空间生命孕育

哺乳动物早期胚胎发育

干细胞的增殖、分化和代谢

干细胞与生物材料应用研究

086000-生物与医药
083100-生物医学工程
071003-生理学

发育生物学，细胞生物学
空间生命科学
生理学

2014-09--2018-06   中国农业大学   博士研究生/理学博士学位
2005-09--2008-06   西北农林科技大学   硕士研究生/农学硕士学位

博士研究生

理学博士学位

2020-09~现在, 中国科学院深圳先进技术研究院, 副研究员
2008-07~2020-09,中国科学院动物研究所, 研实、工程师、高级工程师

2023-03-23-2023-09-30,Bioengineering期刊客座编辑, 客座编辑
2021-06-15-2025-06-15,World Journal Stem Cells, 在线学术编辑
2021-04-01-2022-04-10,Frontiers in Cell and Developmental Biology 客座编辑, 副主编—客座编辑
2021-01-01-2024-12-31,World Journal Biological Chemistry, 杂志编委
2016-09-01-今,中国空间科学学会空间生命专委会, 委员

（1） 中科院特聘研究岗位, , 部委级, 2022
（2） 深圳市高层次人才, 三等奖, 市地级, 2021
（3） 中国科学院关键技术人才, 部委级, 2018

（ 1 ） 一种诱导多能干细胞向造血前体细胞分化的培养基以及方法, 发明专利, 2021, 第 2 作者, 专利号: PCT/CN2021/138097

（ 2 ） 一种跨血脑屏障的多肽及其衍生物和应用, 发明专利, 2021, 第 5 作者, 专利号: 202111486775.0

（ 3 ） 一种诱导多能干细胞向造血前体细胞分化的培养基以及方法, 发明专利, 2021, 第 2 作者, 专利号: 202110396567.5

   

[1] Cheng, Kaixin, Feng, Xiean, Yang, Chen, Ma, Chiyuan, Niu, Shudong, Jia, Longzhong, Yang, Xuebing, Liang, Jing, Bo, Yingnan, Geng, Kaiying, Li, Qin, Zhang, Hua, Lei, Xiaohua, Zhang, Yan. Simulated microgravity reduces quality of ovarian follicles and oocytes by disrupting communications of follicle cells. NPJ MICROGRAVITY[J]. 2023, 9(1): http://dx.doi.org/10.1038/s41526-023-00248-5.
[2] Chiyuan Ma, Xianglong Duan, Xiaohua Lei. 3D cell culture model: From ground experiment to microgravity study. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY[J]. 2023, 11: https://doaj.org/article/8c5ea250d1df495288cba99a896e4699.
[3] Xiong, Yue, Ma, Chiyuan, Li, Qin, Zhang, Wenya, Zhao, Huashan, Ren, Peigen, Zhang, Ke, Lei, Xiaohua. Melatonin ameliorates simulated-microgravity-induced mitochondrial dysfunction and lipid metabolism dysregulation in hepatocytes. FASEB JOURNAL[J]. 2023, 37(9): http://dx.doi.org/10.1096/fj.202301137R.
[4] Zhang, Wenya, Zhang, Jinhua, Cui, Yan, Zhao, Yongxiang, Lei, Xiaohua. Stem Cells and Exosome Applications for Cutaneous Wound Healing: From Ground to Microgravity Environment. STEM CELL REVIEWS AND REPORTS[J]. 2023, http://dx.doi.org/10.1007/s12015-023-10571-9.
[5] Liang, Dong, Ning, Meng, Xie, Hang, He, Xiaoyan, Ren, Peigen, Lei, Xiaohua, Zhang, Xuepei. Radiotherapy Side Effects: Comprehensive Proteomic Study Unraveled Neural Stem Cell Degenerative Differentiation upon Ionizing Radiation. BIOMOLECULES[J]. 2022, 12(12): http://dx.doi.org/10.3390/biom12121759.
[6] Ma, Chiyuan, Xiong, Yue, Han, Pei, Zhang, Xueying, Cao, Yujing, Wang, Baobei, Zhao, Huashan, Duan, Enkui, Zhang, Jian V, Lei, Xiaohua. Simulated Microgravity Potentiates Hematopoietic Differentiation of Human Pluripotent Stem Cells and Supports Formation of 3D Hematopoietic Cluster. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY[J]. 2022, 9: http://dx.doi.org/10.3389/fcell.2021.797060.
[7] Chiyuan Ma, Kaizheng Liu, Qin Li, Yue Xiong, Cuixiang Xu, Wenya Zhang, Changshun Ruan, Xin Li, Xiaohua Lei, Jan Roanc, Chengfei Zhang, Botjan Vihar, Uro Maver. Synthetic Extracellular Matrices for 3D Culture of Schwann Cells, Hepatocytes, and HUVECs. BIOENGINEERING[J]. 2022, 9(9): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9495567/.
[8] Lin, Jinju, Li, Qin, Lei, Xiaohua, Zhao, Huashan. The emerging roles of GPR158 in the regulation of the endocrine system. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGYnull. 2022, 10: http://dx.doi.org/10.3389/fcell.2022.1034348.
[9] 李莹辉, 孙野青, 郑慧琼, 商澎, 曲丽娜, 雷晓华, 刘红, 刘敏, 赫荣乔, 龙勉, 孙喜庆, 王俊峰, 周光明, 孙联文. 中国空间生命科学40年回顾与展望. 空间科学学报[J]. 2021, 41(1): 46-67, http://lib.cqvip.com/Qikan/Article/Detail?id=7104266530.
[10] 马驰原, 曹宇静, 段恩奎, 雷晓华. 太空环境下哺乳动物胚胎发育和生殖研究进展及展望. 中国科学：生命科学[J]. 2021, 51(2): 116-125, https://www.sciengine.com/doi/10.1360/SSV-2020-0136.
[11] Yongcun Qu, Qi Chen, Shanshan Guo, Chiyuan Ma, Yonggang Lu, Junchao Shi, Shichao Liu, Tong Zhou, Taichi Noda, Jingjing Qian, Liwen Zhang, Xili Zhu, Xiaohua Lei, Yujing Cao, Wei Li, Wei Li, Nicolas Plachta, Martin MMatzuk, Masahito Ikawa, Enkui Duan, Ying Zhang, Hongmei Wang. Cooperation-based sperm clusters mediate sperm oviduct entry and fertilization. Protein & Cell[J]. 2021, 12(10): 810-817, https://academic.oup.com/proteincell/article/12/10/810/6746920.
[12] Li, Rongrong, Ma, Chiyuan, Xiong, Yue, Zhao, Huashan, Yang, Yali, Xue, Li, Wang, Baobei, Xiao, Tianxia, Chen, Jie, Lei, Xiaohua, Ma, Baohua, Zhang, Jian. An Antagonistic Peptide of Gpr1 Ameliorates LPS-Induced Depression through the Hypothalamic-Pituitary-Ovarian Axis. BIOMOLECULES[J]. 2021, 11(6): http://dx.doi.org/10.3390/biom11060857.
[13] 雷晓华. 中国空间生命科学40周年回顾与展望. 空间科学学报. 2021, [14] Li, Feng, Ye, Ying, Lei, Xiaohua, Zhang, Wensheng. Effects of Microgravity on Early Embryonic Development and Embryonic Stem Cell Differentiation: Phenotypic Characterization and Potential Mechanisms. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGYnull. 2021, 9: http://dx.doi.org/10.3389/fcell.2021.797167.
[15] Lei Zhao, Chengyu Bao, Yuxuan Shang, Xinye He, Chiyuan Ma, Xiaohua Lei, Dong Mi, Yeqing Sun. The Determinant of DNA Repair Pathway Choices in Ionising Radiation-Induced DNA Double-Strand Breaks. BIOMED RESEARCH INTERNATIONAL[J]. 2020, 2020: https://doaj.org/article/e9c7b63fa4844d6bb285748cb46358c0.
[16] Lei, Xiaohua, Cao, Yujing, Ma, Baohua, Zhang, Yunfang, Ning, Lina, Qian, Jingjing, Zhang, Liwen, Qu, Yongcun, Zhang, Tao, Li, Dehong, Chen, Qi, Shi, Junchao, Zhang, Xudong, Ma, Chiyuan, Zhang, Ying, Duan, Enkui. Development of mouse preimplantation embryos in space. NATIONAL SCIENCE REVIEW[J]. 2020, 7(9): 1437-1446, http://dx.doi.org/10.1093/nsr/nwaa062.
[17] Zhao, Lei, He, Xinye, Shang, Yuxuan, Bao, Chengyu, Peng, Ailin, Lei, Xiaohua, Han, Pei, Mi, Dong, Sun, Yeqing. Identification of potential radiation-responsive biomarkers based on human orthologous genes with possible roles in DNA repair pathways by comparison between Arabidopsis thaliana and homo sapiens. SCIENCE OF THE TOTAL ENVIRONMENT[J]. 2020, 702: http://dx.doi.org/10.1016/j.scitotenv.2019.135076.
[18] Zhao, Qian, Li, Na, Zhang, Huishan, Lei, Xiaohua, Cao, Yujing, Xia, Guoliang, Duan, Enkui, Liu, Shuang. Chemically induced transformation of human dermal fibroblasts to hair-inducing dermal papilla-like cells. CELL PROLIFERATION. 2019, 52(5): https://www.webofscience.com/wos/woscc/full-record/WOS:000474006100001.
[19] Lei, XiaoHua, Yang, YiQing, Ma, ChiYuan, Duan, EnKui. Induction of differentiation of human stem cells ex vivo: Toward large-scale platelet production. WORLD JOURNAL OF STEM CELLS[J]. 2019, 11(9): 666-676, http://lib.cqvip.com/Qikan/Article/Detail?id=7003026078.
[20] Dai, Zhongquan, Lei, Xiaohua, Yang, Chao, Zhao, Lei, Lu, Liang, Li, Yinghui. Systematic biomedical research of the NASA Twins Study facilitates the hazard risk assessment of long-term spaceflight missions. PROTEIN & CELL[J]. 2019, 10(9): 628-630, http://lib.cqvip.com/Qikan/Article/Detail?id=7002965330.
[21] Shaopeng Zhang, Tianzhi Chen, Naixin Chen, Dengfeng Gao, Bingbo Shi, Shuangbo Kong, Rachel Claire West, Ye Yuan, Minglei Zhi, Qingqing Wei, Jinzhu Xiang, Haiyuan Mu, Liang Yue, Xiaohua Lei, Xuepeng Wang, Liang Zhong, Hui Liang, Suying Cao, Juan Carlos Izpisua Belmonte, Haibin Wang, Jianyong Han. Implantation initiation of self-assembled embryo-like structures generated using three types of mouse blastocyst-derived stem cells. NATURE COMMUNICATIONS[J]. 2019, 10(1): 1-17, https://doaj.org/article/7ac0b1da37484bc9a2f0c73efcf90ab1.
[22] Zhang, Yunfang, Zhang, Xudong, Shi, Junchao, Tuorto, Francesca, Li, Xin, Liu, Yusheng, Liebers, Reinhard, Zhang, Liwen, Qu, Yongcun, Qian, Jingjing, Pahima, Maya, Liu, Ying, Yan, Menghong, Cao, Zhonghong, Lei, Xiaohua, Cao, Yujing, Peng, Hongying, Liu, Shichao, Wang, Yue, Zheng, Huili, Woolsey, Rebekah, Quilici, David, Zhai, Qiwei, Li, Lei, Zhou, Tong, Yan, Wei, Lyko, Frank, Zhang, Ying, Zhou, Qi, Duan, Enkui, Chen, Qi. Dnmt2 mediates intergenerational transmission of paternally acquired metabolic disorders through sperm small non-coding RNAs. NATURE CELL BIOLOGY[J]. 2018, 20(5): 535-+, http://dx.doi.org/10.1038/s41556-018-0087-2.
[23] Lei, Xiaohua, Cao, Yujing, Zhang, Ying, Qian, Jingjing, Zhao, Qian, Liu, Fangwu, Zhang, Tao, Zhou, Jiaxi, Gu, Ying, Xia, Guoliang, Duan, Enkui. Effect of microgravity on proliferation and differentiation of embryonic stem cells in an automated culturing system during the TZ-1 space mission. CELL PROLIFERATION[J]. 2018, 51(5): http://dx.doi.org/10.1111/cpr.12466.

（1） 生物反应器在干细胞生物学中应用, Bioreactor in Stem Cell Biology, Humana Press, 2016-06, 第 其他 作者
（2） 空间生命科学：SJ-10返回式科学卫星实验, Life Science in Space: Experiments on Board the SJ-10 Recoverable Satellite, Springer, 2019-08, 第 其他 作者
（3） 生物反应器在干细胞生物学中应用-2, High-Efficiency Differentiation of Human Pluripotent Stem Cells to Hematopoietic Stem/Progenitor Cells in Random Positioning Machine Bioreactors. In: Kursad Turksen (eds). Bioreactors in Stem Cell Biology II-Methods and Protocols., Humana Press, 2021-12, 第 1 作者

   

（ 1 ） 空间站工程空间应用系统第二批科学实验项目-空间微重力环境下干细胞3D生长及组织构建, 负责人, 国家任务, 2020-01--2022-12
（ 2 ） 中国科学院关键技术人才2018年度, 负责人, 中国科学院计划, 2019-01--2021-12
（ 3 ） 新引进人才科研启动基金, 负责人, 研究所自选, 2021-01--2023-12
（ 4 ） 空间低敏感小鼠模型建立及微重力影响胚胎发育机制, 负责人, 国家任务, 2021-12--2026-11
（ 5 ） 极低剂量慢性电离辐射暴露对小鼠早期胚胎组蛋白修饰影响及作用机制, 负责人, 地方任务, 2022-01--2024-12
（ 6 ） 模拟太空环境条件下小鼠早期胚胎基因水平变化及表观遗传特征的研究, 负责人, 国家任务, 2023-01--2026-12

（1）太空环境下哺乳动物早期胚胎发育和胚胎干细胞研究   第一届中国空间科学大会   XiaoHua Lei, Yujing Cao, Baohua Ma, Tao Zhang, Enkui Duan   2019-10-25
（2）The effect of space microgravity on proliferation and differentiation of mouse embryonic stem cells   第十二届亚洲微重力学术研讨会   2. Xiaohua Lei, Yujing Cao, Ying Zhang, Enkui Duan*   2018-11-03
（3）实时显微观察胚胎干细胞在太空增殖和分化的研究   中国空间科学学会空间生命专委会第二十二届学术研讨会   2018-10-25
（4）微重力条件下哺乳动物早期胚胎和干细胞研究（SJ-10和TZ-1空间生命科学实验）   第十届全国微重力科学学术会议   2017-08-12
（5）The Effect of microgravity environment on stem cells growth and differentiation fate   中国科学院—美国科学院 第六届空间科学青年领军人物论坛   2017-05-12
（6）Development of Mouse Pre-implantation Embryos in SJ-10 satellite   中国科学院—美国科学院 第五届空间科学青年领军人物论坛   2016-12-28
（7）Effects of microgravity on preimplantation embryo development and embryonic stem cell differentiation in vitro   2014年度国际空间生物学与生物医学工程国际研讨会   2014-04-20