基本信息
谢平 男 博导 物理研究所
电子邮件:pxie@aphy.iphy.ac.cn 
联系电话:  010-82649387
通信地址:海淀区中关村南三街8号
邮政编码:100190
部门/实验室:软物质实验室

研究领域

生物物理

主要理论和实验研究各种生物马达蛋白(例如:kinesin, myosin, dynein, Fo-F1 ATPase等)和核酸酶(例如:DNA helicase, DNA polymerase, RNA polymerase, viral reverse transcriptase, telomerase, ribosome, topoisomerase等)的运动和工作机理。

招生信息

计划每年招收硕博连读生2名,博士生1名,博士后1名。
欢迎物理、化学、生物、专业的考生。

教育背景

   
学历
1980 – 1984, 北京理工大学, 获学士学位
1988 – 1991, 北京理工大学, 获硕士学位
1991 – 1994, 中科院物理所,获博士学位

出版信息

已发表学术论文百余篇

近年来有关分子马达的部分论文如下:

Xie P, A nucleotide binding rectification Brownian ratchet model for translocation of Y-family DNA polymerases. Theor. Biol. Med. Mod. 8:22 (2011). 

Xie P, A model for the dynamics of mammalian family X DNA polymerases. J. Theor. Biol. 277, 111–122 (2011). 

Xie P, Sayers J.R., A model for transition of 5’-nuclease domain of DNA polymerase I from inert to active modes. Plos One 6, e16213 (2011). 

Xie P, A modified model for translocation events of processive nucleotide and repeat additions by the recombinant telomerase. Biophys. Chem. 153, 83–96 (2010). 

Xie P, Mechanism of processive movement of monomeric and dimeric kinesin molecules. Int. J. Biol. Sci. 6, 665–674 (2010) (Review Article) 

Xie P, A model for processive movement of single-headed myosin-IX. Biophys. Chem. 151, 71–80 (2010) 

Xie P, Dynamics of strand passage catalyzed by topoisomerase II. Eur. Biophys. J. 39, 1251–1259 (2010) 

Xie P, Dynamics of DNA polymerases. Chapter 7 (pp. 228-262), in Bacterial DNA, DNA polymerase and DNA helicases, Edited by W.D. Knudsen and S.S. Bruns (New York : Nova Science, 2010) (invited article) 

Xie P, Modeling DNA translocation and unwinding by helicase RecG. Chapter 9 (pp. 283-298), in Bacterial DNA, DNA polymerase and DNA helicases, Edited by W.D. Knudsen and S.S. Bruns (New York : Nova Science, 2010) (invited article) 

Xie P, A polymerase-site-jumping model for strand transfer during DNA synthesis by reverse transcriptase. Virus Research 144, 65–73 (2009) 

Xie P, A possible mechanism for the dynamics of transition between polymerase and exonuclease sites in a high-fidelity DNA polymerase. J. Theor. Biol. 259, 434–439 (2009) 

Xie P, On chemomechanical coupling of the F1-ATPase molecular motor. Biochim. Biophys. Acta – Bioenergetics 1787, 955–962 (2009) 

Xie P, Dynamics of backtracking long pauses of RNA polymerase. Biochim. Biophys. Acta – Gene Regulatory mechanisms 1789, 212–219 (2009) 

Xie P, Processive hand-over-hand motion of homodimeric nanomotors induced by the interaction between two monomeric components and thermal noise. Phys. Rev. E 79, 011920 (2009) 

Xie P, Model for RuvAB-mediated branch migration of Holliday junctions. J. Theor. Biol. 249, 566–573 (2007) 

Xie P, On translocation mechanism of ring-shaped helicase along single-stranded DNA. Biochim. Biophys. Acta – Proteins and Proteomics 1774, 737–748 (2007) 

Xie P, Model for forward polymerization and switching transition between polymerase and exonuclease sites by DNA polymerase molecular motors. Arch. Biochem. Biophys. 457, 73–84 (2007) 

Xie P, Dou SX, Wang PY, Processivity of single-headed kinesin motor. Biochim. Biophys. Acta – Bioenergetics 1767, 1418–1427 (2007) 

Xie P, Dou SX, Wang PY, Limping of homodimeric kinesin motors. J. Mol. Biol. 266, 976–985 (2007) 

Xie P, Model for helicase translocating along single-stranded DNA and unwinding double-stranded DNA. Biochim. Biophys. Acta – Proteins and Proteomics 457, 1719–1729 (2006)