基本信息

洪伟  男    中国科学院深圳先进技术研究院
电子邮件: wei.hong@siat.ac.cn
通信地址: 广东省深圳市南山区学苑大道1068号
邮政编码: 518055

部门/实验室:脑所

招生信息

   
招生专业
071006-神经生物学
071010-生物化学与分子生物学
071009-细胞生物学
招生方向
阿尔茨海默症研究模型、发生机制和诊疗策略

教育背景

2009-09--2014-06   武汉大学   博士
2005-09--2009-06   武汉大学   学士

工作经历

2014-11~2019-10, 哈佛大学医学院, 博士后

专利与奖励

深圳市海外高层次人才,2020

出版信息

   
发表论文
(1) PrP is a central player in toxicity mediated by soluble aggregates of neurodegeneration-causing proteins, Acta Neuropathologica, 2020, 第 3 作者
(2) ImKTx96, a peptide blocker of the Kv1. 2 ion channel from the venom of the scorpion Isometrus maculates, Peptides, 2020, 通讯作者
(3) PrP-grafted antibodies bind certain amyloid β-protein aggregates, but do not prevent toxicity, Brain Research, 2019, 第 2 作者
(4) A vicious cycle of beta amyloid-dependent neuronal hyperactivation, Science, 2019, 第 3 作者
(5) Identification of neurotoxic cross-linked amyloid-beta dimers in the Alzheimer's brain, Brain, 2019, 第 2 作者
(6) Diffusible, highly bioactive oligomers represent a critical minority of soluble Abeta in Alzheimer's disease brain, Acta Neuropathologica, 2018, 第 1 作者
(7) An in vitro paradigm to assess potential anti-Abeta antibodies for Alzheimer's disease, Nature Communications, 2018, 第 3 作者
(8) Histidine-rich Modification of a Scorpion-derived Peptide Improves Bioavailability and Inhibitory Activity against HSV-1, Theranostics, 2018, 第 3 作者
(9) Cellular Prion Protein Mediates the Disruption of Hippocampal Synaptic Plasticity by Soluble Tau In Vivo, Journal of Neuroscience, 2018, 第 5 作者
(10) Human Brain-Derived Abeta Oligomers Bind to Synapses and Disrupt Synaptic Activity in a Manner That Requires APP, Journal of Neuroscience, 2017, 第 3 作者
(11) A Tat-conjugated Peptide Nucleic Acid Tat-PNA-DR Inhibits Hepatitis B Virus Replication In Vitro and In Vivo by Targeting LTR Direct Repeats of HBV RNA, Mol Ther Nucleic Acids, 2016, 第 3 作者
(12) A Scorpion Defensin BmKDfsin4 Inhibits Hepatitis B Virus Replication in Vitro, Toxins, 2016, 第 3 作者
(13) A p7 Ion Channel-derived Peptide Inhibits Hepatitis C Virus Infection in Vitro, J Biol Chem, 2015, 第 1 作者
(14) Dual-pH Sensitive Charge-Reversal Polypeptide Micelles for Tumor-Triggered Targeting Uptake and Nuclear Drug Delivery, Small, 2015, 第 6 作者
(15) Inhibitory activity and mechanism of two scorpion venom peptides against herpes simplex virus type 1, Antiviral Research, 2014, 第 1 作者
(16) Sj7170, a unique dual-function peptide with a specific alpha-chymotrypsin inhibitory activity and a potent tumor-activating effect from scorpion venom, J Biol Chem, 2014, 第 4 作者
(17) Design of histidine-rich peptides with enhanced bioavailability and inhibitory activity against hepatitis C virus, Biomaterials, 2013, 第 1 作者
(18) The genome of Mesobuthus martensii reveals a unique adaptation model of arthropods, Nature Communications, 2013, 其他(合作组作者)
(19) Molecular diversity of Chaerilidae venom peptides reveals the dynamic evolution of scorpion venom components from Buthidae to non-Buthidae, J Proteomics, 2013, 第 6 作者
(20) Mucroporin-M1 inhibits hepatitis B virus replication by activating the mitogen-activated protein kinase (MAPK) pathway and down-regulating HNF4alpha in vitro and in vivo, J Biol Chem, 2012, 第 2 作者
(21) Virucidal activity of a scorpion venom peptide variant mucroporin-M1 against measles, SARS-CoV and influenza H5N1 viruses, Peptides, 2011, 第 5 作者
(22) A new natural alpha-helical peptide from the venom of the scorpion Heterometrus petersii kills HCV, Peptides, 2011, 第 6 作者

科研活动

   
科研项目
( 1 ) 非人灵长类动物模型分析, 主持, 院级, 2020-05--2020-12
参与会议
(1)Identification of neurotoxic cross-linked Aβ heterodimers in Alzheimer's disease brain   第48届神经科学学会年会(SFN)   2018-11-07
(2)Diffusible Alzheimer’s disease brain-derived Aβ disrupts synaptic plasticity   第47届神经科学学会年会(SFN)   2017-11-15