以研发治疗糖尿病的天然药物为目的，建立多层次有特色的动物、细胞和分子水平筛选及作用机理研究平台，发展以植物特有化合物为探针的药物活性检测技术，从胰岛素释放、葡萄糖摄取、糖原向糖转化、葡萄糖重吸收等方面对天然化合物进行筛选，为转化天然化合物成为天然药物提供有效的活性基础。并以这些活性化合物为小分子探针，围绕与糖尿病发生密切相关的信号通路研究其与靶细胞和靶蛋白之间的相互作用,阐明其治疗糖尿病的作用机制,为治疗糖尿病提供新的治疗策略和药物作用机理依据

欢迎药理学、细胞生物学、分子生物学和生物化学背景，以及生物医学背景考生报考。

100706-药理学
071010-生物化学与分子生物学

抗糖尿病药物发现与药理研究

1999-09--2004-08   中国科学院昆明动物研究所   博士
1995-09--1999-07   陕西师范大学   学士

   

2011-03~现在, 中国科学院昆明植物研究所, 研究员
2007-07~2011-02,Cornell University, 博士后
2004-09~2007-06,University of Southern California, 博士后

   

   

[1] Cao, TuanWu, Liu, Xia, Ye, YanSong, Zhou, HuiMin, Liu, DaoWei, Xiong, WenYong, Xu, Gang. anti-adipogenic adamantane type polycyclic polyprenylated acylphloroglucinols from Hypericum subsessile (vol 147, 104755, 2020). FITOTERAPIA. 2021, 149: http://dx.doi.org/10.1016/j.fitote.2020.104791.
[2] Su, HaiGuo, Wang, Qian, Zhou, Lin, Peng, XingRong, Xiong, WenYong, Qiu, MingHua. Highly oxygenated lanostane triterpenoids from Ganoderma applanatum as a class of agents for inhibiting lipid accumulation in adipocytes. BIOORGANIC CHEMISTRY[J]. 2020, 104: http://dx.doi.org/10.1016/j.bioorg.2020.104263.
[3] HuiMin Zhou, YanSong Ye, NaNa Jiang, RongFang Mu, Qian Wang, Jing Hu, Xia Liu, WanYing Qin, Gang Xu, WenYong Xiong. Adipogenesis Inhibitory Activity of Hypersampsone P from Hypericum subsessile. 应用天然产物(英文)[J]. 2020, 10(3): 163-170, http://lib.cqvip.com/Qikan/Article/Detail?id=7105125430.
[4] RongFang Mu, YanFen Niu, Qian Wang, HuiMin Zhou, Jing Hu, WanYing Qin, WenYong Xiong. Eriocalyxin B Inhibits Adipogenesis in 3T3-L1 Adipocytes by Cell Cycle Arrest. 应用天然产物(英文)[J]. 2020, 10(3): 131-140, http://lib.cqvip.com/Qikan/Article/Detail?id=7105125427.
[5] Mu, RongFang, Niu, YanFen, Wang, Qian, Zhou, HuiMin, Hu, Jing, Qin, WanYing, Xiong, WenYong. Eriocalyxin B Inhibits Adipogenesis in 3T3-L1 Adipocytes by Cell Cycle Arrest (vol 10, pg 131, 2020). NATURAL PRODUCTS AND BIOPROSPECTING. 2020, 10(4): 269-269, [6] Wang, Qian, Mu, RongFang, Liu, Xing, Zhou, HuiMin, Xu, YuHui, Qin, WanYing, Yang, ChongRen, Wang, LiBin, Li, HaiZhou, Xiong, WenYong. Steaming Changes the Composition of Saponins of Panax notoginseng (Burk.) FH Chen That Function in Treatment of Hyperlipidemia and Obesity. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY[J]. 2020, 68(17): 4865-4875, https://www.webofscience.com/wos/woscc/full-record/WOS:000529960100013.
[7] Cao, TuanWu, Liu, Xia, Ye, YanSong, Zhou, HuiMin, Liu, DaoWei, Xiong, WenYong, Xu, Gang. Anti-adipogenicadamantane type polycyclic polyprenylated acylphloroglucinols from Hypericum subsessile. FITOTERAPIA[J]. 2020, 147: http://dx.doi.org/10.1016/j.fitote.2020.104755.
[8] Lu, Yanting, Ma, Xiuli, Kong, Qinghua, Xu, Yuhui, Hu, Jing, Wang, Fang, Qin, Wanying, Wang, Libin, Xiong, Wenyong. Novel dual-color drug screening model for GLUT4 translocation in adipocytes. MOLECULAR AND CELLULAR PROBES[J]. 2019, 43: 6-12, http://ir.kib.ac.cn/handle/151853/64244.
[9] Fang Wang, Xiaoyan Yang, Yanting Lu, Zhenghui Li, Yuhui Xu, Jing Hu, Jikai Liu, Wenyong Xiong. The natural product antroalbol H promotes phosphorylation of liver kinase B1 (LKB1) at threonine 189 and thereby enhances cellular glucose uptake. THE JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2019, 294(27): 10415-10427, http://dx.doi.org/10.1074/jbc.RA118.007231.
[10] Hu, Jing, Li, Xingren, Tian, Weifeng, Lu, Yanting, Xu, Yuhui, Wang, Fang, Qin, Wanying, Ma, Xiuli, Puno, PemaTenzin, Xiong, Wenyong. Adenanthin, a Natural ent-Kaurane Diterpenoid Isolated from the Herb Isodon adenantha Inhibits Adipogenesis and the Development of Obesity by Regulation of ROS. MOLECULES[J]. 2019, 24(1): http://ir.kib.ac.cn/handle/151853/64459.
[11] Wang, Fang, Yang, Xiaoyan, Lu, Yanting, Li, Zhenghui, Xu, Yuhui, Hu, Jing, Liu, Jikai, Xiong, Wenyong. The natural product antroalbol H promotes phosphorylation of liver kinase B1 (LKB1) at threonine 189 and thereby enhances cellular glucose uptake. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2019, 294(27): 10415-10427, http://dx.doi.org/10.1074/jbc.RA118.007231.
[12] 熊文勇. Single molecule glucose transporting process revealed by force tracing and molecular dynamics simulations. Nanoscale Horizons. 2018, [13] YanTing Lu, XiuLi Ma, YuHui Xu, Jing Hu, Fang Wang, WanYing Qin, WenYong Xiong. A Fluorescent Glucose Transport Assay for Screening SGLT2 Inhibitors in Endogenous SGLT2-Expressing HK-2 Cells. NATURAL PRODUCTS AND BIOPROSPECTING[J]. 2018, 9(1): 13-21, https://doaj.org/article/31f4a64f1ed1434085167e691ab03e7e.
[14] Xiong, Wenyong, Zhu, Huajie, Zou, Cheng-Gang, Li, Ling, Niu, Yanfen, Lin, Hua, Zhou, Yuanfang, Gao, Li-Hui. Inhibition of 3,5,2 ',4 '-Tetrahydroxychalcone on Production of Uric Acid in Hypoxanthine-Induced Hyperuricemic Mice. REVIEW OF PALAEOBOTANY AND PALYNOLOGY[J]. 2018, 248: 41-51, http://ir.kib.ac.cn/handle/151853/63397.
[15] 熊文勇. Mechanistic insights into GLUT1 activating and clustering revealed by super-resolution imaging. Proc Natl Acad Sci U S A. 2018, [16] Yan, Qiuyan, Lu, Yanting, Zhou, Lulu, Chen, Junling, Xu, Haijiao, Cai, Mingjun, Shi, Yan, Jiang, Junguang, Xiong, Wenyong, Gao, Jing, Wang, Hongda. Mechanistic insights into GLUT1 activation and clustering revealed by super-resolution imaging. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2018, 115(27): 7033-7038, http://ir.kib.ac.cn/handle/151853/64712.
[17] Qiuyan Yan, Yanting Lu, Lulu Zhou, Junling Chen, Haijiao Xu, Mingjun Cai, Yan Sh, Junguang Jiang, Wenyong Xiong, Jing Gao, Hongda Wang. Mechanistic insights into GLUT1 activation and clustering revealed by super-resolution imaging. PNAS[J]. 2018, 1-, http://ir.kib.ac.cn/handle/151853/61194.
[18] Niu, Yanfen, Zhou, Yuanfang, Lin, Hua, Gao, LiHui, Xiong, Wenyong, Zhu, Huajie, Zou, ChengGang, Li, Ling. Inhibition of 3,5,2 ',4 '-Tetrahydroxychalcone on Production of Uric Acid in Hypoxanthine-Induced Hyperuricemic Mice. BIOLOGICAL & PHARMACEUTICAL BULLETIN[J]. 2018, 41(1): 99-105, https://www.webofscience.com/wos/woscc/full-record/WOS:000419663100014.
[19] Gao, Lan, Chen, Junling, Gao, Jing, Wang, Hongda, Xiong, Wenyong. Super-resolution microscopy reveals the insulin-resistance-regulated reorganization of GLUT4 on plasma membranes. JOURNAL OF CELL SCIENCE[J]. 2017, 130(2): 396-405, http://ir.kib.ac.cn/handle/151853/46038.
[20] Li Peng, Yanting Lu, Yuhui Xu, Jing Hu, Fang Wang, Yumei Zhang, Wenyong Xiong. Pyrocincholic acid 3β-O-β-D-quinovopyranosyl-28-O-β-Dglucopyranoside suppresses adipogenesis and regulates lipid metabolism in 3T3-L1 adipocytes. 应用天然产物(英文)[J]. 2017, 7(3): 225-234, http://lib.cqvip.com/Qikan/Article/Detail?id=7105123500.
[21] Niu, Yanfen, Li, Hongjian, Gao, Lihui, Lin, Hua, Kung, Hsiangfu, Lin, Marie Chiami, Leung, KwongSak, Wong, ManHon, Xiong, Wenyong, Li, Ling. Old drug, new indication: Olsalazine sodium reduced serum uric acid levels in mice via inhibiting xanthine oxidoreductase activity. JOURNAL OF PHARMACOLOGICAL SCIENCES[J]. 2017, 135(3): 114-120, http://dx.doi.org/10.1016/j.jphs.2017.10.007.
[22] Xu, Yuhui, Niu, Yanfen, Gao, Yuan, Wang, Fang, Qin, Wanying, Lu, Yanting, Hu, Jing, Peng, Li, Liu, Jikai, Xiong, Wenyong. Borapetoside E, a Clerodane Diterpenoid Extracted from Tinospora crispa, Improves Hyperglycemia and Hyperlipidemia in High-Fat-Diet-Induced Type 2 Diabetes Mice. JOURNAL OF NATURAL PRODUCTS[J]. 2017, 80(8): 2319-2327, https://www.webofscience.com/wos/woscc/full-record/WOS:000408702600016.
[23] Li Peng, Yanting Lu, Yuhui Xu, Jing Hu, Fang Wang, Yumei Zhang, Wenyong Xiong. Pyrocincholic Acid 3β-O-β-D-Quinovopyranosyl-28-O-β-D-Glucopyranoside Suppresses Adipogenesis and Regulates Lipid Metabolism in 3T3-L1 Adipocytes. NAT. PROD. BIOPROSPECT.[J]. 2017, 7: 225–234-, http://ir.kib.ac.cn/handle/151853/55002.
[24] Xu Yuhui, Niu Yanfen, Gao Yuan, Wang Fang, Qin Wanying, Lu Yanting, Hu Jing, Peng Li, Liu Jikai, Xiong Wenyong. Borapetoside E, a Clerodane Diterpenoid Extracted from Tinospora crispa , Improves Hyperglycemia and Hyperlipidemia in High-Fat-Diet-Induced Type 2 Diabetes Mice. JOURNAL OF NATURAL PRODUCTS[J]. 2017, [25] Xiong Wenyong, Peng Li, Lu Yanting, Xu Yuhui, Hu Jing, Wang Fang, Zhang Yumei. Pyrocincholic acid 3beta-O-beta-D-quinovopyranosyl-28-O-beta-D-glucopyranoside suppresses adipogenesis and regulates lipid metabolism in 3T3-L1 adipocytes.. NATURAL PRODUCTS AND BIOPROSPECTING[J]. 2017, 7(3): 225-234, http://ir.kib.ac.cn/handle/151853/64842.
[26] Kong, Qinghua, Gao, Lan, Niu, Yanfen, Gongpan, Pianchou, Xu, Yuhui, Li, Yan, Xiong, Wenyong. RACK1 is required for adipogenesis. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY[J]. 2016, 311(5): C831-C836, http://ir.kib.ac.cn/handle/151853/33789.
[27] 熊文勇. AS160 regulates cell cycle and cell proliferation through p21. Cell cycle. 2016, [28] xiong wenyong. Super-resolution microscopy reveals the reorganization of GLUT4 on plasma membrane regulated by insulin resistance. J CELL SCI[J]. 2016, 1-, http://ir.kib.ac.cn/handle/151853/33825.
[29] Chen, Junling, Liu, Tianzhou, Gao, Jing, Gao, Lan, Zhou, Lulu, Cai, Mingjun, Shi, Yan, Xiong, Wenyong, Jiang, Junguang, Tong, Ti, Wang, Hongda. Variation in Carbohydrates between Cancer and Normal Cell Membranes Revealed by Super-Resolution Fluorescence Imaging. ADVANCED SCIENCE[J]. 2016, 3(12): http://ir.kib.ac.cn/handle/151853/33797.
[30] Gongpan, Pianchou, Lu, Yanting, Wang, Fang, Xu, Yuhui, Xiong, Wenyong. AS160 controls eukaryotic cell cycle and proliferation by regulating the CDK inhibitor p21. CELLCYCLE[J]. 2016, 15(13): 1733-1741, http://ir.kib.ac.cn/handle/151853/28516.
[31] Yuan Gao, YanFen Niu, Fei Wang, Ping Hai, Fang Wang, YinDong Fang, WenYong Xiong, JiKai Liu. Clerodane Diterpenoids with Anti-hyperglycemic Activity from Tinospora crispa. 应用天然产物(英文)[J]. 2016, 6(5): 247-255, http://lib.cqvip.com/Qikan/Article/Detail?id=7105123488.
[32] 熊文勇. The Development and Application of the Glucose Uptake Stimulating Cell Model. Plant Diversity and Resources. 2015, [33] 胡海军, 田维锋, 逯艳婷, 刘海洋, 胡敬, 贡潘偏抽, 王芳, 张玉梅, 熊文勇, 孔清华. 促葡萄糖摄取细胞模型的构建及应用. 植物分类与资源学报[J]. 2015, 37(6): 821-827, http://ir.kib.ac.cn/handle/151853/25818.
[34] Kun Wei, Gang-Qiang Wang, Xue Bai, Yan-Fen Niu, He-Ping Chen, Chun-Nan Wen, Zheng-Hui Li, Ze-Jun Dong, Zhi-Li Zuo, Wen-Yong Xiong, Ji-Kai Liu. Structure-Based Optimization and Biological Evaluation of Pancreatic Lipase Inhibitors as Novel Potential Antiobesity Agents. NATURAL PRODUCTS AND BIOPROSPECTING[J]. 2015, 5(3): 129-157, http://ir.kib.ac.cn/handle/151853/33812.
[35] Tian, LiWen, Tao, MuKe, Xu, Min, Hu, Jing, Zhu, HongTao, Xiong, WenYong, Wang, Dong, Yang, ChongRen, Zhang, YingJun. Carboxymethyl- and Carboxyl-Catechins from Ripe Pu-er Tea. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY[J]. 2014, 62(50): 12229-12234, http://www.irgrid.ac.cn/handle/1471x/959012.
[36] Liang, ChengQin, Hu, Jing, Shi, YiMing, Shang, ShanZhai, Du, Xue, Zhan, Rui, Wang, WeiGuang, Xiong, WenYong, Xiao, WeiLie, Zhang, HongBin, Sun, HanDong. Five New Nortriterpenoids from the Stems of Schisandra neglecta. HELVETICA CHIMICA ACTA[J]. 2013, 96(7): 1376-1385, http://www.irgrid.ac.cn/handle/1471x/784357.
[37] Liang, ChengQin, Hu, Jing, Shi, YiMing, Shang, ShanZhai, Du, Xue, Zhan, Rui, Xiong, WenYong, Zhang, HongBin, Xiao, WeiLie, Sun, HanDong. Schisphenlignans A-E: Five New Dibenzocyclooctadiene Lignans from Schisandra sphenanthera. CHEMICAL & PHARMACEUTICAL BULLETIN[J]. 2013, 61(1): 96-100, http://www.irgrid.ac.cn/handle/1471x/596096.
[38] Sadacca, L Amanda, Bruno, Joanne, Wen, Jennifer, Xiong, Wenyong, McGraw, Timothy E. Specialized sorting of GLUT4 and its recruitment to the cell surface are independently regulated by distinct Rabs. MOLECULAR BIOLOGY OF THE CELL[J]. 2013, 24(16): 2544-2557, https://www.webofscience.com/wos/woscc/full-record/WOS:000324492900006.
[39] Wenyong Xiong, Ingrid Jordens, Eva Gonzalez, Timothy McGraw. GLUT4 is Sorted into Vesicles Whose Accumulation Beneath and Insertion to the Plasma Membrane is Differentially Regulated by Insulin and Selectively by Insulin Resistance. MOLECULAR BIOLOGY OF THE CELL[J]. 2010, 21(8): 1375-1386, http://www.irgrid.ac.cn/handle/1471x/832372.
[40] Xiong, Wenyong, Jordens, Ingrid, Gonzalez, Eva, McGraw, Timothy E. GLUT4 Is Sorted to Vesicles Whose Accumulation Beneath and Insertion into the Plasma Membrane Are Differentially Regulated by Insulin and Selectively Affected by Insulin Resistance. MOLECULAR BIOLOGY OF THE CELL[J]. 2010, 21(8): 1375-1386, https://www.webofscience.com/wos/woscc/full-record/WOS:000276635900006.
[41] Ingrid Jordens, Dorothee Molle, Wenyong Xiong, Susanna R. Keller, Timothy McGraw. Insulin-regulated Aminopeptidase Is a Key Regulator of GLUT4 Trafficking by Controlling Sorting from Endosomes to Specialized Insulin-regulated Vesicles. MOLECULAR BIOLOGY OF THE CELL[J]. 2010, 21(12): 2034-2044, http://www.irgrid.ac.cn/handle/1471x/832373.
[42] 熊文勇. IRAP is a key regulator of GLUT4 trafficking by controlling sorting from endosomes to specialized insulin-regulated vesicles. Molecular Biology of the Cell. 2010, [43] 熊文勇. Calcium-induced ER stress as a major component of tumor cell death induced by 2,5-dimethyl-celecoxib (DMC), a non-coxib derivative of celecoxib. Molecular Cancer Therap. 2007, [44] Peter Pyrko, Adel Kardosh, Yen-Ting Liu, Nathaniel Soriano, Wenyong Xiong, Robert H Chow, Jasim Uddin, Nicos A Petasis, Austin K Mircheff, Robert A Farley, Stan G Louie, Thomas C Chen, Axel H Schönthal. Calcium-activated Endoplasmic Reticulum Stress as a Major Component of Tumor Cell Death Induced by 2,5-dimethyl-celecoxib, a Non-coxib Analogue of Celecoxib. MOLECULAR CANCER THERAPUTICS[J]. 2007, 6(4): 1262-1275, http://www.irgrid.ac.cn/handle/1471x/832376.
[45] Michael, Darren J, Xiong, Wenyong, Geng, Xuehui, Drain, Peter, Chow, Robert H. Human insulin vesicle dynamics during pulsatile secretion. DIABETES[J]. 2007, 56(5): 1277-1288, http://www.irgrid.ac.cn/handle/1471x/832374.
[46] Pyrko, Peter, Kardosh, Adel, Wang, Weijun, Xiong, Wenyong, Schoenthal, Axel H, Chen, Thomas C. HIV-1 protease inhibitors nelfinavir and atazanavir induce malignant glioma death by triggering endoplasmic reticulum stress. CANCER RESEARCH[J]. 2007, 67(22): 10920-10928, http://www.irgrid.ac.cn/handle/1471x/832375.
[47] Michael, Darren J, Cai, Haijiang, Xiong, Wenyong, Ouyang, Justin, Chow, Robert H. Mechanisms of peptide hormone secretion. TRENDS IN ENDOCRINOLOGY AND METABOLISM[J]. 2006, 17(10): 408-415, http://dx.doi.org/10.1016/j.tem.2006.10.011.
[48] 谢玉波, 熊文勇, 徐林. 咪唑安定拮抗戊四氮对大鼠海马CA1区动作电位和突触传递的影响. 广西医学[J]. 2006, 27(5): 654-656, http://www.irgrid.ac.cn/handle/1471x/832380.
[49] Darren J. Michael, Haijiang Cai, Wenyong Xiong, Justin Ouyang, Robert H. Chow. Mechanisms of peptide hormone secretion. TRENDS IN ENDOCRINOLOGY & METABOLISM. 2006, 17(10): 408-415, http://dx.doi.org/10.1016/j.tem.2006.10.011.
[50] Xiong, WY, Wei, HM, Xiang, XJ, Cao, J, Dong, ZF, Wang, YF, Xu, TL, Xu, L. The effect of acute stress on LTP and LTD induction in the hippocampal CA1 region of anesthetized rats at three different ages. BRAINRESEARCH[J]. 2004, 1005(1-2): 187-192, http://dx.doi.org/10.1016/j.brainres.2004.01.051.
[51] Yuexiong Yang, Jun Cao, Wenyong Xiong, Jichuan Zhang, Qixin Zhou, Huiming Wei, Chongli Liang, Jianhua Deng, Tianfei Li, Shangchuan Yang, Lin Xu. Both Stress Experience and Age Determined the Impairment or Enhancement Effect of Stress on Spatial Memory Retrieval. JOURNAL OF ENDOCRINOLOGY[J]. 2003, 178(1): 45-54, http://www.irgrid.ac.cn/handle/1471x/832384.
[52] Xiong, WY, Yang, YX, Cao, J, Wei, HM, Liang, CL, Yang, SC, Xu, L. The stress experience dependent long-term depression disassociated with stress effect on spatial memory task. NEUROSCIENCE RESEARCH[J]. 2003, 46(4): 415-421, http://dx.doi.org/10.1016/S0168-0102(03)00120-2.

已指导学生

田维锋  硕士研究生  085238-生物工程  

胡海军  硕士研究生  071010-生物化学与分子生物学  

贡潘偏抽  博士研究生  100701-药物化学  

牛艳芬  博士研究生  100706-药理学  

高蓝  博士研究生  100701-药物化学  

彭莉  硕士研究生  071010-生物化学与分子生物学  

许宇辉  博士研究生  100706-药理学  

胡敬  博士研究生  100706-药理学  

逯艳婷  博士研究生  100706-药理学  

马秀丽  硕士研究生  078006-药理学  

王芳  博士研究生  100706-药理学  

现指导学生

秦婉莹  博士研究生  100706-药理学  

母蓉芳  硕士研究生  078006-药理学  

周慧敏  硕士研究生  078006-药理学  

王倩  博士研究生  100706-药理学  

陈成  博士研究生  100706-药理学