基本信息
赵勤实  男  博导  中国科学院昆明植物研究所
电子邮件: qinshizhao@mail.kib.ac.cn
通信地址: 昆明市蓝黑路132号
邮政编码: 650201
部门/实验室:植物化学与西部植物资源持续利用国家重点实验室

研究领域

天然药物化学,创新药与药现代化

招生信息

   
招生专业
100701-药物化学
招生方向
创新药和中药现代化

教育背景

1992-09--1995-10   中国科学院昆明植物研究所   理学博士
1989-09--1992-07   云南大学化学系   理学硕士
1981-09--1985-07   云南师范大学   学士
学历
中科院昆明植物研究所 -- 研究生
学位
中科院昆明植物研究所 -- 博士
出国学习工作
1999年至2000年3月,日本静冈县立大学客座研究

工作经历

   
工作简历
2010-07~2015-07,中国科学院昆明植物研究所, 公共技术服务中心主任
2006-11~2013-06,中国科学院昆明植物研究所, 国家重点实验室副主任
2006-01~2006-03,日本静冈县立大学药学部生化教室, 访问学者
2002-04~2013-06,中国科学院昆明植物研究所, 研究员
2000-04~2002-03,中国科学院昆明植物研究所, 副研究员
1999-01~2000-03,日本静冈县立大学药学部药品制造教室, 客座研究
1998-04~1999-01,中国科学院昆明植物研究所, 副研究员
1995-12~1998-03,军事医学科学院毒物药物研究所, 博士后
1985-07~1989-08,大理师范专科学校, 助教
社会兼职
2013-01-01-2018-12-30,中国植物学会植物资源与植物化学专业委员会, 委员
2010-11-01-2014-12-31,中国花卉协会蕨类植物协会, 理事
2010-08-01-2013-08-31,广西植物功能物质研究与利用重点实验室学术委员会, 主任
2008-01-01-2013-12-31,中国植物学会植物资源与植物化学专业委员会, 委员

教授课程

天然药物化学

专利与奖励

1. 5/7/6型紫杉烷二萜化合物,其药物组合物和其合成方法和用途,授权号 CN 101260040 B 
2. 5/7/6型13(15)位环氧紫杉烷二萜化合物,其药物组合物和其合成方法和用途,公开号 CN 101255146 A
奖励信息
(1) 朱李月华优秀教师奖, 一等奖, 院级, 2014
(2) 云南省政府特殊津贴, 一等奖, 省级, 2013
(3) 云南省自然科学奖, 二等奖, 省级, 2003
专利成果
( 1 )  5/7/6型紫杉烷二萜化合物,其药物组合物和其合成方法和用途, 发明, 2011, 第 1 作者, 专利号: CN 101260040 B
( 2 ) 5/7/6型13(15)位环氧紫杉烷二萜化合物,其药物组合物和其用途, 发明, 2008, 第 1 作者, 专利号: CN 101255146 A
( 3 ) 贝壳杉烷型二萜衍生物及其药物组合物和其在医药中的用途, 发明, 2014, 第 1 作者, 专利号: CN102603519B
( 4 ) 景洪哥纳香甲素衍生物及其在制药中的应用, 发明, 2015, 第 1 作者, 专利号: ZL201310034985.5
( 5 ) 石松生物碱类化合物,其药物组合物及其制备方法和用途, 发明, 2017, 第 1 作者, 专利号: ZL201610800773.7

出版信息

1. He, J.; Chen, X. Q.; Li, M. M.; Zhao, Y.; Xu, G.; Cheng, X.; Peng, L. Y.; Xie, M. J.; Zheng, Y. T.; Wang, Y. P.; Zhao, Q. S., Lycojapodine A, a Novel Alkaloid from Lycopodium japonicum. Organic Letters 2009, 11 (6), 1397-1400
2. Li, X. L.; Cheng, X.; Yang, L. M.; Wang, R. R.; Zheng, Y. T.; Xiao, W. L.; Zhao, Y.; Xu, G.; Lu, Y.; Chang, Y.; Zheng, Q. T.; Zhao, Q. S.; Sun, H. D., Dichotomains A and B: Two new highly oxygenated phenolic derivatives from Dicranopteris dichotoma. Organic Letters 2006, 8 (9), 1937-1940
3. Xu, G.; Hou, A. J.; Wang, R. R.; Liang, G. Y.; Zheng, Y. T.; Liu, Z. Y.; Li, X. L.; Zhao, Y.; Huang, S. X.; Peng, L. Y.; Zhao, Q. S., Przewalskin A: A new C-23 terpenoid with a 6/6/7 carbon ring skeleton from Salvia przewalskii maxim. Organic Letters 2006, 8 (20), 4453-4456
4. Xu, G.; Hou, A. J.; Zheng, Y. T.; Zhao, Y.; Li, X. L.; Peng, L. Y.; Zhao, Q. S., Przewalskin B, a novel diterpenoid with an unprecedented skeleton from Salvia przewalskii maxim. Organic Letters 2007, 9 (2), 291-293.
5. Zhao, Y.; Zhang, H. B.; Liu, J. K.; Su, J.; Li, Y.; Yao, Z. J.; Zhao, Q. S., Fragmentations of 13-oxo-taxyunnansin A and their application to preparation of abeo-paclitaxel and abeo-docetaxel analogues. Tetrahedron Letters 2011, 52 (1), 139-142
6. Wang, K.; Zhou, X. Y.; Wang, Y. Y.; Li, M. M.; Li, Y. S.; Peng, L. Y.; Cheng, X. A.; Li, Y.; Wang, Y. P.; Zhao, Q. S., Macrophyllionium and Macrophyllines A and B, Oxindole Alkaloids from Uncaria macrophylla. Journal of Natural Products 2011, 74 (1), 12-15
7. Pan, Z. H.; Cheng, J. T.; He, J. A.; Wang, Y. Y.; Peng, L. Y.; Xu, G.; Sun, W. B.; Zhao, Q. S., Splendidins A-C, Three New Clerodane Diterpenoids from Salvia splendens. Helvetica Chimica Acta 2011, 94 (3), 417-422
8. Hu, J. A.; Chen, X. Q.; Zhao, Q. S., Triterpenoids from Viburnum betulifolium. Journal of Asian Natural Products Research 2011, 13 (2), 105-110
9. Dong, L. B.; He, J.; Wang, Y. Y.; Wu, X. D.; Deng, X.; Pan, Z. H.; Xu, G.; Peng, L. Y.; Zhao, Y.; Li, Y.; Gong, X.; Zhao, Q. S., Terpenoids and Norlignans from Metasequoia glyptostroboides. Journal of Natural Products 2011, 74 (2), 234-239
10. Chen, X. Q.; Li, Y.; He, J.; Cheng, X.; Wang, K.; Li, M. M.; Pan, Z. H.; Peng, L. Y.; Zhao, Q. S., Triterpenoids and Diterpenoids from Viburnum chingii. Chemical & Pharmaceutical Bulletin 2011, 59 (4), 496-498
11. Zhao, Q. S.; Ji, Q. X.; Cheng, X. J.; Sun, G. Z.; Ran, C.; Zhao, B.; Chen, X. G., Preparation of alginate coated chitosan hydrogel beads by thermosensitive internal gelation technique. Journal of Sol-Gel Science and Technology 2010, 54 (2), 232-237
12. Xu, G.; Yang, J.; Wang, Y. Y.; Peng, L. Y.; Yang, X. W.; Pan, Z. H.; Liu, E. D.; Li, Y.; Zhao, Q. S., Diterpenoid Constituents of the Roots of Salvia digitaloides. Journal of Agricultural and Food Chemistry 2010, 58 (23), 12157-12161
13. Xu, G.; Peng, L. Y.; Shen, X. L.; Zhao, Q. S., Interconvertible Eudesmanolides Containing a 6,12-Hemiketal Function from Salvia castanea DIELS f. tomentosa STIB. Helvetica Chimica Acta 2010, 93 (9), 1773-1778
14. Wang, K.; Li, M. M.; Chen, X. Q.; Peng, L. Y.; Cheng, X.; Li, Y.; Zhao, Q. S., Phenolic Constituents from Brainea insignis. Chemical & Pharmaceutical Bulletin 2010, 58 (6), 868-871
15. Pan, Z. H.; Wang, Y. Y.; Li, M. M.; Xu, G.; Peng, L. Y.; He, J. A.; Zhao, Y.; Li, Y.; Zhao, Q. S., Terpenoids from Salvia trijuga. Journal of Natural Products 2010, 73 (6), 1146-1150
16. Pan, Z. H.; He, J. A.; Li, Y.; Zhao, Y.; Wu, X. D.; Wang, K.; Peng, L. Y.; Xu, G.; Zhao, Q. S., Castanolide and epi-castanolide, two novel diterpenoids with a unique seco-norabietane skeleton from Salvia castanea Diels f. pubescens Stib. Tetrahedron Letters 2010, 51 (38), 5083-5085
17. Chen, X. Q.; Li, Y.; Cheng, X.; Wang, K.; He, J.; Pan, Z. H.; Li, M. M.; Peng, L. Y.; Xu, G.; Zhao, Q. S., Polycyclic Polyprenylated Acylphloroglucinols and Chromone O-Glucosides from Hypericum henryi subsp uraloides. Chemistry & Biodiversity 2010, 7 (1), 196-204
18. Xu, G.; Peng, L. Y.; Tu, L.; Li, X. L.; Zhao, Y.; Zhang, P. T.; Zhao, Q. S., Three New Diterpenoids from Salvia przewalskii MAXIM. Helvetica Chimica Acta 2009, 92 (2), 409-413
19. Tu, L.; Xu, G.; Zhao, Y.; Peng, L. Y.; He, J.; Guo, N.; Zhao, Q. S., Seven New Phenolic Glucosides from Viburnum cylindricum. Helvetica Chimica Acta 2009, 92 (7), 1324-1332
20. Li, M. M.; Wang, K.; Pan, Z. H.; Chen, X. Q.; Peng, L. Y.; Li, Y.; Cheng, X.; Zhao, Q. S., Two New Sesquiterpene Glucosides from Dennstaedtia scabra (WALL.) MOORE. Chemical & Pharmaceutical Bulletin 2009, 57 (10), 1123-1125
21. Zhao, Y.; Guo, N.; Lou, L. G.; Cong, Y. W.; Peng, L. Y.; Zhao, Q. S., Synthesis, cytotoxic activity, and SAR analysis of the derivatives of taxchinin A and brevifoliol. Bioorganic & Medicinal Chemistry 2008, 16 (9), 4860-4871
22. Xu, G.; Peng, L. Y.; Hou, A. J.; Yang, J.; Han, Q. B.; Xu, H. X.; Zhao, Q. S., Isolation, structural elucidation, and chemical transformation of interconvertible 8,12-hemiketal germacranolide sesquiterpenoids from Salvia castanea Diels f. tomentosa Stib. Tetrahedron 2008, 64 (40), 9490-9494
23. Tu, L.; Zhao, Y.; Yu, Z. Y.; Cong, Y. W.; Xu, G.; Peng, L. Y.; Zhang, P. T.; Cheng, X.; Zhao, Q. S., Six new dammarane triterpenoids from Viburnum cylindricum. Helvetica Chimica Acta 2008, 91 (8), 1578-1587
24. Li, X. L.; Tu, L.; Zhao, Y.; Peng, L. Y.; Xu, G.; Cheng, X.; Zhao, Q. S., Terpenoids from two Dicranopteris species. Helvetica Chimica Acta 2008, 91 (5), 856-861
25. Zhao, Y.; Niu, X. M.; Qian, L. P.; Liu, Z. Y.; Zhao, Q. S.; Sun, H. D., Synthesis and cytotoxicity of some new eriocalyxin B derivatives. European Journal of Medicinal Chemistry 2007, 42 (4), 494-502
26. Zhao, Q. S.; Cong, Y. W., Michael reaction acceptor molecules in chemical biology. Progress in Chemistry 2007, 19 (12), 1972-1976
27. Li, X. L.; Yang, L. M.; Zhao, Y.; Wang, R. R.; Xu, G.; Zheng, Y. T.; Tu, L.; Peng, L. Y.; Cheng, X.; Zhao, Q. S., Tetranorclerodanes and clerodane-type diterpene glycosides from Dicranopteris dichotoma. Journal of Natural Products 2007, 70 (2), 265-268
28. Zhao, Y.; Wang, F. S.; Peng, L. Y.; Li, X. L.; Xu, G.; Luo, X. X.; Lu, Y.; Wu, L.; Zheng, Q. T.; Zhao, Q. S., Taxoids from Taxus chinensis. Journal of Natural Products 2006, 69 (12), 1813-1815
29. Xu, G.; Peng, L. Y.; Lu, L.; Weng, Z. Y.; Zhao, Y.; Li, X. L.; Zhao, Q. S.; Sun, H. D., Two new abietane diterpenoids from Salvia yunnanensis. Planta Medica 2006, 72 (1), 84-86
30. Li, X. L.; Zhao, Y.; Cheng, X.; Tu, L.; Peng, L. Y.; Xu, G.; Zhao, Q. S., Japonicumins A-D: Four new compounds from Lycopodium japonicum. Helvetica Chimica Acta 2006, 89 (7), 1467-1473
31. Xu, G.; Peng, L. Y.; Zhao, Y.; Li, X. L.; Tu, L.; Zhao, Q. S.; Sun, H. D., Two new icetexane diterpenoids from Salvia przewalskii. Chemical & Pharmaceutical Bulletin 2005, 53 (12), 1575-1576
发表论文
(1) Salvihispin A and its glycoside, two neo-clerodane diterpenoids with neurotrophic activities from Salvia hispanica L., Tetrahedron Letters, 2017, 通讯作者
(2) Lycodine-Type Lycopodium Alkaloids from the Whole Plants of Huperzia serrata., Natural Products and Bioprospecting, 2017, 通讯作者
(3) Protostane-type triterpenoids from Alisma orientale., Chem. Biodiversity, 2017, 通讯作者
(4) A biomimetic semisynthesis enables structural elucidation of selaginellin U: a tautomeric cyclic alkynylphenol from Selaginella tamariscina, Royal Society Open Science, 2017, 通讯作者
(5) Sesquiterpenoids from the twigs and leaves of Fokienia hodginsii, Journal of Asian Natural Products Research, 2017, 通讯作者
(6) Guaiane-type sesquiterpenoids from alismatis rhizoma and their anti-inflammatory activity, Chem. Pharm. Bull., 2017, 通讯作者
(7) Sauruchinenols A and B, unprecedented monocyclic diterpenes with new carbon skeleton from the aerial parts of Saururus chinensis., Fitoterapia, 2017, 通讯作者
(8) New neo-clerodane diterpenoids with neurotrophic activity from the aerial parts of Salvia tiliifolia., Fitoterapia, 2017, 通讯作者
(9) Synthesis of selective 11β-HSD1 inhibitors based on dammarane scaffold, Eur. J. Med. Chem., 2017, 通讯作者
(10) Total synthesis of (±)-cermizine B., J. Org. Chem., 2017, 通讯作者
(11) Lycoplanine A, a C16N Lycopodium alkaloid with a 6/9/5 tricyclic skeleton from Lycopodium complanatum., Org. Lett, 2017, 通讯作者
(12) Design, synthesis, and biological activities of vibsanin B Derivatives: A new class of HSP90 C-terminal inhibitors., J. Med. Chem., 2017, 通讯作者
(13) Natural Product Vibsanin A Induces Differentiation of Myeloid Leukemia Cells through PKC Activation., Cancer research, 2016, 通讯作者
(14) Collective formal synthesis of (+/-)-rhynchophylline and homologues, Rsc Advances, 2016, 通讯作者
(15) Bioactive sesquiterpenoids from the flowers of Inula japonica, Phytochemistry, 2016, 通讯作者
(16) Synthesis of hupehenols A, B, and E from protopanaxadiol., Rsc Advances, 2016, 通讯作者
(17) Synthesis of a Small-Molecule Library with Skeletal Diversity from Hemslecin A via the Reaction-Discovery Strategy, Organic letters, 2016, 通讯作者
(18) neo-Clerodanes from the aerial parts of Salvia leucantha., Tetrahedron, 2016, 通讯作者
(19) Obscurumines H-P, new Lycopodium alkaloids from the club moss Lycopodium obscurum., Fitoterapia, 2016, 通讯作者
(20) Vibsane-type diterpenes from leaves and twigs of Viburnum odoratissimum, Fitoterapia, 2016, 通讯作者
(21) Phleghenrines A-D and Neophleghenrine A, Bioactive and Structurally Rigid Lycopodium Alkaloids from Phlegmariurus henryi., Organic letters, 2016, 通讯作者
(22) Vinmajorines C-E, Monoterpenoid Indole Alkaloids from Vinca major, Helvetica Chimica Acta, 2016, 通讯作者
(23) Three new monoterpenoid indole alkaloids from Vinca major, Journal of Asian Natural Products Research, 2016, 通讯作者
(24) Hypophyllins A-D, labdane-type diterpenoids with vasorelaxant activity from Hypoestes phyllostachya ‘Rosea’., Org. Lett, 2016, 通讯作者
(25) Lyconadins G and H, Two Rare Lyconadin-Type Lycopodium alkaloids from Lycopodium complanatum., Nat. Prod. Bioprospect, 2016, 通讯作者
(26) Vibsanin B preferentially targets HSP90β, inhibits interstitial leukocyte migration, and ameliorates experimental autoimmune encephalomyelitis., The Journal of Immunology, 2015, 通讯作者
(27) Hupehenols A-E, selective 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) iInhibitors from Viburnum hupehense, Journal of Natural Products, 2015, 通讯作者
(28) Nor-lupane triterpenoid and guaiane sesquiterpenoids from Scheffler avenulosa, Fitoterapia, 2015, 通讯作者
(29) New cytotoxic and anti-inflammatory compounds isolated from Morus alba L, Nat Prod Res., 2015, 通讯作者
(30) Geissoschizine methyl ether N-oxide, a new alkaloid with antiacetylcholinesterase activity from Uncaria rhynchophylla., Nat Prod Res, 2015, 通讯作者
(31) Four new fawcettimine-related alkaloids from Phlegmariurus squarrosus, J Asian Nat Prod Res, 2015, 通讯作者
(32) Three new iridoids from two Viburnum species, J Asian Nat Prod Res, 2015, 通讯作者
(33) (±)-Salviaprione, a pair of unprecedented abietane-type diterpenoids from Salvia prionitis, Tetrahedron Lett, 2015, 通讯作者
(34) Identification and validation of p50 as the cellular target of eriocalyxin B, Oncotarget, 2014, 通讯作者
(35) Isolation and complete structural assignment of Lycopodium alkaloid cernupalhine A: theoretical prediction and total synthesis validation, Organic Letters, 2014, 通讯作者
(36) Vibsatins A and B, two new tetranorvibsane-type diterpenoids from Viburnum tinus cv. variegatus, Organic Letters, 2014, 通讯作者
(37) Isolation, characterisation, and antioxidant activities of flavonoids from chufa (Eleocharis tuberosa) peels, Food Chemistry, 2014, 通讯作者
(38) Sesquiterpenoids from Tussilago farfara and their inhibitory effects on nitric oxide production, Planta Medica, 2014, 通讯作者
(39) Synthesis and neurite outgrowth promoting activity of vibsanin B derivatives,  Tetrahedron Letters, 2014, 通讯作者
(40) Construction of tetracyclic 3-spirooxindole through cross-dehydrogenation of pyridinium: applications in facile synthesis of (±)-corynoxine and (±)-corynoxine B , Journal of the American Chemical Society , 2014, 通讯作者
(41) Hydrogen peroxide/ATR-Chk2 activation mediates p53 protein stabilization and anti-cancer activity of cheliensisin A in human cancer cells , Oncotarget, 2014, 通讯作者
(42) Vincamajorines A and B, monoterpenoid indole alkaloids with new carbon skeletons from Vinca major , Tetrahedron Letters, 2014, 通讯作者
(43) Crucial role of c-jun phosphorylation at Ser63/73 mediated by PHLPP protein degradation in the Cheliensisin A inhibition of cell transformation, Cancer Prevention Research, 2014, 通讯作者
(44) Lycospidine A, a New Type of Lycopodium Alkaloid from Lycopodium complanatum, Organic Lettes, 2013, 通讯作者
(45) Isopalhinine A, a unique pentacyclic Lycopodium alkaloid from Palhinhaea cernua , Organic Letters, 2013, 通讯作者
(46) Discovery and structure-activity relationships of ent-Kaurene diterpenoids as potent and selective 11β-HSD1 inhibitors: Potential impact in diabetes, European Journal of Medicinal Chemistry, 2013, 通讯作者
(47) Further lignans from Saururus chinensis , Planta Medica, 2013, 通讯作者
(48) Casuarines A and B, Lycopodium alkaloids from Lycopodium casuarinoides , Tetrahedron Letters, 2013, 通讯作者
(49)  Diterpenoids from the twigs and leaves of Fokienia hodginsii, Jounal of Natural Products, 2013, 通讯作者
(50)  Triterpenoids and steroids with cytotoxic activity from Emmenopterys henryi, Planta Medica, 2013, 通讯作者
(51) Cheliensisin A Inhibits EGF-Induced Cell Transformation with Stabilization of p53 Protein Via a Hydrogen Peroxide/Chk1- Q2 Dependent Axis, Cancer Prevention Research, 2013, 通讯作者
(52) Dual-functional abeo-taxane derivatives destabilizing microtubule equilibrium and inhibiting NF-κB activation,  Journal of Medicinal Chemistry, 2013, 通讯作者
(53) Lycopalhine A, a novel sterically congested Lycopodium alkaloid with an unprecedented skeleton from Palhinhaea cernuaw,  Chemical Communications, 2012, 通讯作者
(54) Pseudoferic acids A-C, three novel triterpenoids from the root barks of Pseudolarix kaempferi, Tetrahedron Letters, 2012, 通讯作者
(55) Development of novel comformation-constrained cytotoxi derivatives of cheliensisin A by embedment of small heterocycles, European Journal of Medicinal Chemistry, 2011, 通讯作者
(56) dment of small heterocycles European Journal of Medicinal Chemistry,  Tetrahedron Letters, 2011, 通讯作者
(57) ragmentations of 13-oxo-taxyunnansin A and their application to preparation of abeo-paclitaxel and abeo-docetaxel analogues, Tetrahedron Letters , 2011, 通讯作者
(58) Macrophyllionium and Macrophyllines A and B, Oxindole Alkaloids from Uncaria macrophylla, Journal of Natural Products, 2011, 通讯作者
(59) Three New Clerodane Diterpenoids from Salvia splendens, Helvetica Chimica Acta, 2011, 通讯作者
(60) Terpenoids and Norlignans from Metasequoia glyptostroboides, Journal of Natural Products, 2011, 通讯作者
(61) Triterpenoids and Diterpenoids from Viburnum chingii, Chemical Pharmaceutical Bulletin , 2011, 通讯作者
(62)  Diterpenoid constituents of the roots of Salvia digitaloides , Journal of Agricultural and Food Chemistry, 2010, 通讯作者
(63) Diterpenoid Constituents of the Roots of Salvia digitaloides, Journal of Agricultural and Food Chemistry , 2010, 通讯作者
(64) Terpenoids from Salvia trijuga,  Journal of Natural Products, 2010, 通讯作者
(65) Castanolide and epi-castanolide, two novel diterpenoids with a unique seco-norabietane skeleton from Salvia castanea Diels f. pubescens Stib, Tetrahedron Letters , 2010, 通讯作者
(66) Polycyclic Polyprenylated Acylphloroglucinols and Chromone O-Glucosides from Hypericum henryi subsp uraloides, Chemistry Biodiversity , 2010, 通讯作者
(67)  Lycojapodine A, a Novel Alkaloid from Lycopodium japonicum, Organic Letters, 2009, 通讯作者
(68) Synthesis, cytotoxic activity, and SAR analysis of the derivatives of taxchinin A and brevifoliol, Bioorganic Medicinal Chemistry, 2008, 通讯作者
(69)  Isolation, structural elucidation, and chemical transformation of interconvertible 8,12-hemiketal germacranolide sesquiterpenoids from Salvia castanea Diels f. tomentosa Stib, Tetrahedron, 2008, 通讯作者
(70) Synthesis and cytotoxicity of some new eriocalyxin B derivatives, European Journal of Medicinal Chemistry, 2007, 通讯作者
(71) Przewalskin B, a novel diterpenoid with an unprecedented skeleton from Salvia przewalskii maxim, Organic Letters, 2007, 通讯作者
(72) Synthesis and cytotoxicity of some new eriocalyxin B derivatives, European Journal of Medicinal Chemistry, 2007, 通讯作者
(73) Tetranorclerodanes and clerodane-type diterpene glycosides from Dicranopteris dichotoma, Journal of Natural Products, 2007, 通讯作者
(74) Two new abietane diterpenoids from Salvia yunnanensis, Planta Medica, 2006, 通讯作者
(75) Taxoids from Taxus chinensis, Jouranl of Natural Products, 2006, 通讯作者
(76)  Dichotomains A and B: Two new highly oxygenated phenolic derivatives from Dicranopteris dichotoma, Organic Letters , 2006, 通讯作者
(77) Przewalskin A: A new C-23 terpenoid with a 6/6/7 carbon ring skeleton from Salvia przewalskii maxim., Organic Letters, 2006, 通讯作者

科研活动

1. 国家重点基础研究发展计划(973计划)“蛋白质配体与资源化合物库的建设 ”(2011CB915503)
2. 国家自然科学基金-云南省联合基金“西南地区特有蕨类植物中先导化合物的发现与作用机制研究”(0919221211)
3. 国家重大科技专项“毛兰属等18种对照品备选原料的研究”(Y0174212D1)
4. 知识创新工程“西部药用植物资源可持续利用研究”(0806321211)
5. 国家自然科学基金“靶向NF-KB通路的迈克尔反应受体小分子探针发现与功能研究”(0801961211)
6. 西部之光,“迈克尔反应受体分子化学生物学研究”,(09226211W1)

科研项目
( 1 ) 国家重点基础研究发展计划(973计划)"蛋白质配体与资源化合物库的建设", 主持, 国家级, 2011-01--2015-12
( 2 ) 国家自然科学基金-云南省联合基金“西南地区特有蕨类植物中先导化合物的发现与作用机制研究”, 主持, 国家级, 2010-01--2014-12
( 3 ) 国家重大科技专项“毛兰属等18种对照品备选原料的研究”, 主持, 国家级, 2010-01--2011-12
( 4 ) 国家自然科学基金“靶向NF-KB通路的迈克尔反应受体小分子探针发现与功能研究”, 主持, 国家级, 2009-01--2011-12
( 5 ) 西部之光,“迈克尔反应受体分子化学生物学研究”, 主持, 部委级, 2010-01--2011-12
( 6 ) 中国特有植物和微生物药用活性物质的基础研究, 参与, 国家级, 2009-07--2013-12
( 7 ) 抑制11β-羟化类固醇脱氢酶1天然产物活性成分结构优化与成药性研究, 主持, 国家级, 2016-01--2019-12
( 8 ) 治疗心血管疾病药物研究与开发, 主持, 省级, 2018-01--2020-12
参与会议
(1)Phytochemical Study on Plants Distributed in Southwest of China   第三届中泰天然产物与药物发现双边学术研讨会   赵勤实   2010-08-18
(2)药用蕨类植物化学研究   赵勤实   2009-08-04

指导学生

已指导学生

赵昱  博士研究生  071001-植物学  

张鹏涛  硕士研究生  100701-药物化学  

李晓莉  博士研究生  071001-植物学  

郭娜  硕士研究生  100701-药物化学  

陈宣钦  博士研究生  071001-植物学  

李明明  硕士研究生  100701-药物化学  

潘争红  博士研究生  100701-药物化学  

胡疆  博士研究生  100701-药物化学  

王扣  博士研究生  100701-药物化学  

何隽  博士研究生  100701-药物化学  

夏志华  博士研究生  071001-植物学  

吴兴德  博士研究生  100701-药物化学  

程锦堂  硕士研究生  077901-药物化学  

邓旭  博士研究生  100701-药物化学  

张雪媛  硕士研究生  077901-药物化学  

邵立东  博士研究生  100701-药物化学  

董廖斌  博士研究生  100701-药物化学  

刘菲  硕士研究生  077901-药物化学  

范敏  硕士研究生  077901-药物化学  

高秀  博士研究生  100701-药物化学  

姜薇薇  博士研究生  100701-药物化学  

徐君  博士研究生  100701-药物化学  

任健  博士研究生  100701-药物化学  

刘宇晨  博士研究生  100701-药物化学  

现指导学生

石鑫  博士研究生  100701-药物化学  

朱煜  硕士研究生  078001-药物化学  

祁艳艳  硕士研究生  078001-药物化学  

张治军  博士研究生  100701-药物化学  

范敏  博士研究生  100701-药物化学  

李来伟  博士研究生  100701-药物化学  

毕冉  硕士研究生  078001-药物化学  

邓振涛  博士研究生  100701-药物化学  

朱勤凤  博士研究生  100701-药物化学  

蒋帅  硕士研究生  078001-药物化学  

杨坤  硕士研究生  105500-药学