病毒学

病毒复制机制

病毒-宿主互作

病毒致病机理

抗病毒药物、疫苗

细胞生物学

JAK-STAT信号转导

炎症反应

   

071005-微生物学
071010-生物化学与分子生物学
100102-免疫学

病毒与宿主相互作用、免疫响应
新发病毒感染与致病机理
抗病毒药物、疫苗研究

2008-09--2015-06   中国科学院武汉病毒研究所   理学博士学位(PhD)

2023-09~现在, 中国科学院武汉病毒研究所, 研究员(Full Professor)
2021-09~2023-08,中国科学院武汉病毒研究所, 青年研究员(Special-term Professor)
2017-08~2021-09,中国科学院武汉病毒研究所, 副研究员(Associate Professor)
2015-07~2017-07,中国科学院武汉病毒研究所, 助理研究员(Assistant Professor)

2023-03-30-今,湖北合成生物学会, 会员
2022-07-01-今,江夏实验室, 兼职研究员
2021-05-01-今,湖北省生物工程学会, 会员
2020-01-01-今,中国科学院青年创新促进会, 会员

疫情期间研究生线上“科研达人论坛”
实验技术讲座-细胞培养
孙思邈论坛第二十九讲-讲评
东湖学术论坛暨第七届全国病毒学研究生论坛-讲评

   

（1） Outstanding Paper 2022, 其他, 2023
（2） 中国科学院武汉病毒研究所优秀青年科研骨干, 研究所（学校）, 2020
（3） 中国科学院青年创新促进会成员, 部委级, 2019
（4） 中国科学院武汉病毒研究所优秀青年科研骨干, 研究所（学校）, 2019
（5） 病毒学国家重点实验室优秀青年骨干, 其他, 2017
（6） 湖北省优秀博士学位论文奖, , 其他, 2017
（7） 湖北省优秀自然科学论文奖, , 其他, 2016
（8） 北京市高校优秀毕业生, 研究所（学校）, 2015
（9） 中国科学院优秀毕业生, 其他, 2015
（10） 中国科学院院长奖, , 其他, 2015

[1] 闵远琴, 张存环, 孙修炼, 宁云佳, 类承凤, 胡葭. 一种靶向病毒-宿主互作的抗病毒多肽及应用. CN: CN116478301A, 2023-07-25.

[2] 宁云佳, 张优, 王华林, 邓菲. 吡咯烷二硫代甲酸铵盐的新的应用. CN: CN114306326A, 2022-04-12.

[1] 宁云佳. Pathogenesis and virulence of Heartland virus. Virulence[J]. 2024, [2] Chang, Meng, Min, YuanQin, Xu, Zhao, Deng, Fei, Wang, Hualin, Ning, YunJia. Host factor MxA restricts Dabie bandavirus infection by targeting the viral NP protein to inhibit NP-RdRp interaction and ribonucleoprotein activity. JOURNAL OF VIROLOGY. 2023, 98(1): http://dx.doi.org/10.1128/jvi.01568-23.
[3] Feng, Kuan, Zhang, Huijiao, Jiang, Zhenyu, Zhou, Min, Min, YuanQin, Deng, Fei, Li, Peiqing, Wang, Hualin, Ning, YunJia. SFTS bunyavirus NSs protein sequestrates mTOR into inclusion bodies and deregulates mTOR-ULK1 signaling, provoking pro-viral autophagy. JOURNAL OF MEDICAL VIROLOGY[J]. 2023, 95(1): [4] Min, YuanQin, Huang, Mengzhuo, Feng, Kuan, Yajie Jia, Xiulian Sun, Ning, YunJia. A new cellular interactome of SARS-CoV-2 nucleocapsid protein and its biological implications. MOLECULAR & CELLULAR PROTEOMICS[J]. 2023, https://www.sciencedirect.com/science/article/pii/S1535947623000907?via%3Dihub.
[5] Dai, Shiyu, Min, YuanQin, Li, Qi, Feng, Kuan, Jiang, Zhenyu, Wang, Zhiying, Zhang, Cunhuan, Ren, Fuli, Fang, Yaohui, Zhang, Jingyuan, Zhu, Qiong, Wang, Manli, Wang, Hualin, Deng, Fei, Ning, YunJia. Interactome profiling of Crimean-Congo hemorrhagic fever virus glycoproteins. NATURE COMMUNICATIONS[J]. 2023, 14(1): http://dx.doi.org/10.1038/s41467-023-43206-1.
[6] LiFen Hu, YunJia Ning, JiaBin Li. Editorial: Severe fever with thrombocytopenia syndrome. FRONTIERS IN MICROBIOLOGY[J]. 2023, 14: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10509281/.
[7] 宁云佳. SARS-CoV-2 NSP13 interacts with host IRF3, blocking antiviral immune responses. J Med Virol[J]. 2023, [8] Qiong Mo, Kuan Feng, Shiyu Dai, Qiaoli Wu, Zhong Zhang, Ashaq Ali, Fei Deng, Hualin Wang, YunJia Ning. Transcriptome profiling highlights regulated biological processes and type III interferon antiviral responses upon Crimean-Congo hemorrhagic fever virus infection. VIROLOGICA SINICA[J]. 2023, 38(1): 34-46, http://dx.doi.org/10.1016/j.virs.2022.09.002.
[9] Jiawen Sun, YuanQin Min, Yunjie Li, Xiulian Sun, Fei Deng, Hualin Wang, Ning, Yun-Jia. Animal Model of Severe Fever With Thrombocytopenia Syndrome Virus Infection. FRONTIERS IN MICROBIOLOGY[J]. 2022, 12: [10] Ni, Longquan, Li, Yi, Wu, Ke, Deng, Fei, Wang, Hualin, Ning, YunJia. Antitumor efficacy of CRISPR/Cas9-engineered ICP6 mutant herpes simplex viruses in a mouse xenograft model for lung adenocarcinoma. JOURNAL OF MEDICAL VIROLOGY[J]. 2022, 94(12): 6000-6015, http://dx.doi.org/10.1002/jmv.28069.
[11] Min, YuanQin, Huang, Mengzhuo, Sun, Xiulian, Deng, Fei, Wang, Hualin, Ning, YunJia. Immune evasion of SARS-CoV-2 from interferon antiviral system. COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNALnull. 2021, 19: 4217-4225, https://doaj.org/article/0a1032770b5d4ff19775dd0668ec1292.
[12] Kuan Feng, YuanQin Min, Xiulian Sun, Fei Deng, Peiqing Li, Hualin Wang, YunJia Ning. Interactome profiling reveals interaction of SARS-CoV-2 NSP13 with host factor STAT1 to suppress interferon signaling. JOURNAL OF MOLECULAR CELL BIOLOGY[J]. 2021, [13] Dai, Shiyu, Deng, Fei, Wang, Hualin, Ning, Yunjia. Crimean-Congo Hemorrhagic Fever Virus: Current Advances and Future Prospects of Antiviral Strategies. VIRUSES-BASEL[J]. 2021, 13(7): http://dx.doi.org/10.3390/v13071195.
[14] Ren, Fuli, Shen, Shu, Ning, YunJia, Wang, Qiongya, Dai, Shiyu, Shi, Junming, Zhou, Min, Wang, Hualin, Huang, Chaolin, Zhang, DingYu, Deng, Fei. Non-structural Proteins of Severe Fever With Thrombocytopenia Syndrome Virus Suppress RNA Synthesis in a Transcriptionally Active cDNA-Derived Viral RNA Synthesis System. FRONTIERS IN MICROBIOLOGY[J]. 2021, 12: http://dx.doi.org/10.3389/fmicb.2021.709517.
[15] Fuli Ren, Shu Shen, Qiongya Wang, Gang Wei, Chaolin Huang, Hualin Wang, YunJia Ning, DingYu Zhang, Fei Deng. Recent Advances in Bunyavirus Reverse Genetics Research: Systems Development, Applications, and Future Perspectives. FRONTIERS IN MICROBIOLOGY[J]. 2021, 12: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8689132/.
[16] Haijun Wang, Zili Zhang, Junfen Zhou, Shuqing Han, Zhenyu Kang, Haoyu Chuang, Heng Fan, Hongyang Zhao, Lin Wang, Yunjia Ning, Alexey Sarapultsev, Willis X Li, Jinghong Li, Zhicheng Lin, Shanshan Luo, Nian Xiong, Desheng Hu. Next-Generation Sequencing and Proteomics of Cerebrospinal Fluid From COVID-19 Patients With Neurological Manifestations. FRONTIERS IN IMMUNOLOGY[J]. 2021, 12: [17] Shiyu Dai, Fei Deng, Hualin Wang, Yunjia Ning. Crimean-Congo Hemorrhagic Fever Virus: Current Advances and Future Prospects of Antiviral Strategies. VIRUSES[J]. 2021, 13: https://doaj.org/article/ca3d905a33a34de19d9d00e0aa306990.
[18] Min, YuanQin, Mo, Qiong, Wang, Jun, Deng, Fei, Wang, Hualin, Ning, YunJia. SARS-CoV-2 nsp1: Bioinformatics, Potential Structural and Functional Features, and Implications for Drug/Vaccine Designs. FRONTIERS IN MICROBIOLOGY[J]. 2020, 11: https://doaj.org/article/aeb6d47f471c4fcb8ec25d38057890c9.
[19] Min, YuanQin, Shi, Chen, Yao, Ting, Feng, Kuan, Mo, Qiong, Deng, Fei, Wang, Hualin, Ning, YunJia. The Nonstructural Protein of Guertu Virus Disrupts Host Defenses by Blocking Antiviral Interferon Induction and Action. ACS INFECTIOUS DISEASES[J]. 2020, 6(5): 857-870, https://www.webofscience.com/wos/woscc/full-record/WOS:000535176700010.
[20] Ren, Fuli, Zhou, Min, Deng, Fei, Wang, Hualin, Ning, YunJia. Combinatorial Minigenome Systems for Emerging Banyangviruses Reveal Viral Reassortment Potential and Importance of a Protruding Nucleotide in Genome "Panhandle" for Promoter Activity and Reassortment. FRONTIERS IN MICROBIOLOGY[J]. 2020, 11: https://doaj.org/article/ddaf545c2216480b95ea08d46db39143.
[21] Min Yuan-Qin, Shi，Chen, Yao，Ting, feng kuan, Mo, Qiong, Deng, Fei, Wang, Hualin, Ning, Yun-Jia. Guertu virus NSs protein disrupts host defense by blocking antiviral interferon induction and action. ACS infectious diseases[J]. 2020, [22] Qiong Mo, Zhao Xu, Fei Deng, Hualin Wang, YunJia Ning. Host restriction of emerging high-pathogenic bunyaviruses via MOV10 by targeting viral nucleoprotein and blocking ribonucleoprotein assembly. PLOS PATHOGENS[J]. 2020, 16(12): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7746268/.
[23] YuanQin Min, YunJia Ning, Hualin Wang, Fei Deng. A RIG-I–like receptor directs antiviral responses to a bunyavirus and is antagonized by virus-induced blockade of TRIM25-mediated ubiquitination. THE JOURNAL OF BIOLOGICAL CHEMISTRY. 2020, 295(28): 9691-9711, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7363118/.
[24] Min, YuanQin, Ning, YunJia, Wang, Hualin, Deng, Fei. A RIG-I?like receptor directs antiviral responses to a bunyavirus and is antagonized by virus-induced blockade of TRIM25-mediated ubiquitination. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2020, 295(28): 9691-9711, http://dx.doi.org/10.1074/jbc.RA120.013973.
[25] Ning, YunJia, Mo, Qiong, Feng, Kuan, Min, YuanQin, Li, Mingyue, Hou, Dianhai, Peng, Cheng, Zheng, Xin, Deng, Fei, Hu, Zhihong, Wang, Hualin. Interferon-gamma-Directed Inhibition of a Novel High-Pathogenic Phlebovirus and Viral Antagonism of the Antiviral Signaling by Targeting STAT1. FRONTIERS IN IMMUNOLOGY[J]. 2019, 10: http://dx.doi.org/10.3389/fimmu.2019.01182.
[26] 梅琳达温纳莫耶, 宁云佳, 戴诗雨, 莫琼, 王华林. 疫苗具有“万能”效应？. 环球科学[J]. 2019, 54-61, http://lib.cqvip.com/Qikan/Article/Detail?id=7002346321.
[27] Feng, Kuan, Deng, Fei, Hu, Zhihong, Wang, Hualin, Ning, YunJia. Heartland virus antagonizes type I and III interferon antiviral signaling by inhibiting phosphorylation and nuclear translocation of STAT2 and STAT1. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2019, 294(24): 9503-9517, http://dx.doi.org/10.1074/jbc.RA118.006563.
[28] Kuan Feng, Fei Deng, Zhihong Hu, Hualin Wang, YunJia Ning. Heartland virus antagonizes type I and III interferon antiviral signaling by inhibiting phosphorylation and nuclear translocation of STAT2 and STAT1. THE JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2019, 294(24): 9503-9517, http://dx.doi.org/10.1074/jbc.RA118.006563.
[29] Hu, Liangbo, Li, Yimeng, Ning, YunJia, Deng, Fei, Vlak, Just M, Hu, Zhihong, Wang, Hualin, Wang, Manli. The Major Hurdle for Effective Baculovirus Transduction into Mammalian Cells Is Passing Early Endosomes. JOURNAL OF VIROLOGY[J]. 2019, 93(15): [30] YunJia Ning, Zhenyu Kang, Jingjun Xing, YuanQin Min, Dan Liu, Kuan Feng, Manli Wang, Fei Deng, Yiwu Zhou, Zhihong Hu, Hualin Wang. Ebola virus mucin-like glycoprotein (Emuc) induces remarkable acute inflammation and tissue injury: evidence for Emuc pathogenicity in vivo. PROTEIN & CELL[J]. 2018, 9(4): 389-393, [31] Ning, YunJia, Deng, Fei, Hu, Zhihong, Wang, Hualin. The roles of ebolavirus glycoproteins in viral pathogenesis. VIROLOGICA SINICAnull. 2017, 32(1): 3-15, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=5983330&detailType=1.
[32] Ning, YunJia, Feng, Kuan, Min, YuanQin, Deng, Fei, Hu, Zhihong, Wang, Hualin. Heartland virus NSs protein disrupts host defenses by blocking the TBK1 kinase-IRF3 transcription factor interaction and signaling required for interferon induction. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2017, 292(40): 16722-16733, http://dx.doi.org/10.1074/jbc.M117.805127.
[33] Du, Ruikun, Wang, Lili, Xu, Hao, Wang, Zhiying, Zhang, Tao, Wang, Manli, Ning, Yunjia, Deng, Fei, Hu, Zhihong, Wang, Hualin, Li, Yi. A novel glycoprotein D-specific monoclonal antibody neutralizes herpes simplex virus. ANTIVIRAL RESEARCH[J]. 2017, 147: 131-141, http://www.corc.org.cn/handle/1471x/2373306.
[34] Ning, YunJia, Feng, Kuan, Min, YuanQin, Cao, WuChun, Wang, Manli, Deng, Fei, Hu, Zhihong, Wang, Hualin. Disruption of Type I Interferon Signaling by the Nonstructural Protein of Severe Fever with Thrombocytopenia Syndrome Virus via the Hijacking of STAT2 and STAT1 into Inclusion Bodies. JOURNAL OF VIROLOGY[J]. 2015, 89(8): 4227-4236, https://www.webofscience.com/wos/woscc/full-record/WOS:000352218400018.
[35] 戴维·J·埃克, 宁云佳, 李淑芬, 王曼丽. 搭建流行病探测网络. 环球科学[J]. 2014, 42-47, http://lib.cqvip.com/Qikan/Article/Detail?id=50003225.
[36] Ning, YunJia, Wang, Manli, Deng, Maping, Shen, Shu, Liu, Wei, Cao, WuChun, Deng, Fei, Wang, YanYi, Hu, Zhihong, Wang, Hualin. Viral suppression of innate immunity via spatial isolation of TBK1/IKK epsilon from mitochondrial antiviral platform. JOURNAL OF MOLECULAR CELL BIOLOGY[J]. 2014, 6(4): https://www.webofscience.com/wos/woscc/full-record/WOS:000339916900006.

（1） 搭建流行病探测网络, Germ Catcher, 环球科学杂志出版社, 2014-07, 第 1 作者
（2） 疫苗具有“万能效应”？, Vaccines Reimagined, 环球科学出版社, 2019-07, 第 1 作者

   

（ 1 ） 宿主因子调控新布尼亚病毒复制的功能及机制研究, 负责人, 国家任务, 2019-01--2022-12
（ 2 ） 发热伴血小板减少综合征病毒对抗炎信号的调节机制, 负责人, 国家任务, 2017-01--2019-12
（ 3 ） 病毒转录复制过程关键蛋白质机器的功能及调控机制, 参与, 国家任务, 2018-05--2023-04
（ 4 ） 新发布尼亚病毒调节炎症信号的机制研究, 负责人, 地方任务, 2016-01--2017-12
（ 5 ） 病毒与宿主相互作用的分子机理, 参与, 国家任务, 2017-01--2019-12
（ 6 ） 病毒的免疫逃逸及致病机制研究, 参与, 研究所自主部署, 2016-01--2020-12
（ 7 ） 中科院青年创新促进会项目, 负责人, 中国科学院计划, 2020-01--2023-12
（ 8 ） 国际合作_病毒感染的免疫介导机制：新途径和新挑战, 参与, 国家任务, 2021-03--2023-02
（ 9 ） 细胞因子与布尼亚病毒互作的功能与机制研究, 负责人, 国家任务, 2022-01--2025-12
（ 10 ） 病毒致病机制和干预策略, 参与, 国家任务, 2022-12--2025-11
（ 11 ） 病毒感染与跨种传播机制, 参与, 研究所自主部署, 2023-01--2023-12
（ 12 ） 潜在媒介传播病毒的感染致病及防治, 参与, 国家任务, 2023-12--2026-12

现指导学生

黄梦卓  硕士研究生  086000-生物与医药  

邓薇  硕士研究生  086000-生物与医药