主要从事基于纳米材料的的疾病早期诊断、有效治疗及材料生物学效应研究

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080501-材料物理与化学

纳米材料肿瘤诊疗应用，纳米材料生物学效应

2018-08--2019-06   中国科学院大学   博士
2007-09--2010-06   上海师范大学   硕士
2003-09--2019-06   山西农业大学信息学院   本科

研究生

博士

2018-12~现在, 中国科学院宁波材料技术与工程研究所, 高级工程师
2012-12~2018-12,中国科学院宁波材料技术与工程研究所, 助理研究员
2010-06~2012-12,中国科学院宁波材料技术与工程研究所, 研究实习员

   

（ 1 ） 三元纳米复合药物、其制备方法和其用于制备治疗肿瘤的药学组合物的用途, 发明, 2013, 第 1 作者, 专利号: ZL201310103775.7
（ 2 ） 一种基于纳米粒子的肿瘤细胞主动靶向给药体系及其构建方法, 发明, 2011, 第 1 作者, 专利号: ZL201110397312.7
（ 3 ） 一种肿瘤治疗复合纳米材料及其制备, 发明, 2014, 第 1 作者, 专利号: ZL201410175018.5
（ 4 ） 一种纳米复合材料及其在示踪淋巴结中的应用, 发明, 2017, 第 2 作者, 专利号: 201710092810.8
（ 5 ） 一种纳米复合材料、其制备方法及在H IFU增效剂中的应用, 发明, 2018, 第 1 作者, 专利号: 201810429878.5

   

[1] Kaiwei Xu, Lufei Jin, Liu Xu, Yuchao Zhu, Lu Hong, Chunshu Pan, Yanying Lli, Junlie Yao, Ruifen Zhou, Weiwei Tang, Jianhua Wang, Aiguo Wu, Wenzhi Ren. IGF1 receptor‑targeted black TiO2 nanoprobes for MRI‑guided synergetic photothermal‑chemotherapy in drug resistant pancreatic tumor. Journal of Nanobiotechnology[J]. 2022, 20: 315-, [2] Dai, Ting, He, Wenming, Tu, Shuangshuang, Han, Jinru, Yuan, Bo, Yao, Chenyang, Ren, Wenzhi, Wu, Aiguo. Black TiO2 nanoprobe-mediated mild phototherapy reduces intracellular lipid levels in atherosclerotic foam cells via cholesterol regulation pathways instead of apoptosis. BIOACTIVE MATERIALS[J]. 2022, 17(11): 18-28, http://lib.cqvip.com/Qikan/Article/Detail?id=7107690927.
[3] Zhang, Tao, Wu, Bihan, Akakuru, Ozioma Udochukwu, Yao, Chenyang, Sun, Shan, Chen, Libin, Ren, Wenzhi, Wu, Aiguo, Huang, Pintong. Hsp90 inhibitor-loaded IR780 micelles for mitochondria-targeted mild-temperature photothermal therapy in xenograft models of human breast cancer. CANCER LETTERS[J]. 2021, 500: 41-50, http://dx.doi.org/10.1016/j.canlet.2020.12.028.
[4] Dai, Ting, He, Wenming, Yao, Chenyang, Ma, Xuehua, Ren, Wenzhi, Mai, Yifeng, Wu, Aiguo. Applications of inorganic nanoparticles in the diagnosis and therapy of atherosclerosis. BIOMATERIALS SCIENCEnull. 2020, 8(14): 3784-3799, http://dx.doi.org/10.1039/d0bm00196a.
[5] Lin, Jie, Ren, Wenzhi, Li, Anran, Yao, Chenyang, Chen, Tianxiang, Ma, Xuehua, Wang, Xiaotian, Wu, Aiguo. Crystal-Amorphous Core-Shell Structure Synergistically Enabling TiO2 Nanoparticles' Remarkable SERS Sensitivity for Cancer Cell Imaging. ACS APPLIED MATERIALS & INTERFACES[J]. 2020, 12(4): 4204-4211, http://dx.doi.org/10.1021/acsami.9b17150.
[6] Zhang, Tao, Jiang, Zhenqi, Chen, Libin, Pan, Chunshu, Sun, Shan, Liu, Chuang, Li, Zihou, Ren, Wenzhi, Wu, Aiguo, Huang, Pintong. PCN-Fe(III)-PTX nanoparticles for MRI guided high efficiency chemo-photodynamic therapy in pancreatic cancer through alleviating tumor hypoxia. NANO RESEARCH[J]. 2020, 13(1): 273-281, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=6817920&detailType=1.
[7] Saeed, Madiha, Iqbal, M Zubair, Ren, Wenzhi, Xia, Yuanzhi, Khan, Waheed S, Wu, Aiguo. Tunable fabrication of new theranostic Fe3O4-black TiO2 nanocomposites: dual wavelength stimulated synergistic imaging-guided phototherapy in cancer. JOURNAL OF MATERIALS CHEMISTRY B[J]. 2019, 7(2): 210-223, http://dx.doi.org/10.1039/c8tb02704h.
[8] Wang, Siqi, Ren, Wenzhi, Wang, Jianhua, Jiang, Zhenqi, Saeed, Madiha, Zhang, Lili, Li, Aiguo, Wu, Aiguo. Black TiO2-based nanoprobes for T-1-weighted MRI-guided photothermal therapy in CD133 high expressed pancreatic cancer stem-like cells. BIOMATERIALS SCIENCE[J]. 2018, 6(8): 2209-2218, http://dx.doi.org/10.1039/c8bm00454d.
[9] Saeed, Madiha, Ren, Wenzhi, Wu, Aiguo. Therapeutic applications of iron oxide based nanoparticles in cancer: basic concepts and recent advances. BIOMATERIALS SCIENCEnull. 2018, 6(4): 708-725, http://dx.doi.org/10.1039/c7bm00999b.
[10] Zubair Iqbal M, Ren Wenzhi, Saeed Madiha, Chen Tianxiang, Ma Xuehua, Yu Xu, Zhang Jichao, Zhang Lili, Li Aiguo, Wu Aiguo. A facile fabrication route for binary transition metal oxide-based Janus nanoparticles for cancer theranostic applications. NANO RESEARCH[J]. 2018, 11(10): 5735-5750, http://lib.cqvip.com/Qikan/Article/Detail?id=676513437.
[11] Saeed, Madiha, Iqbal, M Zubair, Ren, Wenzhi, Xia, Yuanzhi, Liu, Chuang, Khan, Waheed S, Wu, Aiguo. Controllable synthesis of Fe3O4 nanoflowers: enhanced imaging guided cancer therapy and comparison of photothermal efficiency with black-TiO2. JOURNAL OF MATERIALS CHEMISTRY B[J]. 2018, 6(22): 3800-3810, http://ir.nimte.ac.cn/handle/174433/17398.
[12] Ren, Wenzhi, Iqbal, M Zubair, Zeng, Leyong, Chen, Tianxiang, Pan, Yuanwei, Zhao, Jinshun, Yin, Hao, Zhang, Lili, Zhang, Jichao, Li, Aiguo, Wu, Aiguo. Black TiO2 based core-shell nanocomposites as doxorubicin carriers for thermal imaging guided synergistic therapy of breast cancer. NANOSCALE[J]. 2017, 9(31): 11195-11204, http://dx.doi.org/10.1039/c7nr04039c.
[13] Ren, Wenzhi, Yan, Yong, Zeng, Leyong, Shi, Zhenzhi, Gong, An, Schaaf, Peter, Wang, Dong, Zhao, Jinshun, Zou, Baobo, Yu, Hongsheng, Chen, Ge, Brown, Eric Michael Bratsolias, Wu, Aiguo. A Near Infrared Light Triggered Hydrogenated Black TiO2 for Cancer Photothermal Therapy. ADVANCED HEALTHCARE MATERIALS[J]. 2015, 4(10): 1526-1536, http://ir.iphy.ac.cn/handle/311004/60200.
[14] Du, Yang, Ren, Wenzhi, Li, Yaqian, Zhang, Qian, Zeng, Leyong, Chi, Chongwei, Wu, Aiguo, Tian, Jie. The enhanced chemotherapeutic effects of doxorubicin loaded PEG coated TiO2 nanocarriers in an orthotopic breast tumor bearing mouse model. JOURNAL OF MATERIALS CHEMISTRY B[J]. 2015, 3(8): 1518-1528, http://ir.iphy.ac.cn/handle/311004/60870.
[15] Shi, Zhenzhi, Ren, Wenzhi, Gong, An, Zhao, Xinmei, Zou, Yuehong, Brown, Eric Michael Bratsolias, Chen, Xiaoyuan, Wu, Aiguo. Stability enhanced polyelectrolyte-coated gold nanorod-photosensitizer complexes for high/low power density photodynamic therapy. BIOMATERIALS[J]. 2014, 35(25): 7058-7067, http://dx.doi.org/10.1016/j.biomaterials.2014.04.105.
[16] Ren, Wenzhi, Zeng, Leyong, Shen, Zheyu, Xiang, Lingchao, Gong, An, Zhang, Jichao, Mao, Chengwen, Li, Aiguo, Paunesku, Tatjana, Woloschak, Gayle E, Hosmane, Narayan S, Wu, Aiguo. Enhanced doxorubicin transport to multidrug resistant breast cancer cells via TiO2 nanocarriers. RSC ADVANCES[J]. 2013, 3(43): 20855-20861, http://ir.sinap.ac.cn/handle/331007/13613.

（1） TiO2 Nanoparticles: Applications in Nanobiotechnology and Nanomedicine, Wiley‐VCH Verlag GmbH & Co. KG, 2020-02, 第 2 作者

   

（ 1 ） 中空黑TiO2纳米探针的构建及其HIFU增效精准治疗肝癌研究, 主持, 省级, 2019-01--2021-12
（ 2 ） 二维光热转换纳米载体的仿生合成及双模 式一体化肿瘤诊疗, 参与, 国家级, 2019-01--2022-12
（ 3 ） 近红外光激发黑TiO2纳米粒子的肿瘤光热治 疗与药物控释研究, 主持, 省级, 2015-01--2017-12
（ 4 ） 叶酸偶联的超顺磁Fe3O4-TiO2纳米粒子用于 恶性肿瘤的MRI早期诊断与声动力治疗研究, 主持, 省级, 2014-03--2016-02
（ 5 ） 肿瘤微血管与实体瘤双靶向型超声激 发TiO2基-MRI增强复合剂及其声动力治疗与可视化研, 参与, 国家级, 2015-01--2017-12