王怀雨 男 博士生导师 中国科学院深圳先进技术研究院
电子邮件： hy.wang1@siat.ac.cn
通信地址： 深圳市南山区西丽深圳大学城学苑大道1068号
邮政编码： 518055
研究领域
骨科植入材料
纳米生物材料
表面功能化修饰
招生信息
招收生物材料及相关领域研究生
招生专业
招生方向
教育背景
发表论文
1. Xu Chen, Xinrui Li, Wenbo He, Miao Wang, Ang Gao, *Liping Tong, Shun Guo, *Huaiyu Wang(Corresponding author), *Guoqing Pan. Rational Multivalency Construction Enables Bactericidal Effect Amplification and Dynamic Biomaterial Design. The Innovation, In press.
2. Yaoyao Xu, Yanyue Li, *Ang Gao, *Paul K. Chu, *Huaiyu Wang(Corresponding author). Gasotransmitter Delivery for Bone Diseases and Regeneration. The Innovation Life, 1, 100015, 2023.
3. #Weifang Zhang, #Lvhua Liu, Huang Zhou, Chanjuan He, Xueli Yang, Jingjing Fu, *Huaiyu Wang(Corresponding author), *Ying Liu, *Yanyan Zheng. Surface Bisphosphonation of Polyetheretherketone to Manipulate Immune Response for Advanced Osseointegration. Materials & Design, 232, 112151, 2023.
4. Zhen Zhang, Yi Liu, Xuelian Tao, Ping Du, Myagmartsend Enkhbat, Khoon S. Lim, *Huaiyu Wang(Corresponding author), *Pengyuan Wang. Engineering Cell Microenvironment Using Nanopattern-Derived Multicellular Spheroids and Photo-Crosslinked Gelatin/Hyaluronan Hydrogels. Polymers, 15, 1925, 2023.
5. Zhen Zhang, Yuanliang Lv, Javad Harati, Jianan Song, Ping Du, Peiyan Ou, Jiaqi Liang, *Huaiyu Wang(Corresponding author), *Pengyuan Wang. Submicron-Grooved Films Modulate the Directional Alignment and Biological Function of Schwann Cells. Journal of Functional Biomaterials, 14, 238, 2023.
6. Wanling Chen, Wanlin Wang, Hongyun Xing, Wan Li, Haiwei He, Wei Li, Chu, Paul K. Chu, *Guofen Song, *Huaiyu Wang(Corresponding author), *Penghui Li. Interfacial Self-Assembled Dual-Functional Nanocomposite Films for SERS Monitoring of Visible-Light Photocatalytic Degradation of Organic Dye Pollutants. Surfaces and Interfaces, 38, 102808, 2023.
7. Manshan Xie, *Yunhua Chen, Qian Yang, Qingtao Li, Runlin Zhang, Wenzhi Bi, Yong-Guang Jia, Paul K. Chu, *Huaiyu Wang(Corresponding author), *Xuetao Shi. Nano-Enabled DNA Supramolecular Sealant for Soft Tissue Surgical Applications. Nano Today, 50, 101825, 2023.
8. #Kai Zheng, #Jiaxiang Bai, #Wanling Chen, Yaozeng Xu, Huilin Yang, Wei Li, Penghui Li, *Liping Tong, *Huaiyu Wang(Corresponding author), Paul K. Chu, *Dechun Geng. Multifunctional BPs/MT@PLGA-ALE Nanospheres for Treatment of Osteoporotic Fracture with Near-Infrared Irradiation. Advanced Functional Materials, 2214126, 2023.
9. #Yuzheng Wu, #Dezhi Xiao, Pei Liu, Qing Liao, Qingdong Ruan, Chao Huang, Liangliang Liu, Dan Li, Xiaolin Zhang, Wei Li, Kaiwei Tang, *Zhengwei Wu, *Guomin Wang, *Huaiyu Wang(Corresponding author), *Paul K. Chu. Nanostructured Conductive Polypyrrole for Antibacterial Components in Flexible Wearable Devices. Research, 6, 0044, 2023.
10. #Shi Mo, #Kaiwei Tang, Qing Liao, Lingxia Xie, Yuzheng Wu, Guomin Wang, Qingdong Ruan, Ang Gao, Yuanliang Lv, Kaiyong Cai, *Liping Tong, *Zhengwei Wu, Paul K Chu, *Huaiyu Wang(Corresponding author). Tuning the Arrangement of Lamellar Nanostructures: Achieving Dual Functions of Physical Killing Bacteria and Promoting Osteogenesis. Materials Horizons, 10, 881-888, 2023.
11. #Xiaoxue Ren, #Xiaoting Gao, *Yicheng Cheng, Lingxia Xie, Liping Tong, *Wei Li, Paul K. Chu, *Huaiyu Wang(Corresponding author). Maintenance of Multipotency of Bone Marrow Mesenchymal Stem Cells on Poly(ε-caprolactone) Nanoneedle Arrays through the Enhancement of Cell-Cell Interaction. Frontiers in Bioengineering and Biotechnology, 10, 1076345, 2023.
12. Kai Zheng, *Jiaxiang Bai, Huilin Yang, Yaozeng Xu, Guoqing Pan, *Huaiyu Wang(Corresponding author), *Dechun Geng. Nanomaterial-assisted Theranosis of Bone Diseases. Bioactive Materials, 24, 263-312, 2023.
13. Guofen Song, Haiwei He, Wanling Chen, Yuanliang Lv, Paul K. Chu, *Huaiyu Wang(Corresponding author), *Penghui Li. Reversibly Migratable Fluorescent Probe for Precise and Dynamic Evaluation of Cell Mitochondrial Membrane Potentials. Biosensors, 12, 798, 2022.
14. Guofen Song, Lei Yan, Qing Liao, Wanling Chen, Liping Tong, Yi Zeng, Paul K. Chu, *Penghui Li, *Huaiyu Wang(Corresponding author). Mitochondria/RNA Cascade-targeted and Fluorescence-switchable Photosensitizer for Photodynamic Therapy Augmentation and Real-time Efficacy Self-monitoring. Sensors and Actuators B: Chemical, 369, 132260, 2022.
15. #Lei Yu, #Wenming Li, #Peng Yang, Wei Zhang, Huaqiang Tao, Gaoran Ge, Huilin Yang, *Jiaxiang Bai, *Huaiyu Wang(Corresponding author), *Dechun Geng. Osteoblastic MicroRNAs in Skeletal Disease: Biological Functions and Therapeutic Implications. Engineered Regeneration, 3, 241-257, 2022.
16. #Yanyan Zheng, #Ang Gao, #Jiaxiang Bai, Qing Liao, Yuzheng Wu, Wei Zhang, Min Guan, *Liping Tong, *Dechun Geng, Xin Zhao, Paul K. Chu, *Huaiyu Wang(Corresponding author). A Programmed Surface on Polyetheretherketone for Sequentially Dictating Osteoimmunomodulation and Bone Regeneration to Achieve Ameliorative Osseointegration under Osteoporotic Conditions. Bioactive Materials, 14, 364-376, 2022.
17. Junfeng Chen, Lingxia Xie, Qingdong Ruan, Ang Gao, Qing Liao, Shi Mo, Yuanliang Lv, *Liping Tong, *Huaiyu Wang(Corresponding author), Paul K. Chu, *Xiaoming Li. Diamond-like Carbon Coating and Surface Grafting of Osteoprotegerin and Alendronate on Polyetheretherketone to Ameliorate the Mechanical Performance and Osseointegration Simultaneously. Composites Part B: Engineering, 236, 109815, 2022.
18. #Yuzheng Wu, #Qingdong Ruan, Chao Huang, Qing Liao , Liangliang Liu, Pei Liu, Shi Mo, *Guomin Wang, *Huaiyu Wang(Corresponding author), *Paul K. Chu. Balancing the Biocompatibility and Bacterial Resistance of Polypyrrole by Optimized Silver Incorporation. Biomaterials Advances, 134, 112701, 2022.
19. #Meng Li, #Jiaxiang Bai, #Huaqiang Tao, Li Hao, Weiling Yin, Xiaoxue Ren, Ang Gao, Ning Li, Miao Wang, Shiyuan Fang, Yaozeng Xu, Liang Chen, Huilin Yang, *Huaiyu Wang(Corresponding author), *Guoqing Pan, *Dechun Geng. Rational Integration of Defense and Repair Synergy on PEEK Osteoimplants via Biomimetic Peptide Clicking Strategy. Bioactive Materials, 8, pp 309-324, 2022.
20. #Yuzheng Wu, #Qing Liao, #Lie Wu, Yongxiang Luo, Wei Zhang, Min Guan, Haobo Pan, *Liping Tong, *Paul K. Chu, *Huaiyu Wang(Corresponding author). ZnL2-BPs Integrated Bone Scaffold under Sequential Photothermal Mediation: A Win-Win Strategy Delivering Antibacterial Therapy and Fostering Osteogenesis Thereafter. ACS Nano, 15, 17854-17869, 2021.
21. #Lingxia Xie, #Guomin Wang, Yuzheng Wu, Qing Liao, Shi Mo, Xiaoxue Ren, Liping Tong, Wei Zhang, Min Guan, Haobo Pan, Paul K. Chu, *Huaiyu Wang(Corresponding author). Programmed Surface on Poly(Aryl-Ether-Ether-Ketone) Initiating Immune Mediation and Fulfilling Bone Regeneration Sequentially. The Innovation, 2, 100148, 2021.
22. #Shi Mo, #Feilong Zhao, #Ang Gao, Yuzheng Wu, Qing Liao, Lingxia Xie, *Liping Tong, *Paul K. Chu, *Huaiyu Wang(Corresponding author). Simultaneous Application of Diamond-like Carbon Coating and Surface Amination on Polyether Ether Ketone: Towards Superior Mechanical Performance and Osseointegration. Smart Materials in Medicine, 2, pp 219-228, 2021.
23. Nan Hu, Lingxia Xie, Qing Liao, Ang Gao, Yanyan Zheng, Haobo Pan, *Liping Tong, *Dazhi Yang, Nong Gao, Marco J. Starink, Paul K. Chu, *Huaiyu Wang(Corresponding author). A More Defective Substrate Leads to a Less Defective Passive Layer: Enhancing the Mechanical Strength, Corrosion Resistance and Anti-inflammatory Response of the Low-Modulus Ti-45Nb Alloy by Grain Refinement. Acta Biomaterialia, 126, pp 524-536, 2021.
24. Saud Khalid, Ang Gao, *Guomin Wang, Paul K. Chu, *Huaiyu Wang(Corresponding author). Tuning Surface Topographies on Biomaterials to Control Bacterial Infection. Biomaterials Science, 8, pp 6840-6857, 2020.
25. #Zhibin Li, #Guanghong Luo, #Weiping Hu, Jianlan Hua, Shengyong Geng, Paul K. Chu, *Jing Zhang, *Huaiyu Wang(Corresponding author), *Xuefeng Yu. Mediated Drug Release from Nano-Vehicles by Black Phosphorus Quantum Dots for Efficient Therapy of Chronic Obstructive Pulmonary Disease. Angewandte Chemie International Edition, 59, pp 20568-20576, 2020.
26. #Jiaxiang Bai, #Huaiyu Wang (Co-first author), #Hao Chen, Gaoran Ge, Miao Wang, Ang Gao, Liping Tong, Yaozeng Xu, Huiling Yang, *Guoqing Pan, *Paul K. Chu, *Dechun Geng. Biomimetic Osteogenic Peptide with Mussel Adhesion and Osteoimmunomodulatory Functions to Ameliorate Interfacial Osseointegration under Chronic Inflammation. Biomaterials, 255, 120197, 2020.
27. #Nan Hu, #Yuzheng Wu, Lingxia Xie, Shahir Mohd Yusuf, Nong Gao, Marco J. Starink, *Liping Tong, *Paul K. Chu, *Huaiyu Wang(Corresponding author). Enhanced Interfacial Adhesion and Osseointegration of Anodic TiO2 Nanotube Arrays on Ultra-Fine-Grained Titanium and Underlying Mechanisms. Acta Biomaterialia, 106, pp360-375, 2020.
28. Ang Gao, Qing Liao, Lingxia Xie, Guomin Wang, Wei Zhang, Yuzheng Wu, Penghui Li, Min Guan, Haobo Pan, *Liping Tong, *Paul K. Chu, *Huaiyu Wang(Corresponding author). Tuning the Surface Immunomodulatory Functions of Polyetheretherketone for Enhanced Osseointegration. Biomaterials, 230, 119642, 2020.
29. Guomin Wang, Wenjuan Jiang, Shi Mo, Lingxia Xie, Qing Liao, Liangsheng Hu, Qingdong Ruan, Kaiwei Tang, Babak Mehrjou, Mengting Liu, Liping Tong, *Huaiyu Wang(Corresponding author), *Jie Zhuang, *Guosong Wu, *Paul K. Chu. Nonleaching Antibacterial Concept Demonstrated by In Situ Construction of 2D Nanoflakes on Magnesium. Advanced Science, 7, 1902089, 2020.
30. Penghui Li, Jin Chen, *Paul K. Chu, *Huaiyu Wang(Corresponding author). Fundamentals and Applications of Surface-enhanced Raman Spectroscopy (SERS) Based Biosensor. Current Opinion in Biomedical Engineering, 13, pp 51-59, 2020.
31. *Wei Zhang, Jun Liu, Kun Yang, Wei Qu, Ke Liu, Na Liu, Bin Gu, Nan Hu, Junhui Ji, Paul K. Chu, *Huaiyu Wang(Corresponding author). Unique Role of Arginine in Positively-Charged Surface for Promotion of Antibacterial and Osteogenetic Capabilities. Advanced Materials Interfaces, 6, 1901414, 2019.
32. Nan Hu, Tao Hu, Ang Gao, Nong Gao, Marco J. Starink, Ying Chen, Wanting Sun, Qing Liao, *Liping Tong, *Xiaochang Xu, Paul K. Chu, *Huaiyu Wang(Corresponding author). Homogeneous Anodic TiO2 Nanotube Layers on Ti-6Al-4V Alloy with Improved Adhesion Strength and Corrosion Resistance. Advanced Materials Interfaces, 6, 1801964, 2019.
33. #Zhibin Li, #Lie Wu, *Huaiyu Wang(Corresponding author), Wenhua Zhou, Hanxia Liu, Haodong Cui, Penghui Li, *Paul K. Chu, *Xuefeng Yu. Synergistic Antibacterial Activity of Black Phosphorus Nanosheets Modified with Titanium Aminobenzenesulfanato Complexes. ACS Applied Nano Materials, 2, pp 1202-1209, 2019.
34. Liping Tong, Qing Liao, Yuetao Zhao, Hao Huang, Ang Gao, Wei Zhang, Xiaoyong Gao, Wei Wei, Min Guan, Paul K. Chu, *Huaiyu Wang(Corresponding author). Near-Infrared Light Control of Bone Regeneration with Biodegradable Photothermal Osteoimplant. Biomaterials, 193, pp 1-11, 2019.
35. #Guomin Wang, #Hongqing Feng, Liangsheng Hu, Weihong Jin, Qi Hao, Ang Gao, Xiang Peng, Wan Li, Kwok-Yin Wong, *Huaiyu Wang(Corresponding author), *Zhou Li, *Paul K. Chu. An Antibacterial Platform Based on Capacitive Carbon-Doped TiO2 Nanotubes after Direct or Alternating Current Charging. Nature Communications, 9, 2055, 2018.
36. #Yuchang Weng, #Hanxia Liu, Shunping Ji, Qian Huang, Hao Wu, Zhibin Li, *Zhongzhen Wu, *Huaiyu Wang(Corresponding author), Liping Tong, Ricky K.Y. Fu, *Paul K. Chu, Feng Pan. A Promising Orthopedic Implant Material with Enhanced Osteogenic and Antibacterial Activity: Al2O3-Coated Aluminum Alloy. Applied Surface Science, 457, pp 1025-1034, 2018.
37. Jundong Shao, Changshun Ruan, Hanhan Xie, Zhibin Li, *Huaiyu Wang(Corresponding author), Paul K. Chu, *Xuefeng Yu. Black-Phosphorus-Incorporated Hydrogel as a Sprayable and Biodegradable Photothermal Platform for Postsurgical Treatment of Cancer. Advanced Science, 5, 1700848, 2018.
38. Huaiyu Wang, *Xuefeng Yu. Few-Layered Black Phosphorus: From Fabrication and Customization to Biomedical Applications. Small, 14, 1702830, 2018.
39. #Jundong Shao, #Hanhan Xie, *Huaiyu Wang(Corresponding author), Wenhua Zhou, Qian Luo, *Xuefeng Yu, *Paul K. Chu. 2D Material-Based Nanofibrous Membrane for Photothermal Cancer Therapy. ACS Applied Materials & Interfaces, 10, pp 1155-1163, 2018.
40. Ang Gao, Ruiqiang Hang, Wan Li, Wei Zhang, Penghui Li, Guomin Wang, Long Bai, Xuefeng Yu, *Huaiyu Wang(Corresponding author), *Liping Tong, *Paul K. Chu. Linker-free Covalent Immobilization of Heparin, SDF-1α, and CD47 on PTFE Surface for Antithrombogenicity, Endothelialization and Anti-Inflammation. Biomaterials, 140, pp 201-211, 2017.
41. Zhibin Li, Jundong Shao, Qian Luo, *Xuefeng Yu, Hanhan Xie, Haidi Fu, Siying Tang, *Huaiyu Wang(Corresponding author), Guangli Han, *Paul K. Chu. Cell-Borne 2D Nanomaterials for Efficient Cancer Targeting and Photothermal Therapy. Biomaterials, 133, pp 37-48, 2017.
42. Zhengbo Sun, Yuetao Zhao, Zhibin Li, Haodong Cui, Yayan Zhou, Weihao Li, Wei Tao, *Han Zhang, *Huaiyu Wang(Corresponding author), Paul K. Chu, *Xuefeng Yu. TiL4-Coordinated Black Phosphorus Quantum Dots as an Efficient Contrast Agent for In Vivo Photoacoustic Imaging of Cancer. Small, 13, 1602896, 2017.
43. Yuetao Zhao, *Huaiyu Wang(Corresponding author), Hao Huang, Quanlan Xiao, Yanhua Xu, Zhinan Guo, Hanhan Xie, Jundong Shao, Zhengbo Sun, Weijia Han, *Xuefeng Yu, Penghui Li, *Paul K. Chu. Surface Coordination of Black Phosphorus for Robust Air and Water Stability. Angewandte Chemie International Edition, 55, pp 5003-5007, 2016.
44. Yuetao Zhao, Liping Tong, Yong Li, Haobo Pan, Wei Zhang, Min Guan, Weihao Li, Yixin Chen, Qing Li, Zhongjun Li, *Huaiyu Wang(Corresponding author), *Xuefeng Yu, *Paul K. Chu. Lactose-Functionalized Gold Nanorods for Sensitive and Rapid Serological Diagnosis of Cancer. ACS Applied Materials & Interfaces, 8, pp 5813-5820, 2016.
45. #Zhibin Li, #Siying Tang, #Beike Wang, Yong Li, Hao Huang, *Huaiyu Wang(Corresponding author), Penghui Li, *Chengzhang Li, *Paul K. Chu, Xuefeng Yu. Metabolizable Small Gold Nanorods: Size-Dependent Cytotoxicity, Cell Uptake and In Vivo Biodistribution. ACS Biomaterials Science & Engineering, 2, pp 789-797, 2016.
46. #Liping Tong, #Wenhua Zhou, Yuetao Zhao, Xuefeng Yu, *Huaiyu Wang(Corresponding author), *Paul K. Chu. Enhanced Cytocompatibility and Reduced Genotoxicity of Polydimethylsiloxane Modified by Plasma Immersion Ion Implantation. Colloids and Surfaces B: Biointerfaces, 148, pp 139-146, 2016.
书籍章节
Characterization of biomaterials, Chapter 4: Surface characterization of biomaterials, Elsevier, 2013-07
获批项目
- 国家自然科学基金委面上项目，82272157，PEEK植入材料表/界面时序功能设计与构建及其调节骨组织再生机理研究，2023年01月~2026年12月，52万，在研，主持；
- 中国科学院青年创新促进会优秀会员，Y2021099，2022年01月~2024年12月，150万，在研，主持；
- 国家重点研发计划，2021YFB3800800，精准生物适配型骨再生修复材料及关键技术，2021年12月-2025年11月，2100万(270万)，在研，课题负责人
- 广东省科学技术厅联合基金重点项目，2020B1515120078，植介入器械表界面仿生功能涂层及其摩擦学研究，2020年10月~2023年09月，100万(50万)，在研，参与；
荣誉奖励
广东省科技创新青年拔尖人才；
深圳市海外高层次“孔雀计划”B类人才；
中国科学院青年促进会会员;
中国科学院青年促进会优秀会员；
深圳市自然科学一等奖（2/5）