基本信息
赵强 男 博导 生态环境研究中心
电子邮件:qiangzhao@rcees.ac.cn 
通信地址:中国科学院生态环境研究中心环境化学与生态毒理学国家重点实验室
邮政编码: 100085

研究领域

化学和生物分析与传感,新型分析分离方法发展和应用,环境和健康相关分子的检测和识别传感,新型亲和配体的分析传感应用,纳米材料的分析检测应用

教育背景

2000-09--2005-07 北京大学化学与分子工程学院 理学博士
1996-09--2000-07 北京大学化学与分子工程学院 理学学士

工作经历

2005.7-2009.7 加拿大阿尔伯塔大学 博士后
2009.9-2014.7 山西大学  教授
2014.7-至今  中国科学院生态环境研究中心环境化学和生态毒理学国家重点实验室  研究员

出版信息

   
发表论文
(1) An Immunoassay for Ochratoxin A Using Tetramethylrhodamine Labeled Ochratoxin A as a Probe Based on Binding Induced Fluorescence Change, Analyst, 2020, 通讯作者
(2) A sensitive thrombin-linked sandwich immunoassay for protein targets using high affinity phosphorodithioate modified aptamer for thrombin labeling, Talanta, 2020, 通讯作者
(3) A Competitive Electrochemical Aptamer-Based Method for Aflatoxin B1 Detection with Signal-off Response, Analytical Methods, 2020, 通讯作者
(4) A signal-on electrochemical aptasensor for rapid detection of aflatoxin B1 based on competition with complementary DNA, Biosensors Bioelectronics, 2019, 通讯作者
(5) A Competitive Thrombin-Linked Aptamer Assay for Small Molecule, Aflatoxin B1, Analytical Bioanalytical Chemistry, 2019, 通讯作者
(6) Fluorometric Determination of Aflatoxin B1 Using a Labeled Aptamer and Gold Nanoparticles Modified with a Complementary Sequence Acting as a Quencher, Microchimica Acta, 2019, 通讯作者
(7) Aptamer-Structure Switch Coupled with Horseradish Peroxidase Labeling on a Microplate for the Sensitive Detection of Small Molecules, Analytical Chemistry, 2019, 通讯作者
(8) Nucleic Acid Aptamers Improving Fluorescence Anisotropy and Fluorescence Polarization Assays for Small Molecules, Trends in Analytical Chemistry, 2019, 第 1 作者
(9) Aptamer Structure Switch Fluorescence Anisotropy Assay for Small Molecules Using Streptavidin as an Effective Signal Amplifier Based on Proximity Effect, Analytical Chemistry, 2019, 通讯作者
(10) A Simple Aptamer Molecular Beacon Assay for Rapid Detection of Aflatoxin B1, Chinese Chemical Letter, 2019, 通讯作者
(11) An Aptamer Assay for Aflatoxin B1 Detection Using Mg2+ Mediated Free Zone Capillary Electrophoresis Coupled with Laser Induced Fluorescence, Talanta, 2019, 通讯作者
(12) Affinity Interactions by Capillary Electrophoresis: Binding, Separation, and Detection,, Analytical Chemistry, 2019, 第 2 作者
(13) A Simple Fluorescent Aptamer Based Assay Coupled with Fluorescence Scanning Capillary Array for Aflatoxin B1, Analyst, 2018, 通讯作者
(14) Direct Fluorescence Anisotropy Approach for Aflatoxin B1 Detection and Affinity Binding Study by Using Single Tetramethylrhodamine Labeled Aptamer, Talanta, 2018, 通讯作者
(15) Development of Aptamer Fluorescent Switch Assay for Aflatoxin B1 by Using Fluorescein-Labeled Aptamer and Black Hole Quencher 1-Labeled Complementary DNA, Analytical Bioanalytical Chemistry, 2018, 通讯作者
(16) Competitive Horseradish Peroxidase-Linked Aptamer Assay for Sensitive Detection of Aflatoxin B1, Talanta, 2018, 通讯作者
(17) Crystal structures of thrombin in complex with chemically modified thrombin DNA aptamers reveal the origins of enhanced affinity, Nucleic Acids Research, 2018, 第 4 作者
(18) Aptamer based surface plasmon resonance sensor for aflatoxin B1, Microchimica Acta, 2017, 通讯作者
(19) Rapid Fluorescence Detection of Immunoglobulin E Using an Aptamer Switch Based on Binding-Induced Pyrene Excimer, Analytical Methods, 2017, 通讯作者
(20) Enhancing the Affinity of Anti-Human α-Thrombin 15-mer DNA Aptamer and Anti-Immunoglobulin E Aptamer by PolyT Extension, Analytical Chemistry, 2017, 通讯作者
(21) Investigation of Effects of Metal Ions in Sample Buffer on Capillary Electrophoresis Coupled with Laser-Induced Fluorescence Analysis of Thrombin Using Dye-Labeled 29-mer DNA Aptamer,, Analytical Methods, 2017, 通讯作者
(22) Detection of Human Neutrophil Elastase by Aptamer Affinity Capillary Electrophoresis Coupled with Laser-induced Fluorescence Using Specified Site Fluorescently Labeled Aptamer, Analytical Bioanalytical Chemistry, 2017, 通讯作者
(23) Direct fluorescence anisotropy assay for cocaine using tetramethylrhodamine-labeled aptamer, Analytical Bioanalytical Chemistry, 2017, 通讯作者
(24) Competitive fluorescence anisotropy polarization assay for ATP using aptamer as affinity ligand and dye-labeled ATP as fluorescence tracer, Talanta, 2017, 通讯作者
(25) Microplate based assay for thrombin detection using an RNA aptamer as aff inity ligand and cleavage of a chromogenicor a fluorogenic peptide substrate, Microchimica Acta, 2016, 通讯作者
(26) Fluorescence anisotropy assay for D-vasopressin with a tetramethylrhodamine-labeled aptamer, Analytical Methods, 2016, 通讯作者
(27) Using fluoro modified RNA aptamers as affinity ligands on magnetic beads for sensitive thrombin detection through affinity capture and thrombin catalysis, Analytical Methods, 2016, 通讯作者
(28) Thrombin-Linked Aptamer Assay for Detection of Platelet Derived Growth Factor BB on Magnetic Beads In a Sandwich Format, Talanta, 2016, 通讯作者
(29) An aptamer assay using rolling circle amplification coupled with thrombin catalysis for protein detection, Analytical Bioanalytical Chemistry, 2016, 通讯作者
(30) Determination of the platelet-derived growth factor BB by a competitive thrombin-linked aptamer-based fluorometric assay, Microchimica Acta, 2016, 通讯作者
(31) Affinity capillary electrophoresis with laser induced fluorescence detection for thrombin analysis using nuclease resistant RNA aptamers, Journal of Chromatography A, 2016, 通讯作者
(32) Nanoparticles-Free Fluorescence Anisotropy Amplification Assay for Detection of RNA Nucleotide-Cleaving DNAzyme Activity, Analytical Chemistry, 2015, 第 3 作者
(33) A fluorescein labeled aptamer switch for thrombin with fluorescence decrease response, Analytical Methods, 2015, 通讯作者
(34) Aptamer fluorescence anisotropy sensors for adenosine triphosphate by comprehensive screening tetramethylrhodamine labeled nucleotides, Biosensors Bioelectronics, 2015, 通讯作者
(35) Aptamer and rolling circle amplification-involved sandwich assay for platelet-derived growth factor BB with absorbance analysis, Analytical Methods, 2015, 通讯作者
(36) Sensitive and selective detection of thrombin by using a cyclic peptide as affinity ligand, Biosensors Bioelectronics, 2015, 通讯作者
(37) Identification of allosteric nucleotide sites of tetramethylrhodamine-labeled aptamer for noncompetitive aptamer-based fluorescence anisotropy detection of a small molecule, ochratoxin A, Analytical Chemistry, 2014, 第 1 作者
(38) An affinity capture involved enzymatic assay for thrombin by using peptide aptamers as affinity ligands on magnetic beads, Chemical Communications, 2013, 第 1 作者
(39) Detection of thrombin using excimer aptamer switch labeled with dual pyrene molecules, Analytical Bioanalytical Chemistry, 2013, 第 1 作者
(40) Fluorescent sensing cchratoxin A with single fluorophore labeled aptamer, Analytical Biaoanalytical Chemistry, 2013, 第 1 作者
(41) Screening interaction between ochratoxin A and aptamers by fluorescence anisotropy approach, Analytical Bioanalytical Chemistry, 2013, 通讯作者
(42) Fluorogenic assays for activated protein C using aptamer-modified magnetic beads, Microchimica Acta, 2013, 第 1 作者
(43) Aptamer-capture based assays for human neutrophil elastase, Talanta, 2013, 第 1 作者
(44) Fluorescence anisotropy reduction of allosteric aptamer for sensitive and specific protein signaling, Analytical Chemistry, 2012, 第 2 作者
(45) Applications of aptamer affinity chromatography, Trends in Analytical Chemistry, 2012, 第 1 作者
(46) A fluorescent sandwich assay for thrombin using aptamer modified magnetic beads and quantum dots, Microchimica Acta, 2012, 第 2 作者
(47) An Aptamer-capture based chromogenic assay for thrombin, Biosensors Bioelectronics, 2012, 第 1 作者
(48) Aptamer capturing of enzymes on magnetic beads to enhance assay specificity and sensitivity, Analytical Chemistry, 2011, 第 1 作者
(49) Electrochemical sensor for ultrasensitive determination of doxorubicin and methotrexate based on cyclodextrin-graphene hybrid nanosheets, Electroanalysis, 2011, 第 3 作者
(50) Detection of Escherichia coli O157:H7 using gold nanoparticle labeling and inductively coupled plasma-mass spectrometry, Analytical Chemistry, 2010, 第 2 作者

科研活动

   
科研项目
(1) 国家自然科学基金重点项目,参与,国家级,2015-01--2019-12
(2) 国家自然科学基金委优秀青年基金,主持,国家级,2013-01--2015-12
(3) 山西省青年拔尖人才支持计划项目,主持,省级,2013-01--2015-12
(4) 核酸适配体在环境分析检测中的应用,主持,部委级,2012-01--2015-12