基本信息
王坤  男  硕导  中国科学院自动化研究所
电子邮件: kun.wang@ia.a.cn
通信地址: 北京市海淀区中关村东路95号,中国科学院自动化研究所,智能大厦903
邮政编码: 100190

研究领域

专注于分子影像、医学影像人工智能等前沿领域的技术研发和临床应用。研究工作覆盖了相关医学成像技术的模型算法研究,仪器设备研发,生物医学应用与临床医学转化。其研究目标是利用光学多模融合分子影像技术和影像组学大数据人工智能分析技术,提高肿瘤等重大疾病的影像检测灵敏度和定量分析精确度,从而促进疾病的早期检测和精准治疗的发展。以第一或通讯作者(含并列)在Gut(影响因子19.819)、Advanced Materials(影响因子27.390)、Nature Communications(影响因子12.121)、Medical Image Analysis(影响因子11.148)、IEEE Transactions on Medical Imaging(影响因子6.685)等SCI检索期刊发表论文30余篇,另获得授权国家发明专利10项。先后承担国家自然科学基金委青年项目、面上项目,中国科学院科技服务网络计划(STS计划)重点项目、科研仪器设备研发项目;荣获中国科学院青年创新促进会优秀会员;并作为课题骨干参与国家重大科研仪器设备研制专项、国家重点基础研究发展计划(973计划)、国家重点研发计划纳米科技重点专项等。 现任IEEE医学和生物工程学会北京分会秘书长,中国医师协会放射医师分会第四届专业委员会委员,中国研究型医院学会消化内镜分子影像学专业委员会常务委员,以及中国科学院青年创新促进会会员。曾担任世界分子影像大会(World Molecular Imaging Congress2015年执行委员会委员,以及中国生物物理学会分子影像专业委员会副秘书长(2014-2017年)。

招生信息

   
招生专业
081203-计算机应用技术
招生方向
光学分子影像,超声影像组学,多模态融合成像,医疗大数据人工智能分析

教育背景

2008-01--2011-12   英国纽卡斯尔大学医学院   医学影像博士
2006-09--2007-12   比利时鲁汶大学医学院   医学影像硕士
2005-09--2006-07   比利时鲁汶大学工程学院   电子电气工程硕士
2003-09--2005-07   比利时鲁汶大学工程学院   电子电气工程学士
2002-09--2006-07   北京交通大学电子信息技术学院   通讯工程学士

工作经历

   
工作简历
2021-01~现在, 中国科学院自动化研究所, 研究员
2014-10~2021-01,中国科学院自动化研究所, 副研究员
2012-11~2014-10,中国科学院自动化研究所, 助理研究员
学术兼职
2018-01-01-今,中国医师协会放射医师分会第四届专业委员会委员,
2016-01-01-今,中国科学院青年创新促进会会员,
2014-12-31-2015-12-30,世界分子影像学会程序委员会委员,
2014-01-01-今,IEEE医学和生物工程学会北京分会秘书,
2013-12-30-2017-12-31,中国生物物理学会分子影像专业委员会副秘书长,

专利与奖励

   
专利成果
( 1 ) 一种基于迭代重加权范数优化策略的生物自发荧光断层成像方法, 发明, 2015, 第 4 作者, 专利号: ZL201310254346.x
( 2 ) 基于契伦科夫效应的内窥平面成像系统和方法, 发明, 2015, 第 4 作者, 专利号: ZL2014103022055
( 3 ) 一种光声与X射线断层成像融合的成像系统, 发明, 2016, 第 5 作者, 专利号: ZL201310723609.7
( 4 ) 一种用于光动力治疗的靶向探针及制备方法, 发明, 2016, 第 3 作者, 专利号: CN105879029A
( 5 ) 基于纯光学系统的生物自发光三维成像方法, 发明, 2016, 第 2 作者, 专利号: CN106097437A
( 6 ) 一种光声成像和光学成像多模态融合成像系统, 发明, 2016, 第 2 作者, 专利号: CN106124469A
( 7 ) 近红外纳米探针、制备方法及全息分子影像导航系统, 发明, 2017, 第 4 作者, 专利号: CN107349433A

出版信息

   
部分发表论文
(1) Adaptive Grouping Block Sparse Bayesian Learning Method for Accurate and Robust Reconstruction in Bioluminescence Tomography, IEEE Transactions on Biomedical Engineering, 2021, 第 1 作者
(2) Deep pyramid local attention neural network for cardiac structure segmentation in two-dimensional echocardiography, Medical Image Analysis, 2021, 第 1 作者
(3) Dynamic Contrast-Enhanced Ultrasound Radiomics for Hepatocellular Carcinoma Recurrence Prediction After Thermal Ablation, Molecular Imaging and Biology, 2021, 通讯作者
(4) K-nearest Neighbor Based Locally Connected Network for Fast Morphological Reconstruction in Fluorescence Molecular Tomography, IEEE Transactions on Medical Imaging (SCI IF = 7.816), 2020, 通讯作者
(5) In vivo three-dimensional evaluation of tumor hypoxia in nasopharyngeal carcinomas using FMT-CT and MSOT, European Journal of Nuclear Medicine and Molecular Imaging (SCI IF = 7.182), 2020, 第 1 作者
(6) Deep Learning Radiomics Based on Contrast-Enhanced Ultrasound Might Optimize Curative Treatments for Very-Early or Early-Stage Hepatocellular Carcinoma Patients, Liver Cancer (SCI IF = 5.944), 2020, 第 1 作者
(7) Domain Transform Network for Photoacoustic Tomography from Limited-view and Sparsely Sampled Data, Photoacoustics (SCI IF = 5.25), 2020, 第 1 作者
(8) Cascaded one-shot deformable convolutional neural networks: Developing a deep learning model for respiratory motion estimation in ultrasound sequences, Medical Image Analysis, 2020, 通讯作者
(9) The first visualization of chemotherapy-induced tumor apoptosis via magnetic particle imaging in a mouse model, Physics in Medicine & Biology, 2020, 第 2 作者
(10) Construction of a novel bispecific fusion protein to enhance targeting for pancreatic cancer imaging, Biomaterials, 2020, 通讯作者
(11) Differential Diagnosis of Benign and Malignant Thyroid Nodules Using Deep Learning Radiomics of Thyroid Ultrasound Images, European Journal of Radiology, 2020, 通讯作者
(12) Deep learning Radiomics of shear wave elastography significantly improved diagnostic performance for assessing liver fibrosis in chronic hepatitis B: a prospective multicentre study, Gut (SCI IF = 17.943), 2019, 第 1 作者
(13) Lung cancer deficient in the tumor suppressor GATA4 is sensitive to TGFBR1 inhibition, Nature Communications (SCI IF = 12.353), 2019, 第 1 作者
(14) Adaptive Gaussian Weighted Laplace Prior Regularization Enables Accurate Morphological Reconstruction in Fluorescence Molecular Tomography, IEEE Transactions on Medical Imaging (SCI IF = 7.816), 2019, 第 1 作者
(15) Reconstruction of Fluorescence Molecular Tomography via a Fused LASSO Method Based on Group Sparsity Prior, IEEE Transactions on Biomedical Engineering (SCI IF = 4.491), 2019, 通讯作者
(16) Improved Block Sparse Bayesian Learning Method Using K-Nearest Neighbor Strategy for Accurate Tumor Morphology Reconstruction in Bioluminescence Tomography, IEEE Transactions on Biomedical Engineering (SCI IF = 4.491), 2019, 第 1 作者
(17) Fluorescence Molecular Tomography Based on Group Sparsity Priori for Morphological Reconstruction of Glioma, IEEE Transactions on Biomedical Engineering (SCI IF = 4.491), 2019, 通讯作者
(18) Improved generative adversarial networks using the total gradient loss for the resolution enhancement of fluorescence images, Biomedical Optics Express (SCI IF = 3.910), 2019, 第 1 作者
(19) Near-infrared Intraoperative Molecular Imaging of Thoracic Sympathetic Nerves:From Preclinical Study to Clinical Trial, Theranostics (SCI IF: 8.712), 2018, 通讯作者
(20) Sparse reconstruction of fluorescence molecular tomography using variable splitting and alternating direction scheme, Molecular Imaging and Biology (SCI IF: 3.466), 2018, 通讯作者
(21) Sorafenib-loaded polymeric micelles as passive targeting therapeutic agents for hepatocellular carcinoma therapy, Nanomedicine (SCI IF: 4.727), 2018, 第 1 作者
(22) Ferritin Nanocarrier Traverses the Blood Brain Barrier and Kills Glioma, ACS Nano (SCI IF: 13.942), 2018, 第 4 作者
(23) In vivo CRISPR screening unveils histone demethylase UTX as an important epigenetic regulator in lung tumorigenesis, PNAS (SCI IF: 9.661), 2018, 第 10 作者
(24) Non Model-based Bioluminescence Tomography Using a Machine-learning Reconstruction Strategy, Optica (SCI IF = 7.536), 2018, 通讯作者
(25) A novel plectin/integrin-targeted bispecific molecular probe for magnetic resonance/near-infrared imaging of pancreatic cancer, Biomaterials (SCI IF = 8.806), 2018, 通讯作者
(26) Core-Shell Gold Nanorod@Metal-Organic Framework Nanoprobes for Multimodality Diagnosis of Glioma, Advanced Materials (SCI IF: 19.791), 2017, 通讯作者
(27) Bioluminescence Tomography Based on Gaussian Weighted Laplace Prior Regularization for in vivo Morphological Imaging of Glioma, IEEE Transactions on Medical Imaging (SCI IF: 3.942), 2017, 第 1 作者
(28) Reconstruction Method for in vivo bioluminescence tomography Based on the Split Bregman Iterative and Surrogate Functions, Molecular Imaging and Biology (SCI IF: 3.466), 2017, 通讯作者
(29) Development and application of the near-infrared and white-light thoracoscope system for minimally invasive lung cancer surgery, Journal of Biomedical Optics (SCI IF: 2.556), 2017, 第 1 作者
(30) A new approach to predict progression-free survival in stage IV EGFR-mutant NSCLC patients with EGFR-TKI therapy, Clinical Cancer Research (SCI IF: 9.619), 2017, 第 6 作者
(31) From Detection to Resection: Photoacoustic Tomography and Surgery Guidance with Indocyanine Green Loaded Gold Nanorod@liposome Core-Shell Nanoparticles in Liver Cancer, Bioconjugate Chemistry (SCI IF: 4.818), 2017, 通讯作者
(32) Precise diagnosis in different scenarios using photoacoustic and fluorescence imaging with dual-modality nanoparticles, Nanoscale (SCI IF: 7.76), 2016, 通讯作者
(33) Curve-driven-based Acoustic Inversion for Photoacoustic Tomography, IEEE Transactions on Medical Imaging (SCI IF: 3.942), 2016, 通讯作者
(34) Lung lesion extraction using a toboggan based growing automatic segmentation approach, IEEE Transactions on Medical Imaging (SCI IF: 3.942), 2016, 第 4 作者
(35) Lp regularization for bioluminescence tomography based on the Split Bregman method, Molecular Imaging and Biology (SCI IF: 3.466), 2016, 通讯作者
(36) Metal–Organic-Framework-Derived Mesoporous Carbon Nanospheres Containing Porphyrin-Like Metal Centers for Conformal Phototherapy, Advanced Materials (SCI IF: 19.791), 2016, 第 6 作者
(37) Targeted Aucore-Agshell nanorods as a dual-functional contrast agent for photoacoustic imaging and photothermal therapy, Biomedical Optics Express (SCI IF: 3.648), 2016, 第 3 作者
(38) Dye-conjugated single-walled carbon nanotubes induce photothermal therapy under the guidance of near-infrared imaging, Cancer Letters (SCI IF: 6.375), 2016, 第 5 作者
(39) Intraoperative Identification of Liver Cancer Microfoci Using a Targeted Near-Infrared Fluorescent Probe for Imaging-Guided Surgery, Scientific Reports (SCI IF: 4.259), 2016, 第 1 作者
(40) In vivo nanoparticle-mediated radiopharmaceutical-excited fluorescence molecular imaging, Nature Communications (SCI IF: 12.124), 2015, 第 1 作者
(41) Multispectral Hybrid Cerenkov Luminescence Tomography based on the Finite Element SPn Method, Journal of Biomedical Optics (SCI IF: 2.556), 2015, 通讯作者
(42) Optical Molecular Imaging Frontiers in Oncology: The Pursuit of Accuracy and Sensitivity, Engineering, 2015, 第 1 作者
(43) Bioluminescence Tomography by an Iterative Reweighted l2 Norm Optimization Using Structure Priors, IEEE Transactions on Biomedical Engineering (SCI IF: 3.577), 2014, 第 3 作者
(44) Probability method for Cerenkov luminescence tomography based on conformance error minimization, Biomedical Optics Express (SCI IF: 3.648), 2014, 第 2 作者

科研活动

   
科研项目
( 1 ) 基于多光谱混合组织特异性模型的契伦科夫荧光高精度三维成像研究, 主持, 国家级, 2015-01--2017-12
( 2 ) 脑胶质瘤精准诊疗技术的关键科学问题研究, 参与, 国家级, 2015-01--2019-12
( 3 ) 小动物光学和光声断层多模融合分子影像设备, 参与, 部委级, 2014-01--2015-12
( 4 ) 小动物光学多模融合分子影像成像设备, 参与, 国家级, 2013-01--2017-12
( 5 ) 外源性与内源性光学三维断层成像融合新方法研究, 主持, 国家级, 2017-01--2020-12
( 6 ) 基于近红外纳米探针的肝癌分子影像及其手术导航技术研发, 参与, 国家级, 2017-08--2022-07