基本信息
魏滨 男 博导 武汉病毒研究所
电子邮件:weibin@wh.iov.cn
通信地址:湖北省武汉市小洪山中区44号武汉病毒研究所保藏楼305室
邮政编码: 430071

研究领域

长期从事免疫细胞活化和分化的信号转导机制和人类疾病的免疫病理损伤机制研究。同时关注病毒入侵受体和免疫细胞表面受体介导的异常炎症反应,包括炎症-肿瘤演变的机制研究。为肿瘤的免疫治疗、早期诊断,抗病毒新药研发提供作用靶点,同时为新型疫苗的设计和效力评估提供新技术手段。
研究方向
病毒与宿主细胞间相互作用;淋巴细胞受体所介导的信号转导通路和表观遗传调控机制与病毒性疾病的关系;淋巴细胞活化和分化在病毒感染引起的炎症和肿瘤发生中的作用。

招生信息

   
招生专业
071009-细胞生物学
招生方向
淋巴细胞信号转导

教育背景

1998-09--2001-07 中国预防医学科学院 博士
1995-09--1998-07 兰州医学院 硕士
学历
研究生
学位
博士

工作经历

   
工作简历
2014-10--今 中国科学院武汉病毒所 研究员
2012-04--2013-12 德国勃林格殷格翰亚洲研发中心 高级研究员
2009-07--2012-04 中国科学院上海生科院生化细胞所 副研究员
2002-06--2009-07 英国牛津大学&英国剑桥大学 博士后

专利与奖励

   
奖励信息
(1) 赛诺菲—中国科学院上海生命科学研究院优秀青年人才奖励,院级级,2011

出版信息

“*”通讯作者及共同通讯作者,“#”共同第一作者,IF为2014影响因子。

1. Chen J#, Han L#, Xu X, Tang H*, Wang H, Wei B*, Serum biomarkers VEGF-C and IL-6 are associated with severe human Peripheral Artery Stenosis. J Inflamm (Lond). 2015 Aug 18;12. (IF: 2.7).
2. Weiyun Li#, Jun Xiao#, Xin Zhou, Ming Xu, Chaobo Hu, Xiaoyan Xu, Yao Lu, Chang Liu, Shengjie Xue, Lei Nie, Haibin Zhang, Zhiqi Li, Yanbo Zhang, Fu Ji, Lijian Hui, Wufan Tao, Bin Wei*, Hongyan Wang*. STK4 regulates TLR pathway and protects against chronic inflammation-related hepatocellular carcinoma. J Clin Invest, 2015, (November issue, In Press) (IF: 14)
3. Li CY#; Jiao SZ#; Wang G; Li W; Gao Y; Xiao J; He X; Liu C; Zhang G; Wei B; Chen H*; Wang H*.The immune adaptor ADAP regulates reciprocal TGF-β1-integrin crosstalk to protect from influenza virus infection. PLOS Pathogen. 2015, 11(4), (IF: 8.0)
4. Li CY, Xiao J, Jiao SZ, Sheng Chun, Leng QB, Rudd CE, Wei B*, Wang H*. ADAP and SKAP55 deficiency suppresses PD-1 expression in CD8+ cytotoxic T lymphocytes for enhanced anti-tumor immunotherapy. EMBO Mol Med, 2015, (IF: 8.245)
5. Huang S*, Mao J, Wei B, Pei G. The anti-spasticity drug baclofen alleviates collagen-induced arthritis and regulates dendritic cells. J Cell Physio, 2015 Jan 3. ( IF:4.218)
6. Li H, Yue R, Wei B, Gao G, Du J, Pei G*. Lysophosphatidic acid acts as a nutrient-derived developmental cue to regulate early hematopoiesis. EMBO J. 2014 Jun 17;33(12):1383-96. ( IF:10.748)
7. Zhang YB, Lu Y, Ma L, Li DS, He YL, Wei B*,Wang H*. VEGFR-3 restrains TLR4-NF-κB triggered inflammation and protects from endotoxin shock. Immunity, 2014, 40; 1-14. ( IF:19.748)
8. Wei B#, Lei H#, Abbink T, Groppelli E, Gao W, Lim D, Thaker Y, Lever AM, Jolly C, Wang H*, Rudd CE*. Adhesion and degranulation-promoting adaptor protein (ADAP) and the ADAP-SLP-76 module regulate HIV-1 cell-cell spread and replication in T-cells. Retrovirology. 2013 Sep 18;10(1):101.(IF: 4.767)
9. Li J#, Wei B#, Guo A, Liu C, Huang SC, Du F, Fan W, Bao CD, Pei G*. Deficiency of ?-arrestin1 ameliorates the development of rheumatoid arthritis with impaired TH17 cell differentiation. PNAS 2013, 110 (18): 7395–7400.(IF:9.808)
10. Zhang Y, Liu C, Wei B*, Pei G. Loss of β-Arrestin 2 exacerbates experimental autoimmune encephalomyelitis and impairs differentiation of Foxp3+CD4+ regulatory T cells. Immunology. 2013 Dec;140(4):430-40. (IF:3.735)
11. Chun Li, Xiao, Xu, Wang H, Wei B*. PD-1 and CTLA-4 mediated inhibitory signaling for T cell exhaustion during chronic viral infections. Journal of Clinical & Cellular Immunology, 2013.S12: 010.(IF:4.2)
12. Wei B*, Pei G. microRNAs: critical regulators in TH17 cells and players in diseases. Cell Mol Immunol. 2010 May; 7(3):175-81.(IF:4.185)
13. Wei B*, Chapman S, Wieckiewicz J, Wood KJ*. IFN-γ triggered JAK-STAT-1-AKT signaling pathway influences the function of alloreactive regulatory T cells. Am J Transplant. 2010 Jan; 10 (1):69-80.(IF:6.19)
14. Yue R#, Li H#, Liu H, Li YY, Wei B, Gao G, Liu TX, Wei L, Du JL, Pei G*. Thrombin receptor signaling regulates endothelial to haematopoietic transition. Developmental Cell. 2012 May 15; 22 (5):1092-100.(IF:10.366)
15. Chen T#, Yuan D#, Wei B, Jiang J, Kang J, Ling K, Gu Y, Li J, Xiao L, Pei G*. E-cadherin-Mediated Cell-Cell Contact is Critical for Induced Pluripotent Stem Cell Generation. Stem Cells. 2010 Jun 2. 28:1315–1325. (IF:7.133)
16. Cao N, Liu Z, Chen Z, Wang J, Chen TT, Zhao X, Ma Y, Qin L, Kang JH, Wei B, Wang L, Jin Y, Yang HT*. Ascorbic acid enhances the cardiac differentiation of induced pluripotent stem cells promoting the proliferation of cardiac progenitor cells. Cell Research. 2012 Jan;22(1):219-36.(IF:11.981)
17. Gog J R, Murcia A, Osterman N, Restif O, McKinley T J, Sheppard M, Achouri S, Wei B, Mastroeni P, Wood JL, Maskell DJ, Cicuta P, Bryant CE*. Dynamics of Salmonella infection of macrophages at the single cell level. J R Soc Interface. 2012 Oct 7;9(75):2696-707.(IF:3.856)
18. Wang H. Wei B, Bismuth G, Rudd CE*. ADAP-SLP-76 binding integrates TcR/LFA-1 signals to regulate calcium mobilization for T-cell spreading and IL-2 amplification. PNAS. 2009 Jul 28;106 (30):12436-41.(IF:9.808)
19. Walsh C, Gangloff M, Monie T, Smyth T, Wei B, McKinley TJ, Maskell D, Gay NJ and Bryant CE*, Elucidation of the MD-2/TLR4 interface required for signaling by Lipid IVa. J Immunol. 2008 Jul 15;181(2):1245-54. (IF:5.362)
20. Wood KJ*, Feng G, Wei B, Sawitzki B, Bushell AR. Interferon gamma: Friend or foe? Transplantation. 2007 Jul 15; 84: S4-5. (IF:3.535)
21. Wei B, da Rocha Dias S, Wang H, Rudd CE*. TcR-CTLA-4 Co-ligation induced rapid polarization that depends on phosphatidylinositol 3-Kinase, Vav-1, Cdc42 and myosin light chain kinase. J Immunol, 2007, 179: 400-408. (IF:5.362)
22. Wang H, Lv Y, Lovatt M, Wei B, Rudd CE. Functional defects of SKAP-55 deficient T-cells identify a regulatory role for the adaptor in LFA-1 adhesion without ADAP expression. Mol Cell Biol. 2007. Oct; 27(19):6863-75. (IF: 5.7)
23. Schneider H, Downey J, Smith A, Zinselmeyer BH, Rush C, Brewer JM, Wei B, Hogg N, Garside P, Rudd CE*. Reversal of the TCR stop signal by CTLA-4. Science. 2006 Sep 29; 313 (5795):1972-5. (IF:31.477)
24. Schneider H, Valk E, da Rocha Dias S, Wei B, Rudd CE*. CTLA-4 up-regulation of lymphocyte function-associated antigen 1 adhesion and clustering as an alternate basis for coreceptor function. PNAS. 2005 Sep 6;102 (36):12861-6. (IF:9.808)

科研活动

   
科研项目
(1) 人类烈性病毒感染的核糖核酸生物学研究,主持,研究所(学校)级,2015-01--2018-12
(2) 烈性病毒病理损伤机制,主持,研究所(学校)级,2014-11--2017-12
(3) 胸腺的起源、发生、维持与退化,参与,国家级,2010-06--2015-08

指导学生

现指导学生

张芳  博士研究生  071005-微生物学