主要研究方向：（1）具有光学活性贵金属纳米结构的设计、可控制备和性质研究；相关纳米结构在生物医学领域应用的探索研究；（2）发展具有光学活性/类酶催化活性有机/无机杂化纳米结构的高灵敏度和高选择性测量方法并用于生化检测；（3）纳米尺度功能特性类标准物质/样品研制，纳米结构表征和性质测量的国家标准/国际标准制定。以上研究在Adv. Mater.，J.Am.Chem.Soc.Nano Lett., Biomaterials, Chem. Commun. Chem. Mater. 等SCI杂志上发表论文80余篇,申请中国发明专利10项（其中5项授权）。自2006年以来主持和参与各类项目10余项。2006年作为首席科学家承担了科技部重大研究计划《纳米标准物质和检测用纳米标准样品的可控合成、量产及微纳加工方法标准化研究》(2006CB932600)，发布纳米金颗粒标准样品/物质12个，编制相关国家标准10余项。

   

070304-物理化学（含：化学物理）
070205-凝聚态物理

纳米材料的可控设计,光学催化性质,纳米传感
非传统纳米加工技术

   

博士

博士

1992/09 - 1995/06, 南开大学，现代光学研究所，博士，导师: 陈文驹 1989/09 –1992/06, 吉林大学，环境科学系，硕士，导师: 魏庆珣 1985/09 - 1989/06, 四川大学，化学系，学士

   

2003-08~2004-12,德国明斯特大学, 博士后研究
2000-08~2003-08,德国马普固体物理研究所, 博士后研究
1999-01~2000-09,德国慕尼黑工业大学, 洪堡奖学金
1995-07~1997-07,中国科学院物理研究所, 博士后研究

纳米科技进展

   

（1） 河南省科学技术进步奖, 二等奖, 省级, 2015

[1] 孟德静, 吴晓春. 一种手性组装体及其制备方法. CN: CN111299569B, 2022-02-22.

[2] 陈佳琪, 吴晓春. 一种手性贵金属纳米颗粒及其制备方法和用途. CN: CN111112596B, 2021-12-28.

[3] 陈佳琪, 孟德静, 吴晓春. 一种圆偏振发光物质及其制备方法和应用. CN: CN112300778A, 2021-02-02.

[4] 吴晓春, 阿迪蒂亚·萨兰, 张会, 纪英露, 李海芸. 一种全等离激元酶联免疫吸附试剂盒及其应用. CN: CN108008123B, 2020-06-30.

[5] 蔡瑞, 吴晓春. 一种半胱氨酸修饰的金纳米棒作为类过氧化物酶的应用. CN: CN110102344A, 2019-08-09.

[6] 樊慧真, 吴晓春. 一种催化氧化多巴胺为多巴色素的方法. CN: CN109293553A, 2019-02-01.

[7] 孟德静, 吴晓春. 一种增强诱导等离激元圆二色性的方法. CN: CN108680554A, 2018-10-19.

[8] 张会, 吴晓春. 一种纳米尺度热源反应器及其应用. CN: CN108324944A, 2018-07-27.

[9] 吴晓春, 阿迪蒂亚·萨兰, 张会, 纪英露, 李海芸. 一种新型全等离激元酶联免疫吸附试剂盒及其应用. CN: CN108008123A, 2018-05-08.

[10] 李海芸, 吴晓春, 颜姣, 王黎明, 陈春英. 一种具有一氧化氮合酶活性的贵金属纳米材料及其应用. CN: CN107598159A, 2018-01-19.

[11] 陈远东, 孟德静, 吴晓春. 一种银包金纳米棒肩并肩手性寡聚体及其制备方法和用途. CN: CN107552778A, 2018-01-09.

[12] 樊慧真, 吴晓春. 一种增强ICG单线态氧产量的方法及ICG包覆的纳米金颗粒及其制备方法. CN: CN107213462A, 2017-09-29.

[13] 颜姣, 侯帅, 吴晓春. 一种离散贵金属纳米颗粒及其制备方法. CN: CN106238728A, 2016-12-21.

[14] 张会, 吴晓春. 激子‑等离激元耦合体系、其构建方法及利用该耦合体系增强光敏剂单线态氧产生的方法. CN: CN106139145A, 2016-11-23.

[15] 陈佳琪, 侯帅, 吴晓春. 一种促进银在金纳米球表面再生长的方法及其应用. CN: CN105499560A, 2016-04-20.

[16] 葛广路, 王瑞敏, 陈岚, 纪英露, 吴晓春. 一种棒状纳米颗粒几何形状的测定方法. CN: CN105300857A, 2016-02-03.

[17] 侯帅, 吴晓春. 一种测定硫醇分子在金表面上的吸附常数的方法. CN: CN104865193A, 2015-08-26.

[18] 颜姣, 侯帅, 吴晓春. 一种放大金纳米棒组装体等离激元圆二色响应的方法. CN: CN104713833A, 2015-06-17.

[19] 温涛, 刘文奇. 一种金纳米棒及其制备方法. CN: CN103132143B, 2015-04-08.

[20] 纪英露, 吴晓春. 一种类球形金颗粒及其逐级快速合成方法. CN: CN104308175A, 2015-01-28.

[21] 刘文奇, 吴晓春. 一种贵金属纳米颗粒的处理方法. CN: CN104174840A, 2014-12-03.

[22] 温涛, 吴晓春. 一种纳米棒的处理方法. CN: CN103962545A, 2014-08-06.

[23] 温涛, 侯帅, 张会, 颜娇, 吴晓春. 一种金纳米棒手性结构构建方法及一种铜离子的检测方法. CN: CN103940746A, 2014-07-23.

[24] 时晓伟, 吴晓春. 金核氧化亚铜壳复合纳米结构的制备方法及复合纳米结构. CN: CN103934466A, 2014-07-23.

[25] 胡晓娜, 吴晓春. 一种纳米棒及其制备方法与应用. CN: CN103894618A, 2014-07-02.

[26] 陈春英, 仉振江, 王静, 王黎明, 吴晓春. 药物载体及其制备方法和药物组合物及其应用. CN: CN103893764A, 2014-07-02.

[27] 谢勇, 梁宇佳, 刘前, 吴晓春. 四方超晶格的核壳贵金属纳米棒及其自组装方法. CN: CN103862032A, 2014-06-18.

[28] 侯帅, 吴晓春. 一种测定纳米颗粒表面上一端为巯基的双官能团小分子酸碱解离常数的方法. CN: CN103728255A, 2014-04-16.

[29] 吴晓春, 阿迪蒂亚萨兰, 胡晓娜, 张会. 一种铂基合金结构的纳米棒模拟酶溶液及在ELISA中的应用. CN: CN103645315A, 2014-03-19.

[30] 温涛, 刘文奇, 吴晓春. 一种金纳米棒及其制备方法. CN: CN103132143A, 2013-06-05.

[31] 刘建波, 吴晓春. 金核/铂壳纳米棒模拟酶溶液的用途及检测过氧化氢、葡萄糖和胆固醇的方法. CN: CN102998413A, 2013-03-27.

[32] 张珂, 吴晓春, 韩东. 一种将生物样品制备成扫描电镜样品的方法. CN: CN102680289A, 2012-09-19.

[33] 陈春英, 许利耕, 吴晓春. 金纳米棒的修饰方法及金纳米棒-功能分子复合体. CN: CN102397557A, 2012-04-04.

[34] 张珂, 吴晓春. 铂诱导的金核/钯铂岛状合金壳结构纳米棒溶液及制法. CN: CN102039124A, 2011-05-04.

[35] 何伟伟, 吴晓春. 一种金核/铂壳纳米棒模拟酶溶液及其制备方法. CN: CN102019179A, 2011-04-20.

[36] 何伟伟, 吴晓春. 金核/银铂合金壳结构的岛状多孔三金属纳米棒及其制法. CN: CN101623762A, 2010-01-13.

[37] 冯莉莉, 吴晓春. 一种树枝状金核/铂壳结构的双金属纳米棒及制备方法. CN: CN101450380A, 2009-06-10.

[38] 吴晓春, 向彦娟, 解思深. 一种长方形金核/钯壳双金属纳米棒及其制备方法. CN: CN101130883A, 2008-02-27.

 

[1] Gao, Xinshuang, Zheng, Qiang, Li, Hanbo, Zhang, Chenqi, Cai, Rui, Ji, Yinglu, Hu, Zhijian, Wu, Xiaochun. Modulation of plasmonic chiral shell growth on gold nanorods via nonchiral surfactants. NANOSCALE[J]. 2023, 15(25): 10651-10660, http://dx.doi.org/10.1039/d3nr01371e.
[2] Cai, Rui, Shoukat, Chaudhary Ammar, Zhang, Chenqi, Gao, Xinshuang, Li, Hanbo, Chen, Jiaqi, Ji, Yinglu, Wu, Xiaochun. A colorimetric chemosensor for sensitive and selective detection of copper(ii) ions based on catalytic oxidation of 1-naphthylamine. ANALYST[J]. 2023, 148(14): 3306-3311, http://dx.doi.org/10.1039/d3an00536d.
[3] Zhang, Chenqi, Gao, Xinshuang, Li, Hanbo, Ji, Yinglu, Cai, Rui, Hu, Zhijian, Wu, Xiaochun. Regulation of Chirality Transfer and Amplification from Chiral Cysteine to Gold Nanorod Assemblies using Nonchiral Surface Ligands. ADVANCED OPTICAL MATERIALS. 2023, http://dx.doi.org/10.1002/adom.202202804.
[4] Zhao, Tonghan, Meng, Dejing, Hu, Zhijian, Sun, Wenjing, Ji, Yinglu, Han, Jianlei, Jin, Xue, Wu, Xiaochun, Duan, Pengfei. Enhanced chiroptic properties of nanocomposites of achiral plasmonic nanoparticles decorated with chiral dye-loaded micelles. NATURE COMMUNICATIONS[J]. 2023, 14(1): http://dx.doi.org/10.1038/s41467-022-35699-z.
[5] Wang, YiFeng, Zhang, Qingrong, Tian, Falin, Wang, Hongda, Wang, Yufei, Ma, Xiaowei, Huang, Qianqian, Cai, Mingjun, Ji, Yinglu, Wu, Xiaochun, Gan, Yaling, Yan, Yan, Dawson, Kenneth A, Guo, Shutao, Zhang, Jinchao, Shi, Xinghua, Shan, Yuping, Liang, XingJie. Spatiotemporal Tracing of the Cellular Internalization Process of Rod-Shaped Nanostructures. ACS NANO[J]. 2022, 16(3): 4059-4071, http://dx.doi.org/10.1021/acsnano.1c09684.
[6] 吴晓春. gold nanoparticles-based chiral plasmonic nanostructures and their biomedical applications. Biosensors[J]. 2022, [7] Xiaochun Wu. Improving peroxidase activity of gold nanorod nanozymes by dragging substrates to the catalysis sites via cysteine modification. Nanotechnology. 2021, [8] Chen, Jiaqi, Gao, Xinshuang, Zheng, Qiang, Liu, Jianbo, Meng, Dejing, Li, Haiyun, Cai, Rui, Fan, Huizhen, Ji, Yinglu, Wu, Xiaochun. Bottom-Up Synthesis of Helical Plasmonic Nanorods and Their Application in Generating Circularly Polarized Luminescence. ACS NANO[J]. 2021, 15(9): 15114-15122, http://dx.doi.org/10.1021/acsnano.1c05489.
[9] Xiaochun Wu. Temperature Effect of Plasmonic Circular Dichroism in Dynamic Oligomers of Au@Ag Nanorods Driven by Cysteine:The Role of Surface Atom Migration. Adv. Opt. Mater. 2021, [10] 蔡瑞, 刘建波, 吴晓春. 贵金属基纳米酶的研究进展. 高等学校化学学报[J]. 2021, 42(4): 1188-1201, https://kns.cnki.net/KCMS/detail/detail.aspx?dbcode=CJFQ&dbname=CJFDLAST2021&filename=GDXH202104016&v=Mjg2NTRxVHJXTTFGckNVUjd1ZlllZG1GaURtVXI3SUlpblRackc0SE5ETXE0OUVZb1I4ZVgxTHV4WVM3RGgxVDM=.
[11] Meng, Dejing, Chen, Yuandong, Ji, Yinglu, Shi, Xinghua, Wang, Hui, Wu, Xiaochun. Temperature Effect of Plasmonic Circular Dichroism in Dynamic Oligomers of AuNR@Ag Nanorods Driven by Cysteine: The Role of Surface Atom Migration. ADVANCED OPTICAL MATERIALS[J]. 2021, 9(2): https://www.webofscience.com/wos/woscc/full-record/WOS:000588678700001.
[12] Cai Rui, Liu Jianbo, Wu Xiaochun. Research Progress of Noble Metal-based Nanozymes. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESEnull. 2021, 42(4): 1188-1201, http://dx.doi.org/10.7503/cjcu20200591.
[13] Meng, Dejing, Li, Xu, Gao, Xinshuang, Zhang, Chenqi, Ji, Yinglu, Hu, Zhijian, Ren, Lingling, Wu, Xiaochun. Constructing chiral gold nanorod oligomers using a spatially separated sergeants-and-soldiers effect. NANOSCALE[J]. 2021, 13(21): 9678-9685, http://dx.doi.org/10.1039/d1nr01458g.
[14] Li, Haiyun, Yan, Jiao, Meng, Dejing, Cai, Rui, Gao, Xinshuang, Ji, Yinglu, Wang, Liming, Chen, Chunying, Wu, Xiaochun. Gold Nanorod-Based Nanoplatform Catalyzes Constant NO Generation and Protects from Cardiovascular Injury. ACS NANO[J]. 2020, 14(10): 12854-12865, http://dx.doi.org/10.1021/acsnano.0c03629.
[15] Li, Haiyun, Wen, Tao, Wang, Tao, Ji, Yinglu, Shen, Yaoyi, Chen, Jiaqi, Xu, Haiyan, Wu, Xiaochun. In Vivo Metabolic Response upon Exposure to Gold Nanorod Core/Silver Shell Nanostructures: Modulation of Inflammation and Upregulation of Dopamine. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES[J]. 2020, 21(2): https://doaj.org/article/a8784470084043d49ababc0c6d1f2b96.
[16] Fan, Huizhen, Fan, Yu, Du, Wenna, Cai, Rui, Gao, Xinshuang, Liu, Xinfeng, Wang, Hao, Wang, Lei, Wu, Xiaochun. Enhanced type I photoreaction of indocyanine green via electrostatic-force-driven aggregation. NANOSCALE[J]. 2020, 12(17): 9517-9523, http://dx.doi.org/10.1039/d0nr01208d.
[17] Cai, Rong, Ren, Jiayu, Ji, Yinglu, Wang, Yaling, Liu, Ying, Chen, Zhigiang, Sabet, Zeinab Farhadi, Wu, Xiaochun, Lynch, Iseult, Chen, Chunying. Corona of Thorns: The Surface Chemistry-Mediated Protein Corona Perturbs the Recognition and Immune Response of Macrophages. ACS APPLIED MATERIALS & INTERFACES[J]. 2020, 12(2): 1997-2008, https://www.webofscience.com/wos/woscc/full-record/WOS:000508464500004.
[18] Long, Lin, Cai, Rui, Liu, Jianbo, Wu, Xiaochun. A Novel Nanoprobe Based on Core-Shell Au@Pt@Mesoporous SiO(2)Nanozyme With Enhanced Activity and Stability for Mumps Virus Diagnosis. FRONTIERS IN CHEMISTRY[J]. 2020, 8: https://doaj.org/article/9746033253e54152a1a4d8eb34e1ab61.
[19] Li, Haiyun, Chen, Jiaqi, Fan, Huizhen, Cai, Rui, Gao, Xinshuang, Meng, Dejing, Ji, Yinglu, Chen, Chunying, Wang, Liming, Wu, Xiaochun. Initiation of protective autophagy in hepatocytes by gold nanorod core/silver shell nanostructures. NANOSCALE[J]. 2020, 12(11): 6429-6437, https://www.webofscience.com/wos/woscc/full-record/WOS:000522124800019.
[20] Hu Nan, Shi Xiaoli, Zhang Qiang, Liu Wentao, Zhu Yuting, Wang Yuqing, Hou Yi, Ji Yinglu, Cao Yupeng, Zeng Qian, Ao Zhuo, Sun Quanmei, Zhou Xiaohan, Wu Xiaochun, Han Dong. Special interstitial route can transport nanoparticles to the brain bypassing the blood-brain barrier. NANO RESEARCH[J]. 2019, 12(11): 2760-2765, http://lib.cqvip.com/Qikan/Article/Detail?id=7101888822.
[21] Chen, Jiaqi, Meng, Dejing, Wang, Hui, Li, Haiyun, Ji, Yinglu, Shi, Xinghua, Wu, Xiaochun. Aromatic thiol-modulated Ag overgrowth on gold nanoparticles: tracking the thiol's position in the core-shell nanoparticles. NANOSCALE[J]. 2019, 11(37): 17471-17477, https://www.webofscience.com/wos/woscc/full-record/WOS:000487944000032.
[22] Hu, Zhijian, Mi, Yang, Ji, Yinglu, Wang, Rui, Zhou, Weiya, Qiu, Xiaohui, Liu, Xinfeng, Fang, Zheyu, Wu, Xiaochun. Multiplasmon modes for enhancing the photocatalytic activity of Au/Ag/Cu2O core-shell nanorods. NANOSCALE[J]. 2019, 11(35): 16445-16454, http://dx.doi.org/10.1039/c9nr03943k.
[23] Wang, Liming, Quan, Peiyu, Chen, Serena H, Bu, Wei, Li, YuFeng, Wu, Xiaochun, Wu, Junguang, Zhang, Leili, Zhao, Yuliang, Jiang, Xiaoming, Lin, Binhua, Zhou, Ruhong, Chen, Chunying. Stability of Ligands on Nanoparticles Regulating the Integrity of Biological Membranes at the Nano-Lipid Interface. ACS NANO[J]. 2019, 13(8): 8680-8693, http://dx.doi.org/10.1021/acsnano.9b00114.
[24] Fan, Huizhen, Li, Yiye, Liu, Jianbo, Cai, Rui, Gao, Xinshuang, Zhang, Hui, Ji, Yinglu, Nie, Guangjun, Wu, Xiaochun. Plasmon-Enhanced Oxidase-Like Activity and Cellular Effect of Pd-Coated Gold Nanorods. ACS APPLIED MATERIALS & INTERFACES[J]. 2019, 11(49): 45416-45426, https://www.webofscience.com/wos/woscc/full-record/WOS:000502689000006.
[25] Hu, Zhijian, Meng, Dejing, Lin, Feng, Zhu, Xing, Fang, Zheyu, Wu, Xiaochun. Plasmonic Circular Dichroism of Gold Nanoparticle Based Nanostructures. ADVANCED OPTICAL MATERIALSnull. 2019, 7(10): https://www.webofscience.com/wos/woscc/full-record/WOS:000471340100004.
[26] Si, Yuelei, Cao, Shuang, Wu, Zhijiao, Ji, Yinglu, Mi, Yang, Wu, Xiaochun, Liu, Xinfeng, Piao, Lingyu. What is the predominant electron transfer process for Au NRs/TiO2 nanodumbbell heterostructure under sunlight irradiation?. APPLIED CATALYSIS B-ENVIRONMENTAL[J]. 2018, 220: 471-476, http://dx.doi.org/10.1016/j.apcatb.2017.08.024.
[27] Sun, Quanmei, Shi, Xiaoli, Feng, Jiantao, Zhang, Qiang, Ao, Zhuo, Ji, Yinglu, Wu, Xiaochun, Liu, Dongsheng, Han, Dong. Cytotoxicity and Cellular Responses of Gold Nanorods to Smooth Muscle Cells Dependent on Surface Chemistry Coupled Action. SMALL[J]. 2018, 14(52): https://www.webofscience.com/wos/woscc/full-record/WOS:000456505700011.
[28] Long, Lin, Liu, Jianbo, Lu, Kaishun, Zhang, Tao, Xie, Yunqing, Ji, Yinglu, Wu, Xiaochun. Highly sensitive and robust peroxidase-like activity of Au-Pt core/shell nanorod-antigen conjugates for measles virus diagnosis. JOURNAL OF NANOBIOTECHNOLOGY[J]. 2018, 16(1): https://doaj.org/article/21f500f80ad5418aa823aba6e5b8b1aa.
[29] Wang, Peng, Zhang, Lingmin, Zheng, Wenfu, Cong, Liman, Guo, Zhaorong, Xie, Yangzhouyun, Wang, Le, Tang, Rongbing, Feng, Qiang, Hamada, Yoh, Gonda, Kohsuke, Hu, Zhijian, Wu, Xiaochun, Jiang, Xingyu. Thermo-triggered Release of CRISPR-Cas9 System by Lipid-Encapsulated Gold Nanoparticles for Tumor Therapy. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2018, 57(6): 1491-1496, http://www.corc.org.cn/handle/1471x/2177932.
[30] Ma, Yang, Qiao, ShengLin, Wang, Yi, Lin, YaoXin, An, HongWei, Wu, XiaoChun, Wang, Lei, Wang, Hao. Nanoantagonists with nanophase-segregated surfaces for improved cancer immunotherapy. BIOMATERIALS[J]. 2018, 156: 248-257, http://www.corc.org.cn/handle/1471x/2177868.
[31] Unique role of non-mercapto groups in thiol-pinning- mediated Ag growth on Au nanoparticles. 纳米研究：英文版[J]. 2018, 11(2): 614-624, http://lib.cqvip.com/Qikan/Article/Detail?id=674733659.
[32] Zhang T, Tian F, Long L, Liu JB, Wu XC. Diagnosis of rubella virus using antigen-conjugated Au@Pt nanorods as nanozyme probe. INTERNATIONAL JOURNAL OF NANOMEDICINE[J]. 2018, 13: 4795-4805, https://doaj.org/article/d90e1c163b6d4b4ba6707933ae08a63d.
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[112] 汤国庆, 邹炳锁, 余保龙, 吴晓春, 陈文驹, 张桂兰. 亚甲兰对纳米CdS有机溶胶体系光谱性质的影响. 科学通报[J]. 1996, 41(1): 95-, http://lib.cqvip.com/Qikan/Article/Detail?id=2063138.
[113] 张桂兰, 汤国庆, 陈文驹, 余保龙, 吴晓春. 纳米材料SnO2表面声子模的红外光谱研究. 物理学报[J]. 1996, 45(6): 1003-, http://lib.cqvip.com/Qikan/Article/Detail?id=2208717.
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（ 1 ） 金纳米棒的制备、性质及应用, 科学出版社, 2014-03, 第 1 作者

   

（ 1 ） 金属纳米颗粒形状可控的生长和SPR性质调控, 主持, 国家级, 2008-01--2010-12
（ 2 ） 纳米标准物质和检测用纳米标准样品的可控合成、量产及微纳加工方法标准化研究, 主持, 国家级, 2006-12--2010-12
（ 3 ） 纳米技术标准化的基础研究, 参与, 国家级, 2011-05--2015-05
（ 4 ） 铂及其二元金属纳米结构：模拟酶性质调控及生物检测应用, 主持, 国家级, 2012-01--2015-12
（ 5 ） 金纳米棒/有机分子线性自组装结构的构建及在生物识别中的应用, 主持, 国家级, 2012-01--2014-12
（ 6 ） 基于肿瘤微环境调控的抗肿瘤纳米材料设计和机制研究, 参与, 国家级, 2012-01--2016-12
（ 7 ） 纳米产业技术标准的共性关键科学问题研究, 主持, 国家级, 2016-07--2021-06

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