基本信息
熊文勇  男  博导  中国科学院昆明植物研究所
电子邮件: xiong.wenyong@mail.kib.ac.cn
通信地址: 昆明市蓝黑路132号
邮政编码: 650201
部门/实验室:植物化学与西部植物资源持续利用国家重点实验室

研究领域

        以研发治疗糖尿病的天然药物为目的,建立多层次有特色的动物、细胞和分子水平筛选及作用机理研究平台,发展以植物特有化合物为探针的药物活性检测技术,从胰岛素释放、葡萄糖摄取、糖原向糖转化、葡萄糖重吸收等方面对天然化合物进行筛选,为转化天然化合物成为天然药物提供有效的活性基础。并以这些活性化合物为小分子探针,围绕与糖尿病发生密切相关的信号通路研究其与靶细胞和靶蛋白之间的相互作用,阐明其治疗糖尿病的作用机制,为治疗糖尿病提供新的治疗策略和药物作用机理依据

招生信息

欢迎药理学、细胞生物学、分子生物学和生物化学背景,以及生物医学背景考生报考。

招生专业
100706-药理学
071010-生物化学与分子生物学
招生方向
抗糖尿病药物发现与药理研究

教育背景

1999-09--2004-08   中国科学院昆明动物研究所   博士
1995-09--1999-07   陕西师范大学   学士

工作经历

   
工作简历
2011-03~现在, 中国科学院昆明植物研究所, 研究员
2007-07~2011-02,Cornell University, 博士后
2004-09~2007-06,University of Southern California, 博士后

专利与奖励

   

出版信息

   
发表论文
(1) The natural product antroalbol H promotes phosphorylation of liver kinase B1 (LKB1) at threonine 189 and thereby enhances cellular glucose uptake, Journal of Biological Chemistry, 2019, 通讯作者
(2) Novel Dual-color Drug Screening Model for GLUT4 Translocation in Adipocytes, Molecular and Cellular Probes, 2019, 通讯作者
(3) Adenanthin, a Natural ent-Kaurane Diterpenoid Isolated from the Herb Isodon adenantha Inhibits Adipogenesis and the Development of Obesity by Regulation of ROS, Molecules, 2019, 通讯作者
(4) A Fluorescent Glucose Transport Assay for Screening SGLT2 Inhibitors in Endogenous SGLT2-Expressing HK-2 Cells, Natural Products and Bioprospecting, 2019, 通讯作者
(5) Mechanistic insights into GLUT1 activating and clustering revealed by super-resolution imaging, Proc Natl Acad Sci U S A, 2018, 通讯作者
(6) Single molecule glucose transporting process revealed by force tracing and molecular dynamics simulations, Nanoscale Horizons, 2018, 通讯作者
(7) Inhibition of 3,5,2',4'-tetrahydroxychalcone on production of uric acid in hypoxanthine-induced hyperuricemic mice, Biol. Pharm. Bull, 2018, 第 5 作者
(8) Super-resolution microscopy reveals the reorganization of GLUT4 on plasma membrane regulated by insulin resistance, Journal of Cell Science, 2017, 通讯作者
(9) Old Drug, New Indication: Olsalazine Sodium Reduced Serum Uric Acid Levels in Mice via Inhibiting Xanthine Oxidoreductase Activity, Journal of Pharmacological Sciences, 2017, 通讯作者
(10) Borapetoside E, a Clerodane Diterpenoid Extracted from Tinospora crispa, Improves Hyperglycemia and Hyperlipidemia in High-Fat-Diet-Induced Type 2 Diabetes Mice, Journal of Natural Products, 2017, 通讯作者
(11) Pyrocincholic Acid 3β-O-β-D-quinovopyranosyl-28-O-β-D-glucopyranoside Suppresses Adipogenesis and Regulates Lipid Metabolism in 3T3-L1 Adipocytes, Natural Products and Bioprospecting, 2017, 通讯作者
(12) AS160 regulates cell cycle and cell proliferation through p21, Cell cycle, 2016, 通讯作者
(13) Clerodane Diterpenoids with Anti-hyperglycemic Activity from Tinospora crispa, Natural Products and Bioprospecting, 2016, 通讯作者
(14) RACK1 is required for adipogenesis, American Journal of Physiology-Cell Physiology, 2016, 通讯作者
(15) Variation in carbohydrates between Cancer and Normal Cell Membranes Revealed by Super-Resolution Fluorescence Imaging, Advanced Science, 2016, 第 8 作者
(16) Structure-Based Optimization and Biological Evaluation of Pancreatic Lipase Inhibitors as Novel Potential Antiobesity Agents, Natural Products and Bioprospecting, 2015, 通讯作者
(17) The Development and Application of the Glucose Uptake Stimulating Cell Model, Plant Diversity and Resources, 2015, 通讯作者
(18) Carboxymethyl- and Carboxyl-Catechins from Ripe Pu-er Tea, Journal of Agricultural and Food Chemistry, 2014, 第 4 作者
(19) Specialized sorting of GLUT4 and its recruitment to the cell surface are independently regulated by distinct Rabs, Molecular Biology of the Cell, 2013, 第 4 作者
(20) GLUT4 is sorted into vesicles whose accumulation beneath and insertion to the plasma membrane is differentially regulated by insulin and selectively by insulin resistance,  Molecular Biology of the Cell, 2010, 第 1 作者
(21) IRAP is a key regulator of GLUT4 trafficking by controlling sorting from endosomes to specialized insulin-regulated vesicles, Molecular Biology of the Cell, 2010, 第 2 作者
(22) Human Insulin Vesicle Dynamics During Pulsatile Secretion, Diabetes, 2007, 第 1 作者
(23) HIV-1 protease inhibitors nelfinavir and atazanavir induce malignant glioma death by triggering endoplasmic reticulum stress, Cancer Research, 2007, 第 4 作者
(24) Calcium-induced ER stress as a major component of tumor cell death induced by 2,5-dimethyl-celecoxib (DMC), a non-coxib derivative of celecoxib, Molecular Cancer Therap, 2007, 第 4 作者
(25) Mechanisms of peptide hormone secretion, TRENDS in Endocrinology and Metabolism, 2006, 第 3 作者
(26) The Effect of Acute Stress on LTP and LTD Induction in the Hippocampal CA1 Region of Anesthetized Rats at Three Different Ages, Brain Research, 2004, 第 1 作者
(27) The stress experience dependent long-term depression disassociated with stress effect on spatial memory task, Neuroscience Research, 2003, 第 1 作者

指导学生

已指导学生

田维锋  硕士研究生  085238-生物工程  

胡海军  硕士研究生  071010-生物化学与分子生物学  

贡潘偏抽  博士研究生  100701-药物化学  

牛艳芬  博士研究生  100706-药理学  

高蓝  博士研究生  100701-药物化学  

彭莉  硕士研究生  071010-生物化学与分子生物学  

许宇辉  博士研究生  100706-药理学  

胡敬  博士研究生  100706-药理学  

逯艳婷  博士研究生  100706-药理学  

马秀丽  硕士研究生  078006-药理学  

王芳  博士研究生  100706-药理学  

现指导学生

秦婉莹  博士研究生  100706-药理学  

母蓉芳  硕士研究生  078006-药理学  

周慧敏  硕士研究生  078006-药理学  

王倩  博士研究生  100706-药理学  

陈成  博士研究生  100706-药理学