基本信息
邱声祥 男 博导 中国科学院华南植物园
电子邮件： sxqiu@scbg.ac.cn
通信地址： 广州市天河区兴科路723号
邮政编码： 510650
电子邮件： sxqiu@scbg.ac.cn
通信地址： 广州市天河区兴科路723号
邮政编码： 510650
研究领域
美国University of Illinois药学博士，博士生导师，中国科学院华南植物园天然产物化学生物学研究组负责人。研究方向为岭南药用植物化学资源的系统研究与综合利用，包括天然产物药物化学、天然产物新药创制、药用植物化学资源利用与功能性植物产品研发。主持和参加卫生部、科技部、国家自然科学基金、中国科学院、广东省和广州市等多个科研项目，主要有：“十一五”艾滋病和病毒性肝炎等重大传染病防治科技重大专项2项，“十一五”新药创制国家科技重大专项2项，国家863研究计划1项，国家自然科学基金2项，广州市重大新药创制科技重大专项2项，以及中国科学院重要方向性项目、广东省自然科学基金项目等。已发表学术论文100多篇，其中SCI论文70余篇，申请国家发明专利5项。
招生信息
招生专业
071010-生物化学与分子生物学
招生方向
植物化学天然产物化学生物学药物化学
教育背景
1994-08--1998-10 美国University of Illinois 博士研究生1985-08--1988-08 中国科学院昆明植物研究所 硕士研究生1981-09--1985-07 江西大学(现南昌大学) 大学本科
学历
研究生
学位
博士
工作经历
1989,03-1994,07 中国医药研究开发中心 助理研究员
1998,09-2000,10 美国Monsanto公司 Senior Scientist
2000,11-2002,10 美国Watson Pharmaceuticals公司 Principal Scientist
2002,11-2007,10 美国Washington University Research Scientist
2007,11-至今 中国科学院华南植物园 首席研究员、博导
工作简历
2007-11~现在, 中国科学院华南植物园, 首席研究员2002-11~2007-10,美国Washington University, Research Scientist2000-11~2002-10,美国Watson 制药公司, Principal Scientist1998-10~2000-10,美国Monsanto公司, Senior Scientist1989-05~1993-07,中国医药研究开发中心, 助理研究员
社会兼职
2012-10-01-今,佛山南海留学生联谊会理事长,
2011-01-01-今,广州国际企业孵化器火炬创业导师,
2011-01-01-今,广州国际企业孵化器火炬创业导师,
专利与奖励
专利成果
[1] 邱声祥, 赵丽云, 李玉林, 林婷婷. 一种天然抗病毒液及其制备方法和应用. CN114558020A, 2022-05-31.[2] 邱声祥, 赵丽云. 桃金娘酮类化合物在制备抗新型病毒SARS-CoV-2药物中的应用. CN113730391B, 2021-12-03.[3] 邱声祥, 赵丽云. 桃金娘酮类化合物及其在制备抗流感病毒药物中的应用. CN113735814A, 2021-12-03.[4] 邱声祥, 赵丽云. 桃金娘酮类化合物在制备抗病毒兽药中的应用. CN113730392A, 2021-12-03.[5] 余中华, 邓书林, 李顺, 邱声祥. 一种有抗病毒作用的仙人掌果酸性多糖及其制备方法和应用. CN: CN112125980A, 2020-12-25.[6] 赵丽云, 邱声祥, 杨美珍, 杜逸琼. 一种植源天然抑菌剂或防腐剂及其应用. CN: CN111888273A, 2020-11-06.[7] 邱声祥, 赵丽云. 一种复配型天然美白抗皱组合物和应用. CN: CN111821209A, 2020-10-27.[8] 杨玲, 邓书林, 邱声祥, 林丹妮, 李顺, 方雪珊. 一种桃金娘硬枝扦插方法. CN: CN111670702A, 2020-09-18.[9] 邓书林, 杨玲, 邱声祥, 林丹妮, 李顺. 一种提高桃金娘种子组培萌发和降低污染率的处理方法. CN: CN111557138A, 2020-08-21.[10] 邱声祥, 赵丽云, 谭海波, 刘洪新, 徐志防. 闭环桃金娘酮类似物及在抗菌药物中的应用. CN: CN108752305A, 2018-11-06.[11] 谭海波, 刘洪新, 霍璐琼, 王煜, 徐志防, 邱声祥. Myrtuco mmulone J和Myrtucommuacetalone及其类似物的制备方法. CN: CN107501287A, 2017-12-22.[12] 谭海波, 邱声祥, 刘洪新, 赵丽云, 龚亮, 徐志防. 开环桃金娘酮类似物及其制备方法和在抗菌药物中的应用. CN: CN105859537A, 2016-08-17.[13] 邱声祥, 刘洪新, 谭海波, 袁尧, 朱春福, 徐志防. 桃金娘酮化合物及其在制备抗菌药物中的应用. CN: CN104761565A, 2015-07-08.[14] 陆豫, 邱声祥, 张贵林, 徐志防, 王严飞. α-,γ-倒捻子素衍生物及其在制备抗癌药物中的应用. CN: CN103159729A, 2013-06-19.[15] 胡英杰, 邱声祥, 符林春, 郑永唐. 一种治疗艾滋病的药物组合物及其制备方法、质量控制方法和用途. CN: CN102727850A, 2012-10-17.[16] 邱声祥. 一种三萜类抗艾滋病药物. CN: CN101366719A, 2009-02-18.[17] 邱明华, 王瑾, 杜江, 邱声祥, 周琳. 抗肿瘤药物组合物，其制备方法和其应用. CN: CN1305480C, 2007-03-21.
出版信息
发表论文
[1] Zhao, Liyun, Yao, Liyuan, Chen, Rui, He, Jiani, Lin, Tingting, Qiu, Silin, Chen, Guohua, Chen, Hongfeng, Qiu, ShengXiang. Pinostrobin from plants and propolis against human coronavirus HCoV-OC43 by modulating host AHR/CYP1A1 pathway and lipid metabolism. ANTIVIRAL RESEARCH[J]. 2023, 212: http://dx.doi.org/10.1016/j.antiviral.2023.105570.[2] ALBukhaiti, Wedad Q, AlDalali, Sam, Noman, Anwar, Qiu, Silin, Abed, Sherif M, Qiu, ShengXiang. Response Surface Modeling and Optimization of Enzymolysis Parameters for the In Vitro Antidiabetic Activities of Peanut Protein Hydrolysates Prepared Using Two Proteases. FOODS[J]. 2022, 11(20): http://dx.doi.org/10.3390/foods11203303.[3] Li, Xiancai, Yao, Liyuan, Xiong, Binghong, Wu, Yaodan, Chen, Shaohua, Xu, Zhifang, Qiu, ShengXiang. Inhibitory Mechanism of Pinosylvin Monomethyl Ether against Aspergillus flavus. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY[J]. 2022, 70(50): 15840-15847, http://dx.doi.org/10.1021/acs.jafc.2c07240.[4] Wang, Miaomiao, Huo, Luqiong, Liu, Hongxin, Zhao, Liyun, Xu, Zhifang, Tan, Haibo, Qiu, ShengXiang. Thujasutchins N and O, two new compounds from the stems and roots of Thuja sutchuenensis. NATURAL PRODUCT RESEARCH[J]. 2022, 36(9): 2356-2362, http://dx.doi.org/10.1080/14786419.2020.1836627.[5] Zhao, Liyun, Qin, Xubing, Lin, Tingting, Xie, Fuda, Yao, Liyuan, Li, Yulin, Xiong, Binhong, Xu, Zhifang, Ye, Yongchang, Chen, Hongfeng, Qiu, ShengXiang. Multi-target mechanisms against coronaviruses of constituents from Chinese Dagang Tea revealed by experimental and docking studies. JOURNAL OF ETHNOPHARMACOLOGY[J]. 2022, 297: http://dx.doi.org/10.1016/j.jep.2022.115528.[6] 钟艳霞, 陈郊, 莫新良, 徐志防, 邱声祥, 刘新红. 交趾黄檀心材的黄酮类和 三萜类 成分. 热带亚热带植物学报[J]. 2021, 29(5): 573-578, http://lib.cqvip.com/Qikan/Article/Detail?id=7105697046.[7] Zhang, Wenge, Wang, Miaomiao, Zhang, Sha, Xu, Kangping, Tan, Guishan, Qiu, Shengxiang, Zou, Zhenxing, Tan, Haibo. Eutyscoparols A-G, polyketide derivatives from endophytic fungus Eutypella scoparia SCBG-8. FITOTERAPIA[J]. 2020, 146: http://dx.doi.org/10.1016/j.fitote.2020.104681.[8] Zhang, Xiao, Wu, Guiyun, Huo, Luqiong, Guo, Xueying, Qiu, Shengxiang, Liu, Hongxin, Tan, Haibo, Hu, Yingjie. The First Racemic Total Syntheses of the Antiplasmodials Watsonianones A and B and Corymbone B. JOURNAL OF NATURAL PRODUCTS[J]. 2020, 83(1): 3-7, https://www.webofscience.com/wos/woscc/full-record/WOS:000510076700002.[9] Shi, Lili, Wang, Sasa, Huo, Luqiong, Gao, Minli, Zhang, Wenge, Lu, Xiuxiang, Qiu, Shengxiang, Liu, Hongxin, Tan, Haibo. Diastereoselective construction of the benzannulated spiroketal core of chaetoquadrins enabled by a regiodivergent cascade. ORGANIC CHEMISTRY FRONTIERS[J]. 2020, 7(17): 2385-2390, https://www.webofscience.com/wos/woscc/full-record/WOS:000562454200023.[10] Sheng-Xiang QIU. The first racemic total synthesis of the antiplasmodials watsonianones A and B and corymbone B. Journal of Natural Products. 2020, [11] Huo, Luqiong, Dong, Chunmao, Wang, Miaomiao, Lu, Xiuxiang, Zhang, Wenge, Yang, Bao, Yuan, Yunfei, Qiu, Shengxiang, Liu, Hongxin, Tan, Haibo. Biomimetic Total Syntheses of Sanctis A-B with Structure Revision. ORGANIC LETTERS[J]. 2020, 22(3): 934-938, https://www.webofscience.com/wos/woscc/full-record/WOS:000513082700035.[12] Wang, Miaomiao, Zhao, Liyun, Chen, Kai, Shang, Yaxuan, Wu, Jiafeng, Guo, Xueyin, Chen, Yihong, Liu, Hongxin, Tan, Haibo, Qiu, ShengXiang. Antibacterial sesquiterpenes from the stems and roots of Thuja sutchuenensis. BIOORGANIC CHEMISTRY[J]. 2020, 96: http://dx.doi.org/10.1016/j.bioorg.2020.103645.[13] Sheng-Xiang QIU. Diastereoselective construction of the benzannuliated spiroketal core of chaetoquadrins enaled by a regiodivergent cascade. Organic Chemistry Frontiers. 2020, [14] Li, Yan, Wu, JieWei, Tan, HaiBo, Li, BaiLin, Qiu, ShengXiang. Three new pterocarpans from the aerial parts of Abrus Precatorius. NATURAL PRODUCT RESEARCH[J]. 2020, 34(13): 1836-1844, https://www.webofscience.com/wos/woscc/full-record/WOS:000477203400001.[15] Zhao, LiYun, Liu, HongXin, Wang, Lei, Xu, ZhiFang, Tan, HaiBo, Qiu, ShengXiang. Rhodomyrtosone B, a membrane-targeting anti-MRSA natural acylgphloroglucinol from Rhodomyrtus tomentosa. JOURNAL OF ETHNOPHARMACOLOGY[J]. 2019, 228: 50-57, http://dx.doi.org/10.1016/j.jep.2018.09.011.[16] Wu GuiYun, Zhang Xiao, Guo XueYing, Huo LuQiong, Liu HongXin, Shen XiaoLing, Qiu ShengXiang, Hu YingJie, Tan HaiBo. Prenylated stilbenes and flavonoids from the leaves of Cajanus cajan. CHINESE JOURNAL OF NATURAL MEDICINES[J]. 2019, 17(5): 381-386, http://lib.cqvip.com/Qikan/Article/Detail?id=7002208558.[17] Wu, JieWei, Li, BaiLin, Tang, Chunping, Ke, ChangQang, Zhu, NanLin, Qiu, ShengXiang, Ye, Yang. Callistemonols A and B, Potent Antimicrobial Acylphloroglucinol Derivatives with Unusual Carbon Skeletons from Callistemon viminalis. JOURNAL OF NATURAL PRODUCTS[J]. 2019, 82(7): 1917-1922, https://www.webofscience.com/wos/woscc/full-record/WOS:000477917800021.[18] Liu, Cuifang, Huang, Xiaobo, Qiu, Shengxiang, Chen, Wenqiang, Li, Weihong, Zhang, Haiyan, Wang, Tao, Wang, Xue, Wu, Xiling. Chinese Herbal Complex "Bu Shen Jie Du Fang' (BSJDF) Modulated Autophagy in an MPP+-Induced Cell Model of Parkinson's Disease. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE[J]. 2019, 2019: https://doaj.org/article/cb4c60a079544e9885348e9e4d09a4e6.[19] Liu, HongXin, Tan, HaiBo, Li, SaiNi, Chen, YuChan, Li, HaoHua, Qiu, ShengXiang, Zhang, WeiMin. Two new 12-membered macrolides from the endophytic fungal strain Cladosprium colocasiae A801 of Callistemon viminalis. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH[J]. 2019, 21(7): 696-701, https://www.webofscience.com/wos/woscc/full-record/WOS:000469051300014.[20] WU GuiYun, ZHANG Xiao, GUO XueYing, HUO LuQiong, LIU HongXin, SHEN XiaoLing, QIU ShengXiang, HU YingJie, TAN HaiBo. Prenylated stilbenes and flavonoids from the leaves of Cajanus cajan. 中国天然药物:英文版[J]. 2019, 17(5): 381-386, http://lib.cqvip.com/Qikan/Article/Detail?id=7002208558.[21] Li, Yan, Qin, XuBing, Liu, HongXin, Xu, ZhiFang, Tan, HaiBo, Qiu, ShengXiang. Two pairs of enantiomeric propylated flavonoids and a new lignan from the aerial parts of Abrus precatorius. FITOTERAPIA[J]. 2019, 133: 125-129, http://dx.doi.org/10.1016/j.fitote.2018.12.019.[22] Guo, Xueying, Wang, Miaomiao, Wu, Jiafeng, Wu, Guiyun, Zhang, Xiao, Huo, Luqiong, Liu, Hongxin, Chen, Yihong, Xie, Guowen, Tan, Haibo, Qiu, ShengXiang. Chemical constituents of the trunks and roots of Thuja sutchuenensis. FITOTERAPIA[J]. 2019, 134: 264-269, http://dx.doi.org/10.1016/j.fitote.2019.02.025.[23] Song, JiaLing, Yuan, Yao, Nie, LingHui, Li, BaiLin, Qin, XuBing, Li, Yan, Wu, JieWei, Qiu, ShengXiang. A new ent-kaurane diterpene derivative from the stems of Eurya chinensis R.Br. NATURAL PRODUCT RESEARCH[J]. 2018, 32(2): 182-188, https://www.webofscience.com/wos/woscc/full-record/WOS:000415643100010.[24] 黄艳萍, 宋家玲, 吴继平, 袁萍, 沈晓萌, 邱声祥. 凉粉草化学成分分离鉴定. 中国实验方剂学杂志[J]. 2018, 24(6): 77-81, http://lib.cqvip.com/Qikan/Article/Detail?id=674846223.[25] Yao Yuan, Jiewei Wu, Bailin Li, Jia Niu, Haibo Tan, Shengxiang Qiu. Regulation of Signaling Pathways Involved in the Anti-proliferative and Apoptosis-inducing Effects of M22 against Non-small Cell Lung Adenocarcinoma A549 Cells. SCIENTIFIC REPORTS[J]. 2018, 8(1): https://www.webofscience.com/wos/woscc/full-record/WOS:000422716900126.[26] Yang, Ruiyi, Wang, Lu, Xie, Jie, Li, Xiang, Liu, Shan, Qiu, Shengxiang, Hu, Yingjie, Shen, Xiaoling. Treatment of type 2 diabetes mellitus via reversing insulin resistance and regulating lipid homeostasis in vitro and in vivo using cajanonic acid A. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE[J]. 2018, 42(5): 2329-2342, https://www.webofscience.com/wos/woscc/full-record/WOS:000447702700002.[27] Liu, Hongxin, Wang, Yu, Guo, Xueying, Huo, Luqiong, Xu, Zhifang, Zhang, Weimin, Qiu, Shengxiang, Yang, Bao, Tan, Haibo. A Bioinspired Cascade Sequence Enables Facile Assembly of Methanodibenzob,f1,5dioxocin Flavonoid Scaffold. ORGANIC LETTERS[J]. 2018, 20(3): 546-549, http://dx.doi.org/10.1021/acs.orglett.7b03630.[28] Yuan, Yao, Yang, JianXiang, Nie, LingHui, Li, BaiLin, Qin, XuBing, Wu, JieWei, Qiu, ShengXiang. Three new kavalactone dimers from Piper methysticum (kava). JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH[J]. 2018, 20(9): 837-843, https://www.webofscience.com/wos/woscc/full-record/WOS:000452849000002.[29] Zhao, Liyun, Liu, Hongxin, Huo, Luqiong, Wang, Miaomiao, Yang, Bao, Zhang, Weimin, Xu, Zhifang, Tan, Haibo, Qiu, ShengXiang. Structural optimization and antibacterial evaluation of rhodomyrtosone B analogues against MRSA strains. MEDCHEMCOMM[J]. 2018, 9(10): 1698-1707, https://www.webofscience.com/wos/woscc/full-record/WOS:000448343300010.[30] Song, JiaLing, Yuan, Yao, Nie, LingHui, Li, BaiLin, Qin, XuBing, Li, Yan, Wu, JieWei, Qiu, ShengXiang. Two new ent-kaurane diterpenes from the stems of Eurya chinensis. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH[J]. 2018, 20(10): 962-968, https://www.webofscience.com/wos/woscc/full-record/WOS:000457087900008.[31] Shi, Lili, Liu, Hongxin, Huo, Luqiong, Dang, Yaqian, Wang, Yu, Yang, Bao, Qiu, Shengxiang, Tan, Haibo. Site-selective phenol acylation mediated by thioacids via visible light photoredox catalysis. ORGANIC CHEMISTRY FRONTIERS[J]. 2018, 5(8): 1312-1319, http://dx.doi.org/10.1039/c8qo00041g.[32] 孙丽丽, 王宝杰, 高雨秋, 刘艳萍, 邱声祥, 付艳辉. 光滑黄皮枝叶中化学成分研究. 广东化工[J]. 2018, 45(17): 1-2, http://lib.cqvip.com/Qikan/Article/Detail?id=676308850.[33] Jiang, Xiaofei, Liu, Yi, Cao, Jianfeng, Xiong, Nanqiang, Zhang, Nengling, Qiu, Shengxiang. Novel Lipophilic Jatrorrhizine: Synthesis, Antimicrobial, and Cytotoxic Activity Evaluation. LATIN AMERICAN JOURNAL OF PHARMACY[J]. 2017, 36(10): 2105-2111, [34] YuQing Xiang, HongXin Liu, LiYun Zhao, ZhiFang Xu, HaiBo Tan, ShengXiang Qiu. Callistemenonone A, a novel dearomatic dibenzofuran-type acylphloroglucinol with antimicrobial activity from Callistemon viminalis. SCIENTIFIC REPORTS[J]. 2017, 7(1): https://doaj.org/article/ed9d872af76a4747ba79286549cfbfbf.[35] Song, JiaLing, Li, BaiLin, Yuan, Yao, Nie, LingHui, Niu, Jia, Chiu, David, Xu, ZhiFang, Wu, JieWei, Qiu, ShengXiang. Yangonindimers A-C, three new kavalactone dimers from Piper methysticum (kava). NATURAL PRODUCT RESEARCH[J]. 2017, 31(21): 2459-2466, https://www.webofscience.com/wos/woscc/full-record/WOS:000412458800001.[36] 徐志防. Viminone A, a novel dearomatic dibenzofuran-type acylphloroglucinol with antimicrobial activity from Callistemon viminalis. Scientific Reports. 2017, [37] Jiang, Xiaofei, Zhang, Nengling, Xiong, Nanqian, Liu, Yi, Cao, Jianfeng, Qiu, ShengXiang. Synthesis and Biological Evaluation of Novel Jatrorrhizine Derivatives with Amino Groups Linked at the 3-Position as Inhibitors of Acetylcholinesterase. JOURNAL OF CHEMISTRY[J]. 2017, 2017: https://doaj.org/article/1cbbe50620c4457784bf9b8b7ac8566d.[38] 朱春福, 邱声祥, 刘洪新, 谭海波, 袁尧, 徐志防. 桃金娘酮化合物及其在制备抗菌药物中的应用. 2017, http://ir.scbg.ac.cn/handle/344003/19347.[39] 黎灿, 徐汉虹, 刘洪新, 杨晓云, 谭海波, 邱声祥. 垂枝红千层叶化学成分的研究. 天然产物研究与开发[J]. 2017, 29(6): 954-958, http://210.77.82.179/handle/2SCSIERX/2049.[40] Li Can, Liu Hongxin, Zhao Liyun, Zhang Weimin, Qiu Shengxiang, Yang Xiaoyun, Tan Haibo. Antibacterial neolignans from the leaves of Melaleuca bracteata. FITOTERAPIA[J]. 2017, [41] Su, Zhiwei, Ma, Zhonghui, Ye, Li, Liu, Buming, Qiu, ShengXiang. N-CONTAINING PHYTOCHEMICALS FROM THE SEEDS OF Brucea javanica. CHEMISTRY OF NATURAL COMPOUNDS[J]. 2017, 53(4): 799-801, http://dx.doi.org/10.1007/s10600-017-2127-8.[42] Tan, Haibo, Liu, Hongxin, Zhao, Liyun, Yuan, Yao, Li, Bailin, Jiang, Yueming, Gong, Liang, Qiu, Shengxiang. Structure-activity relationships and optimization of acyclic acylphloroglucinol analogues as novel antimicrobial agents. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY[J]. 2017, 125: 492-499, http://dx.doi.org/10.1016/j.ejmech.2016.09.054.[43] Song, JiaLing, Yuan, Yao, Tan, HaiBo, Huang, RiMing, Liu, HongXin, Xu, ZhiFang, Qiu, ShengXiang. Anti-inflammatory and antimicrobial coumarins from the stems of Eurya chinensis. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH[J]. 2017, 19(3): 222-228, https://www.webofscience.com/wos/woscc/full-record/WOS:000395748700004.[44] 张嫩玲, 蔡佳仲, 胡英杰, 陶玲, 田璧榕, 邱声祥. 木豆叶的化学成分研究. 中药材[J]. 2017, 40(5): 1116-1118, http://lib.cqvip.com/Qikan/Article/Detail?id=674634061.[45] Zhou, WenLi, Tan, HaiBo, Qiu, ShengXiang, Chen, GuangYing, Liu, HongXin, Zheng, Chao. Biomimetic total synthesis and structure confirmation of myrtucommulone K. TETRAHEDRON LETTERS[J]. 2017, 58(19): 1817-1821, http://dx.doi.org/10.1016/j.tetlet.2017.03.059.[46] Liu, HongXin, Tan, HaiBo, Liu, Yuan, Chen, YuChan, Li, SaiNi, Sun, ZhangHua, Li, HaoHua, Qiu, ShengXiang, Zhang, WeiMin. 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NATURAL PRODUCT RESEARCH[J]. 2013, 27(20): 1902-1905, http://ir.scbg.ac.cn/handle/344003/18384.[103] 付洪瑜, 杨建香, 邱声祥, 吴惠勤, 黄晓兰, 胡英杰. HPLC-MS_MS法测定大鼠血浆中麻醉椒苦素的浓度及其药动学研究. 药物分析杂志[J]. 2013, 33(9): 1480-1485, http://ir.scbg.ac.cn/handle/344003/18902.[104] Liu, HaiYang, Mahmood, Mian H R, Qiu, ShengXiang Samuel, Chang, Chi K. Recent developments in manganese corrole chemistry. COORDINATION CHEMISTRY REVIEWS[J]. 2013, 257(7-8): 1306-1333, http://dx.doi.org/10.1016/j.ccr.2012.12.017.[105] Koh, JunJie, Qiu, Shengxiang, Zou, Hanxun, Lakshminarayanan, Rajamani, Li, Jianguo, Zhou, Xiaojun, Tang, Charles, Saraswathi, Padmanabhan, Verma, Chandra, Tan, Donald T H, Tan, Ai Ling, Liu, Shouping, Beuerman, Roger W. Rapid bactericidal action of alpha-mangostin against MRSA as an outcome of membrane targeting. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES[J]. 2013, 1828(2): 834-844, http://ir.scbg.ac.cn/handle/344003/17681.[106] 杨建香, 邱声祥, 余志刚, 林永成. 南海红树林内生真菌GX-5b代谢产物研究. 江苏农业科学[J]. 2013, 41(10): 330-332, http://lib.cqvip.com/Qikan/Article/Detail?id=47630625.[107] 苏志维, Qiu Shengxiang. 鸦胆子果实的化学成分研究. 热带亚热带植物学报[J]. 2013, 21(5): 466-470, http://lib.cqvip.com/Qikan/Article/Detail?id=47254677.[108] 杨建香, 邱声祥, 佘志刚, 林永成. 南海红树林内生真菌5094代谢产物研究. 时珍国医国药[J]. 2013, 24(5): 1059-1061, http://lib.cqvip.com/Qikan/Article/Detail?id=46104968.[109] Su, Zhiwei, Hao, Jing, Xu, Zhifang, Huang, Riming, Zhang, Nenling, Qiu, Shengxiang. A new quassinoid from fruits of Brucea javanica. NATURAL PRODUCT RESEARCH[J]. 2013, 27(21): 2016-2021, http://ir.scbg.ac.cn/handle/344003/17758.[110] Zhong Yanxia, Huang Riming, Zhou Xiaojun, Zhu Yuehui, Xu Zhifang, Qiu Shengxiang. 交趾黄檀心材化学成分的研究. 天然产物研究与开发[J]. 2013, 25(11): 1515-15108, http://ir.scbg.ac.cn/handle/344003/18964.[111] Sheng-Xiang QIU. Chemical Compositions and Cytotoxic Activities of petroleum ether extract from fruits of Brucea Javanica (Simarubaceae). Tropical Journal of Pharmaceutical Research. 2013, [112] 杨建香, 邱声祥, 余志刚, 林永成. 南海红树林内生真菌Gx-4c代谢产物研究. 广西农学报[J]. 2013, 28(1): 12-14, http://lib.cqvip.com/Qikan/Article/Detail?id=45980603.[113] Sheng-Xiang QIU. Chemical Constituents from the Heartwood of Dalbergia cochinensis. 天然产物研究与开发. 2013, [114] Sheng-Xiang QIU. A minor quassinoid from fruits of Brucea javanica. Natural Product Research. 2013, [115] Sheng-Xiang QIU. Rapid bactericidal action of a-mangostin against MRSA as an outcome of membrane targeting. Biochim Biophys Acta-biomembrane. 2013, [116] Zou, Hanxun, Koh, JunJie, Li, Jianguo, Qiu, Shenxiang, Aung, Thet Tun, Lin, Huifen, Lakshminarayanan, Rajamani, Dai, Xiaoping, Tang, Charles, Lim, Fang Hui, Zhou, Lei, Tan, Ai Ling, Verma, Chandra, Tan, Donald T H, Chan, Hardy Sze On, Saraswathi, Padmanabhan, Cao, Derong, Liu, Shouping, Beuerman, Roger W. Design and Synthesis of Amphiphilic Xanthone-Based, Membrane-Targeting Antimicrobials with Improved Membrane Selectivity. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2013, 56(6): 2359-2373, http://ir.scbg.ac.cn/handle/344003/17709.[117] 杨建香, 邱声祥, 佘志刚, 林永成. 南海红树林内生真菌Gx-5代谢产物研究. 化工技术与开发[J]. 2013, 42(3): 1-3+57, http://lib.cqvip.com/Qikan/Article/Detail?id=45923168.[118] Chen, Yinning, Li, Na, Zhu, Yuehui, Zhang, Cuilan, Jiang, Xiaofei, Yang, Jianxiang, Xu, Zhifang, Qiu, Samuel X, Huang, Riming. Dibenzylbutane Lignans from the Stems of Schisandra bicolor. NATURAL PRODUCT COMMUNICATIONS[J]. 2013, 8(8): 1121-1122, http://ir.scbg.ac.cn/handle/344003/17646.[119] 苏志维, 邱声祥. 鸦胆子果实的化学成分研究. 热带亚热带植物学报[J]. 2013, 21(5): 466-470, http://lib.cqvip.com/Qikan/Article/Detail?id=47254677.[120] Falodun, A, Qiu ShengXiang, Parkinson, G, Gibbons, S. ISOLATION AND CHARACTERIZATION OF A NEW ANTICANCER DITERPENOID FROM JATROPHA GOSSYPIFOLIA. PHARMACEUTICAL CHEMISTRY JOURNAL[J]. 2012, 45(10): 636-639, http://ir.scbg.ac.cn/handle/344003/17397.[121] 张贵林, 洪挺, 张嫩玲, 余勃, 邱声祥, 陆豫. _E_2_3_3_三甲基_4_甲_省略_3_二氢苯并呋喃的合成及机理研究. 化学通报[J]. 2012, 75(6): 565-568, http://ir.scbg.ac.cn/handle/344003/13590.[122] Man-qin FU, Dun DENG, Shi-xiu FENG, Ri-ming HUANG, Shuai TIAN, Sheng-xiang QIU. Chemical Constituents from Roots of Flemingia philippinensis. CHINESE HERBAL MEDICINES[J]. 2012, 4(1): 8-11, http://lib.cqvip.com/Qikan/Article/Detail?id=1002074371.[123] Sheng-Xiang QIU. Interaction of apseudolaric acid B with the colchicine site of tubulin. Biochemical Pharmacology. 2012, [124] Sheng-Xiang QIU. Metabolites of mangrove endophytic fungus SK7RN3G1 from South China Sea. zhongguo Shiyan Fangjixue Zazhi. 2012, [125] 徐志防. Polyprenylated isoflavanone and isoflavonoids from Ormosia henryi and their cytotoxic and anti-oxidation activity. Fitoterapia. 2012, [126] Feng, Shixiu, Bai, Jijiang, Qiu Samuel, Shengxiang, Li, Yong, Chen, Tao. Iridoid and Phenolic Glycosides from the Roots of Prismatomeris connata. NATURAL PRODUCT COMMUNICATIONS[J]. 2012, 7(5): 561-562, http://ir.scbg.ac.cn/handle/344003/17408.[127] Fu, Manqin, Feng, Shixiu, Zhang, Nenling, Zhou, Xiaojun, Huang, Riming, Huang, Huijuan, Xu, Zhifang, Li, Xue, Qiu, Samuel X. A New Prenylated Isoflavone and a New Flavonol Glycoside from Flemingia philippinensis. HELVETICA CHIMICA ACTA[J]. 2012, 95(4): 598-605, http://dx.doi.org/10.1002/hlca.201100360.[128] Zhang, NenLing, Zhu, YueHui, Huang, RiMing, Fu, ManQin, Su, ZhiWei, Cai, JiaZhong, Hu, YingJie, Qiu, ShengXiang. Two New Stilbenoids from Cajanus cajan. ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES[J]. 2012, 67(12): 1314-1318, http://ir.scbg.ac.cn/handle/344003/17522.[129] 张贵林, 洪挺, 张嫩玲, 余勃, 邱声祥, 陆豫. （E）-2，3，3-三甲基-4-甲氧基-5-（3’-甲基-2’-丁烯基）-6-苯乙烯基-2，3-二氢苯并呋喃的合成及机理研究. 化学通报[J]. 2012, 75(6): 565-568, http://lib.cqvip.com/Qikan/Article/Detail?id=42388906.[130] Zhang NenLing, Zhu YueHui, Huang RiMing, Fu ManQin, Su ZhiWei, Cai JiaZhong, Hu YingJie, Qiu ShengXiang. Two New Stilbenoids from Cajanus cajan. ZEITSCHRIFT FÜR NATURFORSCHUNG B[J]. 2012, [131] Zhou, Xiaojun, Huang, Riming, Hao, Jing, Huang, Huijuan, Fu, Manqin, Xu, Zhifang, Zhou, Yongmei, Li, XuE, Qiu, Samuel X, Wang, Bin. Two New Prenylated Xanthones from the Pericarp of Garcinia mangostana (Mangosteen). HELVETICA CHIMICA ACTA[J]. 2011, 94(11): 2092-2098, http://ir.scbg.ac.cn/handle/344003/17268.[132] Sheng-Xiang QIU. Kava and kava hepatotoxicity: requirements for novel experimental, ethanobotanical, and clinical studies based on a review of evidence. Phytotherapy Research. 2011, [133] 张嫩玲, 蔡佳仲, 黄日明, 胡英杰, 薛云, 邱声祥. 滇杠柳的化学成分研究. 中草药[J]. 2011, 42(10): 1909-1912, http://lib.cqvip.com/Qikan/Article/Detail?id=39648383.[134] Teschke, Rolf, Qiu, Samuel X, Lebot, Vincent. Herbal hepatotoxicity by kava: Update on pipermethystine, flavokavain B, and mould hepatotoxins as primarily assumed culprits. DIGESTIVE AND LIVER DISEASE[J]. 2011, 43(9): 676-681, http://dx.doi.org/10.1016/j.dld.2011.01.018.[135] 郝静, 冯世秀, 邱声祥, 陈涛. 黄根中的蒽醌苷成分（英文）. 中国天然药物[J]. 2011, 9(1): 42-45, http://lib.cqvip.com/Qikan/Article/Detail?id=36487548.[136] Hao, Jing, Pei, Ying, Ji, Guiyuan, Li, Weijie, Feng, Shixiu, Qiu, Shengxiang. Autophagy is induced by 3 beta-O-succinyl-lupeol (LD9-4) in A549 cells via up-regulation of Beclin 1 and down-regulation mTOR pathway. EUROPEAN JOURNAL OF PHARMACOLOGY[J]. 2011, 670(1): 29-38, http://dx.doi.org/10.1016/j.ejphar.2011.08.045.[137] Jing Hao, Ying Pei, Guiyuan Ji, Weijie Li, Shixiu Feng, Shengxiang Qiu. Autophagy is induced by 3β-O-succinyl-lupeol (LD9-4) in A549 cells via up-regulation of Beclin 1 and down-regulation mTOR pathway. EUROPEAN JOURNAL OF PHARMACOLOGY[J]. 2011, 670(1): 29-38, http://dx.doi.org/10.1016/j.ejphar.2011.08.045.[138] Feng, Lingling, Zhou, Li, Sun, Yao, Gui, Jie, Wang, Xiaofeng, Wu, Ping, Wan, Jian, Ren, Yanliang, Qiu, Shengxiang, Wei, Xiaoyi, Li, Jun. Specific inhibitions of annonaceous acetogenins on class II 3-hydroxy-3-methylglutaryl coenzyme A reductase from Streptococcus pneumoniae. BIOORGANIC & MEDICINAL CHEMISTRY[J]. 2011, 19(11): 3512-3519, http://dx.doi.org/10.1016/j.bmc.2011.04.019.[139] Feng SX, Hao J, Chen T, Qiu SX. A new anthraquinone and two new tetrahydroanthraquinone from the root of Prismatomeris connata. HELVETICA CHIMICA ACTA[J]. 2011, 94(10): 1843-1849, http://ir.scbg.ac.cn/handle/344003/17333.[140] 洪挺, 余勃, 陆豫, 邱声祥. 鸡蛋花中化学成分及生物活性研究进展. 天然产物研究与开发[J]. 2011, 23(3): 565+568-570+589, http://lib.cqvip.com/Qikan/Article/Detail?id=38510803.[141] Sheng-Xiang QIU. Prismatomeris connata; Anthraquinone glycosides; Cytotoxic activity. Chinese Journal of Natural Medicines. 2011, [142] Qi, Jin, Li, Na, Zhou, JiaHong, Yu, BoYang, Qiu, Samuel X. Isolation and Anti-Inflammatory Activity Evaluation of Triterpenoids and a Monoterpenoid Glycoside from Harpagophytum procumbens. PLANTAMEDICA[J]. 2010, 76(16): 1892-1896, https://www.webofscience.com/wos/woscc/full-record/WOS:000284144400020.[143] 关中, 邱声祥, 许海艳, 徐杰. 山竹酮抑制人下咽癌FaDu细胞株的增殖作用及其机制研究. 国际医药卫生导报[J]. 2010, 16(19): 2330-2333, http://lib.cqvip.com/Qikan/Article/Detail?id=35489558.[144] Zhang, Yaozheng, Song, Zhijun, Hao, Jing, Qiu, Shengxiang, Xu, Zhifang. Two new prenylated xanthones and a new prenylated tetrahydroxanthone from the pericarp of Garcinia mangostana. FITOTERAPIA[J]. 2010, 81(6): 595-599, http://ir.scbg.ac.cn/handle/344003/17186.[145] Zhou P, Gross S, Liu JH, Yu BY, Feng LL, Nolta J, Sharma V, David PW, Qiu SX. Flavokawain B, the hepatotoxic constituent from kava root, induces GSH-sensitive oxidative stress through modulation of IKK/NF- B and MAPK signaling pathways. FASEB JOURNAL[J]. 2010, 24(12): 4722-4732, http://ir.scbg.ac.cn/handle/344003/17072.[146] Prasad, K Nagendra, Xie, Haihui, Hao, Jing, Yang, Bao, Qiu, Shengxiang, Wei, Xiaoyi, Chen, Fang, Jiang, Yueming. Antioxidant and anticancer activities of 8-hydroxypsoralen isolated from wampee Clausena lansium (Lour.) Skeels peel. FOOD CHEMISTRY[J]. 2010, 118(1): 62-66, http://dx.doi.org/10.1016/j.foodchem.2009.04.073.[147] Wang, Nan, Shen, Lianqing, Qiu, Shengxiang, Wang, Xiangyang, Wang, Kuiwu, Hao, Jing, Xu, Mingfeng. Analysis of the isothiocyanates present in three Chinese Brassica vegetable seeds and their potential anticancer bioactivities. EUROPEAN FOOD RESEARCH AND TECHNOLOGY[J]. 2010, 231(6): 951-958, http://ir.scbg.ac.cn/handle/344003/17103.[148] Feng, Shixiu, Xu, Liangxiong, Wu, Min, Hao, Jing, Qiu, Samuel X, Wei, Xiaoyi. A new coumarin from Sarcandra glabra. FITOTERAPIA[J]. 2010, 81(6): 472-474, http://ir.scbg.ac.cn/handle/344003/17200.[149] Sheng-Xiang QIU. A novel D2-symmetric chiral tetraoxazoline ligand for highly enantioselective hydrosilylation of aromatic ketones. Advanced Synthesis Catalysis. 2010, [150] Li, Wei Jie, Le Xu, Zun, Qiu, Sheng Xiang. Concise methods for the synthesis of chiral polyoxazolines and their application in asymmetric hydrosilylation. BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY[J]. 2010, 6(1): http://ir.scbg.ac.cn/handle/344003/17182.[151] Li, Wei Jie, Qiu, Sheng Xiang. A Facile and Efficient Synthesis of Bis(oxazoline)s. JOURNAL OF HETEROCYCLIC CHEMISTRY[J]. 2010, 47(6): 1340-1343, https://www.webofscience.com/wos/woscc/full-record/WOS:000284740700013.[152] Prasad, K Nagendra, Hao, Jing, Yi, Chun, Zhang, Dandan, Qiu, Shengxiang, Jiang, Yueming, Zhang, Mingwei, Chen, Feng. Antioxidant and Anticancer Activities of Wampee (Clausena lansium (Lour.) Skeels) Peel. JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY[J]. 2009, http://ir.scbg.ac.cn/handle/344003/16968.[153] Qiu, Samuel X. Natural Products Regain Attention in Oncology. TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH. 2009, 8(5): 383-384, http://ir.scbg.ac.cn/handle/344003/17000.[154] Prasad, K Nagendra, Hao, Jing, Shi, John, Liu, Ting, Li, Jiang, Wei, Xiaoyi, Qiu, Shengxiang, Xue, Sophia, Jiang, Yueming. Antioxidant and anticancer activities of high pressure-assisted extract of longan (Dimocarpus longan Lour.) fruit pericarp. INNOVATIVE FOOD SCIENCE & EMERGING TECHNOLOGIES[J]. 2009, 10(4): 413-419, http://dx.doi.org/10.1016/j.ifset.2009.04.003.[155] Sheng-Xiang QIU. Analysis of flavone-C-glycosides from Passiflora Incarnate L. by tandem mass spectrometry. 分析测试学报. 2008, [156] Gu, Qiong, Zhang, XueMei, Zhou, Jun, Qiu, ShengXiang, Chen, JiJun. One new dihydrobenzofuran lignan from Vitex trifolia. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH[J]. 2008, 10(6): 499-502, https://www.webofscience.com/wos/woscc/full-record/WOS:000257341400003.[157] 戚进, 周家宏, 陈露, 陈纪军, 邱声祥, 余伯阳. 魔鬼爪化学成分的研究. 中国药学杂志[J]. 2006, 41(21): 1613-1615, http://www.irgrid.ac.cn/handle/1471x/432845.[158] 刘荣华, 余伯阳, 邱声祥, 白桂昌. 山楂叶中多元酚类成分抗超氧阴离子活性研究及构效关系分析. 中国药学杂志[J]. 2005, 40(14): 1066-1069, http://lib.cqvip.com/Qikan/Article/Detail?id=18057132.[159] 周俊, 邱声祥, 张壮鑫. 雀瓢的黄酮醇成分. 云南植物研究[J]. 1990, 12(2): 227-, http://www.irgrid.ac.cn/handle/1471x/432914.[160] 周俊, 邱声祥, 张壮鑫. 蔓生白薇中白薇新甙的分离和结构鉴定. 药学学报[J]. 1990, 25(6): 473-, http://www.irgrid.ac.cn/handle/1471x/432797.[161] 张壮鑫, 周俊, 邱声祥. 合掌消的甾体成分. 云南植物研究[J]. 1990, 12(1): 107-, http://www.irgrid.ac.cn/handle/1471x/432524.[162] 陈纪军, 周俊, 张壮鑫, 邱声祥. 云南匙羹藤的化学成分. 云南植物研究[J]. 1989, 11(2): 203-, http://www.irgrid.ac.cn/handle/1471x/433276.[163] 邱声祥, 李德铢, 张壮鑫, 周, 俊, 吴征镒. 鹅绒藤属及其近缘属的化学分类-兼论Vincetoxicum 的恢复问题. 云南植物研究[J]. 1989, 11(1): 41-50, http://www.irgrid.ac.cn/handle/1471x/431817.[164] Li Shenghong, Qiu Shengxiang, Yao Ping, Sun Handong, Fong Harry H. S., Zhang Hongjie. Compounds from the Fruits of the Popular European Medicinal Plant Vitex agnus-castus in Chemoprevention via NADP(H):Quinone Oxidoreductase Type 1 Induction. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE : ECAM. 2013: http://www.irgrid.ac.cn/handle/1471x/660298.
科研活动
科研项目
（ 1 ） 调控基质干细胞定向分化新结构天然产物的发现及其减肥作用机制研究, 主持, 省级, 2010-10--2012-09（ 2 ） 三种岭南特色植物抗癌活性先导化合物的研究, 主持, 国家级, 2010-01--2012-12（ 3 ） 治疗糖尿病候选药物树豆酮酸A的研究, 主持, 省级, 2010-01--2013-06（ 4 ） 岭南特色药用植物的生物活性成分及其作用机制研究, 主持, 部委级, 2009-01--2013-12（ 5 ） 功能性天然生物色素产学研结合示范基地, 参与, 省级, 2012-02--2014-02（ 6 ） 广州市功能性类胡萝卜素研究企业重点实验室, 参与, 省级, 2013-03--2015-02（ 7 ） 千斤拔抗癌活性先导化合物及其作用机制, 主持, 国家级, 2014-01--2014-12（ 8 ） 抗HIV天然药物及中药复方优化和中医动物模型研究, 主持, 国家级, 2008-01--2010-12（ 9 ） 抗艾滋病中药新药艾可清II号的研究, 主持, 国家级, 2009-01--2011-12（ 10 ） 治疗糖尿病1类新药树豆酮酸A的研究与开发, 主持, 国家级, 2009-01--2011-12（ 11 ） 华南植物资源药物筛选网络实验室, 主持, 部委级, 2009-10--2010-09（ 12 ） 饲料级植物源性虾青素的研发及产业化, 参与, 省级, 2010-01--2011-12（ 13 ） 万寿菊花的精深加工技术及其产业化, 参与, 省级, 2009-01--2010-12（ 14 ） 微生物发酵生产虾青素关键技术研发与产业化, 参与, 省级, 2014-12--2017-11（ 15 ） 桃金娘抗耐药金黄色葡萄球菌活性成分的发现、作用机制和产业化应用, 主持, 省级, 2016-01--2018-12（ 16 ） 潜伏病毒活化中药方药的优化研究, 主持, 国家级, 2014-01--2016-12（ 17 ） Betulinic acid的高效提取和产业化及重要资源植物米粹花的品种选育, 主持, 部委级, 2016-11--2018-06（ 18 ） 妇女更年期综合症和男性疲劳综合症特殊功能食品及相关配套产品的研发, 主持, 院级, 2017-02--2022-02（ 19 ） 特殊功能食品及相关配套产品的研发, 主持, 院级, 2017-02--2022-02（ 20 ） 植物精华功能性护肤品研发及产业化, 主持, 院级, 2018-02--2023-02（ 21 ） 癌症健康管理相关配套天然植物产品的研发, 主持, 院级, 2017-02--2022-04（ 22 ） 男女性亚健康调理等相关产品研发及产业化, 主持, 院级, 2018-01--2021-01
指导学生
已指导学生
郝静 博士研究生 071010-生物化学与分子生物学
冯世秀 博士研究生 071010-生物化学与分子生物学
张耀政 硕士研究生 071010-生物化学与分子生物学
傅曼琴 博士研究生 071010-生物化学与分子生物学
张嫩玲 博士研究生 071010-生物化学与分子生物学
钟艳霞 硕士研究生 071010-生物化学与分子生物学
苏志维 博士研究生 071010-生物化学与分子生物学
贺峦 硕士研究生 071010-生物化学与分子生物学
张巧 硕士研究生 071010-生物化学与分子生物学
刘洪新 博士研究生 071010-生物化学与分子生物学
刘新红 硕士研究生 071010-生物化学与分子生物学
张立得 硕士研究生 071010-生物化学与分子生物学
宋家玲 博士研究生 071010-生物化学与分子生物学
牛佳 硕士研究生 071010-生物化学与分子生物学
袁尧 博士研究生 071010-生物化学与分子生物学
李百琳 硕士研究生 071010-生物化学与分子生物学
现指导学生
赵丽云 博士研究生 071010-生物化学与分子生物学
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