General

Yun-Jia Ning

Ph.D, Associate Professor
State Key Laboratory of Virology
Wuhan Institute of Virology
Chinese Academy of Sciences
Xiaohongshan No. 44, WuChang district, Wuhan city 430071, P.R. China

Research Areas

Virology

virus replication

virus-host interactions

pathogenesis

antiviral drugs/vaccines


Cell biology

JAK-STAT signaling

inflammation

Education

2008-09--2015-06   Wuhan Institute of Virology, CAS   PhD
2004-09--2008-06   Qingdao University of Science & Technology   BA


Experience

   
Work Experience
2017-08~    , Wuhan Institute of Virology, Associate Professor
2015-07~2017-07, Wuhan Institute of Virology, Assistant Professor


Publications

   
Papers

(1) Heartland virus antagonizes type I and III interferon antiviral signaling by inhibiting phosphorylation and nuclear translocation of STAT2 and STAT1, Journal of Biological Chemistry, 2019, Corresponding Author
(2) Interferon-gamma-Directed Inhibition of a Novel High-Pathogenic Phlebovirus and Viral Antagonism of the Antiviral Signaling by Targeting STAT1, Frontiers in Immunology, 2019, 1st Author
(3) The major hurdle for effective baculovirus transduction into mammalian cells is passing early endosomes, Journal of Virology, 2019, 3rd Author
(4) Ebola virus mucin-like glycoprotein (Emuc) induces remarkable acute inflammation and tissue injury: evidence for Emuc pathogenicity in vivo, Protein & Cell, 2018, 1st Author
(5) The roles of ebolavirus glycoproteins in viral pathogenesis, Virologica Sinica, 2017, 1st Author
(6) Heartland virus NSs protein disrupts host defenses by blocking the TBK1 kinase-IRF3 transcription factor interaction and signaling required for interferon induction, Journal of Biological Chemistry, 2017, 1st Author
(7) A novel glycoprotein D-specific monoclonal antibody neutralizes herpes simplex virus, Antiviral Research, 2017, 7th Author
(8) Disruption of type I interferon signaling by the nonstructural protein of severe fever with thrombocytopenia syndrome virus via the hijacking of STAT2 and STAT1 into inclusion bodies, Journal of Virology, 2015, 1st Author

(9) Viral suppression of innate immunity via spatial isolation of TBK1/IKKepsilon from mitochondrial antiviral platform, Journal of Molecular Cell Biology, 2014, 1st Author

(10) Guertu virus NSs protein disrupts host defense by blocking antiviral interferon induction and action, ACS infectious diseases, 2020, Corresponding Author

(11) Combinatorial Minigenome Systems for Emerging Banyangviruses Reveal Viral Reassortment Potential and Importance of a Protruding Nucleotide in Genome “Panhandle” for Promoter Activity and Reassortment, Frontiers in Microbiology, 2020, Corresponding Author
(12) A RIG-I-like Receptor Directs Antiviral Responses to a Bunyavirus and Is Antagonized by Virus-Induced Blockade of TRIM25-mediated Ubiquitination, Journal of Biological Chemistry, 2020, Corresponding Author