基本信息
李秀男 男 硕导 过程工程研究所
电子邮件:xnli@ipe.ac.cn
通信地址:北京市海淀区中关村北二街1号
邮政编码:100190

招生信息

   
招生专业
081703-生物化工
招生方向
生化分离工程,生物材料

教育背景

2000-07--2005-12 北京化工大学 硕博连读
1996-07--2000-07 北京化工大学 本科

工作经历

   
工作简历
2009-07--今 中国科学院过程工程研究所 副研究员
2006-01--2009-07 中国科学院过程工程研究所 助理研究员

专利与奖励

   
奖励信息
(1) 过程所科研和管理工作交流会青年科技创新优秀奖,研究所(学校)级,2014
(2) 过程所科研和管理工作交流会青年科技创新优秀奖,研究所(学校)级,2013
(3) 中国分析测试协会科学技术奖,一等奖,省级,2013
(4) 中国仪器仪表学会2011科技创新奖,省级,2011
专利成果
(1) 蛋白层析系统,发明,2014,第1作者,专利号:ZL 2010 1 0127899.5.,具有完全自主知识产权的 “智能化蛋白层析系统” 设备成果已进入产业化阶段,打破了国外仪器的垄断,并为国内相关仪器树立了标杆,目前,国内外用户达20余家。
(2) 电极清洗、校正和保存装置及方法,发明,2013,第1作者,专利号:201310062061.6
(3) 一种多参数一体化色谱流通池,发明,2013,第1作者,专利号:201310088098.6
(4) 生物技术药物高效纯化分析系统及其药物分离检测方法,发明,2015,第1作者,专利号: ZL 201310198644.1.
(5) 一种车载便携式液相色谱仪,发明,2013,第1作者,专利号:201310701298.4.
(6) 一种荧光和紫外-可见吸收一体化流通池,发明,2013,第1作者,专利号:201310701299.9

出版信息

   
发表论文
(1) Pore size analysis from low field NMR spin-spin relaxation measurements of porous microspheres,Journal of Porous Materials,2015,第1作者
(2) Interaction of arginine with protein during refolding process probed by amide HD exchange mass spectrometry and isothermal titration calorimetry,Biochimica et Biophysica Acta (BBA)- Proteins and Proteomics,2015,第5作者
(3) Konjac glucomannan microspheres for low-cost desalting of protein solution,Carbohydrate Polymers,2014,第4作者
(4) Membrane Combined with Hydrophilic Macromolecules Enhances Protein Refolding at High Concentration,Process Biochemistry,2014,第4作者
(5) Improving stability of virus-like particles by ion-exchange chromatographic supports with large pore size: Advantages of gigaporous media beyond enhanced binding capacity,Journal of Chromatography A,2014,第4作者
(6) Determination of leakage from antibody adsorbent: composition analysis and pH effect,Biomedical Chromatography,2013,第5作者
(7) 低场核磁法测定凝胶过滤介质的孔径分布,化工学报,2013,通讯作者
(8) PEGylation of G-CSF in organic solvent markedly increase the efficacy and reactivity through protein unfolding, hydrolysis inhibition and solvent effect,Journal of Biotechnology,2013,第3作者
(9) Human serum albumin stability and toxicity of anthraquinone dye alizarin complexone: An albumin–dye model,Ecotoxicology and Environmental safety,2012,第4作者
(10) Chiral recognition of metalaxyl enantiomers by human serum albumin: evidence from molecular modeling and photophysical approach,Chirality,2012,第2作者
(11) An oriented adsorption strategy for efficient solid phase PEGylation of recombinant staphylokinase by immobilized metal-ion affinity chromatography,Process Biochemistry,2012,第4作者
(12) Potential toxicity and affinity of triphenylmethane dye malachite green to lysozyme,Ecotoxicology and Environmental safety,2012,第2作者
(13) Facile purification and characterization of recombinant human antithrombin III from transgenic goat milk, Journal of Chemical Technology and Biotechnology,2011,第5作者
(14) Deliberate manipulation of the surface hydrophobicity of an adsorbent for an efficient purification of a giant molecule with multiple subunits,Journal of Separation Science,2011,第4作者
(15) An automatic system for multidimensional integrated protein chromatography,Journal of Chromatography A,2010,通讯作者
(16) Cooperative effects of urea and L-arginine on protein refolding, Protein Expression and Purification,2009,第3作者
(17) Cooperative effects of urea and L-arginine on protein refolding, Protein Expression and Purification,2009,第3作者
(18) Systematic purification of polydatin, resveratrol and anthraglycoside B from Polygonum cuspidatum Sieb. et Zucc.,Separation and Purification Technology,2009,第2作者
(19) Preparative purification of polyethylene glycol derivatives with polystyrene-divinylbenzene beads as chromatographic packing,Bioorganic and Medicinal Chemistry Letters,2007,第2作者
(20) Rapid purification of huperzine A and B with two polystyrene based resins by preparative low‐pressure liquid chromatography, Journal of liquid chromatography and related technologies,2006,第1作者
(21) Polystyrene-type uniform porous microsphere enables high resolution and low-pressure chromatography of natural products–a case study with Icariin purification,Chromatographia,2005,第2作者
(22) A facile two-column chromatographic process for efficient purification of paclitaxel from crude extract,Journal of Liquid Chromatography and Related technologies,2005,第2作者
(23) A cyanopropyl reversed phase chromatography enables resolution of huperzine A and B on analytical and preparative scales,Journal of Separation Science,2005,第1作者

科研活动

   
科研项目
(1) 高效分离纯化装备研制及应用开发,主持,国家级,2014-01--2016-12
(2) 低场核磁共振分析蛋白质层析传质过程,主持,国家级,2014-01--2017-12
(3) 生物技术药物纯化分析仪器的开发和应用,主持,国家级,2013-10--2017-10
(4) 疫苗类生物颗粒分离纯化工作站的研发,参与,院级级,2012-11--2014-10
(5) 生物制造分离过程技术与装备,主持,国家级,2012-01--2015-12