruitian. Efficient co-delivery of neo-epitopes using dispersion-stable layered double hydroxide nanoparticles for enhanced melanoma immunotherapy. BIOMATERIALS[J]. 2018, 174: 54-66, http://dx.doi.org/10.1016/j.biomaterials.2018.05.015.
[9] Ji, Mei, Xie, Xixiu, Liu, Dongqun, Yu, Xiaolin, Zhang, Yue, Zhang, Lingxiao, Wang, Shaowei, Huang, Yaru, Liu, Ruitian. Hepatitis B core VLP-based mis-disordered tau vaccine elicits strong immune response and alleviates cognitive deficits and neuropathology progression in Tau. P301S mouse model of Alzheimer's disease and frontotemporal dementia. ALZHEIMERS RESEARCH & THERAPY[J]. 2018, 10(1): http://ir.ipe.ac.cn/handle/122111/26690.
[10] 马仕坤, 关剑, 王丹, 甄宏楠, 谢喜秀. 融合表达白细胞介素10与卵清蛋白重组腺病毒口服变应原疫苗的构建及鉴定. 中华临床免疫和变态反应杂志[J]. 2018, 12(3): 263-269, http://lib.cqvip.com/Qikan/Article/Detail?id=675957581.
[11] Shaowei Wang, Dongqun Liu, Lingxiao Zhang, Mei Ji, Yangxin Zhang, Quanxiu Dong, Shuying Liu, Xixiu Xie, Ruitian Liu. A vaccine with Aβ oligomer-specific mimotope attenuates cognitive deficits and brain pathologies in transgenic mice with Alzheimer’s disease. ALZHEIMER’S RESEARCH & THERAPY[J]. 2017, 9(1): 1-14, http://dx.doi.org/10.1186/s13195-017-0267-5.
[12] Zhang, Lingxiao, Liu, Dongqun, Wang, Shaowei, Yu, Xiaolin, Ji, Mei, Xie, Xixiu, Liu, Shuying, Liu, Ruitian. MgAl-layered double hydroxide nanoparticles co-delivering siIDO and Trp2 peptide effectively reduce IDO expression and induce cytotoxic T-lymphocyte responses against melanoma tumor in mice. JOURNAL OF MATERIALS CHEMISTRY B[J]. 2017, 5(31): 6266-6276, http://www.irgrid.ac.cn/handle/1471x/1763716.
[13] Wang, Teng, Xie, Xixiu, Ji, Mei, Wang, Shaowei, Zha, Jun, Zhou, Weiwei, Yu, Xiaolin, Wei, Chen, Ma, Shan, Xi, Zhiying, Pang, Guangli, Liu, Ruitian. Naturally occurring autoantibodies against A beta oligomers exhibited more beneficial effects in the treatment of mouse model of Alzheimer's disease than intravenous immunoglobulin. NEUROPHARMACOLOGY[J]. 2016, 105(JUNE): 561-576, http://dx.doi.org/10.1016/j.neuropharm.2016.02.015.
[14] 王腾, 季梅, 谢喜秀, 汪维云. 天然Aβ寡聚体抗体的制备研究. 四川大学学报：自然科学版[J]. 2016, 53(3): 652-656, http://lib.cqvip.com/Qikan/Article/Detail?id=668829971.
[15] Zhou, Weiwei, Lu, Shuai, Su, Yajing, Xue, Di, Yu, Xiaolin, Wang, Shaowei, Zhang, He, Xu, Pengxin, Xie, Xixiu, Liu, Ruitian. Decreasing oxidative stress and neuroinflammation with a multifunctional peptide rescues memory deficits in mice with Alzheimer disease. FREE RADICAL BIOLOGY AND MEDICINE[J]. 2014, 74(SEP.): 50-63, http://dx.doi.org/10.1016/j.freeradbiomed.2014.06.013.
[16] Xie, Xixiu, Liu, Yanchun, Zhang, Ting, Xu, Yanying, Bao, Qifeng, Chen, Xue, Liu, Hongyang, Xu, Xuemei. Human papillomavirus type 58 L1 virus-like particles purified by two-step chromatography elicit high levels of long-lasting neutralizing antibodies. ARCHIVES OF VIROLOGY[J]. 2013, 158(1): 193-199, https://www.webofscience.com/wos/woscc/full-record/WOS:000313294200022.

   

（ 1 ） 温敏凝胶作为EV71手足口病疫苗佐剂的研究, 主持, 国家级, 2014-01--2017-12
（ 2 ） 治疗APOE-e4型阿尔茨海默病的特异识别A淀粉样蛋白寡聚体抗体的临床前研究, 参与, 部委级, 2017-01--2019-12
（ 3 ） 应用天然A寡聚体抗体治疗老年性痴呆的临床研究, 参与, 国家级, 2015-01--2018-12