基本信息

王鹏元  男  博导  中国科学院深圳先进技术研究院
电子邮件: py.wang@siat.ac.cn
通信地址: 深圳市南山区西丽深圳大学城学苑大道1068号
邮政编码: 518055

部门/实验室:医药所

研究领域

1.干细胞分化(Stem Cell Differentiation)

2.细胞体外模型(In Vitro Modeling and Organoids)

3.生物材料界面 (Biomaterials and Biointerfaces)

4.纳米颗粒制备与自组装 (Nanoparticle and Self-Assembly)

5.表面微纳结构制备与改质 (Nanotopography and Biografting)


招生信息

本实验室专注于体外仿生材料与微环境的构建,利用先进材料与生物工程技术,在体外定向分化干细胞与构建类器官,用于再生医学与精准医疗。

欢迎具有生物、工程、材料等背景的优秀学生加入本实验室。

在读期间,有文章发表者,将优先推荐读博。表现优异者可进行学术交流,包含澳大利亚、美国、香港、日本、台湾。

本课题组四大方向:

1. 干细胞与再生医学

2. 肿瘤细胞与药物学

3. 生物工程

4. 生物材料



招生专业
083100-生物医学工程
081701-化学工程
0710J6-再生医学
招生方向
生物工程与生物介面
干细胞分化与重编程
生医材料与表面修饰

教育背景

2006-09--2011-07   台湾大学化学工程研究所   化学工程博士
2004-09--2006-07   台湾大学化学工程研究所   化学工程硕士
2000-09--2004-07   台北科技大学   化学工程学士

工作经历

   
工作简历
2018-08~现在, 中科院深圳先进技术研究院医药所 人体组织与器官退行性研究中心, 研究员
2016-09~2018-07,台北医科大学纳米医学与医学工程研究所, 助理教授
2012-06~2018-06,Swinburne University of Technology, 讲师
2011-09~2012-06,台湾大学化学工程研究所, 迈顶计划博士后

教授课程

表面工程专论;纳米科技,生医工程导论;纳米科技在生医的应用
纳米制造技术,化学实验,研究技巧

专利与奖励

   
奖励信息
(1) 第十三批国家“****”青年项目, , 国家级, 2017
(2) 维多利亚州政府学者奖 (Veski Victoria Fellowship), , 省级, 2017
(3) 斯威本理工大学学者交流奖学金 (Visiting Fellowship Scheme), , 研究所(学校), 2016
(4) 澳大利亚杰出青年 (Discovery Early Career Researcher Award Fellowship), , 国家级, 2015
(5) 中澳青年学者交流计划 (Australia-China Young Scientists Exchange Program), , 国家级, 2015
(6) 斯威本理工大学副校长奖 (Vice-Chancellor’s Research Excellence Award (Early Career)), , 研究所(学校), 2015
专利成果
( 1 ) 生物制品的制作方法、生物制品和应用, 发明, 2019, 第 1 作者, 专利号: PA18073056
( 2 ) 材料的表面改性方法及其改性后的材料和应用、医疗产品, 发明, 2019, 第 1 作者, 专利号: PA18073055
( 3 ) 膜以及使用其培养和分化细胞的方法, 发明, 2019, 第 1 作者, 专利号: PO19008475

出版信息

   
发表论文
(1) Binary colloidal crystals (BCCs) drive spheroid formation and accelerate maturation of human induced pluripotent stem cells-derived cardiomyocytes, ACS Appl Mater Inter, 2019, 通讯作者
(2) A fibrous hybrid patch couples cell-derived matrix and poly (L-lactide-co-caprolactone) for endothelial cells delivery and skin wound repair, ACS Biomaterials Science & Engineering, 2019, 第 4 作者
(3) Binary colloidal crystals (BCCs): Interactions, fabrication, and applications, Advances in Colloid and Interface Science, 2018, 通讯作者
(4) The influence of PEG-thiol derivatives on controlling cellular and bacterial interactions with gold surfaces, Applied Surface Science, 2018, 通讯作者
(5) Controlled attachment of pseudomonas aeruginosa with binary colloidal crystal based topographies, Small, 2018, 通讯作者
(6) Binary colloidal crystal layers as platforms for surface patterning of puroindoline-based antimicrobial peptides, ACS Appl Mater Inter, 2018, 第 3 作者
(7) Topographical modulation of pluripotency and differentiation of human embryonic stem cells, IEEE Transactions on Nanotechnology., 2017, 通讯作者
(8) Fibroblast responses toward colloidal assembles and plasma polymer coating, IEEE Transactions on Nanotechnology., 2017, 第 1 作者
(9) Modulation of PEI-mediated gene transfection through controlling cytoskeleton organization and nuclear morphology via nanogrooved topographies, ACS Biomaterials Science & Engineering, 2017, 第 1 作者
(10) Heterogeneity of mesenchymal and pluripotent stem cell populations grown on nanogrooves and nanopillars, J Mater Chem B, 2017, 通讯作者
(11) Tuning the Density of Poly(ethylene glycol) Chains to Control Mammalian Cell and Bacterial Attachment, Polymers, 2017, 通讯作者
(12) Modulation of human mesenchymal and pluripotent stem cell behaviour using biophysical and biochemical cues: a review, Biotechnol Bioeng, 2017, 通讯作者
(13) Binary colloidal crystals (BCCs) as a feeder-free system to generate human induced pluripotent stem cells (hiPSCs), Sci Rep, 2016, 通讯作者
(14) Modulation of human multipotent and pluripotent stem cells using surface nanotopographies and surface-immobilised bioactive signals: a review, Acta Biomater, 2016, 通讯作者
(15) A novel approach to quantitatively assess the uniformity of binary colloidal crystal assemblies, Crystals, 2016, 第 3 作者
(16) Enhanced attachment of human mesenchymal stem cells on nanograined titania surfaces, RSC Adv, 2016, 第 1 作者
(17) Rapid self-assembly of shaped microtiles into large, close-packed crystalline monolayers on solid surfaces, Small, 2016, 第 1 作者
(18) Stimulation of early osteochondral differentiation of human mesenchymal stem cells using binary colloidal crystals (BCCs), ACS Appl Mater Inter, 2016, 通讯作者
(19) Self-assembled binary colloidal crystal layers as cell culture substrates, J Mater Chem B, 2015, 第 1 作者
(20) Screening rat mesenchymal stem cell attachment and differentiation on surface chemistries using plasma polymer gradients, Acta Biomater, 2015, 第 1 作者
(21) Response of MG63 osteoblast-like cells to ordered nanotopographies fabricated using colloidal self-assembly and glancing angle deposition, Biointerphases, 2015, 第 1 作者
(22) Colloidal crystal based plasma polymer patterning to control Pseudomonas aeruginosa attachment to surfaces, Biointerphases, 2015, 第 2 作者
(23) Guiding the dewetting of thin polymer films by colloidal imprinting, Adv Mater Interfaces, 2015, 第 2 作者
(24) Modulation of human mesenchymal stem cell behaviour on ordered tantalum nanotopographies fabricated by colloidal lithography and glancing angle deposition, ACS Appl Mater Inter, 2015, 第 1 作者
发表著作
(1) Stem cell response to surface micro- and nano topography” Stem Cell Nanoengineering, Wiley-Blackwell, 2015-03, 第 1 作者
(2) Manufacture of chemically modified antibacterial surfaces, Springer, 2015-11, 第 2 作者
(3) New Combination/Application of Polymer-based Nanoparticles for Biomedical Fields, Springer, 2018-06, 第 2 作者

科研活动

   
科研项目
( 1 ) ****项目, 主持, 国家级, 2017-07--2020-07
参与会议
(1)Controlling mammalian cell and bacterial attachment by varying the density of poly(ethylene glycol) brush   2018-09-22
(2)Harnessing Surface Nanotopographies to Influence Stem Cell Fate   2018-07-05
(3)Modulation Of A549 Lung Cancer Cell Behaviour Using Nanotopography   2018-04-26
(4)Functional Improvement Of Human Induced Pluripotent Stem Cell-derived Cardiomyocytes Using Nanotopography   2018-04-03
(5)Modulation of human stem cell behaviour using binary colloidal crystals   2018-01-15
(6)Modulation of Stem Cell Behavior using Monolayer Binary Colloidal Crystals   2017-12-01
(7)Modulation of Stem Cell Behavior using Monolayer Binary Colloidal Crystals   2017-08-22
(8)Modulation of human stem cell behaviour using binary colloidal crystals   2017-07-10
(9)Modulation of stem cell behaviour using binary colloidal crystals with complex surface topography and chemistry   2016-10-20
(10)“Modulation of stem cell behaviour using binary colloidal crystals”   2016-08-26
(11)Modulation of stem cell behaviour using complex surface properties   2015-09-22
(12)Modulation of mesenchymal and pluripotent stem cell behaviour using ordered surface topographies and chemistries using binary colloidal crystals   2015-04-07
(13)Modulation of human mesenchymal stem cell behaviour using highly ordered surface topographies   2014-05-10
(14)Modulation of cell behaviours using self-assembled colloidal crystals   2013-10-11
(15)Modulation of cell behaviours using self-assembled colloidal crystals   2013-07-20
(16)Alignment and Differentiation of Skeleton Myoblasts on PLGA Membrane with Submicron Ridges/Grooves Topography and RGD/YIGSR Peptide   2013-07-09
(17)Modulation of cell behaviours using self-assembled colloidal crystals   2013-04-17
(18)Alignment and Differentiation of Skeletal Myoblasts on PLGA Patch with Submicron Ridges/Grooves Topography and RGD/YIGSR Peptide   2012-05-07
(19)Osteogenesis, adipogenesis, and myogenesis of rat mesenchymal stem cells on the nanogrooved surfaces   2011-09-20
(20)“Osteogenesis, adipogenesis, and myogenesis of rat mesenchymal stem cells on the nano/submicron grooved surfaces   2011-07-20
(21)Mesenchymal Stem Cell Differentiation on Laterally Graded Porous Silicon with Submicron Pore Sizes   2010-05-10
(22)Interactive effects of surface topography and substrate elasticity on orientation and beating of neonatal rat cardiomyocytes   2010-04-15
(23)Stiffness gradient polydimethylsiloxane (PDMS) for mesenchymal stem cell culture and differentiation   2010-03-09
(24)Alignment and differentiation of skeletal myoblasts on submicron grooved surface   2009-08-23
(25)“The influences of nano-groove/ridge surfaces on the alignment and differentiation of skeletal myoblasts   2009-05-21
(26)“The influence of scaffold properties and dynamic compression on articular cartilage tissue engineering   2008-07-12
(27)The effect of dynamic mechanical compression on articular cartilage tissue engineering   2007-04-10

合作情况

   
项目协作单位
   

指导学生