基本信息
张晓梅 女 博导 成都有机化学研究所
电子邮件:xmzhang@cioc.ac.cn
通信地址:四川省成都市一环路南二段十六号中国科学院成都有机化学研究所
邮政编码:610041

研究领域

1、不对称合成
2、手性药物合成

招生信息

   
招生专业
070303-有机化学
招生方向
不对称合成

教育背景

1997-09--2001-07 中国科学院成都有机化学研究所 博士
1994-09--1997-07 中国科学院成都有机化学研究所 理学硕士
学历
-- 研究生
学位
-- 博士
出国学习工作
2001.7-2003.2 香港大学化学系 博士后,研究助理。
2003.8-2004.9 德国 Osnabrueck 大学化学研究所 博士后。

工作经历

   
工作简历
2008-08--今 中国科学院成都有机化学研究所 研究员,博士导师
2005-02--2008-07 中国科学院成都有机化学研究所 副研究员
2003-08--2004-08 德国奥斯纳布吕克大学 博士后
2001-08--2003-02 香港大学化学系 研究助理

出版信息

   
发表论文
(1) A Facile Direct Synthesis of 3-Methyleneisoindolin-1-ones by Annulation of Methyl 2-Acylbenzoates with Amines, ChemSelect, 2019, 通讯作者
(2) Synthesis of Chiral α-Mercapto-β-acylamido Esters via One-pot Asymmetric Hydrosilylation-transacylation of α-Acylthio-β-Enamino Esters, Asian J. Org. Chem., 2019, 通讯作者
(3) Unprecedented Tandem Conjugate Addition/C-O Ester Migration of α-Cyano Arylacetates with a Quinone Monoimine, ChemSelect, 2019, 通讯作者
(4) Enantioselective Arylation of 3-Carboxamide Oxindoles with Quinone Monoimines and Synthesis of Chiral Spirooxindolebenzofuranones, Synlett, 2019, 通讯作者
(5) Synthesis of Novel Pterocarpen Analogues via [3 + 2] Coupling‐Elimination Cascade of α,α‐Dicyanoolefins with Quinone Monoimines, J. Heterocycl. Chem., 2019, 通讯作者
(6) One-pot diastereo- and enantioselective hydrosilylation-transacylation of α-acyloxy β-enamino esters, Org. Chem. Front., 2018, 通讯作者
(7) Enantioselective α-Arylation of Cyclic β-Ketoamides with a Quinone Monoimine, ChemSelect, 2018, 通讯作者
(8) Construction of Novel Kojic Acid Fused Furans by Domono Reactions of a Kojic Acid Derivative with (z)-Bromonitroalkenes, ChemSelect, 2018, 通讯作者
(9) Enantioselective Synthesis of Tetrahydrocarbazoles via Chiral Phosphoric Acid Promoted Domino Friedel-Crafts-type Reaction of Indole-3-butanal with Indoles, J. Heterocycl. Chem., 2018, 通讯作者
(10) Facile Synthesis of 2,3-Disubstituted Indoles by NBS/CuCl Mediated Oxidative Cyclization of N-Aryl Enamines, ChemSelect, 2017, 通讯作者
(11) Dynamic Kinetic Resolution in Enantioselective Reductive Amination of a-Branched Aldehydes by Lewis Base Organocatalyzed Hydrosilylation, ChemSelect, 2017, 通讯作者
(12) Catalyst-free Synthesis of Spiro[indoline-3,10-pyrazolo[5,1-a] isoquinolines] via Diastereoselective 1,3-dipolar Cycloaddition under Mild Conditions, J. Heterocycl. Chem., 2017, 通讯作者
(13) Efficient Synthesis of 9H-Pyrrolo[1,2-α]Indoles via Michael Addition–Condensation of 3-Substituted Indoles with α,β-Unsaturated Ketimines, J. Heterocycl. Chem., 2016, 通讯作者
(14) Construction of Novel Tetrahydro-β-carboline-1-thione Spirooxindoles by Brønsted Acid Mediated Formal [3+3] Cyclization of 3-Indolylmethanols with 3-Isothiocyanato Oxindoles, J. Heterocycl. Chem., 2016, 通讯作者
(15) 二芳基甲酮亚胺的不对称催化氢化硅烷化反应研究, 有机化学, 2016, 通讯作者
(16) Highly Enantioselective [3+2] Coupling of Cyclic Enamides with Quinone Monoimines Promoted by a Chiral Phosphoric Acid, Chem. Commun., 2016, 通讯作者
(17) Lewis Acid Catalyzed [3+2] Coupling of Quinone Monoacetals or Quinone Imine Ketals with Vinylcarbamates, Synlett, 2015, 通讯作者
(18) Synthesis and Secondary Conformations of Homochiral beta-Oligopeptides Containing Aryl Side Chains, Chem. Res. Chin. Univ., 2015, 通讯作者
(19) Rhodium(III)- Catalyzed Oxidative Annulation of 7-Azaindoles and Alkynes via Double C-H Activation, Org. Lett., 2015, 第 4 作者
(20) Ruthenium-catalyzed direct C3 alkylation of indoles with alpha,beta-unsaturated ketones, Org. Biomol. Chem., 2015, 第 3 作者
(21) Highly Enantioselective [3+2] Coupling of Indoles with Quinone Monoimines Promoted by a Chiral Phosphoric Acid, Angew. Chem. Int. Ed. , 2014, 通讯作者
(22) Enantioselective Lewis-Base-Catalyzed Asymmetric Hydrosilylation of Substituted Benzophenone N-Aryl Imines: Efficient Synthesis of Chiral (Diarylmethyl)amines, Adv. Synth. Catal. , 2014, 通讯作者
(23) Lewis Acid Catalyzed [3+2] Coupling of Indoles with Quinone Monoacetals or Quinone Imine Ketal, Eur. J. Org. Chem., 2014, 通讯作者
(24) Lewis Base Catalyzed Asymmetric Hydrosilylation of α-Substituted β-Enamino Esters: Facile Access to Enantioenriched β2-Amino Esters via Dynamic Kinetic Resolution, Synlett, 2014, 通讯作者
(25) Organocatalytic enantioselective tandem Michael addition- oxidation of 3-substituted oxindoles with 1,4-benzoquinone, Tetrahedron, 2014, 通讯作者
(26) Asymmetric Michael addition of a-cyano acetates to (E)-1,4-diaryl-2-buten- 1,4-diones, Tetrahedron, 2014, 通讯作者
(27) Lewis Base Organocatalyzed Enantioselective Hydrosilylation of α-Keto Ketimines, Chem. Res. Chinese U., 2014, 通讯作者
(28) Synthesis of a series of novel chiral Lewis base catalysts and their application in promoting asymmetric hydrosilylation of β-enamino esters, Org. Biomol. Chem., 2013, 通讯作者
(29) Highly enantioselective hydrosilylation of N-(1,2- diarylethylidene)arylamines, Org. Biomol. Chem., 2013, 通讯作者
(30) Stereoselective Lewis Base Catalyzed Asymmetric Hydrosilylation of α-Acetamido-β-Enamino Esters: Straightforward Approach for the Construction of α,β-Diamino Acid Derivatives, Adv. Synth. Catal., 2013, 通讯作者
(31) Highly Enantioselective Lewis Base Organocatalyzed Hydrosilylation of γ-Imino Esters, Eur. J. Org. Chem., 2012, 通讯作者
(32) Organocatalytic Synthesis of Enantioenriched β-Aryl- splitomicins, Synlett, 2012, 通讯作者
(33) Organocatalytic enantioselective Michael addition of a kojic acid derivative to nitro olefins, Org. Biomol. Chem., 2012, 通讯作者
(34) Lewis Base Organocatalyzed Enantioselective Hydrosilylation of 1,4-Benzoxazines, Synlett, 2012, 通讯作者
(35) lAddition of Purines to N-Boc Imines Generated in Situ in Water: Efficient Synthesis of Novel Acyclic Purine Azanucleosides, Synlett, 2012, 通讯作者
(36) Highly Diastereoselective and Enantioselective Synthesis of α-hydroxy-β-Amino Acid Derivatives by the Lewis Base Organocatalyzed Hydrosilylation of α-acetoxy-β-Enamino Esters, Angew. Chem. Int. Ed. , 2011, 通讯作者
(37) Enantioselective Synthesis of 4-Substituted 4,5-Dihydro- 1H-[1,5]benzodiazepine-2(3H)-ones by the Lewis Base-Catalyzed Hydrosilylation, J. Org. Chem., 2011, 通讯作者
(38) The First General, Highly Enantioselective Lewis Base Organocatalyzed Hydrosilylation of Benzoxazinones and Quinoxalinones., Adv. Synth. Catal., 2010, 通讯作者
(39) The First Highly Enantioselective Lewis Base Organocatalyzed Hydrosilylation of α-Imino Esters. , Eur. J. Org. Chem., 2010, 通讯作者
(40) Organocatalytic Enantioselective Friedel–Crafts Alkylation of Sesamol with Nitro Olefins., Eur. J. Org. Chem., 2010, 通讯作者
(41) Remarkably Mild and Efficient Cetrimonium Bromide Catalyzed Friedel–Crafts Amidoalkylation of Sesamols with N-Boc Imines Generated In Situ in Aqueous Medium., Synlett , 2010, 通讯作者
(42) Highly Enantioselective Synthesis of β-Amino Acid Derivatives by the Lewis Base Catalyzed Hydrosilylation of β-Enamino Esters., Chem. Eur. J., 2008, 通讯作者

科研活动

   
科研项目
(1) 醌单缩二醇及其亚胺的不对称催化[3+2]环化反应的研究 ,主持,部委级,2014-01--2017-12
(2) β-氨基酸衍生物的不对称合成及其在β-多肽合成中的应用,主持,部委级,2012-01--2015-12
(3) β-烯胺基酯的不对称催化氢化硅烷化反应的研究,主持,部委级,2010-01--2012-12

指导学生

已指导学生

张辉  博士研究生  070303-有机化学  

薛州洋  博士研究生  070303-有机化学  

蒋燕  博士研究生  070303-有机化学  

王继宇  博士研究生  070303-有机化学  

王九霞  博士研究生  070303-有机化学  

陈兴  博士研究生  070303-有机化学  

刘立鑫  博士研究生  070303-有机化学  

郑永胜  博士研究生  070303-有机化学  

张永红  博士研究生  070303-有机化学  

崔宝东  博士研究生  070303-有机化学  

舒畅  博士研究生  070303-有机化学  

廖立华  博士研究生  070303-有机化学  

扈晓艳  博士研究生  070303-有机化学  

现指导学生

陈续玲  硕士研究生  070303-有机化学  

于硕文  硕士研究生  070303-有机化学  

廖益均  博士研究生  070303-有机化学  

敬毅  博士研究生  070303-有机化学  

李帅帅  博士研究生  070303-有机化学  

陈慧  硕士研究生  070303-有机化学  

胡方芝  博士研究生  070303-有机化学  

张敏敏  博士研究生  070303-有机化学  

赵思涵  硕士研究生  070303-有机化学