基本信息
薛超友  男  博导  中国科学院天津工业生物技术研究所
电子邮件: xuechy@tib.cas.cn
通信地址: 天津市东丽区西七道32号
邮政编码:

招生信息

   
招生专业
071010-生物化学与分子生物学
071007-遗传学
招生方向
基因编辑,DNA修复,合成生物学,绿色生物制造,单分子DNA帘,单分子荧光能量共振转移

教育背景

2013-08--2017-12   美国爱荷华州立大学   博士学位
2010-08--2013-07   天津大学   硕士学位
2006-09--2010-07   西北农林科技大学   学士学位

工作经历

   
工作简历
2021-01~现在, 中国科学院天津工业生物技术研究所, 研究员
2017-12~2020-12,美国哥伦比亚大学, 博士后

教授课程

分子生物物理实验

专利与奖励

   
奖励信息
(1) 最佳博士论文奖, , 研究所(学校), 2017
(2) 天津市优秀硕士论文奖, 省级, 2015

出版信息

   
发表论文
[1] Madison B Adolph, Taha M Mohamed, Swati Balakrishnan, Chaoyou Xue, Florian Morati, Mauro Modesti, Eric C Greene, Walter J Chazin, David Cortez. RADX controls RAD51 filament dynamics to regulate replication fork stability. Molecular cell. 2021, 81(5): 1074-1083.e5, [2] Unciuleac, MihaelaCarmen, Meir, Aviv, Xue, Chaoyou, Warren, Garrett M, Greene, Eric C, Shuman, Stewart. Clutch mechanism of chemomechanical coupling in a DNA resecting motor nuclease. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2021, 118(11): https://www.webofscience.com/wos/woscc/full-record/WOS:000629635100083.
[3] Xue, Chaoyou, Greene, Eric C. DNA Repair Pathway Choices in CRISPR-Cas9-Mediated Genome Editing. TRENDS IN GENETICSnull. 2021, 37(7): 639-656, http://dx.doi.org/10.1016/j.tig.2021.02.008.
[4] Xue, Chaoyou, Molnarova, Lucia, Steinfeld, Justin B, Zhao, Weixing, Ma, Chujian, Spirek, Mario, Kaniecki, Kyle, Kwon, Youngho, Belan, Ondrej, Krejci, Katerina, Boulton, Simon J, Sung, Patrick, Greene, Eric C, Krejci, Lumir. Single-molecule visualization of human RECQ5 interactions with single-stranded DNA recombination intermediates. NUCLEIC ACIDS RESEARCH[J]. 2021, 49(1): 285-305, https://www.webofscience.com/wos/woscc/full-record/WOS:000610552100027.
[5] Kong, Muwen, Cutts, Erin E, Pan, Dongqing, Beuron, Fabienne, Kaliyappan, Thangavelu, Xue, Chaoyou, Morris, Edward P, Musacchio, Andrea, Vannini, Alessandro, Greene, Eric C. Human Condensin I and II Drive Extensive ATP-Dependent Compaction of Nucleosome-Bound DNA. MOLECULAR CELL[J]. 2020, 79(1): 99-+, http://dx.doi.org/10.1016/j.molcel.2020.04.026.
[6] Yan, Zhenxin, Xue, Chaoyou, Kumar, Sandeep, Crickard, J Brooks, Yu, Yang, Wang, Weibin, Nhung Pham, Li, Yuxi, Niu, Hengyao, Sung, Patrick, Greene, Eric C, Ira, Grzegorz. Rad52 Restrains Resection at DNA Double-Strand Break Ends in Yeast. MOLECULAR CELL[J]. 2019, 76(5): 699-+, http://dx.doi.org/10.1016/j.molcel.2019.08.017.
[7] Crickard, J Brooks, Xue, Chaoyou, Wang, Weibin, Kwon, Youngho, Sung, Patrick, Greene, Eric C. The RecQ helicase Sgs1 drives ATP-dependent disruption of Rad51 filaments. NUCLEIC ACIDS RESEARCH[J]. 2019, 47(9): 4694-4706, https://www.webofscience.com/wos/woscc/full-record/WOS:000473756300031.
[8] Xue, Chaoyou, Daley, James M, Xue, Xiaoyu, Steinfeld, Justin, Kwon, Youngho, Sung, Patrick, Greene, Eric C. Single-molecule visualization of human BLM helicase as it acts upon double- and single-stranded DNA substrates. NUCLEIC ACIDS RESEARCH[J]. 2019, 47(21): 11225-11237, [9] Jia, Ning, Unciuleac, Mihaela C, Xue, Chaoyou, Greene, Eric C, Patel, Dinshaw J, Shuman, Stewart. Structures and single-molecule analysis of bacterial motor nuclease AdnAB illuminate the mechanism of DNA double-strand break resection. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2019, 116(49): 24507-24516, [10] Chaoyou Xue, Dipali G Sashital. Mechanisms of type I-E and I-F CRISPR-Cas systems in Enterobacteriaceae. EcoSal Plus. 2019, 8(2): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368399/.
[11] Phan, Phong T, Schelling, Michael, Xue, Chaoyou, Sashital, Dipali G, Bailey, S. Fluorescence-based methods for measuring target interference by CRISPR-Cas systems. CRISPR-CAS ENZYMESnull. 2019, 616: 61-85, [12] Xue, Chaoyou, Greene, Eric C. New roles for RAD52 in DNA repair. CELL RESEARCHnull. 2018, 28(12): 1127-1128, http://lib.cqvip.com/Qikan/Article/Detail?id=6100228433.
[13] Xue, Chaoyou, Zhu, Yicheng, Zhang, Xiangmei, Shin, YeonKyun, Sashital, Dipali G. Real-Time Observation of Target Search by the CRISPR Surveillance Complex Cascade. CELL REPORTS[J]. 2017, 21(13): 3717-3727, http://dx.doi.org/10.1016/j.celrep.2017.11.110.
[14] Xue, Chaoyou, Whitis, Natalie R, Sashital, Dipali G. Conformational Control of Cascade Interference and Priming Activities in CRISPR Immunity. MOLECULAR CELL[J]. 2016, 64(4): 826-834, http://dx.doi.org/10.1016/j.molcel.2016.09.033.

科研活动

   
科研项目
( 1 ) 单分子技术介导的微生物基因组工程改造及应用, 主持, 省级, 2021-01--2024-01