基本信息
许执恒  男  博导  中国科学院遗传与发育生物学研究所
电子邮件: zhxu@genetics.ac.cn
通信地址: 北京市朝阳区北辰西路1号院-2
邮政编码: 100101

研究领域

利用本课题组在信号转导领域的优势,结合不同的模式动物,进行神经和肿瘤生物学研究,争取在阐明不同的重要疾病发生的分子机制方面有所突破。目前,我们的研究重点是JNK,NF?B和AKT信号通路, 这些信号通路与肿瘤、神经发育及神经退行性疾病均密切相关。 有关研究将为疾病的预防和治疗提供理论依据,同时为个体正常发育的分子机理提供新见解。

招生信息

   
招生专业
071010-生物化学与分子生物学
071009-细胞生物学
071006-神经生物学
招生方向
信号转导与脑发育
人类与动物细胞生物学
信号转导与神经功能

教育背景

2005-12--今 中科院遗传发育所 “****”
学历

1989年获上海第二军医大学医学学士系学位

1999年获美国新泽西Rutgers大学博士学位。

学位
-- 博士

工作经历

1999-2005在美国哥伦比亚大学神经生物学和精神病中心做博士后及高级研究助理。

先后获得美国NIH的 Ruth L. Kirschstein National Research Service Award (2002-03)

Rutgers大学Bush Fellowship (1997-1999)和Waksman Fellowship (1993-1997)

2005年中国科学院****入选者

2007年国家杰出青年科学基金获得者。


教授课程

神经生物学
入学教育与交流
发现生命奥秘
毕业设计指导(非课程)
高级神经科学
信号转导
Basic Neuroscience
神经科学中的动物模型
发育生物学专业研讨课
分子遗传学
遗传发育学系列讲座

出版信息

1.       Zhao Z, Zhang D, Yang F, Xu M, Zhao S, Pan T, Liu C, Liu Y, Wu Q, Tu Q, Zhou P, Li R, Kang J, Zhu L, Gao F, Wang Y, Xu Z*. (2022) Evolutionarily conservative and non-conservative regulatory networks during primate interneuron development revealed by single-cell RNA and ATAC sequencing. Cell Research. Mar 10. doi: 10.1038/s41422-022-00635-9. (IF: 47)

2.       Yao M., et al. Xu Z*. (2022) POSH Regulates the Assembly of the NMDAR/PSD-95/Shank Complex and Synaptic Function. Cell Reports. Doi.org/10.1016/j.celrep.2022.110642

3.       Jiang YS et al., Xu Z*. (2022) Treatment of SARS-CoV-2 induced pneumonia with NAD+ and NMN in two mouse models. Cell Discovery 10.1038/s41421-022-00409-y. (IF: 38)

4.       Ma TT, Zhang Feng, Wang YQ, Xu Z*. (2022) Molecular mechanisms underlying cTAGE5/MEA6-mediated cargo transport and biological functions. J Genetics and Genomics. doi.org/10.1016/j.jgg.2022.04.001

5.       Pang HH, Jiang YS… Xu Z*, Hu ZP* (2021) Aberrant NAD+ metabolism underlies ZIKA virus-induced microcephaly Nature Metabolism Doi: 10.1038/s42255-021-00437-0

6.       Chang YF, Jiang YS, et al., Xu Z* (2021) Dissecting of the Gene Networks Affected by Zika Virus Infection in a Mouse Microcephaly Model. Genomics Proteomics & Bioinformatics doi.org/10.1016/j.gpb.2019.06.004 (IF:7.69)

7.       Li C, Zheng Y, et al., Xu Z* (2021) SRPS Associated Protein WDR60 Regulates the Multipolar-to-Bipolar Transition of Migrating Neurons during Cortical Development. Cell Death & Disease. 12;12(1):75. doi: 10.1038/s41419-020-03363-3. (IF: 9.4)

8.       Wang XT, Zhou L, Cai XY, Xu FX, Xu Z, Li XY, Shen Y. (2021) Deletion of Mea6 in cerebellar granule cells impairs synaptic development and motor performance. Frontiers in Cell and Developmental Biology doi.org/10.3389/fcell.2020.627146

9.       Li C*, Xu D, Xu Z* (2021) The development of human antibodies against Zika virus. Zika Virus Control, Vaccines, Therapy, and Associated Conditions. Elsevier (book chapter)

10.    Xu D*, Li C, Xu Z* (2021) Zika virus infection disrupts the development of both neurons and glial cells. Zika Virus Biology, Transmission, and Pathology. Elsevier (book chapter)

11.    Zhao Z et al.,…Zhang XH*, Xu Z*(2020) Zika Virus Infection Leads to Variable Defects in Multiple Neurological Functions and Behaviors in Mice and Children. Advanced Science DOI:10.1002/advs.201901996 (IF:15.8)

12.    Shohayeb B, Ho U, Yeap YY, Parton RG, Millard SS, Xu Z, Piper M, Ng DCH. (2020) The association of microcephaly protein WDR62 with CPAP/IFT88 is required for cilia formation and neocortical development. Human Molecular Genetics2020,29(2):248-263,

13.    Zhang M, Fu Z, Li C, Liu A, Peng D, Xue F, He W, Gao S, Xu F, Xu D, Yuan L, Zhang F, Xu Z, Xu T, Xu P. Fast Super-Resolution Imaging Technique and Immediate Early Nanostructure Capturing by a Photoconvertible Fluorescent Protein. Nano Letter. 2020 Apr 8;20(4):2197-2208 (IF: 11.2)

14.    Wang J, Li T, Wang JL, Xu Z, Meng W, Wu QF. (2020) Talpid3-Mediated Centrosome Integrity Restrains Neural Progenitor Delamination to Sustain Neurogenesis by Stabilizing Adherens Junctions. Cell Reports 15;33(11):108495. doi: 10.1016/j.celrep.2020.108495.

15.    Xu D, Li C, Qin CF, Xu Z* (2019) Update on the animal models and underlying mechanisms for zikv-induced microcephaly. Annu. Rev. Virol.  doi.org/10.1146/annurev-virology-092818-015740 (IF: 10.4)

16.    Nielsen-Saines K…, Xu Z, Cheng G, Moreira ME. (2019) Delayed childhood neurodevelopment and neurosensory alterations in the second year of life in a prospective cohort of ZIKV-exposed children.  Nature Medicine.  25(8):1213-1217. doi: 10.1038/s41591-019-0496-1 (IF: 30.6)

17.    Li H, Saucedo-Cuevas L…Xu Z, Gleeson JG. (2019). Zika Virus Protease Cleavage of Host Protein Septin-2 Mediates Mitotic Defects in Neural Progenitors. Neuron. 20;101(6):1089-1098.e4. doi: 10.1016/j.neuron.2019.01.010.

18.    Wang XT et al., Xu Z*, Shen Y* (2019) MEA6 deficiency impairs cerebellar development and motor performance by tethering protein trafficking.  Frontiers in Cellular Neuroscience 11;13:250. doi: 10.3389/fncel.2019.00250

19.    Xu YP, Qiu Y, Zhang B, Chen G, Chen Q, Wang M, Mo F, Xu J, Wu J, Zhang RR, Cheng ML, Zhang NN, Lyu B, Zhu WL, Wu MH, Ye Q, Zhang D, Man JH, Li XF, Cui J, Xu Z, Hu B, Zhou X, Qin CF. (2019) Zika virus infection induces RNAi-mediated antiviral immunity in human neural progenitors and brain organoids. Cell Res. 2019 Apr;29(4):265-273. doi: 10.1038/s41422-019-0152-9.

20.    《寨卡病毒与寨卡病毒病》第十章 徐丹,许执恒 寨卡病毒与寨卡病毒病。(2019)人民卫生出版社

21.    Wang S. et al., Xu Z*. (2018). Sh3rf2 haploinsufficiency leads to unilateral neuronal development deficits and autistic-like behaviors in mice.  Cell Reports DOI:10.1016/ j.celrep.2018.11.044 (新华社与中国科学报进行了采访报道)

22.    Zhang et al., Xu Z* (2018) cTAGE5/MEA6 Controls Brain Development through Regulation of Neuronal Trafficking of Cellular Components. PNAS doi/10.1073/pnas.1804083115

(Direct Submission Plus)

23.    Xu D.,  Zhu Y., and Xu Z*. (2018) MEKK3 Coordinates with FBW7 to Regulate WDR62 Stability and Neurogenesis. PLoS Biology 19;16(12):e2006613. doi: 10.1371/journal.pbio. 2006613

24.    Li C et al., Xu Z*, Zhang L*. (2018). A single injection of human neutralizing antibody protects against Zika virus infection and microcephaly in the developing fetuses. Cell Reports DOI: 10.1016/j.celrep.2018.04.005

25.    Li C et al., Xu Z*. (2018). Disruption of Glial Cell Development by Zika Virus Contributes to Severe Microcephalic Newborn Mice. Cell Discovery DOI: 10.1038/s41421-018-0042-1.

26.    Zhu X, Li C, Afridi SK, Zu S, Xu JW, Quanquin N, Yang H, Cheng G*, Xu Z*. (2018). E90 subunit vaccine protects mice from Zika virus infection and microcephaly. Acta Neuropathol Commun. 2018 Aug 10;6(1):77. doi: 10.1186/s40478-018-0572-7. (IF: 7.8)

27.    Zhou Y... Xu Z*, Chen ZJ*, Gao F*. (2018). Wdr62 is involved in meiotic initiation via activating JNK signaling and associated with POI in humans. PLoS Genet. 13;14(8): e1007463. doi: 10.1371/journal.pgen.1007463.

28.    Zhang H...Xu Z, Sun T. (2018). Upregulation of MicroRNA miR-9 Is Associated with Microcephaly and Zika Virus Infection in Mice. Mol Neurobiol. 56(6):4072-4085 doi: 10.1007/s12035-018-1358-4.

29.    Shohayeb B, Lim NR, Ho U, Xu Z, Dottori M, Quinn L, Ng DCH. (2018). The Role of WD40-Repeat Protein 62 (MCPH2) in Brain Growth: Diverse Molecular and Cellular Mechanisms Required for Cortical Development. Mol Neurobiol. 55(7):5409-5424. doi: 10.1007/s12035-017-0778-x.

30.    Ling Y,.. Xu Z*, Qin CF*. (2017). A single mutation in the prM protein of Zika virus contributes to fetal microcephaly. SCIENCE   eaam7120, DOI: 10.1126/science.aam7120 (专文或亮点评述: Nature, Science, Nature Reviews Neurobiology, Nature Reviews Microbiology et al., 100多家世界知名媒体报道,包括 New York Times, Reuters, Washington Post, Los Angeles Times, USA Today, NBC News, NPR, The Scientist, etc.) (第一完成课题组)

31.    Fan et al., Xu Z* (2017) Mea6 Deletion in Pancreatic β Cells Impairs Proinsulin Trafficking and Insulin Biogenesis in Mice. J Cell Biology DOI: 10.1083/jcb.201705027

32.    Wang S., Hong S... Xu Z*. (2017) Transfer of Convalescent Serum to Pregnant Mice Prevents Zika Virus Infection and Microcephaly in Offspring. Cell Research  doi:10.1038/cr.2016.144

33.    Deng et al., Xu Z*, Qin CF*. (2017) Intranasal infection and contact transmission of Zika virus in guinea pigs. Nat. Commun. doi:10.1038/s41467-017-01923-4

34.    Li C, Deng Y-Q, Wang S...Xu Z*, Qin C*, Cheng G*. (2017) 25-Hydroxycholesterol protects host against ZIKV infection and its associated microcephaly. Immunity 46(3):446-456. doi: 10.1016/j.immuni.2017.02.012

35.    Oh Y et al., Xu Z*, Jin P*, Song H., Ming G-L*, Lee G*. (2017) Zika virus directly infects human peripheral neurons and induces cell death. Nature Neuroscience 20(9):1209-1212. doi: 10.1038/nn.4612.

36.    Zhang et al., Xu Z* (2017) American Strain of Zika Virus Causes More Severe Microcephaly than an Old Asian Strain in neonatal Mice. EBioMedicine doi: 10.1016/j.ebiom.2017.10.019.

37.    Li C, Zhu X,. .. Xu Z*, Cheng G*. (2017) Chloroquine, a FDA-approved Drug, Prevents ZIKV Infection and its Associated Congenital Microcephaly in Mice. EBioMedicine doi:10.1016/j.ebiom.2017.09.034  (IF:8.1)

38.    Yoon KJ, et al., Xu Z*, Qian J*, Zhu H*, Song H*, Ming G-L*. (2017) NS2A protein encoded by Zika virus disrupts mammalian cortical neurogenesis. Cell Stem Cell 21(3):349-358.e6. doi: 10.1016/j.stem.2017.07.014. (*Senior author)

39.    Wang S....Z Xu and Z Fan. (2017) Regulatory Innate Lymphoid Cells Control Innate Intestinal Inflammation. CELL 171(1):201-216.e18. doi: 10.1016/j.cell.2017.07.027.

40.    Xu D.,  Zhu Y., and Xu Z*. (2017) Efficient genetic manipulation in the developing brain of tree shrew using in utero electroporation and virus infection. J Genetics and Genomics doi: 10.1016/j.jgg.2017.09.007

41.     Li C, Xu D, .. Qin C*, Xu Z*. (2016) Zika Virus Disrupts Neural Progenitor Development and Leads to Microcephaly in Mice. Cell Stem Cell doi:10.1016/j.stem.2016.04.017 (Previewed or highlighted by Science, Nature Reviews Neurobiology, Nature Reviews Microbiology; Trends in Molecular Medicine, etc. Covered by >300 media, including BBC, Reuters, Los Angeles Times, USA Today, NBC News, Fox News, The Scientist, etc. ‘Best of Cell Stem Cell 2016’)

42.     Zhang HS…. Xu Z*. (2016) Brain-specific Crmp2 deletion leads to neuronal development deficits and behavioural impairments in mice. Nat. Commun. doi: 10.1038/ncomms11773.

43.     Wang Y, Liu L,.. Xu Z*. (2016) Mea6 controls VLDL transport through the coordinated regulation of COPII assembly. Cell Research  doi:10.1038/cr.2016.75

44.     Zhang F. Yu JW, Yang T. Xu D,.Xia YH., Xu Z*. (2016) A Novel c-Jun N-terminal Kinase (JNK) Signaling Complex Involved in Neuronal Migration during Brain Development. J Biol Chem pii: jbc.M116.716811. (Cover story, “Paper of the week” with editorial comments and highlight for the student)

45.     Zhang L, Zhang F,... Xu Z*. (2016) The B cell receptor BR3 modulates cellular branching via Rac1 during neuronal migration. J Mol Cell Biol.  pii: mjw034

46.     Xu D. and Xu Z*. (2016) Driving WDR62 to the Pole. Cell Cycle DOI:10.1080/15384101. 2016.1154374

47.     Shao XM. et al., (2016) Numb Regulates Vesicular Docking for Homotypic Fusion of Early Endosomes via Membrane Recruitment of Mon1b. Cell Research doi: 10.1038/cr.2016.34

48.     Liu B…Xu Z., ZhengYF. (2016) MAZ mediates the cross-talk between CT-1 and NOTCH1 signaling during gliogenesis. Sci Reports 6:21534. doi: 10.1038/srep21534

49.     Liu K, Lei R, Li Q, Wang XX, Wu Q, An P, Zhang J, Zhu M, Xu Z, Hong Y, Wang F, Shen Y, Li H, Li H. (2016) Transferrin Receptor Controls AMPA Receptor Trafficking Efficiency and Synaptic Plasticity. Sci Rep. 6:21019. doi: 10.1038/srep21019

50.      Li P… Xu Z*, and Zhu Z*. (2015) Epigenetic silencing of microRNA-149 in cancer associated fibroblasts mediates prostaglandin E2/interleukin-6 signaling in the tumor microenvironment Cell Research 25(5):588-603

51.     Lim NR, Yeap YY, Zhao TT, Yip YY, Wong SC, Xu D, Ang CS, Xu Z, Bogoyevitch MA, Ng DC. (2015) Opposing roles for JNK and Aurora A in regulating WD40-Repeat Protein 62 association with spindle microtubules. J Cell Sci. 128:527-540

52.     Zhang F. Xu D,. Sun YM., Xu Z*. (2014) Epigenetic regulation of Atrophin1 by lysine-specific demethylase is required for cortical progenitor maintenance. Nat. Commun, 5:5815. doi: 10.1038/ncomms6815

53.     Xu D. Zhang F, Wang Y, Sun Y, Xu Z*. (2014) Microcephaly Associated Protein WDR62 Regulates Neurogenesis through JNK1 in the developmental cortex. Cell Reports 6(1):104-16

54.     Yu J, Zhang F, Zhang Y, Fan M and Xu Z* (2014) TAK1 is activated by TGF-β signaling and controls axonal growth during brain development. J Mol Cell Biol.  6(4):349-51.

55.     Yao M, Wang Y, Zhang P, Chen H, Xu Z, Jiao J, Yuan Z. (2014) BMP2-SMAD Signaling Represses the Proliferation of Embryonic Neural Stem Cells through YAP. J Neuroscience 34(36):12039-48

56.     Zhu Y, Wang C, Yu M, and Xu Z*. (2013)  ULK1 and JNK are Involved in Mitophagy Incurred by LRRK2 G2019S Expression. Protein Cell 4(9): 711-21.

57.     Shi W, Chen Y, Gan G, Ren J, Wang Q, Xu Z, Xie X, and Zhang Y. (2013) Brain tumor regulates neuromuscular synapse growth and endocytosis in Drosophila by suppressing Mad expression. J Neuroscience 24;33(30):12352-63.

58.     Xiong Y, Zhao K, Wu J, Xu Z, Jin S, Zhang YQ. (2013) HDAC6 mutations rescue human tau-induced microtubule defects in Drosophila. PNAS 19;110(12):4604-9.

59.     Yang T., Sun YM…Xu Z* (2012) POSH Localizes Activated Rac1 to Control the Formation of Cytoplasmic Dilation of the Leading Process and Neuronal Migration. Cell Reports 2(3):640-51 


科研活动

   
科研项目
( 1 ) 干细胞专项, 参与, 国家任务, 2012-01--2016-12
( 2 ) MOST技术在人类大脑发育缺陷疾病哺乳动物模型研究中的应用, 参与, 国家任务, 2012-05--2017-05
( 3 ) 小颅畸形相关蛋白WDR62调控大脑发育的分子机制研究, 负责人, 国家任务, 2015-01--2019-12
( 4 ) MEA6 在肿瘤发生过程中的作用及机制研究, 负责人, 国家任务, 2013-01--2016-12
( 5 ) 神经元迁移的分子细胞机制, 负责人, 国家任务, 2014-01--2018-12
( 6 ) 儿童孤独症的遗传基础及其致病的机制研究, 负责人, 国家任务, 2012-01--2016-12
( 7 ) 小头畸形的发病机制与防治研究, 负责人, 中国科学院计划, 2016-08--2020-12
( 8 ) 寨卡病毒感染导致小颅畸形的发病机制与防治研究, 负责人, 国家任务, 2018-01--2022-12
( 9 ) 精神分裂症相关基因CRMP2异常的致病机制研究, 负责人, 中国科学院计划, 2018-01--2020-12

指导学生

已指导学生

任金琪  博士研究生  071009-细胞生物学  

于梅  博士研究生  071009-细胞生物学  

张明  博士研究生  071009-细胞生物学  

崔婕  博士研究生  071009-细胞生物学  

牛竞文  博士研究生  071009-细胞生物学  

王春艳  博士研究生  071009-细胞生物学  

杨涛  博士研究生  071009-细胞生物学  

孙一明  博士研究生  071009-细胞生物学  

张鸿声  博士研究生  071009-细胞生物学  

鲁彬  硕士研究生  071009-细胞生物学  

池智霞  硕士研究生  071007-遗传学  

徐丹  博士研究生  071009-细胞生物学  

刘亮  博士研究生  071009-细胞生物学  

王硕  博士研究生  071006-神经生物学  

张威亚  硕士研究生  071009-细胞生物学  

袁玲  博士研究生  071009-细胞生物学  

张峰  博士研究生  071009-细胞生物学  

刘新异  硕士研究生  071006-神经生物学  

范俊婉  博士研究生  071009-细胞生物学  

祝星亮  博士研究生  071006-神经生物学  

王骎  博士研究生  071006-神经生物学  

王桃  硕士研究生  071006-神经生物学  

洪帅  硕士研究生  071006-神经生物学  

李翠  博士研究生  071009-细胞生物学  

肖嘉盈  硕士研究生  071006-神经生物学  

姜义圣  博士研究生  071009-细胞生物学  

钟杰  博士研究生  071009-细胞生物学  

现指导学生

袁玉婷  博士研究生  071006-神经生物学  

马甜甜  博士研究生  071006-神经生物学  

薛纯  博士研究生  071006-神经生物学  

杨富强  博士研究生  071006-神经生物学  

冯迎航  博士研究生  071006-神经生物学  

郑昱  博士研究生  071009-细胞生物学  

刘思佳  博士研究生  071008-发育生物学  

杨兴达  博士研究生  071009-细胞生物学  

刘靖华  硕士研究生  071006-神经生物学  

陈梓雯  博士研究生  071006-神经生物学  

赵劭俐  硕士研究生  0771Z2-认知神经科学  

高嘉唯  博士研究生  071006-神经生物学  

张丹  博士研究生  071006-神经生物学  

赵子其  博士研究生  071006-神经生物学  

陈海洋  博士研究生  071006-神经生物学  

孙晓梅  博士研究生  071006-神经生物学