Natural product chemistry

Phytochemistry

Natural products bioevaluation/bioassay

Medicinal chemistry

Drug discovery

1994-1998  Ph.D. College of Pharmacy, University of Illinois, USA

1985-1988  M.Sc. Kunming Institute of Botany, CAS, China

1981-1985   B.Sc. Nanchang (formerly Jiangxi) University

1989,03-1994,07 　National Institutes of Pharmaxeutical Research & Development, Research Associate

1998,09-2000,10 　Monsanto Company                 Senior Scientist

2000,11-2002,10 　Watson Pharmaceuticals, Inc.,    Principal Scientist

2002,11-2007,10 　ashington University               Research Scientist

2007,11-至今      South China Botanical Garden, CAS, China, Pricipal Investigator, Group Leader

1. M.M Wang, L.Q. Huo, H.X. Liu, L.Y. Zhao, Z.F. Xu, H.B Tan,**Thujasutchins N and O, two new compounds from the stems and roots of Thuja sutchuenensis. S. X. Qiu.* Natural Product Research, 2020, DOI: 10.1080/14786419.2020.1836627.

2. M. M. Wang, L.Y. Zhao, K. Chen,Y. X. Shang, J. F. Wu, X. Y. Guo, Y. H. Chen, H. X. Liu, H. B. Tan,* S. X. Qiu.* Antibacterial sesquiterpenes from the stems and roots of Thuja sutchuenensis. Bioorganic Chemistry, 2020, 96, 103645, 10.1016/j.bioorg.2020.103645

3. L.L. Shi, S. S. Wang, L. Q. Huo, M. L. Gao, W. G. Zhang, X. X. Lu, S. X. Qiu, H.X. Liu, H. B. Liu. Diastereoselective construction of the benzannuliated spiroketal core of chaetoquadrins enaled by a regiodivergent cascade. Org. Chem. Front., 2020, 7, 2385-

4. X. Zhang, G. Y. Wu, L. Q. Huo, X. Y. Guo, S.X. Qiu, H.X. Liu, H.B. Tan, Y. J. Hu. The first racemic total synthesis of the antiplasmodials watsonianones A and B and corymbone B. J. Nat. Prod., 2020, 83, 3-

5. Y. Li, J. W. Wu, H.B. Tan, B. L. Li, S.X. Qiu.* Three new pterocarpans from the aerial parts of Abrus precatorius. Natural Product Research，2020, 34(13):1836-1844. 

6. L. Q. Huo, C. M. Dong, M. M. Wang, X. X. Lu, W. G. Zhang, B. Yang, Y. F. Yuan, S. X. Qiu, H. X. Liu*, H. B. Tan. * Biomimetic total syntheses of sanctis A–B with structure revision. Org. Lett. 2020, 22, 3, 934-938.

7. W.G. Zhang, M.M. Wang, S. Zhang, K.P. Xu, G. S. Tan, S. X. Qiu, Z.X. Zou,* H.B. Tan.* Eutyscoparols A-G, polyketide derivatives from endophytic fungus Eutypella scoparia SCBG-8. Fitoterapia 2020, 146, 104681.

8. J.W. Wu, B.L. Li, C. P. Tang, C. Q. Ke, N. L. Zhu, S. X. Qiu,* Y. Ye.* Callistemonols A and B, potent antimicrobial acylphloroglucinol derivatives with unusual carbon keletons from Callistemon viminalis. J. Nat. Prod. 2019, 82, 7, 1917-1922.

9. C.F. Liu, X. B. Huang, S. X. Qiu, W. Q. Chen, W. H. Li, H. Y. Zhang, T. Wang, X. Wang and X. L. Wu. Chinese Herbal Complex ‘Bu Shen Jie Du Fang’ (BSJDF) Modulated Autophagy in an MPP+-Induced Cell Model of Parkinson’s Disease. Evidence-Based Complementary and Alternative Medicine 2019, Article ID 8920813, 10 pages https://doi.org/10.1155/2019/8920813

10. Y.P. Liu, Q. Wen, S. Hu, Y. L. Ma, Z. H. Jiang, J.Y. Tang, Y. H. Fu,* and S. X. Qiu.* Furanocoumarins with potential antiproliferative activities from Clausena lenis. Natural Product Research, 2019, 33(18): 2631-2637.

11. H. X. Liu, H. B. Tan, S. N. Li, Y. C. Chen, H. H. Li, S. X. Qiu, W. M. Zhang. Two new 12-membered macrolides from the endophytic fungal strain Cladosprium colocasiae A801 of Callistemon viminalis. Journal of Asian Natural Products Research, 2019, 21(7):696-701. 

12. X, Y. Guo，M. M Wang, J. F. Wu, G.Y. Wu, X. Zhang, L.Q. Huo, H.X. Liu, Y. H. Chen, G.W. Xie,* H. B. Tan,* S. X. Qiu.* Chemical constituents of the trunks and roots of Thuja sutchuenensis. Fitoterapia 2019, 134, 264-269.

13. Y. Li, X. B Qin，H. X. Liu，Z. F. Xu, H. B. Tan, S.X. Qiu.* Two pairs of enantiomeric propylated flavonoids and a new lignan from the aerial parts of Abrus precatorius. Fitoterapia 2019, 133, 125-129.

14. L. Y. Zhao, H. X. Liu, L. Wang, Z. F. Xu, H. B. Tan,* S. X. Qiu.* Rhodomyrtosone B, a membrane-targeting anti-MRSA natural acylgphloroglucinol from Rhodomyrtus tomentosa. Journal of Ethnopharmacology 2019, 228, 50-57.

15. G. Y. Wu, X. Zhang, X. Y. Guo, L. Q. Huo, H. X. Liu, X. L. Shen, S. X. Qiu, Y. J. Hu, H. B. Tan. Prenylated stilbenes and flavonoids from the leaves of Cajanus cajan. Chinese Journal of Natural Medicines, 2019, 17(5):0381-0386.

16. R.Y. Yang, L. Wang, J. Xie, X. Li, S. Liu, S. X. Qiu, Y. J. Hu, X. L. Shen. Treatment of type 2 diabetes mellitus via reversing insulin resistance and regulating lipid homeostasis in vitro and in vivo using cajanonic acid A. International Journal of Molecular Medicine, 2018, 42, 2329-2342.

17. J. L. Song, Y. Yuan, L. H. Nie, B. L. Li, X. B. Qin, Y. Li, J. W. Wu and S. X. Qiu.* Two new ent-kaurane diterpenes from the stems of Eurya chinensis. J. Asian Nat. Prod. Res., 2018，20（10）：962-968.

18. J. L. Song, Y. Yuan, L. H. Nie, B. L. Li, X. B. Qin, Y. Li, J. W. Wu,* S. X. Qiu.* A new ent-kaurane diterpene derivative from the stems of Eurya chinensis R.Br. Natural Product Research, 2018, 32(2): 182-188.

19. Y. Yuan, J. X. Yang, L. H. Nie, B. L. Li, X. B. Qin, J. W. Wu and S. X. Qiu.* Three new kavalactone dimers from Piper methysticum (kava). J. Asian Nat. Prod. Res., 2018, 20(9):837-843。

20. L. Y. Zhao, H.X. Liu, L. Q. Huo, M. M. Wang, B. Yang, W. M. Zhang, Z. F. Xu, H. B Tan, S. X. Qiu.*  Structural optimization and antibacterial evaluation of rhodomyrtosone B analogues against MRSA strains. MedChemComm, 2018, 9,1698-1707.

21. X. F. Jiang, N. L. Zhang, N. Q. Xiong, Y. Liu, J. F. Cao, S. X. Qiu.* Synthesis and biological evaluation of novel jatrorrhizine derivatives with amino groups linked at the 3-position as inhibitors of acetylcholinesterase. Journal of Chemistry, 2017, 3261520, 1-6, 

22. Y. Yuan, J. W. Wu，B. L. Li, J. Niu, H. B, Tan and S. X. Qiu.* Regulation of Signaling Pathways Involved in the Anti-proliferative and Apoptosis-inducing Effects of M22 against Non-small Cell Lung Adenocarcinoma A549 Cells. Scientific Reports, 2018，8 (1): 992-.

23. R. Y. Yang, W. G. Lu, J. Xie, X. Li, S. Liu, S. X. Qiu, Y.J. Hu, and X. L. Shen. Treatment of type 2 diabetes mellitus via reversing insulin resistance and regulating lipid homeostasis in vitro and in vivo using cajanonic acid A. Internal Journal of molecular medicine 2018,42: 2329-2342. 

24. L. L. Shi,  H.X. Liu,  L.Q. Huo, Y.Q. Dang, Y. Wang, B. Yang, S. X. Qiu, H. B..Tan,. Site-selective phenol acylation mediated by thioacids via visible light photoredox catalysis. Organic Chemistry Frontiers, 2018, 5(8): 1312-1319. 

25. H. X. Liu, Y. Wang, X. Y. Guo, L. Q. Huo, Z. F. Xu, W. M. Zhang, S. X. Qiu, B. Yan, H. B. Tan. A bioinspired cascade sequence enables facile assembly of methanodibenzo[b,f][1,5]dioxocin flavonoid scaffold. Organic Letters, 2018, 20 (3): 546-549.  

26. N. L. Zhang,* X. C. Shen, X.F. Jiang, J.Z. Cai, X.L. Shen, Y.J. Hu, S. X. Qiu. Two new cytotoxic stilbenoid dimers isolated from Cajanus cajan. Journal of Natural Medicines 2018, 72 (1): 304-309.

27. Z.W Su, Z. H. Ma, L. Ye, B. M. Liu, S. X. Qiu.* N-containing phytochemicals from the seeds of Brucea javanica. Chemistry of Natural Compounds, 2017, 53(4): 799-801.

28. J. L. Song, B. L. Li, Y. Yuan, L. H. Nie, J. Niu, D. Chiu, Z. F. Xu, J. W. Wu,* S. X. Qiu.* Yangonindimers A-C, three new kavalactone dimers from Piper methysticum (kava). Natural Product Research, 2017, 31（21）: 2459-2466.

29. H. X. Liu, L.Q. Huo, B. Yang, Y. F. Yuan, W. M. Zhang, Z. F. Xu, S. X. Qiu,* H. B.Tan.* Biomimetic inspired syntheses of myrtucommuacetalone and myrtucommulone J．Organic Letters, 2017, 19, 4786-4789.

30. Y. Q. Xiang, H.X. Liu, L.Y. Zhao, Z.F. Xu, H.B. Tan,* S.X. Qiu.* Viminone A, a novel dearomatic dibenzofuran-type acylphloroglucinol with antimicrobial activity from Callistemon viminalis. Scientific Reports, 2017, 7:2363-2368.                                             

31. H. B. Tan, H. X. Liu, L.Y. Zhao, Y. Yuan, B. L. Li, Y. M. Jiang, L. Gong, S. X. Qiu.* Structure-activity relationships and optimization of acyclic acylphloroglucinol analogues as novel antimicrobial agents. Eur. J. Med. Chem., 2017, 125, 492-499.

32. J. L. Song, Y. Yuan, H. B. Tan, R. M. Huang, H. X. Liu, Z.F. Xu, S. X. Qiu.* Anti-inflammatory and antimicrobial coumarins from the stems of Eurya chinensis. J. Asian Nat. Prod. Res. 2017, 19 (3):222-228.

33. H.X. Liu, H.B. Tan, Y. Liu, Y. C. Chen, S.N. Li, Z.H. Sun, H.H. Li, S.X. Qiu, W.M. Zhang. Three new highly-oxygenated metabolites from the endophytic fungus Cytospora rhizophorae A761. Fitoterapia 2017, 117, 1–5.

34. C. Li, H. X. Liu, L. Y. Zhao, W. M. Zhang, S. X. Qiu, X. Y. Yang, H. B. Tan. Antibacterial neolignans from the leaves of Melaleuca bracteata. Fitoterapia 2017, 120, 171-176.

35. W. L. Zhou, H. B. Tan, S. X. Qiu, G. Y. Chen, H. X. Liu, C. Zheng. Biomimetic total synthesis and structure confirmation of myrtucommulone K. Tetrahedron Letters, 2017, 58 (19): 1817-1821.

36. H. X. Liu, Y. Q. Dang, Y. F. Yuan, Z. F. Xu, S. X. Qiu,* H. B. Tan.* Diacyl disulfide: a reagent for chemoselective acylation of phenols enabled by 4-(N,N-dimethylamino) pyridine catalysis. Organic Letters, 2016,18: 5584-5587.

37. H. X. Liu, K. Chen, Y. Liu, C. Li, J.W. Wu, Z. F. Xu, H. B. Tan,* S. X. Qiu.* Callviminols A-E, new terpenoid-conjugated phloroglucinols from the leaves of Callistemon viminalis. Fitoterapia, 2016, 115:142-147.

38. J. L. Song, Y. Yuan, H. B. Tan, J. W. Wu, R. M. Huang, H. Li, Z. F. Xu, N. Na, * S. X. Qiu.* Euryachins A and B, a new type of diterpenoids from Eurya chinensis with potent NO production inhibitory activity. RSC Advances, 2016, 6, 85958 – 85961.

39. H. X. Liu, Y. C. Chen, Y. Liu, W. M. Zhang, J. W. Wu, H. B. Tan,* S. X. Qiu.* Acylphloroglucinols from the leaves of Callistemon viminalis. Fitoterapia, 2016, 114:40-44.

40. H. X. Liu, H. B. Tan, Y. Yuan, S. X. Qiu.* Antimicrobial acylphloroglucinnols from the leaves of Rhodomyrtus tomentosa. J. Asian Nat. Prod. Res. 2016, 18(6): 535-541. 

41. H. X. Liu, K. Chen, Y. Yuan, Z. F. Xu, H. B. Tan* and S. X. Qiu.* Rhodomentones A and B, Novel Meroterpenoids with an Unique NMR Characteristics from Rhodomyrtus tomentosa. Org. Biomol. Chem., 2016, 14, 7354-7360. 

42. H.X. Liu, K. Chen, G.H. Tang, Y.F. Yuan, H.B. Tan,* S. X. Qiu.* Isolation and biomimetic total synthesis of tementodiones A-B, terpenoid-conjugated phloroglucinols from the leaves of Rhodomyrtus tomentosa. RSC Advances 2016, 6, 48231–48236.

43. H. X. Liu, W. M. Zhang, Z. F. Xu,  Y.C. Chen, H. B. Tan,* S. X. Qiu.* Isolation, synthesis, and biological activity of tementosenol A from the leaves of Rhodomyrtus tomentosa. RSC Advances 2016, 6, 25882 - 25886.

44. H. X. Liu, L. Y. Zhao, Y. F. Yuan, Z. F. Xu, K. Chen, S. X. Qiu,* H. B. Tan.* Potassium thioacids mediated selective amide and peptide constructions enabled by visible light photoredox catalysis. ACS Catalysis, 2016, 6, 1732-1736.

45. H. B. Tan,* H. X. Liu, X. Z. Chen, H. Y. Chen, S. X. Qiu.* Racemic total Synthesis of dactyloidin and demethyldactyloidin through DL-proline-catalyzed Knoevenagel condensation/[4+2] cycloaddition cascade. Org. Biomol. Chem. 2015, 13:9977-9983. 

46. Q. Zhang, H. X. Liu, H. B. Tan* and S. X. Qiu.* Novel highly oxygenated and B-ring-seco-ent-diterpene glucosides from the seeds of Prinsepia utilis. Tetrahedron 2015, 71:9415-9419.

47. H. X. Liu, L. He, R. M. Huang, S. X. Qiu.* Chemical constituents from the rhizomes of Tetrastigma hemsleyanum. Chemistry of Natural Compounds 2015, 51(6):1077-1079. 

48. H. B. Tan,* H. X. Liu, X. Z. Chen, Y.F. Yuan, K. Chen, S. X. Qiu.* Concise construction of the tricyclic core of bullataketals enabled by a biomimetic intermolecular (3+3) type cycloaddition. Organic Letters, 2015, 17, 4050-4053. 

49. H. B. Tan,* X. Z. Chen, H. Y. Chen, H. X. Liu and S. X. Qiu.* Proline-catalyzed knoevenagel condensation/[4+2] cycloaddition cascade: application to formal synthesis of averufin. Eur. J. Org. Chem., 2015, 22, 4956-4963.

50. T. Hong, W. Jiang, H. M. Dong, S. X. Qiu, Y. Lu. Synthesis and cytotoxic activities of E-resveratrol derivatives. Chinese Journal of Natural Medicines. 2015, 13(5): 375-382.

51. Y. Shan, T. Hong, N.L. Zhang, Y. F. Wang, B. Yu, Y. Lu,* S. X. Qiu.* Synthesis and cytotoxicity of Longistylin C derivatives. Chinese Journal of Natural Medicines. 2015, 13(4):311-315.

52. J. J. Koh, S.M. Lin, T. T. Aung, F.H. Lim, H.X. Zou,Y. Bai, J.G. Li, H.F. Lin, L. M. Pang, W. L. Koh, S. M. Salleh, R. Lakshminarayanan, L. Zhou, S.X. Qiu, K. Pervushin,C. Verma, D. T. H. Tan, D.R. Cao,* S.P. Liu* and R. W. Beuerman.* Amino acid modified xanthone derivatives: novel, highly promising membrane-active antimicrobials for multidrug-resistant gram-positive bacterial infections. J. Med. Chem. 2015, 58, 739−752.

53. X. J. Zhou, L. He, X.X. Wu, Y.X. Zhong, J. Zhang, Y.X. Wang,* B. Wang, * Z.F. Xu, S. X. Qiu.* Two new xanthones from the pericarp of Garcinia mangostana. Natural Product Research, 2015, 29(1):19-23. 

54. J. Z. Cai, R. Tang, G. F. Ye, S. X. Qiu, N. L. Zhang, Y. J. Hu,* X. L. Shen.* A halogen-containing stilbene derivative from the leaves of Cajanus cajan that induces osteogenic differentiation of human mesenchymal stem cells. Molecules, 2015, 10839-10847.

55. K. Cheng, G. L. Zhang, S. X. Qiu, Y. Q. Liu, Y. F. Wang, S. Liu, Y. Shan, B. Yu and Yu Lu. Synthesis and Antitumor Activities of α-,γ-mangostin Derivatives. Letters in Drug Design & Discovery, 2014, 11, 000-000

56. L. He, C. F. Zhu, Y. Yuan, Z. F. Xu, S. X. Qiu*. Specific glycosylated metabolites of α-mangostin by Cunninghamella blakesleana. Phytochemistry Letters 2014; 9:175-178.

57. N.L. Zhang, R.M. Huang, Y.H. Zhu, M.Q. Fu, J. Z. Cai, J.X. Yang, Z. F. Xu, Y.J. Hu and S. X. Qiu.* A new isoprenylated flavonone from Cajanus cajan. Chemistry of Natural Compounds 2014, 50(3):438-439.

58. J.J. Chen, Z. J. Long, D. F. Xu, R. Z. Xiao, L. L. Liu, Z.F. Xu, S.X. Qiu ,* D. J. Lin,* Q.T. Liu.* Inhibition of autophagy augments the anticancer activity of α-mangostin in chronic myeloid leukemia cells. Leukemia & Lymphoma 2014, 55(3):628-38. 

59. J. X. Yang, S. X. Qiu,* Z. G. She, Y. C. Lin. A new isochroman derivative from the marine fungus Phomopsis sp. (No.Gx-4). Chemistry of Natural Compounds 2014, 50(3): 367-369.

60. S. Feng, Y. Jiang, J. Li, S. X. Qiu, T. Chen. A new bixanthone derivative from the bark of Garcinia oblongifolia. Natural Product Research 2014, 28(2):81-5.

61. J. M. Shi, H.J Huang, S. X. Qiu, S.X. Feng and X.E. Li. Griffipavixanthone from Garcinia oblongifolia Champ induces cell apoptosis in human non-small-cell lung cancer H520 cells in vitro. Molecules 2014, 19:1422-1431.

62. M. Q. Fu, S. X. Qiu, Y. Xu, J. Wu, Y. Chen, Y. Yu, G. Xiao. A new xanthone from the pericarp of Garcinia mangostana. Natural Products Communication 2013, 8(12):1733-4. 

63. S.H. Li, S. X. Qiu, P. Yao, H.D. Sun, H. H. S. Fong and H.J. Zhang. Medicinal Plant Vitex agnus-castus in Chemoprevention via NADP(H):Quinone Oxidoreductase Type 1 Induction. Evidence-Based Complementary and Alternative Medicine 2013,doi.org/10.1155/2013/432829.

64. Z.W. Su, J. Hao, R.M. Huang, Z.F. Xu, S.X. Qiu.*A minor quassinoid from fruits of Brucea javanica. Natural Product Research 2013; 27(21):2016-2021.

65. J. X. Yang, R.M. Huang, S. X. Qiu,* Z.G. She, Y.C. Lin. A new isobenzofuranone from the mangrove endophytic fungus Penicillium sp. (ZH58). Natural Product Research, 2013; 49(1):31-33.

66. Z.W. Su, J.L. Li, Y.H. Zhu, R.M. Huang, S. X. Qiu.* Chemical compositions and cytotoxic activities of petroleum ether extract from fruits of Brucea Javanica (Simarubaceae). Tropical Journal of Pharmaceutical Research 2013; 12(5):735-742. 

67. M.Q. Fu, R.M. Huang, N.L. Zhang, Z.W. Su, S. X. Qiu.* A new flavanocoumarin from the root of Flemingia philippinensis. Natural Product Research 2013, 27:1237-1241.

68. J. X. Yang, S. X. Qiu,* Z. G. She, Y. C. Lin. A new xanthone derivative from the marine fungus Phomopsis sp.(No.SK7RN3G1). Chemistry of Natural Compounds 2013:49(2):246-248. (J. X. Yang, S. X. Qiu,* Z. G. She, Y. C. Lin. A new xanthone derivative from the marine fungus Phomopsis sp.(No.SK7RN3G1). Chemistry of Natural Compounds 2013:49(1):31-33. 

69. H. Y. Liu, M. H. R Mahmood, S. X. Qiu, C. K. Chang. Recent developments in manganese corrole chemistry. Coordination Chemistry Reviews, 2013, 257:1306-1333.

70. H. X. Zou, J.J. Koh, J.G. Li, S.X. Qiu, T.T. Aung, H. Lim, R. Lakshminarayanan, X.P. Dai, C. Tang, F.H. Lim, L. Zhou, A. L. Tan, C. Verma, D. Tan, H. Chan, P. Saraswathi, D.R. Cao, S.P. Liu,* R. W. Beuerman.* Design and synthesis of amphiphilic xanthone based membrane targeting antimicrobials with improved membrane selectivity. Journal of Medicinal Chemistry, 2013, 56, 2359-2373.

71. J. J. Koh,^# S. X. Qiu,^# (equal contribution) H. X. Zou, R. Lakshminarayanan, J. G. Li, X. J. Zhou, C. Tang, S. Pasmanabhan, C. Verma, D. T. H. Tan, T. A. Ling, S. P. Liu,* R. W. Beuerman.* Rapid bactericidal action of a-mangostin against MRSA as an outcome of membrane targeting. Biochim Biophys Acta-biomembrane 2013, 1828: 834–844.

72. Y.N. Chen, N. Li, Y.H. Zhu，C.L. Zhang，X. F. Jiang, Z.F. Xu, S. X. Qiu*，R. M. Huang. Dibenzylbutane Lignans from the Stems of Schisandra bicolor. Natural Product Communications 2013; 8(8): 1121-1122.

73. Z.W. Su, S. X. Qiu*. Chemical constituents from Brucea javanica. Journal of Tropical and Subtropical Botany, 2013, 21(5):466-470.

74. Y. X. Zhong, R. M. Huang, X.J. Zhou, Y.H. Zhu, Z.F. Xu, S. X. Qiu.* Chemical constituents from the heartwood of Dalbergia cochinchinensis. Natural Product Research and Development 2013,25:1515-1516.

75. N.L. Zhang, Y.H. Zhu, R.M. Huang, M.Q. Fu, Z.W. Su, J.Z. Cai, Y.J. Hu, S. X. Qiu.* Two new stilbenoids from Cajanus cajan. Z. Naturforsch, 2012, 67b:1314-1318 [Zeitschrift fuer Naturforschung, B: A Journal of Chemical Sciences 2012, 67(12):1314-1318.

76. R.M. Huang, H.J. Huang, N.L Zhang, Y.H. Zhu, X.F. Jiang, Z.W. Su, J.X. Yang, Z.F. Xu, C.R. Li, S. X. Qiu. Two new lignans from the stems of Schisandra bicolor. Journal of Asian Natural Products Research 2012, 14(12): 1116-1121. 

77. S. X. Feng, J.J. Bai, S.X. Qiu, Y. Li, T. Chen. Iridoid and phenolic glycosides from the roots of Prismatomeris connata. Natural Product Communications 2012,7(5):561-562.

78. T. Sarkar, T. L. Nguyen, Z. W. Su, J. Hao, R. Gussio, S. X. Qiu,* and E. Hamel.* Interaction of pseudolaric acid B with the colchicine site of tubulin. Biochemical Pharmacology 2012, 84, 444-450.

79. M. Q. Fu, S.X. Feng, N. L. Zhang, X. J. Zhou , R.M. Huang, H.J. Huang, Z. F. Xu, X. E. Li, S. X. Qiu.* A new prenylated isoflavone and a new flavonol glycoside from Flemingia philippinensis. Helvetica Chimica Acta 2012, 95(4): 598-605.

80. S. X. Feng, J. Hao, Z. F. Xu, T. Chen and S. X. Qiu.* Polyprenylated isoflavanone and isoflavonoids from Ormosia henryi and their cytotoxic and anti-oxidation activity. Fitoterapia 2012, 83,161-165.

81. A. Falodun, S. X. Qiu (Qiu, S.X), G. Parkinson, and S. Gibbons. Isolation and characterization of a new anticancer diterpenoid from Jatropha gossypifolia. Pharmaceutical Chemistry Journal, 2012, 45 (10), 636-639. 

82. M.Q. Fu, D. Deng, S. X. Feng, R. M. Huang, S. Tian, S. X. Qiu.* Chemical constituents from roots of Flemingia philippinensis. Chinese Herbal Medicines 2012, 4(1): 8-11.

83. X. J. Zhou, R.M. Huang, J. Hao, H. J. Huang, M. Q. Fu, Z. F. Xu, Y. M. Zhou, X. E. Li, S. X. Qiu,* B. Wang.* Two new prenylated xanthones from the pericarp of Garcinia mangostana. Helvetica Chimica Acta 2011, 94, 2092-2098. 

84. J. Hao, Y. Pei, G. Y. Ji, W. J. Li, S. X. Feng, S. X. Qiu. Autophagy is induced by 3β-O-succinyl-lupeol (LD9-4) in A549 cells via up-regulation of Beclin 1 and down-regulation mTOR pathway. European Journal of Pharmacology, 2011, 670: 29-38.  

85. S. X. Feng, J. Hao, T. Chen, S. X. Qiu.* A new anthraquinone and two new tetrahydroanthraquinone from the root of Prismatomeris connata. Helvetica Chimica Acta 2011, 94 (10):1843-1849. 

86. J. Hao, S.X. Feng, S. X. Qiu, T. Chen. Prismatomeris connata; anthraquinone glycosides; cytotoxic activity. Chinese Journal of Natural Medicines. 2011, 9(1): 0042-0045. 

87. R. Teschke, S. X. Qiu, T. D. Xuan, V. Lebot. Kava and kava hepatotoxicity: requirements for novel experimental, ethano-botanical, and clinical studies based on a review of evidence. Phytotherapy Research，2011,25(9):1263-1274. 

88. J. Hao, S.X. Feng, S. X. Qiu, T. Chen. Prismatomeris connata; anthraquinone glycosides; cytotoxic activity. Chinese Journal of Natural Medicines. 2011, 9(1): 0042-0045. 

89. R. Teschke, S. X. Qiu, V. Lebot. Herbal hepatotoxicity by kava: update of pipermethystine, flavokavain B, and mould hepatotoxins as primarily assumed culprits. Digestive and Liver Disease, 2011， 43:676-681.

90. L. L. Feng，L. Zhou, Y. Sun, J. Gui, X. F. Wang, P. Wu, J. Wan, Y. L. Ren, S. X. Qiu, X. Y. Wei and J. Li. Specific inhibitions of annonaceous acetogenins on class II 3-hydroxy-3-methylglutaryl coenzyme A reductase from Streptococcus pneumoniae. Bioorg. Med. Chem. 2011, 19: 3512-3519. 

91. P. Zhou, S Gross, J. H. Liu, B.Y. Yu, L. L. Feng, J. Nolta, V. Sharma, D. Piwnica-Worms and S. X. Qiu.* Flavokawain B, the Hepatotoxic Constituent from Kava Root, Induces GSH-Sensitive Oxidative Stress through Modulation of IKK/NF-kB and MAPK Signaling Pathways. FASEB Journal 2010, 24：4722-4732. 

92. Y. Z. Zhang, Z. J Song, J. Hao, S. X. Qiu,* Z. F. Xu. Two new prenylated xanthones and a new prenylated tetrahydroxanthone from the pericarp of Garcinia mangostana. Fitoterapia, 2010, 81:595-599.

93. N. Wang, L. Q. Shen, S. X. Qiu, X.Y. Wang, K.W. Wang, J. Hao, M. F. Xu. Analysis of the isothiocyanates present in three Chinese Brassica vegetable seeds and their potential anticancer bioactivities. European Food Research and Technology, 2010; 6:951-958.

94. S. X. Feng, L.X. Xu, M. Wu, J. Hao, S. X. Qiu and X. Y. Wei. A new coumarin from Sarcandra glabra. Fitoterapia 2010, 81 (6): 472-474. 

95. W.J. Li and S. X. Qiu. A facile and efficient synthesis of bis(oxazoline)s. J. Heterocyclic Chemistry, 2010, 47, 1340-1343. 

96. W.J. Li and S. X. Qiu. A novel D₂-symmetric chiral tetraoxazoline ligand for highly enantioselective hydrosilylation of aromatic ketones. Advanced Synthesis & Catalysis. 2010, 352:1119-1122. 

97. W.J. Li, Z. L. Xu, S. X. Qiu. Concise methods for the synthesis of chiral polyoxazolines and their application in asymmetric hydrosilylation. Beilstein J. Org. Chem. 2010, 6 (29):1-9.

98. J. Qi, N. Li, J. H. Zhou, B.Y. Yu, S. X. Qiu. Isolation and anti-inflammatory activity evaluation of triterpenoids and a monoterpenoid glycoside from Harpagophytum procumbens. Planta Medica 2010; 76(16): 1892-1896. 

99. K. N. Prasad, J. Hao, C. Yi, D. D. Zhang, S. X. Qiu, Y. M. Jiang, M. W. Zhang, F. Chen. Antioxidant and anticancer activities of Wampee [Clausena lansium (Lour.) Skeels] Peel. Journal of Biomedicine and Biotechnology 2009, doi:10.1155/2009/612805.

100. S. X. Qiu. Natural products regain attention in oncology. Guest Editorial, Tropical Journal of Pharmaceutical Research, 2009; 8(5): 383-384.

101. K. N. Prasad, J. Hao, J. Shi, T. Liu, J. Li, X.Y. Wei, S. X. Qiu, S. Xue, Y.M. Jiang. Antioxidant and anticancer activities of high pressure-assisted extract of longan (Dimocarpus longan Lour.) fruit pericarp. Innovative Food Science and Emerging Technologies 2009; 10: 413-419.

102. K. N. Prasad, H.H. Xie, J. Hao, B. Yang, S. X. Qiu, X. Y. Wei, F. Chen, Y. M. Jiang. Antioxidant and anticancer activities of 8-hydroxypsoralen isolated from wampee [Clausena lansium (Lour.) Skeels] Peel. Food Chemistry 2009; 118(1):62-66.

103. H.Y. Zhang, H.H. Xie, S. X. Qiu, J.H. Xue, X.Y. Wei. Heteroatom-containing antibacterial phenolic metabolites from a terrestrial Ampelomyces fungus. Biosci. Biotechnol. Biochem. 2008; 72 (7):1746-1749. 

104. Q. Gu, X. M. Zhang, J. Zhou, S. X. Qiu, J.J. Chen. One new dihydrobenzofuran lignan from Vitex trifolia. Journal of Asian Natural Products Research 2008, 10 (6):499-502.

105. S. X. Qiu, C. Dan, S. L. Peng, L.S. Ding, S. N. Chen, N. R. Farnsworth, M. L. Gross and P. Zhou. 25-Acetylcimigenol xylopyranoside, a triterpene glycoside from Black cohosh, inhibits osteoclastogenesis by modulating RANKL and TNF signaling pathways. Chemistry & Biology 2007, 14, 860-869.【with a ccompanying editorial‘Mending the bones with Natural Products’by G. Sethi and Bharat Aggarwal, Chemistry & Biology 2007; 14, 738-740】

106. C. Dan, Y. Zhou, D. Ye, S. L. Peng, L. S. Ding, M. L. Gross, S. X. Qiu.* Cimicifugadine from Cimicifuga foetida, a new class of triterpene alkaloids with novel reactivity. Organic Letters 2007, 9(9): 1813-1816. 

107. L.R. Sun, X. M. Niu, C. Qin, Y. L. Zhang, S. Y. Jian, Z. R. Li, S.-J. Pei, M.H. Qiu and S. X. Qiu.* Cimicifoetisides A and B, two cytotoxic cycloartane triterpenoid glycosides from rhizomes of Cimicifuga foetida, inhibit proliferation of cancer cells. Beilstein J. Organic Chemistry 2007, 3:3-8. 

108. J. Qi, J. J. Chen, Z. H. Cheng, J. H. Zhou, B.Y. Yu, and S. X. Qiu. Iridoid glycosides from Harpagophytum procumbens D.C. (Devils’ claw). Phytochemistry 2006, 67:1372-1377. 

109. L.P. Ruan, S. Chen, B. Y. Yu, D. N. Zhu, G.A. Cordell, S. X. Qiu.* Prediction of human absorption of natural products by non-everted rat intestinal sac model. European Journal of Medicinal Chemistry 2006, 41(5): 606-610. 

110. L. Pan, P. Zhou, X.F. Zhang, S.L. Peng, L.S. Ding,* S. X. Qiu.* Skeleton-Rearranged pentacyclic diterpenes possessing a cyclobutane ring from Euphorbia wallichii. Organic Letters 2006, 8 (13): 2775-2778. 

111. Z. H. Cheng, B. Y. Yu, Y. L. Guo, S. X. Qiu. Microbial hydroxylation of quinovic acid glycoside by Streptomyces griseus ACCT 13272. Chinese Journal of Chemistry 2006, 24 (1):95-98.

112. C. Chen, M.H. Chiu, R. L. Nie, G. A. Cordell and S. X. Qiu. Curcurbitacins and Cucurbitane Glycosides: Structures and Biological Activities. Natural Products Reports 2005, 22:386-399.

113. Z. Y. Jiang, X. M. Zhang, J. Zhou, S. X. Qiu and J. J. Chen. Two new triterpenoid glycosides from Cyclocarya paliurus. Journal of Asian Natural Products Research 2005, 8 (1-2):93-98.

114. J. Zhang, Z. H. Cheng, B.Y. Yu, G. A. Cordell and S. X. Qiu.* Novel Biotransformation of pentacyclic triterpenoid acids by microbe Nocardia sp. NRRL 5646. Tetrahedron Letters 2005, 46 (13): 2337-2340.

115. Z. P. J. Lin, S. X. Qiu and L. Shum. Simultaneous determination of glycyrrhizin, a marker component in radix Glycyrrhizae, and its major metabolite glycyrrhetic acid in human plasma by LC-MS/MS. J. Chromatography B, 2005, 814:201-207.

116. Z. H. Chen, B. Y. Yu, G. A. Cordell and S. X. Qiu.* Biotransformation of quinovic acid glycosides by microbes: Direct conversion of the ursane to the oleanane triterpene skeleton by Nocardia sp. NRRL 5646. Organic Letters 2004, 6 (18): 3163-3165. 

117. S. X. Qiu, R. Z. Yang and M. Gross. Synthesis and LC/Tandem Mass Spectrometric Characterization of the Adducts of Bisphenol-A (BPA)-O-quinone with Glutathione and nucleotide monophosphates. Chem. Res. Tox. 2004, 17: 1038-1046.

118. B. M. Johnson, S. X. Qiu, S. D. Zhang, F.G. Zhang, J. E. Burdette, L. N. Yu, J. L. Bolton and R. B. van Breemen. Identification of novel electrophilic metabolites of Piper methysticum Forst (kava). Chem. Res. Tox. 2003, 16 (6):733-740.

119. J. T. Xie, A. B. Wang, S. Mehendale, J. Wu, H. H. Aung, L. Dey, S. X. Qiu, C. S. Yuan. Anti-diabetic effects of Gymnema yunnanense extract. Pharmacological Research 2003, 47 (4), 323-329.   

120. H. J. Zhang, S. X. Qiu, P. Tamez, G. T. Tan, Z. Aydogmus, N. Van Hung, N. M. Cuong, C. Angerhofer, D.D. Soejarto, J. M. Pezzuto and H.S. Fong. Antimalarial agents from plants II. Decursivine, a new antimalarial indole alkaloid from Rhaphidophora decursive. Pharmaceutical Biology 2002, 40(3):221-224.

121. S. H. Li, H. J. Zhang, S. X. Qiu,* X. M. Niu, B. D. Santarsiero, A. D. Mesecar, H.H. S. Fong, N. R. Farnsworth and H. D. Sun. Vitexlactam A, a novel diterpene lactam from the fruits of Vitex agnus-castus. Tetrahedron Letters, 2002, 43: 5131-5134.

122. L. Z. Lin, S. X. Qiu, M. Lindenmaier, X.G. He, T. Featherstone, G. A. Cordell. Patuletin-3-O-rutinoside from the aerial parts of Echinacea angustifolia. Pharmaceutical Biology 2002, 40(2): 92-95.

123. H. J. Zhang, Z.-Z. Lu, G. T. Tan, S. X. Qiu, N.R. Farnsworth, J.M. Pezzuto and H.H. S. Fong. Polyacetyleneginsenoside-R0, a novel triterpene saponin from Panax ginseng. Tetrahedron Letters 2002, 43(6):973-977.

124. S. X. Qiu, N. van Hung, L.T. Xuan, J. Q. Gu, E. Lobkovsky, T.C. Khan, D. D. Soejato, J. Clardy, J.M. Pezzuto, Y. Dong, M.V. Tri, L.M. Huong, H.H. S. Fong. A pregnane steroid from Aglaia lawii and structure confirmation of cabraleadiol monoacetate by X-ray crystallography. Phytochemistry 2001, 56(7):775-780.

125. H. D. Sun, S. X. Qiu,* N. R. Farnsworth, E. B. Lobkovesky, J. Clardy and H.H.S. Fong. Crystal and molecular structures of a natural equimolecular mixture of two epimeric diterpenes from Isodon irrorata. Tetrahedron 2000, 57(1):65-70.

126. S. X. Qiu, X.C. Li, Y.S. Xiong, Y.M. Dong, H.B. Chai, N.R. Farnsworth, J.M. Pezzuto, H.H. S. Fong. Isolation and characterization of cytotoxic saponin chloromaloside A from Chlorophytum malayense. Planta Medica 2000, 66(6):587-590.

127. L. Z. Lin, X.-G. He, M. Lindenmaier, G. Nolan, J. Yang, M. Cleary, S. X. Qiu, G. A. Cordell. Liquid chromatography-electrospray ionization mass spectrometry study of the flavonoids of the roots of Astragalus mongholicus and A. membranaceus. J. Chromatogr. A, 2000, 876(1+2), 87-95.  

128. L. Z. Lin, X. G. He, M. Lindenmaier, J. Yang, M. Cleary, S. X. Qiu and G. A. Cordell. LC-ESI-MS study of the flavonoid glycoside malonates of Red Clover (Trifolium pratense). Journal of Agricultural and Food Chemistry 2000, 48 (2): 354-365. 

129. S. X. Qiu, Z. Z. Lu, L. Luyengi, S.K. Lee, J.M. Pezzuto, N.R. Farnsworth, L.U. Thompson, H.H. S. Fong. Isolation and characterization of flaxssed (Linum usitatissimum) constituents. Pharmaceutical Biology 1999, 37(1):1-7.

130. P. D. N. Lotulung, L. Z. Udin, L.B.S. Kardono, S. X. Qiu, J.M. Pezzuto, H.H.S. Fong, N.R. Farnsworth, H. Kyaw, H.B. Chai, S. Riswan. Cytotoxic constituents of the fruits of Trichosanthes bracteata. Buletin IPT, 1998, 3 (IV): 29-32.

131. S. X. Qiu, G. A. Cordell, B.R. Kumar, Y. N, Rao, M. Ramesh, C. Kokate and A.V.N.A. Rao. Studies on the C-21 steroids from asclepiadaceous plants bisdesmosidic pregnane glycosides from Caralluma lasiantha. Phytochemistry 1998, 50(3): 485-491.

132. S. X. Qiu, H.D. Sun, E. Lobkovsky, H.Y. Chai, J. Clardy, N.R.Farnsworth, J.M. Pezzuto, H.H. S. Fong. Megathyrin B, a cytotoxic diterpene from Isodon megathyrsus. Planta Medica 1998, 64 (8):728-731.

133. S. X. Qiu, F. H. Ge, Y. S. Zhou, J. S. Jia, N. R. Farnsworth, M. E. Johnson, H.H.S. Fong. Isolation, stereochemical assignments and molecular mechanics calculation of ethyl -L-arabinopyranoside. Carbohydrate Research, 1998, 311 (1-2):85-88.

134. J. L. Bolton, E. Pisha, F. Zhang and S. X. Qiu. Role of quinoids in estrogen carcinogenesis. Chem. Res. Tox. 1998, 11 (10): 1113-1127.

135. S. Oeksuez, F. Guerek, S. X. Qiu, G.A. Cordell. Diterpene polyester from Euphorbia seguieriana. J. Nat. Prod. 1998, 61(10):1198-1201.

136. S. X. Qiu, C. Liu, Z.C. Xia, N. R. Farnsworth, H. H. S. Fong. (1R,2S)-(-)-mangochinine, a naturally-occurring dibenzopyrrocoline alkaloid from Manglietia chingii. Tetrahedron Letters 1998, 39(24):4167-4170.

137. C. Peng, G. Bodenhausen, S. X. Qiu, H.H.S. Fong, N.R. Farnsworth, S.G. Yuan, C.Z. Zheng. Computer-assisted structure elucidation: application of CISOC-SES to the resonance assignment and structure generation of butulinic acid. Magnetic Resonance in Chemistry 1998, 36(4):267-278.

138. L. Shen, S. X. Qiu, Y. Chen, F. G. Zhang, Richard B. van Breemen, D. Nikolic and Judy L. Bolton. Alkylation of 2’-deoxynucleosides and DNA by the Premarin Metabolite 4-hydroxyequilenin semiquinone radical. Chem. Res. Tox. 1998, 11 (2): 94-101 (Cover Page); 【Highlight: Featured in Chemical & Engineering News, February 16, 1998】

139. N. Arda, N. Goeren, A. Kuru, Thitima, Pengsuparp, J.M. Pezzuto, S. X. Qiu, G.A. Cordell. Saniculoside N from Sanicula europaea L. J. Nat. Prod. 1997, 60(11):1170-1173.

140. L. Shen, S. X. Qiu, R. B. van Breemen, F. Zhang, Y. Chen and J. L. Bolton. Reaction of the Premarin metabolite, 4-hydroxylequilenin semi-quinone radical with 2’-deoxyguanosine: Formation of highly unusual cyclic adducts. J. Am. Chem. Soc. (Commun.) 1997, 119: 11126-11127. 

141. S. X. Qiu, L.Z. Lin, G.A. Cordell, M. Ramesh, B.R. Kumar, M. Radhakrishna, G.K. Mohan, B.M. Reddy and A.V.N.A. Rao. Acylated C-21 steroidal bisdesmosidic glycosides from Caraluma umbellata. Phytochemistry 1997, 46(2):333-340.

142. D.S.H.L. Kim, Z.D. Chen, N. Van Yuyen, J.M. Pezzuto, S. X. Qiu, Z.Z. Lu. A concise semi-synthetic approach to betulinic acid from butulin. Synthetic Communications 1997, 27(9) :1607-1612.

143. H. D. Sun, S. X. Qiu, L.Z. Lin, R. P. Zhang, Y.S. Zhou, Q.T. Zheng, M.E. Johnson, H.H.S. Fong, N.R. Farnsworth and G.A. Cordell. Crystal structure of a 1:1 complex of natural diterpenoids: absolute configurations and unambiguous NMR spectral assignments of neoangustifolin and epinodosinol. J. Nat. Prod. 1997, 60(3) :203-206.

144. B.Y. Yu, S. X. Qiu, H. Zaw, G.J. Xu, Y. Hirai, J. Shoji, H.H.S. Fong, A.D. Kinghorn. Steroidal glycosides from the subterranean parts of Liriope spicata var. prolifera. Phytochemistry 1996, 43(1) :201-206.

145. H.D. Sun, S. X. Qiu, L.Z. Lin, Z.Y. Wang, Z.W. Lin, T. Pengsuparp, J.M. Pezzuto, H.H.S. Fong, G.A. Cordell and N.R. Farnsworth. Nigranoic acid, a triterpenoid from Schisandra sphaerandra that inhibits HIV-1 reverse trannscriptase. J. Nat. Prod. 1996, 59(5) :525-527.

146. S. X. Qiu, S. Q. Luo, L.Z. Lin, G.A. Cordell. Further polyoxypregnanes from Marsdenia tenacissima. Phytochemistry 1996, 41(5) :1385-1388.

147. S. X. Qiu, L.Z. Lin, Y. Nan, J. J. Chen, Z.X. Zhang, J. Zhou and G. A. Cordell. Structure revision and internal migration of gymnemarsgenin. Phytochemistry, 1995, 40(3) :917-921.

148. S. X. Qiu, Y. Gong and H.T.A. Cheung. A triterpene from Marsdenia globifera. Phytochemistry 1993, 34 (5) : 1385-1387.

149. S. X. Qiu, Z. X. Zhang and J. Zhou. Two new glycosides from the roots of Cynanchum versicolor. Planta Medica, 1991, 57 (5) : 454-456.

150. C. M. Zhou, C. Yao, H. L. Sun, S. X. Qiu, G. Y. Cui. Volatile constituents of the rhizome of Homalomena occulta. Planta Medica 1991; 57: 391-392.

151. S. X. Qiu, Z.X. Zhang and J. Zhou. Three new glycosides from the roots of Cynanchum versicolor. Phytochemistry 1989, 28 (1) : 3175-3178.

1. Application of cajanonic acid A and its analogue in manufacturing drug or health food for treating osteoporosis. By: Shen, Xiaoling; Qiu, Shengxiang; Hu, Yingjie Assignee: Guangzhou Yunzhong Biotechnology Co., Ltd., Peop. Rep. China.Patent Information: Jan 11, 2017, CN 106309419, A Application: Jun 19, 2015, CN 2015-10349178,Priority: Jun 19, 2015, CN 2015-10349178,Source: Faming Zhuanli Shenqing, 9pp., Patent, 2017, CODEN: CNXXEV,Accession Number: 2017:66601, CAN 166:180895, CAPLUS. Language: Chinese

1. Shen, Xiaoling; Wang, Lu; Hu, Yingjie; Qiu, Shengxiang; Fu, Linchun; Mai, Zhao. Application of cajanonic acid A in medical preparation for treating diabetic complications and hyperlipidemia. (2012), CN 102670576 A 20120919.

2. Lu, Yu; Qiu, Shengxiang; Zhang, Guilin; Xu, Zhifang; Wang, Yanfei.α-, γ-Mangostin derivatives and their application in the preparation of anti-cancer drugs. Faming Zhuanli Shenqing (2013), CN 103159729 A 20130619.

3. Qiu, Shengxiang; Liu, Hongxin; Tan, Haibo; Yuan, Yao; Zhu, Chunfu; Xu, Zhifang. Rhodomyrtosone B and tomentosone C separated from Rhodomyrtus tomentosa for use in antibacterial agent. Patent Information: Jul 08, 2015, CN 104761565, A;  Application: Apr 16, 2015, CN 2015-10182272; Priority: Apr 16, 2015, CN 2015-10182272

4. Tan, Haibo; Liu, Hongxin; Huo, Luqiong; Wang, Yu; Xu, Zhifang; Qiu, Shengxiang.Assignee: South China Botanical Garden, Chinese Academy of Sciences, Peop. Rep. ChinaPatent Information: Dec 22, 2017, CN 107501287, A Application: Aug 22, 2017, CN 2017-10726182. Priority: Aug 22, 2017, CN 2017-10726182, Source: Faming Zhuanli Shenqing, 30pp., Patent, 2017

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