基本信息

周欣  男  博导  中国科学院精密测量科学与技术创新研究院
电子邮件: xinzhou@wipm.ac.cn
通信地址: 武汉市小洪山西区30号波谱楼1908室
邮政编码: 430071


导师简介

周欣,基金委创新研究群体项目负责人、杰青、国家“特支计划”领军人才,担任基金委国家重大科研仪器设备研制项目专家委员会委员,中国物理学会波谱专业委员会常务副主任委员。获全国创新争先奖、中科院年度创新人物、首届科学探索奖、CCTV“全国十大科技创新人物”、中科院青年科学家奖、湖北省技术发明一等奖等荣誉。

主要从事医学影像的新仪器、新技术及活体分子成像方面的研究。自主研制了世界上增强倍数最高的人体肺部气体磁共振(MRI)仪器,成功“点亮”肺部,有效解决了肺部无损、定量、可视化检测瓶颈技术背后的科学难题;发展了多核MRI新技术,研制了系列新型造影剂,为脑部重大疾病和肿瘤的早期检测提供了全新的医学影像仪器与手段。在PNAS、Science子刊等学术刊物上发表论文百余篇,授权及受理国内外发明专利百余件。


研究领域

1、Hyperpolarized Instruments


The principle that enables researchers to generate hyperpolarization in gases (e.g. hyperpolarized 129Xe or 3He) via spin exchange collisions. The collisions are mainly binary collisions that depend on thermal velocity at high pressures and also short-lived van der Waals interactions or three-body collisions that depend on the partial pressure at low pressure.

The basic structure diagram of the 129Xe hyperpolarizer is shown above.  It features an optical cell used for optical pumping and spin-exchange collisions, collection system, gas supply system, vacuum system.  A computer is used for monitoring and controlling the process.




2、MRI Methods and Techniques for the Lung


Left image shows conventional proton MR image of lung.  The signal originates from the lung's H2O content (about 10^22 hydrogen atoms).

Right image shows a hyperpolarized MR image of lung.  The signal originates from helium (3He) gas (about 10^10 atoms).


Lung diseases, especially lung cancer, are a major cause of human death.Thus, imaging techniques that can help identify the onset, type and grade of disease at an early stage is critical.  Lungs are normally imaged by x-ray techniques (2D and CT).  However, these techniques rely on ionizing radiation, which represents an additional health risk, and do not provide any information that can help assess the function of the lung. The latter is important because an accurate diagnosis should interrogate not only its structure, but whether or not the lung functions (e.g. ventilates) well.


Conventional MRI, based on the use of proton signal, can depict structure and function of brain and other organs, but cannot image lung.  This is because the lung consists of:

    1) much void space filled with air, which does not yield detectable signal, and

    2) its tissue is made of alveolae, which have a very low proton density and short relaxation times due to their porous structure.


In recent years, the technique of hyperpolarized nobles gas MRI has enabled amplifications of the NMR signal by orders of magnitude compared to that of thermal equilibrium.  This technique is an excellent tool for the study of lung by MRI and has excellent potential for the diagnosis of lung diseases by measuring associated changes in the lung's structure and function.


Our team develops NMR and MRI techniques based on hyperpolarized noble gases to quantify the changes in lung structure and function associated with various lung diseases.  This will, in turn, benefit the medical profession and public health by offering new possibilities for early and accurate diagnosis.




3、Hyperploarized Xenon Molecular Sensors and Molecular Imaging


Hyperpolarized 129Xe MRI has emerged in recent years as one of the most powerful methods for molecular imaging with the development of molecular sensors based on xenon. Hyperpolarized 129Xe nuclei offer unprecedented sensitivity enhancement, along with excellent chemical shift sensitivity for detection of molecular events and chemical substances.   This offers new possibilities for molecular imaging.


Our lab is developing various 129Xe-cryptophane biosensors targeted to cancer cells, proteins, and ions.  We are also developing pH- and temperature-sensitive biosensors for in vivo sensing, thereby expanding the capabilities of Xe biosensors.


Another research direction exploits the rapid and reversible encapsulation of Xe between "bound" (i.e., cryptophane) and "free" (i.e., bulk water) states to report additional information for in vitro and in vivo studies of local chemical environments. Our xenon biosensor developments, which include high detection sensitivity, improve medical diagnostic imaging technology while targeting a broad range of biomedical applications.







4、Atomic Magnetometry and Laser-Detected NMR


Nuclear magnetic resonance (NMR) is a powerful analytical technique that has been used not only in fundamental physics, chemistry and biology research, but also in applications such as medical imaging and oil well logging. However, the detection sensitivity of conventional NMR techniques is poor, especially in low magnetic fields. The conventional method of detection is Faraday induction. Low field NMR and MRI are attractive from the point of view of developing simpler (e.g. smaller), more mobile and less costly instrumentation that does not rely on cryogenic superconducting magnet technology.    Thus, much effort is devoted toward improving detection sensitivity. Our group is developing novel NMR detection technology based on optical atomic magnetometry. Optical magnetometers are usually operated at low magnetic fields and become significantly cheaper and more portable than conventional NMR instruments. This provides an interesting alternative approach for low-field NMR.


Our recent work includes a Cs atomic magnetometer with a sensitivity of 150 fT/Hz1/2 operating near room temperature. The NMR signal of a 125 uL water sample was detected in magnetic fields as low as 47 nT, with a signal-to-noise ratio close to 50 after only eight signal averages. To demonstrate the magnetometer's ability to measure spin-lattice relaxation times, relaxivity experiments using a Gd(DTPA) MRI contrast agent were performed near zero field.


In contrast with Faraday induction detection, our zero-field atomic magnetometer is particularly sensitive in the frequency range from DC to a few kilohertz. NMR in low fields does not require the cryogenics needed to operate superconducting magnets. Cryogens are also needed to operate magnetic sensors based on a superconducting quantum interference devices.


Moreover, because magnetic-field gradients are proportional to the magnetic field, operation in ultra low fields implies that the "external field" can be made extremely homogenous. Homogeneous fields lead to very narrow resonance lines, permitting the measurement of ultra weak spin interactions. The prospect of "pure J coupling" NMR in ultra low fields, where chemical shifts are much weaker, has been recognized by several leading research groups.


As a result, this kind of magnetometer makes NMR increasingly more powerful and accessible to a wider range of applications that involve chemical analysis. Our is focusing its research efforts on the development a new class of SERF magnetometers based on Cs vapor and the understanding spectra in low fields for purposes of ultra sensitive chemical detection.



招生信息

   
招生专业
070302-分析化学
070208-无线电物理
083100-生物医学工程
招生方向
生物医学分子影像
肺部磁共振成像仪器与技术
激光探测磁共振

工作经历

   
工作简历
2009-10~现在, 中国科学院精密测量科学与技术创新研究院, 研究员
2007-09~2009-09,美国加州大学伯克利分校;美国劳伦斯国家实验室, 研究助理
2005-01~2007-09,美国哈佛大学,美国Brigham Women's Hospital, 博士后
2004-07~2004-12,中国科学院武汉物理与数学研究所, 助理研究员
社会兼职
2020-11-13-今,中国仪器仪表学会分析仪器分会, 常务理事
2019-06-01-2022-05-31,中国科学院磁共振技术联盟, 常务副理事长
2017-06-01-2021-05-31,湖北省青年联合会, 副主席/科技界别主任
2017-06-01-2022-05-31,中国生物物理学会分子影像学专业委员会, 副主任委员
2016-07-31-2021-07-30,中国物理学会波谱专业委员会, 常务副主任委员
2015-12-31-今,中国生物医学工程学会生物医学光子学分会, 常委
2015-06-01-今,中华放射学会磁共振专业委员会, 委员/学组组长
2014-04-01-今,基金委国家重大仪器研制专项第二届、第三届专家委员会, 委员
2012-01-01-2017-12-31,《科技中国》杂志, 专家委员会委员
2011-01-01-2011-12-31,第四届亚太磁共振论坛, 秘书长
2008-01-01-2015-12-31,纽约科学学院, 会员
2005-01-01-2015-04-01,国际磁共振医学学会, 会员

专利与奖励



专利成果
( 1 ) 一种无重金属离子卟啉化合物造影剂及其在磁共振共像中的应用, 发明, 2021, 第 1 作者, 专利号: ZL201810308547.6
( 2 ) 一种肺部气道微结构模型的测量方法, 发明, 2020, 第 1 作者, 专利号: ZL201811434681.7
( 3 ) 一种用于超灵敏原子磁力计的主动式磁补偿方法, 发明, 2020, 第 1 作者, 专利号: ZL201910797178.6
( 4 ) 一种RGD‑石墨烯/MnO2磁性纳米球的复合探针和其应用, 发明, 2020, 第 1 作者, 专利号: ZL201710225753.6
( 5 ) 一种用于T1、T2双模态磁共振造影剂的磁性纳米颗粒复合物及其制备方法, 发明, 2019, 第 1 作者, 专利号: ZL201710167283.2
( 6 ) 一种用于人体肺部的快速功能磁共振成像方法, 发明, 2019, 第 1 作者, 专利号: ZL201710405589.7
( 7 ) 一种超极化气体磁共振影像处理方法, 发明, 2019, 第 1 作者, 专利号: ZL201610850867.5
( 8 ) 一种光纤原子滤光装置, 发明, 2019, 第 1 作者, 专利号: ZL201610602759.6
( 9 ) 一种基于变采样率的肺部超极化气体动态成像方法, 发明, 2018, 第 1 作者, 专利号: ZL201610743164.2
( 10 ) 一种近红外氮杂氟硼二吡咯染料及其微波法合成方法, 发明, 2018, 第 1 作者, 专利号: ZL201510534389.2
( 11 ) 一种惰性气体原子核通道装置及磁共振成像方法, 发明, 2018, 第 1 作者, 专利号: ZL201610094660.X
( 12 ) 一种用于超极化氙收集的液氮液位控制和显示装置, 发明, 2017, 第 1 作者, 专利号: ZL201510274966.9
( 13 ) 一种靶向多功能双载药脂质体的制备方法和应用, 发明, 2017, 第 1 作者, 专利号: ZL201510021568.6
( 14 ) 一种微波法制备多色荧光石墨烯量子点的方法, 发明, 2016, 第 1 作者, 专利号: ZL201410778272.4
( 15 ) 一种利用不同温度加热光抽运泡的系统和方法, 发明, 2016, 第 1 作者, 专利号: ZL201310710433.1
( 16 ) 一种基于预扫描和非均匀采样的薄层快速磁共振成像方法, 发明, 2015, 第 2 作者, 专利号: ZL201410313197.4
( 17 ) 一种永磁极化器, 发明, 2014, 第 1 作者, 专利号: ZL201110357356.7
奖励与荣誉

(1) 全国创新争先奖, 国家级, 2020 

(2) 中国科学院年度创新人物, 院级, 2020 

(3) 首届科学探索奖, 其他, 2019 

(4)“国家高层次人才特殊支持计划”科技创新领军人才 , 国家级, 2019 

(5) 湖北省技术发明一等奖, 一等奖, 省级, 2018 

(6) 国家科技部“创新人才推进计划”中青年科技创新领军人才, 国家级, 2018 

(7) 2018年度CCTV“全国科技十大创新人物”, 国家级, 2018 

(8) 中国专利优秀奖, 其他, 2017 

(9) 全国王天眷波谱学奖, 其他, 2016 

(10) 中国科学院青年科学家奖, 院级, 2016 

(11) 湖北五一劳动奖章, 省级, 2016 

(12) 中国专利优秀奖, 其他, 2016 

(13) 2015年度湖北十大科技事件, 省级, 2015 

(14)“国家高层次人才特殊支持计划”青年拔尖人才, 国家级, 2014 

(15) 武汉市优秀青年科技工作者, 市地级, 2014 

(16) 中国产学研合作创新成果奖, 其他, 2013

出版信息

   
发表论文
(1) Photosensitive MRI Biosensor for BCRP-Targeted Uptake and Light-Induced Inhibition of Tumor Cells, Talanta, 2021, 通讯作者
(2) Damaged Lung Gas Exchange Function of Discharged COVID-19 Patients Detected by Hyperpolarized 129Xe MRI, Science Advances, 2021, 通讯作者
(3) Coloring Ultrasensitive MRI with Tunable Metal-Organic Frameworks, Chemical Science, 2021, 通讯作者
(4) Quantitative Evaluation of Lung Injury Caused by PM2.5 Using Hyperpolarized Gas Magnetic Resonance, Magnetic Resonance in Medicine, 2020, 通讯作者
(5) Quantitatively Fine-Tuning the Physicochemical and Biological Properties of Peptidic Polymers through Monodisperse PEGylation, Biomacromolecules, 2020, 通讯作者
(6) A Small Molecular Multifunctional Tool for pH Detection, Fluorescence Imaging, and Photodynamic Therapy, ACS Applied Bio Materials, 2020, 通讯作者
(7) Analysis of Characteristics in Death Patients with COVID-19 Pneumonia without Underlying Diseases, Academic Radiology, 2020, 通讯作者
(8) Silica Nanoparticle Coated Perfluorooctyl Bromide for Ultrasensitive MRI, Journal of Materials Chemistry B, 2020, 通讯作者
(9) Fluorinated Porphyrin-Based Theranostics for Dual Imaging and Chemo-Photodynamic Therapy, Journal of Materials Chemistry B, 2020, 通讯作者
(10) Albumin-constrained Large-scale Synthesis of Renal Clearable Ferrous Sulfide Quantum Dots for T1-Weighted MR Imaging and Phototheranostics of Tumors, Biomaterials, 2020, 通讯作者
(11) Progressive CT Findings and Positive RT-PCR Again of Recovered and Discharged Patients with COVID-19, Journal of Thoracic Disease, 2020, 通讯作者
(12) Hyperpolarized Xe NMR Signal Advancement by Metal-organic Framework Entrapment in Aqueous Solution, Proceedings of the National Academy of Sciences of the United States of America, 2020, 通讯作者
(13) Quieting an Environmental Magnetic Field without Shielding, Review of Scientific Instruments, 2020, 通讯作者
(14) Efficient Temperature-feedback Liposome for 19F MRI Signal Enhancement, Chemical Communications, 2020, 通讯作者
(15) Delicately Designed Cancer Cell Membrane-Camouflaged Nanoparticles for Targeted 19F MR/PA/FL Imaging-Guided Photothermal Therapy, ACS Applied Materials & Interfaces, 2020, 通讯作者
(16) Detection and Chiral Recognition of α-hydroxyl Acid through 1H and CEST NMR Spectroscopy Using a Ytterbium Macrocyclic Complex, Angewandte Chemie - International Edition, 2019, 通讯作者
(17) Engineered Paramagnetic Graphene Quantum Dots with Enhanced Relaxivity for Tumor Imaging, Nano Letters, 2019, 通讯作者
(18) Highly and Adaptively Undersampling Pattern for Pulmonary Hyperpolarized 129Xe Dynamic MRI, IEEE Transactions on Medical Imaging, 2019, 通讯作者
(19) A Fluorinated Aza-BODIPY Derivative for NIR fluorescence/PA/19F MR Tri-modality In Vivo Imaging, Chemical Communications, 2019, 通讯作者
(20) Free-Base Porphyrins as CEST MRI Contrast Agents with Highly Upfield Shifted Labile Protons, Magnetic Resonance in Medicine, 2019, 通讯作者
(21) An Intracellular Diamine Oxidase Triggered Hyperpolarized 129Xe Magnetic Resonance Biosensor, Chemical Communications, 2019, 通讯作者
(22) A Multiscale Fuzzy Metric for Detecting Small Infrared Targets Against Chaotic Cloudy/Sea-Sky Backgrounds, IEEE Transactions on Cybernetics, 2019, 通讯作者
(23) Single Breath‐Hold Measurement of Pulmonary Gas Exchange and Diffusion in Humans with Hyperpolarized 129Xe MR, NMR in Biomedicine, 2019, 通讯作者
(24) 129Xe Hyper-CEST/19F MRI Multimodal Imaging System for Sensitive and Selective Tumor Cells Detection, ACS Applied Bio Materials, 2019, 通讯作者
(25) k-Space-Based Enhancement of Pulmonary Hyperpolarized 129Xe Ventilation Images, IEEE Transactions on Instrumentation and Measurement, 2019, 通讯作者
(26) Single Breath‐Hold Measurement of Pulmonary Gas Exchange and Diffusion in Humans with Hyperpolarized 129Xe MR, NMR in Biomedicine, 2019, 通讯作者
(27) Fluorinated Aza-BODIPY Derivative for NIR fluorescence/PA/19F MR Tri-modality In Vivo Imaging, Chemical Communications, 2019, 通讯作者
(28) Free-Base Porphyrins as CEST MRI Contrast Agents with Highly Upfield Shifted Labile Protons, Magnetic Resonance in Medicine, 2019, 通讯作者
(29) Detection and Chiral Recognition of α-hydroxyl Acid through 1H and CEST NMR Spectroscopy Using a Ytterbium Macrocyclic Complex, Angewandte Chemie - International Edition, 2019, 通讯作者
(30) Considering Low-Rank, Sparse and Gas-Inflow Effects Constraints for Accelerated Pulmonary Dynamic Hyperpolarized 129Xe MRI, Journal of Magnetic Resonance, 2018, 通讯作者
(31) Detection and Differentiation of Cys, Hcy and GSH Mixtures by 19F NMR Probe, Talanta, 2018, 通讯作者
(32) pH-responsive Theranostic Nanocomposites as Synergistically Enhancing Positive and Negative Magnetic Resonance Imaging Contrast Agents., Journal of Nanobiotechnology, 2018, 通讯作者
(33) Lung Morphometry using Hyperpolarized 129Xe Multi-b Diffusion MRI with Compressed Sensing in Healthy Subjects and Patients with COPD, Medical Physics, 2018, 通讯作者
(34) Potential Detection of Cancer with Fluorinated Silicon Nanoparticles in 19F MR and Fluorescence Imaging., Journal of Materials Chemistry B, 2018, 通讯作者
(35) Quantitative Evaluation of Pulmonary Gas-Exchange Function using Hyperpolarized 129Xe CEST MRS and MRI, NMR in Biomedicine, 2018, 通讯作者
(36) An Intracellular Diamine Oxidase Triggered Hyperpolarized 129Xe Magnetic Resonance Biosensor, Chemical Communications, 2018, 通讯作者
(37) Highly and Adaptively Undersampling Pattern for Pulmonary Hyperpolarized 129Xe Dynamic MRI, IEEE Transactions on Medical Imaging, 2018, 通讯作者
(38) Considering Low-Rank, Sparse and Gas-Inflow Effects Constraints for Accelerated Pulmonary Dynamic Hyperpolarized 129Xe MRI, Journal of Magnetic Resonance, 2018, 通讯作者
(39) Mitochondria Targeted and Intracellular Biothiol Triggered Hyperpolarized 129Xe Magnetofluorescent Biosensor, Analytical Chemistry, 2017, 通讯作者
(40) Magnetic Resonance Spectroscopy As a Tool for Assessing Macromolecular Structure and Function in Living Cells, Annual Review of Analytical Chemistry, 2017, 通讯作者
(41) Hyperpolarized 129Xe MRI Sensor for H2S, Chemistry - A European Journal, 2017, 通讯作者
(42) imultaneous Assessment of Both Lung Morphometry and Gas Exchange Function within a Single Breath-hold by Hyperpolarized 129Xe MRI, NMR in Biomedicine, 2017, 通讯作者
(43) Increasing Cancer Therapy Efficiency through Targeting and Localized Light Activation, ACS Applied Materials & Interfaces, 2017, 通讯作者
(44) Small Infrared Target Detection Based on Weighted Local Difference Measure, IEEE Transactions on Geoscience and Remote Sensing, 2016, 通讯作者
(45) Biothiol Xenon MRI Sensor Based on Thiol-Addition Reaction, Analytical Chemistry, 2016, 通讯作者
(46) Image enhancement based on intuitionistic fuzzy sets theory, IET Image Processing, 2016, 通讯作者
(47) Fast Determination of Flip Angle and T1 in Hyperpolarized Gas MRI During a Single Breath-Hold, Scientific Reports, 2016, 通讯作者
(48) Oxygen-dependent Hyperpolarized 129Xe Brain MR, NMR in Biomedicine, 2016, 通讯作者
(49) One-pot Synthesis Polyamines Improved Magnetism and Fluorescence Fe3O4-Carbon Dots Hybrid NPs for Dual Modal Imaging, Dalton Transactions, 2016, 第 10 作者
(50) Discovery of a 19F MRI Sensitive Salinomycin Derivative with High Cytotoxicity towards Cancer Cells, Chemical Communications, 2016, 第 10 作者
(51) Detection of Subnanotesla Oscillatory Magnetic Fields Using MRI, Magnetic Resonance in Medicine, 2016, 第 5 作者
(52) Direct Detection of Optogenetically Evoked Oscillatory Neuronal Electrical Activity in Rats Using SLOE Sequence, NeuroImage, 2016, 第 4 作者
(53) Constant-Variable Flip Angles for Hyperpolarized Media MRI, Journal of Magnetic Resonance, 2016, 通讯作者
(54) MRI-Guided Liposomes for Targeted Tandem Chemotherapy and Therapeutic Response Prediction, Acta Biomaterialia, 2016, 通讯作者
(55) A Molecular Imaging Approach to Mercury Sensing Based on Hyperpolarized 129Xe Molecular Clamp Probe, Chemistry - A European Journal, 2016, 通讯作者
(56) Quantitative Evaluation of Radiation-Induced Lung Injury with Hyperpolarized Xenon Magnetic Resonance, Magnetic Resonance in Medicine, 2016, 通讯作者
(57) A Theoretical Analysis of Chemical Exchange Saturation Transfer Echo Planar Imaging (CEST-EPI) Steady State Solution and the CEST Sensitivity Efficiency-Based Optimization Approach, Contrast Media & Molecular Imaging, 2016, 通讯作者
(58) Entropy-Based Window Selection for Detecting Dim and Small Infrared Targets, Pattern Recognition, 2016, 通讯作者
(59) Quantitative Comparison of Lung Physiological Parameters in Single and Multiple Breathhold with Hyperpolarized Xenon Magnetic Resonance, Biomedical Physics & Engineering Express, 2016, 通讯作者
(60) Design, Synthesis and Evaluation of Novel 19F Magnetic Resonance Sensitive Protein Tyrosine Phosphatase Inhibitors, Medicinal Chemistry Communication, 2016, 第 9 作者
(61) Tissue Characterization with Quantitative High-Resolution Magic Angle Spinning Chemical Exchange Saturation Transfer Z-Spectroscopy, Analytical Chemistry, 2016, 第 5 作者
(62) Adaptive Intuitionistic Fuzzy Enhancement of Brain Tumor MR Images, Scientific Reports, 2016, 通讯作者
(63) Mammogram Enhancement using Intuitionistic Fuzzy Sets, IEEE Transactions on Biomedical Engineering, 2016, 通讯作者
(64) Detection of Smoke-Induced Pulmonary Lesions by Hyperpolarized 129Xe Diffusion Kurtosis Imaging in Rat Models, Magnetic Resonance in Medicine, 2016, 通讯作者
(65) Altered Spontaneous Brain Activity in Patients with Acute Spinal Cord Injury Revealed by Resting-State Functional MRI, PLoS One, 2015, 第 3 作者
(66) Design and Synthesis of Fluorinated Dendrimers for Sensitive 19F MRI, Journal of Organic Chemistry, 2015, 第 4 作者
(67) Design and Synthesis of Fluorinated Amphiphile as 19F MRI/Fluorescence Dual-Imaging Agent by Tuning the Self-Assembly, Journal of Organic Chemistry, 2015, 第 4 作者
(68) Visualize Diffusion Map of COPD Rat with Hyperpolarized Xenon MRI, Chinese Journal of Magnetic Resonance, 2015, 通讯作者
(69) Atomic Filter Based on Stimulated Raman Transition at the Rubidium D1 Line, Optics Express, 2015, 通讯作者
(70) Infrared Small Target Detection using Multiscale-gray-difference Weighted Image Entropy, IEEE Transactions on Aerospace and Electronic Systems, 2015, 通讯作者
(71) MRI-visible Liposome Nanovehicles for Potential Tumor-targeted Delivery of Multimodal Therapies, Nanoscale, 2015, 通讯作者
(72) Body Temperature Sensitive Micelle for MRI Enhancement, Chemical Communications, 2015, 通讯作者
(73) CS-MRI中评价随机欠采样矩阵的新方法, 波谱学杂志, 2015, 通讯作者
(74) A europium-lipoprotein nanocomposite for high-sensitive MR-fluorescence multimodal imaging, RSC Advances, 2015, 通讯作者
(75) PH-Triggered Au-fluorescent Mesoporous Silica Nanoparticles for 19F MR/Fluorescent Multimodal Cancer Cellular Imaging, Chemical Communications, 2014, 通讯作者
(76) Highly Sensitive Detection of Mercury (II) in Aqueous Media by Tetraphenylporphyrin with A Metal Ion Receptor, Supramolecular Chemistry, 2014, 通讯作者
(77) Rational Design of Hyperpolarized Xenon NMR Molecular Sensor for Selective and Sensitive Determination of Zinc Ions, Talanta, 2014, 通讯作者
(78) Ultranarrow Bandwidth Tunable Atomic Filter via Quantum Interference-induced Polarization Rotation in Rb Vapor, Chinese Optics Letters, 2014, 第 4 作者
(79) 超极化气体肺部磁共振成像, 波谱学杂志, 2014, 通讯作者
(80) 锰对比剂在MRI中的应用, 磁共振成像, 2014, 通讯作者
(81) Ultralow Field NMR Spectrometer With An Atomic Magnetometer Near Room Temperature., Journal of Magnetic Resonance, 2013, 通讯作者
(82) NMR Spectroscopic Approach Reveals Metabolic Diversity of Human Blood Plasma Associated with Protein-Drug Interaction, Analytical Chemistry, 2013, 第 4 作者
(83) 超极化129Xe磁共振分子影像学, 波谱学杂志, 2013, 通讯作者
(84) 肺部超极化气体MR成像, 中国医学影像技术, 2013, 通讯作者
(85) 磁共振波谱与成像技术, 物理, 2013, 通讯作者
(86) 高灵敏度原子磁力计研究进展, 物理, 2012, 通讯作者
(87) Doppler-Free Spectroscopy of Rubidium Atoms Driven by a Control Laser, Frontier of Physics in China, 2012, 第 4 作者
(88) MRI of Stroke using Hyperpolarized 129Xe, NMR in Biomedicine, 2011, 第 1 作者
(89) 超极化129Xe磁共振波谱和成像及在生物医学中的应用, 物理, 2011, 通讯作者
(90) Distribution of Hyperpolarized Xenon in the Brain Following Sensory Stimulation: Preliminary MRI Findings, PLoS ONE, 2011, 通讯作者
(91) Quantitative Estimation of SPINOE Enhancement in Solid State, Journal of Magnetic Resonance, 2009, 第 1 作者
(92) Hyperpolarized Xenon NMR and MRI Signal Amplification by Gas Extraction, The Proceedings of the National Academy of Sciences, USA, 2009, 第 1 作者
(93) Reinvestigating Hyperpolarized 129Xe Longitudinal Relaxation Time in the Rat Brain with Noise Considerations, NMR in Biomedicine, 2008, 第 1 作者
(94) Measurement of the Internal Diameter of Plastic Tubes from Projection MR Images using a Model-Based Least-Squares Fit Approach, Medical Physics, 2006, 第 4 作者
(95) Production of Hyerpolarized 129Xe Gas without Nitrogen by Optical Pumping at 133Cs D2 Line in Flow System, Chinese Physics Letter, 2004, 第 1 作者
(96) Experiment and Dynamic Simulations of Radiation Damping of Laser-Polarized Liquid 129Xe at Low Magnetic Field in a Flow System, Applied Magnetic Resonance, 2004, 第 1 作者
(97) Enhancement of Solidstate Proton NMR via SPINOE with Laserpolarized Xenon, Physical Review B, 2004, 第 1 作者
发表著作
(1) In vivo NMR Imaging: Methods and Protocols--Hyperpolarized Noble Gases as Contrast Agents, Humana, 2011-10, 第 1 作者
(2) 脑成像的先进技术:超极化氙脑部磁共振成像, Advances in Brain Imaging-Hyperpolarized Xenon Brain MRI , InTech, 2012-01, 第 1 作者

科研活动

   
参与会议
(1)Hyperpolarized Xenon MRI Quantitatively Evaluates Lung Gas-exchange in Patients with COVID-19   约翰斯·霍普金斯大学磁共振研讨会   2020-10-29
(2)Multi-nuclear MRI for human and in vivo molecular imaging   2019年度人口健康领域研讨会   2019-06-25
(3)Lung Morphological and Functional MRI with Hyperpolarized 129Xe   第28届生物系统磁共振国际会议   2018-08-22
(4)Hyperpolarized Xe Lung MRI and Molecular Imaging   2018欧洲磁共振会议   2018-07-04
(5)Hyperpolarized 129Xe Lung MRI and Biosensors @ China   国际XeMAT 2018论坛   2018-05-07
(6)Functionalized Cryptophane-129Xe MRI Biosensor for Biothiols Detection through Thiol-addition Reaction   第24届国际医学磁共振会议   2016-05-09
(7)Quantitative Evaluation of Radiation-induced Lung Injury by Hyperpolarized Xenon MRI   超极化惰性气体 国际会议 (PING14)   2014-09-29
(8)Modified Cryptophane-A Cage for Multi-targeting 129Xe NMR   第55届实验磁共振会议   2014-03-23
(9)Hyperpolarized 129Xe Lung and Brain MRI   中德高场磁共振 成像联合研讨会 (CGHW)   2013-10-14
(10)Quantitative study chemical exchange of dilute sample by inversion transfer    第18届磁共振学会   2013-05-20
(11)Hyperpolarized Xenon Lung and Brain MRI   印度磁共振学会议   2013-02-05
(12)Ultrasensitive NMR and MRI   第四届海峡两岸磁共振会议   2012-10-25
(13)Hyperpolarized Noble Gas MRI: from Gas to Dissolved Phase   第四届亚太核磁共振研讨会   2011-10-18
(14)Hyperpolarized Xenon NMR and MRI Signal Amplification   第16 届全国波谱学学术会议   2010-11-25
(15)Hyperpolarized Xenon NMR and MRI Signal Amplification by Gas Extraction (Hyper-SAGE)   第51届实验磁共振会议   2010-04-19
(16)Sensitivity Enhancement of Molecular Imaging with Remote Detection NMR   第13届北京分析测试学术报告会及展览会   2009-11-25
科研项目

1)国家自然科学基金委员会,创新研究群体项目,生命波谱与成像,2020-12024-12,在研,主持

2)国家科学技术部,变革性技术关键科学问题,肺癌的超高灵敏谱学与成像新技术研究,2019-92024-8,在研,主持

3)国家自然科学基金委员会,国家杰出青年科学基金,超灵敏磁共振成像,2017-12021-12,在研,主持

4)国家自然科学基金委员会,重大研究计划重点支持项目,外泌体介导的129Xe/19F双核MRI用于肺癌早期探测及其演进机制的研究,2019-12022-12,在研,主持

5)中国科学院,关键技术研发团队,超(高)灵敏磁共振波谱与成像技术研发团队,2020-12022-12,在研,主持

6)中国科学院,基础前沿科学研究计划 从0-1原始创新项目,肺的异构功能性数据获取与智能融合,2019-92029-8,在研,主持

7)国家自然科学基金委员会,国家重大科研仪器设备研制专项(部委推荐),用于人体肺部重大疾病研究的磁共振成像仪器系统研制,2013-12017-12,结题,主持

8)中国科学院,关键技术研发团队,超(高)灵敏磁共振波谱与成像技术,2017-52020-9,结题,主持

9湖北省,创新研究群体项目,活体肺部的超灵敏磁共振分子影像研究,2018-12020-12,结题,主持

10湖北省,技术创新专项重大项目,超灵敏磁共振活体肺部分子影像研究,2018-12019-12,结题,主持

11)中国科学院,科研装备研制项目,零场核磁共振波谱仪研制,2015-12016-12,结题,主持

12中国科学院,知识创新工程重要方向项目,重大疾病的高性能诊疗技术Cluster2011-12014-12,结题,主持

13国家自然科学基金委员会,青年项目,远程探测增强磁共振信号新方法,2011-012013-12,结题,主持

14)国家科学技术部,创新方法工作专项,肺部磁共振成像分析新方法研究,2010-92013-9,结题,主持

合作情况

Harvard University;
UC Berkeley;
Lawrence Berkeley National Lab;


指导学生

已指导学生

张继  硕士研究生  070302-分析化学  

朱筱磊  博士研究生  070302-分析化学  

王琦  硕士研究生  085238-生物工程  

任莉莉  博士研究生  070302-分析化学  

张智颖  博士研究生  070208-无线电物理  

曾庆斌  博士研究生  070302-分析化学  

阮伟伟  博士研究生  070208-无线电物理  

李海东  博士研究生  070208-无线电物理  

肖洒  博士研究生  070302-分析化学  

王崇武  硕士研究生  070302-分析化学  

李莎  博士研究生  070302-分析化学  

谢军帅  博士研究生  070208-无线电物理  

肖康达  博士研究生  070208-无线电物理  

现指导学生

张旭  博士研究生  070302-分析化学  

赵龙辉  博士研究生  070302-分析化学  

单海威  博士研究生  070302-分析化学  

刘小玲  博士研究生  070302-分析化学  

陈小明  硕士研究生  085208-电子与通信工程  

肖忠宇  硕士研究生  070302-分析化学  

乐曲儿  博士研究生  070302-分析化学  

岳森  硕士研究生  070302-分析化学  

隋美菊  博士研究生  070302-分析化学