主要面向载人航天、国防和核事故中的辐射安全需求，开展辐射暴露剂量预测与辐射防护研究，研究方向包括：（1）基于体液分子的新生物辐射剂量计及检测技术；（2）辐射物理剂量与生物效应关系的建模分析；（3）循环生物分子在电离辐射损伤和恢复中的功能及机制研究；（4）靶向循环分子的新辐射防护剂及防护策略研究。

   

071011-生物物理学
071009-细胞生物学

辐射生物学
辐射剂量学
血液学

2012-09--2018-01   中国科学院大学   理学博士
2008-09--2012-06   西北大学   理学学士

   

2021-05~现在, 中国科学院近代物理研究所, 副研究员
2018-02~2021-04,中国科学院近代物理研究所, 助理研究员

   

[1] 危文俊, 王菊芳, 白皓, 张亚楠, 陈亚雄. 检测或评估电离辐射损伤或暴露的试剂及其所用tRNA衍生片段. CN: CN114150054A, 2022-03-08.
[2] 王菊芳, 何进鹏, 华君瑞, 危文俊, 张亚楠. 一种用于骨样本试验的机械力装置. CN: CN209745695U, 2019-12-06.
[3] 危文俊, 王菊芳, 华君瑞, 何进鹏. 一种血清miRNA标志物及其检测电离辐射损伤的方法. CN: CN109385472A, 2019-02-26.
[4] 王菊芳, 危文俊, 王洁, 丁楠, 何进鹏. 循环血miR-34a作为辐射生物标志物在辐射监控中的应用. CN: CN104977398A, 2015-10-14.

   

[1] Yang, Pengfei, Feng, Xiu, Li, Jin, Zhang, Tianyi, Sheng, Chengyan, Zhang, Liying, Hua, Junrui, Wei, Wenjun, Ding, Nan, He, Jinpeng, Zhang, Yanan, Wang, Jufang, Zhou, Heng. Ionizing radiation downregulates estradiol synthesis via endoplasmic reticulum stress and inhibits the proliferation of estrogen receptor-positive breast cancer cells. CELL DEATH & DISEASE[J]. 2021, 12(11): http://dx.doi.org/10.1038/s41419-021-04328-w.
[2] Bai, Hao, Zhang, Tongshan, Wang, Jufang, Hua, Junrui, Wei, Wenjun. Identification of novel biomarkers of heavy ion exposure: Proteins, miRNAs and tRNA-derived fragments in serum. ACTA ASTRONAUTICA[J]. 2021, 186: 329-336, http://dx.doi.org/10.1016/j.actaastro.2021.05.047.
[3] Yang, Pengfei, Luo, Xiangxia, Li, Jin, Zhang, Tianyi, Gao, Xiaoling, Hua, Junrui, Li, Yonghong, Ding, Nan, He, Jinpeng, Zhang, Yanan, Wei, Wenjun, Wang, Jufang, Zhou, Heng. Ionizing Radiation Upregulates Glutamine Metabolism and Induces Cell Death via Accumulation of Reactive Oxygen Species. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY[J]. 2021, 2021: http://dx.doi.org/10.1155/2021/5826932.
[4] Wenjun Wei, Hao Bai, Yaxiong Chen, Tongshan Zhang, Yanan Zhang, Junrui Hua, Jinpeng He, Nan Ding, Heng Zhou, Jufang Wang. Circulating tRNA-Derived Small RNAs as Novel Radiation Biomarkers of Heavy Ion, Proton and X-ray Exposure. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES[J]. 2021, 22: [5] Pengfei Yang, Xiu Feng, Jin Li, Tianyi Zhang, Chengyan Sheng, Liying Zhang, Junrui Hua, Wenjun Wei, Nan Ding, Jinpeng He, Yanan Zhang, Jufang Wang, Heng Zhou. Ionizing radiation downregulates estradiol synthesis via endoplasmic reticulum stress and inhibits the proliferation of estrogen receptor-positive breast cancer cells. CELL DEATH & DISEASE. 2021, 12(11): [6] Ding, Nan, Hua, Junrui, He, Jinpeng, Lu, Dong, Wei, Wenjun, Zhang, Yanan, Zhou, Heng, Zhang, Liying, Liu, Yongqi, Zhou, Guangming, Wang, Jufang. The Role of MiR-5094 as a Proliferation Suppressor during Cellular Radiation Response via Downregulating STAT5b. JOURNAL OF CANCER[J]. 2020, 11(8): 2222-2233, http://dx.doi.org/10.7150/jca.39679.
[7] Wei, Wenjun, Bai, Hao, Feng, Xiu, Hua, Junrui, Long, Kaiqin, He, Jinpeng, Zhang, Yanan, Ding, Nan, Wang, Jufang, Zhou, Heng. Serum Proteins as New Biomarkers for Whole-Body Exposure to High- and Low-LET Ionizing Radiation. DOSE-RESPONSE[J]. 2020, 18(1): https://doaj.org/article/7295872fd1694d16ae1f0e223c21de13.
[8] 危文俊, 王菊芳, 何进鹏, 周珩. 基于循环血miRNAs评估空间铁离子辐射暴露的新方法. 航天医学与医学工程[J]. 2019, 32(3): 189-195, http://lib.cqvip.com/Qikan/Article/Detail?id=7002466686.
[9] 白皓, 危文俊, 王菊芳, 马伟. 小鼠血清中对电离辐射敏感的蛋白分子研究. 辐射研究与辐射工艺学报[J]. 2019, 37(6): 22-29, https://kns.cnki.net/KCMS/detail/detail.aspx?dbcode=CJFQ&dbname=CJFDLAST2020&filename=FYFG201906004&v=MjY1OTZZSVI4ZVgxTHV4WVM3RGgxVDNxVHJXTTFGckNVUjdxZVorWm1GQ3JoVnIvS0l6VE5hYkc0SDlqTXFZOUY=.
[10] Zhang Ya Nan, Shi Wen Gui, Li He, Hua Jun Rui, Feng Xiu, Wei Wen Jun, Wang Ju Fang, He Jin Peng, Lei Su Wen. Bone Loss Induced by Simulated Microgravity, Ionizing Radiation and/or Ultradian Rhythms in the Hindlimbs of Rats. BIOMEDICAL AND ENVIRONMENTAL SCIENCES[J]. 2018, 31(2): 126-135, https://www.webofscience.com/wos/woscc/full-record/WOS:000427925500005.
[11] Wei, Wenjun, Wang, Jufang, He, Jinpeng, Xie, Xiaodong. Serum microRNA as noninvasive indicator for space radiation. ACTA ASTRONAUTICA[J]. 2018, 152: 101-104, http://dx.doi.org/10.1016/j.actaastro.2018.07.038.
[12] 林素兰, 丁楠, 危文俊, 何进鹏, 王菊芳. GANRA纳米药对淋巴母细胞的辐射防护作用及辐射敏感microRNA的影响. 辐射研究与辐射工艺学报[J]. 2017, 35(3): 030201-1,  http://dx.doi.org/10.118879/j.1000-3436.2017.rrj.35.030201.
[13] He, Jinpeng, Feng, Xiu, Hua, Junrui, Wei, Li, Lu, Zhiwei, Wei, Wenjun, Cai, Hui, Wang, Bing, Shi, Wengui, Ding, Nan, Li, He, Zhang, Yanan, Wang, Jufang. miR-300 regulates cellular radiosensitivity through targeting p53 and apaf1 in human lung cancer cells. CELL CYCLE[J]. 2017, 16(20): 1943-1953, https://www.webofscience.com/wos/woscc/full-record/WOS:000414094300015.
[14] Wei, W, Wang, J, He, J. Circulating microRNAs responding to ionizing radiation alleviate radiation damage to immune system. EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERSnull. 2017, 46: S380-S380, https://www.webofscience.com/wos/woscc/full-record/WOS:000416406202139.
[15] Wengui Shi, Yanfang Xie, Jinpeng He, Jian Zhou, Yuhai Gao, Wenjun Wei, Nan Ding, Huiping Ma, Cory J Xian, Keming Chen, Jufang Wang. Microgravity induces inhibition of osteoblastic differentiation and mineralization through abrogating primary cilia. SCIENTIFIC REPORTS[J]. 2017, 7(1): https://doaj.org/article/a0be59ecfd824f6e9e318cb14dc4d29a.
[16] Wei, Wenjun, He, Jinpeng, Wang, Jufang, Ding, Nan, Wang, Bing, Lin, Sulan, Zhang, Xurui, Hua, Junrui, Li, He, Hu, Burong. Serum microRNAs as Early Indicators for Estimation of Exposure Degree in Response to Ionizing Irradiation. RADIATION RESEARCH[J]. 2017, 188(3): 342-354, https://www.webofscience.com/wos/woscc/full-record/WOS:000408424300009.
[17] Wenjun Wei, Jinpeng He, Jufang Wang, Nan Ding, Bing Wang, Sulan Lin, Xurui Zhang, Junrui Hua, Burong Hu. Serum microRNAs as early indicators for estimation of exposure degree in response to ionizing radiation. Radiation Research[J]. 2017, 188(3): 342-354, [18] 危文俊, 华君瑞, 林素兰, 王菊芳. 循环血miR-21在空间辐射监测中的应用潜力. 载人航天[J]. 2016, 714-719,731, http://lib.cqvip.com/Qikan/Article/Detail?id=7000077409.
[19] 危文俊, 李朋飞, 林素兰, 王菊芳. 循环血microRNA对辐射和辐射防护药物的敏感性研究. 载人航天[J]. 2016, 22(2): 246-253, http://lib.cqvip.com/Qikan/Article/Detail?id=668375946.
[20] Zhang, Xurui, Ye, Caiyong, Sun, Fang, Wei, Wenjun, Hu, Burong, Wang, Jufang. Both Complexity and Location of DNA Damage Contribute to Cellular Senescence Induced by Ionizing Radiation. PLOS ONE[J]. 2016, 11(5): https://doaj.org/article/126dc428fad74bd7a78617e4f1c9121a.
[21] Xu, Shuai, Wang, Jufang, Ding, Nan, Hu, Wentao, Zhang, Xurui, Wang, Bing, Hua, Junrui, Wei, Wenjun, Zhu, Qiyun. Exosome-mediated microRNA transfer plays a role in radiation-induced bystander effect. RNA BIOLOGY[J]. 2015, 12(12): 1355-1363, https://www.webofscience.com/wos/woscc/full-record/WOS:000368027500008.
[22] Xu, Shuai, Ding, Nan, Pei, Hailong, Hu, Wentao, Wei, Wenjun, Zhang, Xurui, Zhou, Guangming, Wang, Jufang. MiR-21 is involved in radiation-induced bystander effects. RNA BIOLOGY[J]. 2014, 11(9): 1161-1170, https://www.webofscience.com/wos/woscc/full-record/WOS:000348463500008.

   

（ 1 ） 循环血辐射敏感microRNA调控淋巴细胞辐射损伤的机理研究, 负责人, 国家任务, 2019-01--2021-12
（ 2 ） 血液miRNA分子在电离辐射暴露评估中的应用及功能研究, 负责人, 中国科学院计划, 2019-01--2021-12
（ 3 ） 电离辐射对癌细胞PD-L1蛋白表达的影响及相关机制研究, 负责人, 地方任务, 2020-11--2022-10
（ 4 ） 评估空间辐射风险的新生物分子标志物, 参与, 中国科学院计划, 2018-01--2020-12
（ 5 ） 模拟微重力通过cAMP-PKA通路介导初级纤毛消失抑制骨形成, 参与, 国家任务, 2019-01--2022-12
（ 6 ） 重离子辐射在生命科学应用中的新机制、新方法研究群体, 参与, 地方任务, 2017-09--2020-09
（ 7 ） 空间环境下骨质流失机制及应对措施合作研发, 参与, 其他任务, 2015-04--2018-04
（ 8 ） 基于血液分子的辐射剂量快速检测技术, 参与, 企业委托, 2020-07--2023-06

（1）Serum biomarkers for heavy ions in space:proteins, miRNAs and tRNA-derived fragments   2020-10-12
（2）基于循环血microRNAs 评估 空间重离子辐射损伤的新方法   第五届载人航天学术大会   2018-10-23
（3）3Rs and Biophysics   2017-07-16