1. Molecular imaging based on optical & magnetic resonance imaging.
2. Probes development and the imaging of molecular interactions

Ph.D., Analytical Chemistry, Oct. 2005
Chinese Academy of Sciences, Dalian, China 

M.E, Applied Chemistry, May 2000
Nanjing University of Science and Technology, Nanjing, China 

B.E. Industry Chemistry, June 1997
Nanjing University of Science and Technology, Nanjing, China

   

1. Associate Professor, Lab of Biomedical Materials Engineering,  
Dalian Institute of Chemical Physics (DICP), Chinese Academy of Sciences (CAS))/ Dalian, P.R. China, 10/2010-present  

2. Senior Research Associate, Department of Biomedical Engineering, Case Western Reserve University, 06/2009- 10/2010
 
3. Research Associate, Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, 11/2007-05/2009

4. Postdoctoral Research Fellow, University of Victoria, Victoria/British Columbia,Canada, 04/2006-10/2007

5. Research Associate, Laboratory of Modern Analytical Chemistry and Micro- instruments, Dalian Institute of Chemical Physics (DICP), Chinese Academy of Sciences (CAS)/ Dalian, P.R. China, 09/2000-03/2006

1. Outstanding Graduate Student Award, Dalian Institute of Chemical Physics, Chinese Academy of Sciences (CAS), 01/2005 

2. CAS President Award for graduate student, Chinese Academy Sciences, 10/2004 

3. Jianhao Award of Chinese College Students, All-China Student's Federation, 12/1997 

4. Second Prize of the Fifth "Challenge Cup" Chinese Undergraduates Extracurricular Science and Technology Works Contest, China Association for Science & Technology, Ministry of Education of the P. R. China, 11/1997

   

1) Tan, M., Ye, Z., Wang, G., Yuan, J., Preparation and time-resolved fluorometric application of the luminescent europium nanoparticles. Chem. Mater. 2004, 16, 2494-2498.
2) Tan, M., Wang, G., Hai, X., Ye, Z., Yuan, J., Development of functionalized fluorescent europium nanoparticles for biolabeling and time-resolved fluorometric application. J. Mater. Chem. 2004, 14, 2896-2901.
3) Ye, Z., Tan, M., Wang, G., Yuan, J., Preparation, characterization, and time-resolved fluorometric application of silica-coated terbium(III) fluorescent nanoparticles. Anal. Chem. 2004, 76,513-518.
4) Yuan, J., Tan, M., Wang, G., Synthesis and luminescence properties of lanthanide(III) chelates with polyacid derivatives of thienyl-substituted terpyridine analogues. J. Lumin. 2004, 106, 91-101.
5) Ye, Z., Tan, M., Wang, G., Yuan, J., Novel fluorescent europium chelate-doped silica nanoparticles: preparation, characterization and time-resolved fluorometric application. J. Mater. Chem. 2004, 14, 851-856.
6) Hai, X., Tan, M., Wang, G., Ye, Z., Yuan, J., Kazuko Matsumoto. Preparation and a time-resolved fluoroimmunoassay application of new europium fluorescent nanoparticles. Anal. Sci. 2004, 20, 245-246.
7) Ye, Z., Tan, M., Wang, G., Yuan, J., Development of functionalized terbium fluorescent nanoparticles for antibody labeling and time-resolved fluoroimmunoassay application. Talanta. 2005, 65, 206-210.
8) Ye, Z., Tan, M., Wang, G., Yuan, J., Preparation, characterization and application of fluorescent terbium complex-doped zirconia nanoparticles, J. Fluoresc. 2005, 15(4), 499-505.
9) Song, B., Wang, G., Tan, M., Yuan J., Synthesis and time-resolved fluorimetric application of a europium chelate-based phosphorescence probe specific for singlet oxygen. New J. Chem. 2005, 29(11), 1431-1438.
10) Tan, M., Wang, G., Ye, Z., Yuan, J., Synthesis and characterization of titania-based monodisperse fluorescent europium nanoparticles for biolabeling. J. Lumin. 2006, 117(1), 20-28.
11) Tan, M., Song, Bo., Wang, G., Yuan, J., A new terbium(III) chelate as an efficient singlet oxygen fluorescence probe. Free Radical Bio. Med. 2006, 40(9), 1644-1653.
12) Song, B., Wang, G., Tan, M., Yuan, J., A europium(III) complex as an efficient singlet oxygen luminescence probe. J. Am. Chem. Soc. 2006, 128(41), 13442-13450.
13) Mahalingam, V., Tan, M., Munusamy, P., Van Veggel, F., Raudsepp, M., Electro-luminescence from Eu2+-doped GaN/SiO2 nanomaterial composites. Adv. Funct. Mater. 2007, 17(17), 3462-3469.
14) Tan, M., Mahalingam, V., Van Veggel, F., White electroluminescence from a hybrid polymer-GaN:Mg nanocrystals device. Applied Physics Letters. 2007, 91, 093132. Also featured in the September 10, 2007 issue of Virtual Journal of Nanoscale Science & Technology.
15) Tan, M., Munusamy, P., Mahalingam, V., Van Veggel, F., Blue electroluminescence from InN@SiO2 core/shell nanostructures. J. Am. Chem. Soc. 2007, 129(46), 14122-14123.
16) Tan, M., Wu, X., Jeong, E-K., Chen, Q., Lu, Z-R., Peptide-targeted nanoglobular Gd-DOTA monoamide conjugates for magnetic resonance cancer molecular imaging. Biomacromolecules. 2010, 11 (3), 754–761.
17) Tan, M., Wu, X., Jeong, E-K., Parker, D.L., Chen, Q., Wu, C., Lu, Z-R., A targeted nanoglobular manganese(II) chelate conjugate for magnetic resonance molecular imaging of cancer. Mol. Pharm. 2010, 7(4), 936-943. (Appeared in cover page).
18) Tan, M., Lu, Z-R. Integrin targeted MR imaging. Theranostics. 2011. 1, 83-101.
19) Tan, M., Ye, Z., Jeong, E.K., Wu, X., Parker, D., Lu, Z-R. Synthesis and evaluation of nanoglobular macrocyclic Mn(II) chelate conjugates as non-Gadolinium(III) MRI contrast agents, Bioconjugate Chem. 2011, 22(5), 931-937

1. Kazuko Matsumoto; Jingli Yuan; Guilan Wang; Mingqian Tan. Novel fluorescent labeling compound.  US 07465747
2. Frank C.J.M. van Veggel, Mingqian Tan, Prabhakaran Munusamy, Venkataramanan Mahalingam, Blue light emitting nanomaterials and synthesis thereof.  US 12/994273 
3. Jingli Yuan, Mingqian Tan, Guilan Wang, Rare earth fluorescent marker and its application. Chinese Patent Number: ZL01128075.1
4. Jingli Yuan, Mingqian Tan, Zhiqiang Ye, Guilan Wang, Functional nano-rare earth fluorescent micro particle preparation. Chinese Patent Number: ZL 02144517.6
5. Jingli Yuan, Mingqian Tan, Xiaodan Hai, Guilan Wang, Beta-diketonate-trivalent europium complex nano fluorescent probe, and its preparation and use. Chinese Patent Number: ZL 03133857.7
6. Jingli Yuan, Mingqian Tan, Zhiqiang Ye, Guilan Wang, A titanium oxide nano-europium (Eu) fluorescent probe and application thereof. Chinese Patent Number: ZL200410020716.4
7. Jingli Yuan, Zhiqiang Ye, Mingqian Tan, Guilan Wang, A functional nano-terbium fluorescent probe and application thereof. Chinese Patent Number: ZL 200410020701.8
8. Jingli Yuan, Mingqian Tan, Guilan Wang, Terbium coordination compound singlet oxygen fluorescent probe and application thereof. Chinese Patent Number: ZL 200510045767.7
9. Jingli Yuan, Bo Song, Guilan Wang, Mingqian Tan. Singlet oxygen fluorescence probe based on europium complex and its application. Chinese Patent Number: ZL 200510130851.9

A major focus for our research is the design, synthesis and biological evaluation of biomaterials for molecular imaging, including high sensitive optical molecular probes, targeting small molecular peptides, smart nano-sized carrier materials and their application in MRI/optical molecular imaging for cancer/stem cells.

We currently have two main projects in this area. First, we are developing a synthesis of a new class of near-infred nano-sized probes, functional nano-sized drug carrier materials, targeting MRI/X-ray contrast agents that we will use for molecular imaging. A second project concerns the labeling and tracking of stem cells for in vivo imaging by using the developed probes. Our goals are monitoring the migration and proliferation of stem cells after transplantation using the non-invasive, real-time tracking method.

1. “Blue light emitting diodes with Group-13 nitride nanomaterials”, Poster. The 11th Annual Meeting of the Pacific Center for Advanced Materials and Microstructures (PCAMM) at Simon Fraser University. Vancouver, B.C. Canada, December 26, 2006.
2. “Light-emitting diodes made from GaN:Mg nanocrystals”, Oral. The 90th Canadian Chemistry Conference and Exhibition in Winnipeg, Manitoba, May 26-30, 2007
3. “A fibrin-fibronectin specific nanoglobular contrast agent for cancer molecular imaging with MRI”, Poster. The 14th International Symposium on Recent Advances in Drug Delivery Systems, Salt Lake City, UT, February 16, 2009
4. “A CLT1 peptide targeted nanoglobular contrast agent for cancer molecular imaging with MRI”. E-poster. ISMRM 17th Scientific Meeting & Exhibition April 18-24, 2009. Howai’i
5. “A Peptide Targeted Nanoglobular Contrast Agent for Cancer Molecular Imaging with MRI”. World Molecular Imaging Congress. Montreal, Canada, Sep. 23-26, 2009.
6. “A targeted nanoglobular manganese(II) chelate conjugate for magnetic resonance cancer molecular imaging”. E-poster. ISMRM 18th Scientific Meeting & Exhibition. Stockholm, Sweden, April 26-30, 2010.
7. “MRI of liver fibrosis by fibrin-fibronectin targeted contrast agent”. ISMRM 18th Scientific Meeting & Exhibition. Stockholm, Sweden, April 26-30, 2010.

1. Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, China
2. Division of Trauma Surgery, University Hospital of Zürich, Switzerland
3. Biomedical Engineering Department, Case Western Reserve University