药物化学，有机合成

   

100701-药物化学

小分子药物，抗肿瘤，抗病毒，有机合成方法学

2012-09--2017-07   中国科学院上海药物研究所   博士
2008-09--2012-06   四川大学   学士

   

2018-06~2021-02,Baylor College of Medicine, 博士后
2017-08~2018-06,H. Lee Moffitt Cancer Center and Research Institute, 博士后

   

[1] Xiaowei Wu, Mengdi Dai, Rongrong Cui, Yulan Wang, Chunpu Li, Xia Peng, Jihui Zhao, Bao Wang, Yang Dai, Dan Feng, Tianbiao Yang, Hualiang Jiang, Meiyu Geng, Jing Ai, Mingyue Zheng, Hong Liu. Design, synthesis and biological evaluation of pyrazolo3,4-dpyridazinone derivatives as covalent FGFR inhibitors. ACTA PHARMACEUTICA SINICA B[J]. 2021, 11(3): 781-794, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7982429/.
[2] Zhao, Fei, Gong, Xin, Lu, Yangbin, Qiao, Jin, Jia, Xiuwen, Ni, Hangcheng, Wu, Xiaowei, Zhang, Xiaoning. Additive-Controlled Divergent Synthesis of Tetrasubstituted 1,3-Enynes and Alkynylated 3H-Pyrrolo1,2-aindol-3-ones via Rhodium Catalysis. ORGANIC LETTERS[J]. 2021, 23(3): 727-733, http://dx.doi.org/10.1021/acs.orglett.0c03950.
[3] Wu Xiaowei. Design, Synthesis and pharmacological evaluation of pyrazolo[3,4-d]pyridazinone derivatives as covalent FGFR inhibitors. Acta Pharmaceutica Sinica B. 2021, [4] Wu, Xiaowei, Lu, Yangbin, Qiao, Jin, Dai, Wenhao, Jia, Xiuwen, Ni, Hangcheng, Zhang, Xiaoning, Liu, Hong, Zhao, Fei. Rhodium(III)-Catalyzed C-H Alkenylation/Directing Group Migration for the Regio- and Stereoselective Synthesis of Tetrasubstituted Alkenes. ORGANIC LETTERS[J]. 2020, 22(23): 9163-9168, https://www.webofscience.com/wos/woscc/full-record/WOS:000598141000004.
[5] Xiaowei Wu, Haitao Ji. Ruthenium-Catalyzed C–H Allylation of Alkenes with Allyl Alcohols via C–H Bond Activation in Aqueous Solution. THE JOURNAL OF ORGANIC CHEMISTRY. 2020, 83(19): 12094-12102, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7771258/.
[6] Wu Xiaowei. Synthesis of Indole-Fused Polyheterocycles via Rh(III)-Catalyzed Regioselective [4+2] Annulation/Lactonization of Indoles with 4-Hydroxy-2-Alkynoates. Advanced Synthesis & Catalysis. 2020, [7] Wang, Yulan, Dai, Yang, Wu, Xiaowei, Li, Fei, Liu, Bo, Li, Chunpu, Liu, Qiufeng, Zhou, Yuanyang, Wang, Bao, Zhu, Mingrui, Cui, Rongrong, Tan, Xiaoqin, Xiong, Zhaoping, Liu, Jia, Tan, Minjia, Xu, Yechun, Geng, Meiyu, Jiang, Hualiang, Liu, Hong, Ai, Jing, Zheng, Mingyue. Discovery and Development of a Series of Pyrazolo3,4-dpyridazinone Compounds as the Novel Covalent Fibroblast Growth Factor Receptor Inhibitors by the Rational Drug Design. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2019, 62(16): 7473-7488, http://dx.doi.org/10.1021/acs.jmedchem.9b00510.
[8] Wu Xiaowei. The Discovery and Development of a Series of Pyrazolo[3,4-d]pyridazinone Compounds as Novel Covalent FGFR Inhibitors by Rational Drug Design. Journal of Medicinal Chemistry. 2019, [9] Dai, Wenhao, Wu, Xiaowei, Li, Chunpu, Zhang, Rui, Wang, Jiang, Liu, Hong. Regio-selective and stereo-selective hydrosilylation of internal alkynes catalyzed by ruthenium complexes. RSC ADVANCES[J]. 2018, 8(49): 28261-28265, https://www.webofscience.com/wos/woscc/full-record/WOS:000442078800065.
[10] Wu, Xiaowei, Ji, Haitao. Rhodium(III)-catalyzed C-H allylation of indoles with allyl alcohols via beta-hydroxide elimination. ORGANIC & BIOMOLECULAR CHEMISTRY[J]. 2018, 16(31): 5691-5698, https://www.webofscience.com/wos/woscc/full-record/WOS:000441028200018.
[11] 吴小伟, 王江, 柳红. 先导化合物结构优化策略（六）——改善化合物血浆稳定性. 药学学报[J]. 2018, 53(2): 192-, http://lib.cqvip.com/Qikan/Article/Detail?id=674406146.
[12] Wu, Xiaowei, Ji, Haitao. Ruthenium(II)-Catalyzed Regio- and Stereoselective C-H Allylation of Indoles with Allyl Alcohols. ORGANIC LETTERS[J]. 2018, 20(8): 2224-2227, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7771326/.
[13] Wu Xiaowei. Rhodium-Catalyzed [4 + 1] Cyclization via C-H Activation for Divergent Heterocycle Bearing a Quaternary Carbon Synthesis. Journal of Organic Chemistry. 2018, [14] Wu Xiaowei. Propargyl alcohols as one-carbon synthons: redox-neutral Rh (III)-catalyzed C-H bond activation for the synthesis of isoindolinones bearing a quaternary carbon. Organic Letters. 2017, [15] Wu, Xiaowei, Wang, Bao, Zhou, Yu, Liu, Hong. Propargyl Alcohols as One-Carbon Synthons: Redox-Neutral Rhodium(III)-Catalyzed C-H Bond Activation for the Synthesis of Isoindolinones Bearing a Quaternary Carbon. ORGANIC LETTERS[J]. 2017, 19(6): 1294-1297, https://www.webofscience.com/wos/woscc/full-record/WOS:000397077400008.
[16] Wu, Xiaowei, Wang, Bao, Zhou, Shengbin, Zhou, Yu, Liu, Hong. Ruthenium-Catalyzed Redox-Neutral 4+1 Annulation of Benzamides and Propargyl Alcohols via C-H Bond Activation. ACS CATALYSIS[J]. 2017, 7(4): 2494-2499, https://www.webofscience.com/wos/woscc/full-record/WOS:000398986700030.
[17] Xie, Yanan, Wu, Xiaowei, Li, Chunpu, Wang, Jiang, Li, Jian, Liu, Hong. Ruthenium(II)-Catalyzed Redox-Neutral 3+2 Annulation of Indoles with Internal Alkynes via C-H Bond Activation: Accessing a Pyrroloindolone Scaffold. JOURNAL OF ORGANIC CHEMISTRY[J]. 2017, 82(10): 5263-5273, https://www.webofscience.com/wos/woscc/full-record/WOS:000402023200026.
[18] Wu, Xiaowei, Zhang, Dengyou, Zhou, Shengbin, Gao, Feng, Liu, Hong. Site-specific indolation of proline-based peptides via copper(II)-catalyzed oxidative coupling of tertiary amine N-oxides. CHEMICAL COMMUNICATIONS[J]. 2015, 51(63): 12571-12573, https://www.webofscience.com/wos/woscc/full-record/WOS:000358520200014.
[19] Yang, Wei, Li, Lixuan, Wang, Yulan, Wu, Xiaowei, Li, Tingting, Yang, Nan, Su, Mingbo, Sheng, Li, Zheng, Mingyue, Zang, Yi, Li, Jia, Liu, Hong. Design, synthesis and biological evaluation of isoquinoline-based derivatives as novel histone deacetylase inhibitors. BIOORGANIC & MEDICINAL CHEMISTRY[J]. 2015, 23(17): 5881-5890, http://dx.doi.org/10.1016/j.bmc.2015.06.071.
[20] Yang, Wei, Li, Lixuan, Ji, Xun, Wu, Xiaowei, Su, Mingbo, Sheng, Li, Zang, Yi, Li, Jia, Liu, Hong. Design, synthesis and biological evaluation of 4-anilinothieno2,3-dpyrimidine-based hydroxamic acid derivatives as novel histone deacetylase inhibitors. BIOORGANIC & MEDICINAL CHEMISTRY[J]. 2014, 22(21): 6146-6155, http://dx.doi.org/10.1016/j.bmc.2014.08.030.

   

（ 1 ） 小分子创新药物设计、合成及药理活性研究, 主持, 市地级, 2021-03--2026-03